Lista de obras - Gonzalo Gómez-López - Dominio Público Uruguay

A Braf kinase-inactive mutant induces lung adenocarcinoma.

artículo científico publicado en 2017

A comprehensive database for integrated analysis of omics data in autoimmune diseases

artículo científico publicado en 2021

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

scientific article published on September 2016

A unique role of cohesin-SA1 in gene regulation and development

scientific journal article

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets

artículo científico publicado en 2013

ASXL1, TP53 and IKZF3 mutations are present in the chronic phase and blast crisis of chronic myeloid leukemia.

artículo científico publicado en 2013

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

artículo científico publicado en 2022

Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance

artículo científico publicado en 2016

Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma

artículo científico publicado en 2007

Autocrine CCL5 effect mediates trastuzumab resistance by ERK pathway activation in HER2-positive breast cancer

scientific article published on 13 May 2020

Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data

artículo científico publicado en 2021

CARGO: a web portal to integrate customized biological information

artículo científico publicado en 2007

CSF3R T618I co-occurs with mutations of splicing and epigenetic genes and with a new PIM3 truncated fusion gene in chronic neutrophilic leukemia

artículo científico publicado en 2013

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

artículo científico publicado en 2011

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs.

artículo científico publicado en 2012

Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway

artículo científico publicado en 2011

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.

artículo científico publicado en 2016

DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells

artículo científico publicado en 2008

DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers

artículo científico publicado en 2015

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

scientific article published on 04 June 2018

Downregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype.

artículo científico publicado en 2012

Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells.

artículo científico publicado en 2011

Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm

artículo científico publicado en 2013

Expression and functional validation of new p38α transcriptional targets in tumorigenesis

artículo científico publicado en 2011

Functional characterization of E- and P-cadherin in invasive breast cancer cells

artículo científico publicado en 2009

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

artículo científico publicado en 2012

Genome-wide analysis of Pax8 binding provides new insights into thyroid functions

artículo científico publicado en 2012

Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells

artículo científico publicado en 2017

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

artículo científico publicado en 2020

In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome

artículo científico publicado en 2019

In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer

artículo científico publicado en 2018

Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway.

artículo científico publicado en 2011

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

artículo científico publicado en 2014

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

artículo científico publicado en 2016

MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia

scientific article published on 09 December 2019

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

scientific journal article

Mantle cell lymphoma: transcriptional regulation by microRNAs

artículo científico publicado en 2010

Metastatic risk and resistance to BRAF inhibitors in melanoma defined by selective allelic loss of ATG5.

artículo científico publicado en 2016

MicroRNA expression signatures for the prediction of BRCA1/2 mutation-associated hereditary breast cancer in paraffin-embedded formalin-fixed breast tumors

artículo científico publicado en 2014

MicroRNA signatures in B-cell lymphomas.

artículo científico publicado en 2012

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

artículo científico publicado en 2015

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

artículo científico publicado en 2020

Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer

artículo científico publicado en 2010

New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing ⬇️

artículo científico publicado en 2012

PLCG1 mutations in cutaneous T-cell lymphomas

artículo científico publicado en 2014

PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data.

artículo científico publicado en 2018

Pancreas Cancer Precision Treatment Using Avatar Mice from a Bioinformatics Perspective

artículo científico publicado en 2017

Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis

artículo científico publicado en 2015

PathJam: a new service for integrating biological pathway information

scientific article published on 28 October 2010

PileLine: a toolbox to handle genome position information in next-generation sequencing studies ⬇️

artículo científico publicado el 24 de enero de 2011

PileLineGUI: a desktop environment for handling genome position files in next-generation sequencing studies ⬇️

artículo científico publicado el 6 de junio de 2011

Precision medicine needs pioneering clinical bioinformaticians.

artículo científico publicado en 2017

Prediction of miRNA-mRNA Interactions Using miRGate

artículo científico publicado en 2017

Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation

artículo científico publicado en 2015

Programmed cell senescence during mammalian embryonic development

artículo científico publicado en 2013

Pten positively regulates brown adipose function, energy expenditure, and longevity

artículo científico publicado en 2012

RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway

artículo científico publicado en 2014

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

artículo científico publicado en 2021

RAP1 protects from obesity through its extratelomeric role regulating gene expression

artículo científico publicado en 2013

RUbioSeq+: A multiplatform application that executes parallelized pipelines to analyse next-generation sequencing data

artículo científico publicado en 2016

RUbioSeq+: An Application that Executes Parallelized Pipelines to Analyse Next-Generation Sequencing Data

RUbioSeq: a suite of parallelized pipelines to automate exome variation and bisulfite-seq analyses

artículo científico publicado en 2013

Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas

artículo científico publicado en 2010

SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.

artículo científico publicado en 2012

Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation

artículo científico publicado en 2014

Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells

scientific article published on 01 June 2019

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

artículo científico publicado en 2012

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

artículo científico publicado en 2017

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics.

artículo científico publicado en 2016

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

artículo científico publicado en 2009

The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer

scientific article published on 29 April 2020

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

artículo científico publicado en 2018

The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies

artículo científico publicado en 2015

The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications

artículo científico publicado en 2019

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas

artículo científico publicado en 2015

The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development

artículo científico publicado en 2012

The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer

artículo científico publicado en 2012

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK ⬇️

artículo científico publicado el 14 de agosto de 2012

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.

artículo científico publicado en 2018

Transcriptional characteristics of familial non-BRCA1/BRCA2 breast tumors

artículo científico publicado en 2010

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

artículo científico publicado en 2013

Translational disease interpretation with molecular networks.

artículo científico publicado en 2009

Tumor microRNA expression profiling identifies circulating microRNAs for early breast cancer detection

artículo científico publicado en 2015

Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer

artículo científico publicado en 2016

WhichGenes: a web-based tool for gathering, building, storing and exporting gene sets with application in gene set enrichment analysis

artículo científico publicado en 2009

Whole genome analysis of p38 SAPK-mediated gene expression upon stress.

artículo científico publicado en 2010

miRGate: a curated database of human, mouse and rat miRNA-mRNA targets

artículo científico publicado en 2015

miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditary breast tumors

artículo científico publicado en 2014

p21(Cip1) plays a critical role in the physiological adaptation to fasting through activation of PPARα.

artículo científico publicado en 2016

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors

artículo científico publicado en 2018

vulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer

scientific article published on 01 November 2019

Lista de obras de Gonzalo Gómez-López

A Braf kinase-inactive mutant induces lung adenocarcinoma.

A comprehensive database for integrated analysis of omics data in autoimmune diseases

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

A unique role of cohesin-SA1 in gene regulation and development

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets

ASXL1, TP53 and IKZF3 mutations are present in the chronic phase and blast crisis of chronic myeloid leukemia.

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance

Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma

Autocrine CCL5 effect mediates trastuzumab resistance by ERK pathway activation in HER2-positive breast cancer

Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data

CARGO: a web portal to integrate customized biological information

CSF3R T618I co-occurs with mutations of splicing and epigenetic genes and with a new PIM3 truncated fusion gene in chronic neutrophilic leukemia

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs.

Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.

DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells

DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

Downregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype.

Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells.

Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm

Expression and functional validation of new p38α transcriptional targets in tumorigenesis

Functional characterization of E- and P-cadherin in invasive breast cancer cells

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

Genome-wide analysis of Pax8 binding provides new insights into thyroid functions

Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome

In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer

Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway.

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

Mantle cell lymphoma: transcriptional regulation by microRNAs

Metastatic risk and resistance to BRAF inhibitors in melanoma defined by selective allelic loss of ATG5.

MicroRNA expression signatures for the prediction of BRCA1/2 mutation-associated hereditary breast cancer in paraffin-embedded formalin-fixed breast tumors

MicroRNA signatures in B-cell lymphomas.

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer

New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing ⬇️

PLCG1 mutations in cutaneous T-cell lymphomas

PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data.

Pancreas Cancer Precision Treatment Using Avatar Mice from a Bioinformatics Perspective

Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis

PathJam: a new service for integrating biological pathway information

PileLine: a toolbox to handle genome position information in next-generation sequencing studies ⬇️

PileLineGUI: a desktop environment for handling genome position files in next-generation sequencing studies ⬇️

Precision medicine needs pioneering clinical bioinformaticians.

Prediction of miRNA-mRNA Interactions Using miRGate

Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation

Programmed cell senescence during mammalian embryonic development

Pten positively regulates brown adipose function, energy expenditure, and longevity

RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

RAP1 protects from obesity through its extratelomeric role regulating gene expression

RUbioSeq+: A multiplatform application that executes parallelized pipelines to analyse next-generation sequencing data

RUbioSeq+: An Application that Executes Parallelized Pipelines to Analyse Next-Generation Sequencing Data

RUbioSeq: a suite of parallelized pipelines to automate exome variation and bisulfite-seq analyses

Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas

SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.

Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation

Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics.

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies

The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas

The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development

The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK ⬇️

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.