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Lista de obras de Michael R. Horsman

A combretastatin-mediated decrease in neutrophil concentration in peripheral blood and the impact on the anti-tumor activity of this drug in two different murine tumor models

artículo científico publicado en 2014

A future for hyperthermia in cancer treatment?

artículo científico publicado en 2001

A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo.

artículo científico publicado en 2015

Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study

artículo científico publicado en 2011

Accumulation of nano-sized particles in a murine model of angiogenesis.

artículo científico publicado en 2013

Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia.

artículo científico publicado en 2008

Angiogenesis and vascular targeting: relevance for hyperthermia

artículo científico publicado en 2008

Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET.

artículo científico publicado en 2010

Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials.

artículo científico publicado en 2003

BW12C-induced changes in haemoglobin-oxygen affinity in mice and its influence on the radiation response of a C3H mouse mammary carcinoma

artículo científico publicado en 1992

Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?

artículo científico publicado en 2009

Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

artículo científico publicado en 2011

Carbogen and nicotinamide: expectations too high? (response to J. Martin Brown)

artículo científico publicado el 1 de junio de 1992

Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage.

artículo científico publicado en 2008

Cisplatin and hyperthermia treatment of a C3H mammary carcinoma in vivo. Importance of sequence, interval, drug dose, and temperature

artículo científico publicado en 1992

Combination of vascular targeting agents with thermal or radiation therapy

artículo científico publicado en 2002

Combretastatin A-4 phosphate affects tumor vessel volume and size distribution as assessed using MRI-based vessel size imaging

artículo científico publicado en 2012

Combretastatin-induced hypertension and the consequences for its combination with other therapies.

artículo científico publicado en 2010

Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues.

artículo científico publicado en 2001

Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients

scientific article published on 17 May 2007

Drug induced perturbations in tumor blood flow: therapeutic potential and possible limitations

scientific article published on 01 January 1991

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments.

artículo científico publicado en 2012

Effects of combretastatin on murine tumours monitored by 31P MRS, 1H MRS and 1H MRI.

artículo científico publicado en 1998

Enhanced local tumour control after single or fractionated radiation treatment using the hypoxic cell radiosensitizer doranidazole.

artículo científico publicado en 2008

Enhancement of melphalan cytotoxicity in vivo and in vitro by inhibitors of poly (ADP-ribose) polymerase

artículo científico publicado el 1 de septiembre de 1984

Enhancing the radiation response of tumors but not early or late responding normal tissues using a vascular disrupting agent

artículo científico publicado en 2017

FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach

artículo científico publicado en 2017

Hydralazine-induced changes in tissue perfusion and radiation response in a C3H mammary carcinoma and mouse normal tissues

scientific article published on 01 January 1991

Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo

artículo científico publicado en 1989

Hyperpolarized magnetic resonance spectroscopy for assessing tumor hypoxia.

artículo científico publicado en 2015

Hyperthermia: a potent enhancer of radiotherapy.

artículo científico publicado en 2007

Hypoxia as a Biomarker and for Personalized Radiation Oncology.

artículo científico publicado en 2016

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH.

artículo científico publicado en 2007

Hypoxia positron emission tomography imaging: combining information on perfusion and tracer retention to improve hypoxia specificity

artículo científico publicado en 2017

Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy

artículo científico publicado en 2008

Imaging hypoxia to improve radiotherapy outcome

artículo científico publicado en 2012

Imaging tumour physiology and vasculature to predict and assess response to heat

artículo científico publicado en 2010

Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms.

artículo científico publicado en 2016

In vivo bio-distribution and homing of endothelial outgrowth cells in a tumour model.

artículo científico publicado en 2014

In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors

artículo científico publicado en 2011

Induction of hypoxia by vascular disrupting agents and the significance for their combination with radiation therapy

artículo científico publicado en 2013

Influence of oxygen concentration and pH on expression of hypoxia induced genes.

artículo científico publicado en 2005

Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment.

artículo científico publicado en 2011

Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors

artículo científico publicado en 2001

Intravascular contrast agent-enhanced MRI measuring contrast clearance and tumor blood volume and the effects of vascular modifiers in an experimental tumor

artículo científico publicado en 2005

Intravenous administration of Gd-DTPA prior to DWI does not affect the apparent diffusion constant.

artículo científico publicado en 2005

Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival

artículo científico publicado el 15 de septiembre de 2010

Measurement of tumor oxygenation

artículo científico publicado en 1998

Misonidazole chemosensitization of EMT6 spheroids to melphalan

artículo científico publicado en 1989

Modification of Hypoxia-Induced Radioresistance in Tumors by the Use of Oxygen and Sensitizers

artículo científico publicado en 1996

Modulation of the tumor vasculature and oxygenation to improve therapy

artículo científico publicado en 2015

Nicotinamide and the hypoxia problem

artículo científico publicado el 1 de octubre de 1991

Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing

artículo científico publicado en 1997

Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy

scientific article published on 01 May 1993

Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo

artículo científico publicado el 1 de enero de 1991

Non-invasive imaging of combretastatin activity in two tumor models: Association with invasive estimates

artículo científico publicado en 2010

Overcoming tumour radiation resistance resulting from acute hypoxia

scientific article published on 01 January 1992

Overcoming tumour radiation resistance resulting from acute hypoxia.

artículo científico publicado en 1992

PET imaging of tumor hypoxia using 18F-labeled pimonidazole.

artículo científico publicado en 2013

Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies.

artículo científico publicado en 2006

Pathophysiological Basis for the Formation of the Tumor Microenvironment

artículo científico publicado en 2016

Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model

artículo científico publicado en 2012

Photoelectron Spectra and Electronic Structures of the Radiosensitizer Nimorazole and Related Compounds

artículo científico publicado en 2015

Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial.

artículo científico publicado en 2005

Potentiation of the anti-tumour effect of hyperthermia by combining with the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid.

artículo científico publicado en 2001

Preclinical studies on how to deal with patient intolerance to nicotinamide and carbogen.

artículo científico publicado en 2004

Preclinical studies to predict efficacy of vascular changes induced by combretastatin a-4 disodium phosphate in patients

artículo científico publicado en 2007

Prospective evaluation of angiogenic, hypoxic and EGFR-related biomarkers in recurrent glioblastoma multiforme treated with cetuximab, bevacizumab and irinotecan.

artículo científico publicado en 2010

Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics.

artículo científico publicado en 2009

Radiation administered as a large single dose or in a fractionated schedule: Role of the tumour vasculature as a target for influencing response

artículo científico publicado en 2006

Radiobiological hypoxia in the KHT sarcoma: predictions using the Eppendorf histograph

scientific article published on 01 March 1998

Realistic biological approaches for improving thermoradiotherapy.

artículo científico publicado en 2015

Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing

artículo científico publicado en 1994

Reduction of cisplatinum-induced renal toxicity in mice by tetrahydroindazolonecarboxylic acid (HIDA) [corrected]

artículo científico publicado en 1993

Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model

artículo científico publicado en 1993

Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum.

artículo científico publicado en 2005

Relationship between tumour oxygenation, bioenergetic status and radiobiological hypoxia in an experimental model

artículo científico publicado en 1995

Relationship of hypoxia to metallothionein expression in murine tumors

artículo científico publicado en 1998

Relative biological effectiveness (RBE) and distal edge effects of proton radiation on early damage in vivo.

artículo científico publicado en 2017

Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model.

artículo científico publicado en 2015

Reoxygenation in a C3H mouse mammary carcinoma. The importance of chronic rather than acute hypoxia

scientific article published on 01 January 1995

Resolution in PET hypoxia imaging: voxel size matters.

artículo científico publicado en 2008

Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly.

artículo científico

Segmentation of dynamic contrast enhanced magnetic resonance imaging data

artículo científico publicado en 2008

Simulation of heterogeneous molecular delivery in tumours using μCT reconstructions and MRI validation.

artículo científico publicado en 2016

Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro

artículo científico publicado en 2015

Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors

artículo científico publicado en 2009

Strain and tumour specific variations in the effect of hypoxia on osteopontin levels in experimental models

scientific article published on 21 August 2006

Structure-activity relationships for tumour radiosensitization by analogues of nicotinamide and benzamide.

artículo científico publicado en 1991

Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.

artículo científico publicado en 2015

Targeting therapy-resistant cancer stem cells by hyperthermia

artículo científico publicado en 2017

Targeting tumor blood vessels: an adjuvant strategy for radiation therapy

artículo científico publicado en 2000

Targeting tumour hypoxia to improve outcome of stereotactic radiotherapy

artículo científico publicado en 2015

The Effect of Combining Flavone Acetic Acid and Hyperthermia on the Growth of a C3H Mammary Carcinomain Vivo

artículo científico publicado el 1 de julio de 1991

The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo.

artículo científico publicado en 1999

The ability of nicotinamide to inhibit the growth of a C3H mouse mammary carcinoma

artículo científico publicado en 1995

The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

artículo científico publicado en 2005

The effect of artificially induced hyperglycemia on the radiation response of the Lewis lung and EMT6 tumor models

artículo científico publicado en 1988

The effect of caffeine on the cytotoxicity of misonidazole and some other nitroheterocyclic compounds

artículo científico publicado en 1982

The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: oxygenation and tumour control studies

artículo científico publicado en 1998

The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors

artículo científico publicado en 1998

The effect of combretastatin A4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on water diffusion and blood perfusion in tumours

artículo científico publicado en 2008

The effect of shark cartilage extracts on the growth and metastatic spread of the SCCVII carcinoma

artículo científico publicado en 1998

The effects of the vascular disrupting agents combretastatin A-4 disodium phosphate, 5,6-dimethylxanthenone-4-acetic acid and ZD6126 in a murine tumour: a comparative assessment using MRI and MRS.

artículo científico publicado en 2006

The impact of hypoxia and its modification of the outcome of radiotherapy

artículo científico publicado en 2016

The importance of determining necrotic fraction when studying the effect of tumour volume on tissue oxygenation

scientific article published on 01 January 1995

The influence of tumour temperature on ischemia-induced cell death: potential implications for the evaluation of vascular mediated therapies

scientific article published on 01 January 1994

The new vascular disrupting agent combretastatin-A1-disodium-phosphate (OXi4503) enhances tumour response to mild hyperthermia and thermoradiosensitization.

artículo científico publicado en 2007

The potential of hyperpolarized 13C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents

artículo científico publicado en 2017

The potential of using hyperthermia to eliminate radioresistant hypoxic cells

scientific article published on 01 January 1991

The potentiation of radiation damage by nicotinamide in the SCCVII tumour in vivo

artículo científico publicado en 1990

The radiation response of KHT sarcomas following nicotinamide treatment and carbogen breathing

artículo científico publicado en 1994

The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis

artículo científico

The usability of a 15-gene hypoxia classifier as a universal hypoxia profile in various cancer cell types.

artículo científico publicado en 2015

The use of blood flow modifiers to improve the treatment response of solid tumors

artículo científico publicado el 1 de enero de 1991

The vascular-disrupting agent, combretastatin-A4-phosphate, enhances neurogenic vasoconstriction in rat small arteries.

artículo científico publicado en 2012

Therapeutic potential of using the vascular disrupting agent OXi4503 to enhance mild temperature thermoradiation

artículo científico publicado en 2015

Tissue physiology and the response to heat.

artículo científico publicado en 2006

Tolerance to nicotinamide and carbogen with radiation therapy for glioblastoma.

artículo científico publicado en 1997

Treatment with a vascular disrupting agent does not increase recruitment of indium labelled human endothelial outgrowth cells in an experimental tumour model

artículo científico publicado en 2014

Treatment with the vascular disrupting agent combretastatin is associated with impaired AQP2 trafficking and increased urine output

artículo científico publicado en 2012

Tumor radiosensitizers--current status of development of various approaches: report of an International Atomic Energy Agency meeting

artículo científico publicado en 2006

Tumour hypoxia - a characteristic feature with a complex molecular background

artículo científico publicado en 2006

Tumour microenvironment and radiation response in sarcomas originating from tumourigenic human mesenchymal stem cells.

artículo científico publicado en 2012

Tumour perfusion and associated physiology: characterization and significance for hyperthermia

artículo científico publicado en 2010

Tumour-specific enhancement of thermoradiotherapy at mild temperatures by the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid.

artículo científico publicado en 2004

Tumourigenicity and radiation resistance of mesenchymal stem cells

artículo científico publicado el 7 de diciembre de 2011

Ultra-high field 1H magnetic resonance imaging approaches for acute hypoxia.

artículo científico publicado en 2013

Ultrahigh-field DCE-MRI of angiogenesis in a novel angiogenesis mouse model

scientific article published on 26 October 2011

Use of tetrahydraindazolone dicarboxylic acid (HIDA) to improve the therapeutic effect in vivo of combined cisplatin, heat and radiation treatment

artículo científico publicado en 1993

Vascular effects of photodynamic therapy in an intraocular retinoblastoma-like tumour

artículo científico publicado en 1989

Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.

artículo científico publicado en 2011

Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response

artículo científico publicado en 2003

Vascular-targeting therapies for treatment of malignant disease.

artículo científico publicado en 2004