Lista de obras - Erinna F Lee - Dominio Público Uruguay

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

artículo científico publicado en 2008

A preliminary assessment of oral monepantel's tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

scientific article published on 22 September 2020

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

artículo científico publicado en 2019

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

artículo científico publicado en 2007

A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

artículo científico publicado en 2015

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.

artículo científico publicado en 2017

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

artículo científico publicado en 2003

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

artículo científico publicado en 2012

Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis

artículo científico

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

artículo científico publicado en 2007

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

artículo científico publicado en 2008

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

artículo científico publicado en 2016

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

artículo científico publicado en 2019

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

artículo científico publicado en 2013

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

artículo científico publicado en 2012

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

artículo científico publicado en 2015

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1 ⬇️

artículo científico publicado en 2005

Characterisation of the conformational preference and dynamics of the intrinsically disordered N-terminal region of Beclin 1 by NMR spectroscopy

artículo científico publicado en 2016

Characterization of a novel human BFL-1-specific monoclonal antibody

scientific article published on 12 November 2019

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

artículo científico publicado en 2016

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

artículo científico publicado en 2009

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

artículo científico publicado en 2017

Crosstalk between apoptosis and autophagy signaling pathways

scientific article published on 05 February 2020

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

artículo científico publicado en 2007

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

artículo científico publicado en 2011

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes

artículo científico publicado en 2011

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

artículo científico publicado en 2013

Diversity in the intrinsic apoptosis pathway of nematodes

artículo científico publicado en 2020

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.

artículo científico publicado en 2008

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

artículo científico publicado en 2012

Functional genomics approaches in parasitic helminths.

artículo científico publicado en 2012

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

artículo científico publicado en 2016

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

artículo científico publicado en 2009

In vivo visualizations of drought-induced embolism spread in Vitis vinifera.

artículo científico publicado en 2013

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

artículo científico publicado en 2016

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.

artículo científico publicado en 2018

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

artículo científico publicado en 2011

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

artículo científico publicado en 2009

Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues

artículo científico publicado en 2011

Physiological restraint of Bak by Bcl-xL is essential for cell survival

artículo científico publicado en 2016

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

artículo científico publicado en 2015

Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis

artículo científico publicado en 2015

Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.

artículo científico

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

artículo científico publicado en 2011

Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA

artículo científico publicado en 2003

Structural biology of the intrinsic cell death pathway: what do we know and what is missing?

artículo científico publicado en 2012

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

artículo científico publicado en 2019

Structural insights into the degradation of Mcl-1 induced by BH3 domains

artículo científico publicado en 2007

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

artículo científico publicado en 2008

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

artículo científico publicado en 2013

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

artículo científico publicado en 2009

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

artículo científico publicado en 2014

The BECN1 N-terminal domain is intrinsically disordered

artículo científico publicado en 2016

The Structural Biology of Bcl-xL. ⬇️

artículo científico publicado en 2019

The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.

artículo científico publicado en 2014

The role of BCL-2 family proteins and therapeutic potential of BH3-mimetics in malignant pleural mesothelioma

artículo científico publicado en 2020

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

artículo científico publicado en 2009

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

artículo científico publicado en 2015

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de Erinna F Lee

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

A preliminary assessment of oral monepantel's tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1 ⬇️

Characterisation of the conformational preference and dynamics of the intrinsically disordered N-terminal region of Beclin 1 by NMR spectroscopy

Characterization of a novel human BFL-1-specific monoclonal antibody

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Crosstalk between apoptosis and autophagy signaling pathways

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Diversity in the intrinsic apoptosis pathway of nematodes

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Functional genomics approaches in parasitic helminths.

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

In vivo visualizations of drought-induced embolism spread in Vitis vinifera.

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis

Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA

Structural biology of the intrinsic cell death pathway: what do we know and what is missing?

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

The BECN1 N-terminal domain is intrinsically disordered

The Structural Biology of Bcl-xL. ⬇️

The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.

The role of BCL-2 family proteins and therapeutic potential of BH3-mimetics in malignant pleural mesothelioma

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)