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Lista de obras de Trent M. Woodruff

A Commentary On: "NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease". A cautionary note regarding C3aR.

artículo científico publicado en 2015

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

artículo científico publicado en 2015

A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis

artículo científico publicado en 2005

A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia.

artículo científico publicado en 2013

A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models

artículo científico publicado en 2020

Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

artículo científico publicado en 2020

Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration

artículo científico publicado en 2020

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1 G93A mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2015

Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood

artículo científico publicado en 2021

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

artículo científico publicado en 2015

Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cord

artículo científico publicado en 2015

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.

artículo científico publicado en 2002

Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects

artículo científico publicado en 2016

Brief Report: Complement C5a Promotes Human Embryonic Stem Cell Pluripotency in the Absence of FGF2

artículo científico publicado en 2014

C5L2: a controversial receptor of complement anaphylatoxin, C5a

artículo científico publicado en 2013

C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus

artículo científico publicado en 2015

C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus

artículo científico publicado en 2016

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

artículo científico publicado en 2017

C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice

artículo científico publicado en 2013

C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans

C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages

artículo científico publicado en 2020

COVID-19: Complement, Coagulation, and Collateral Damage

artículo científico publicado en 2020

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling

artículo científico publicado en 2018

Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor

scientific article published on 03 July 2019

Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour

artículo científico publicado en 2018

Co-ordinated expression of innate immune molecules during mouse neurulation

artículo científico publicado en 2015

Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.

artículo científico publicado en 2005

Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis

artículo científico publicado en 2011

Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance

artículo científico publicado en 2018

Complement C5A regulates prolabor mediators in human placenta

artículo científico publicado en 2012

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.

artículo científico publicado en 2018

Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis

artículo científico publicado en 2022

Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice.

artículo científico publicado en 2011

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2017

Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ.

artículo científico publicado en 2017

Complement activation in the injured central nervous system: another dual-edged sword?

artículo científico publicado en 2012

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

artículo científico publicado en 2019

Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4

artículo científico publicado en 2018

Complement component 5a (C5a)

artículo científico publicado en 2009

Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis.

artículo científico publicado en 2018

Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease.

artículo científico publicado en 2012

Complement factors C3a and C5a have distinct hemodynamic effects in the rat.

artículo científico publicado en 2009

Complement in pregnancy: a delicate balance

artículo científico

Complement in stem cells and development.

artículo científico publicado en 2018

Complement in the fundamental processes of the cell

artículo científico publicado en 2016

Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats

scientific journal article

Complement mediators in ischemia-reperfusion injury

artículo científico publicado en 2006

Complement: Bridging the innate and adaptive immune systems in sterile inflammation

scientific article published on 17 March 2020

Complement: The Emerging Architect of the Developing Brain.

artículo científico publicado en 2018

Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis

artículo científico publicado en 2016

Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis

artículo científico publicado en 2014

De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation

artículo científico publicado en 2012

Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis

scientific article published on 23 January 2020

Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway

artículo científico publicado en 2019

Dendritic cell function in allostimulation is modulated by C5aR signaling.

artículo científico publicado en 2009

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a

artículo científico publicado en 2014

Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice.

artículo científico publicado en 2018

Developmental activities of the complement pathway in migrating neurons

artículo científico publicado en 2017

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.

artículo científico publicado en 2016

Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2013

EPHA4-FC TREATMENT REDUCES ISCHEMIA/REPERFUSION-INDUCED INTESTINAL INJURY BY INHIBITING VASCULAR PERMEABILITY.

artículo científico publicado en 2016

Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia.

artículo científico publicado en 2013

Eph/Ephrin signaling in injury and inflammation

artículo científico publicado en 2012

Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods

artículo científico publicado en 2014

Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death

artículo científico publicado en 2010

Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis

artículo científico publicado en 2012

Increased Placental Expression of Fibroblast Growth Factor 21 in Gestational Diabetes Mellitus

scientific article published on 16 January 2014

Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors.

artículo científico publicado en 2010

Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease

artículo científico publicado en 2005

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

artículo científico publicado en 2018

Inflammasomes in CNS Diseases

artículo científico publicado en 2018

Inhibiting the C5-C5a receptor axis

scientific article published on 06 May 2011

Inhibition of Inflammation and Fibrosis by a Complement C5a Receptor Antagonist in DOCA-Salt Hypertensive Rats

article

Insights into the mechanism of C5aR inhibition by PMX53 via implicit solvent molecular dynamics simulations and docking

artículo científico publicado en 2014

Is the C3a receptor antagonist SB290157 a useful pharmacological tool?

artículo científico publicado en 2020

Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth

artículo científico publicado en 2015

Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury

artículo científico publicado en 2014

Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease

artículo científico publicado en 2010

Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse.

artículo científico publicado en 2017

Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis

artículo científico publicado en 2020

Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice

artículo científico publicado en 2016

Neural tube defects, folate, and immune modulation

artículo científico publicado en 2013

Neutrophils--a key component of ischemia-reperfusion injury

artículo científico publicado en 2013

New concepts on the therapeutic control of complement anaphylatoxin receptors

artículo científico

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS

Noninvasive assessment of altered activity following restraint in mice using an automated physiological monitoring system

artículo científico publicado en 2016

Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats

scientific article published on 03 July 2011

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

artículo científico publicado en 2011

Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14

scientific article published on 15 May 2019

Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration

artículo científico publicado en 2008

Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2017

Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke

artículo científico publicado en 2009

Placental lipase expression in pregnancies complicated by preeclampsia: a case-control study

artículo científico publicado en 2015

Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM).

artículo científico publicado en 2014

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

artículo científico publicado en 2004

Preclinical Pharmacokinetics of Complement C5a Receptor Antagonists PMX53 and PMX205 in Mice

artículo científico publicado en 2020

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

artículo científico publicado en 2016

Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanism.

artículo científico publicado en 2017

Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent manner

artículo científico publicado en 2015

Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats

artículo científico publicado en 2004

Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine

artículo científico publicado en 2002

Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats

artículo científico publicado en 2004

Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment

artículo científico publicado en 2010

Recent developments in C5/C5a inhibitors

Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition.

artículo científico publicado en 2016

Role for terminal complement activation in amyotrophic lateral sclerosis disease progression.

artículo científico publicado en 2013

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain.

artículo científico publicado en 2017

Serping1/C1 Inhibitor Affects Cortical Development in a Cell Autonomous and Non-cell Autonomous Manner

artículo científico publicado en 2017

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

artículo científico publicado en 2017

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis.

artículo científico publicado en 2018

T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival.

artículo científico publicado en 2018

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

artículo científico publicado en 2016

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

artículo científico publicado en 2021

Targeting ischemic brain injury with intravenous immunoglobulin

artículo científico publicado en 2008

The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury.

artículo científico publicado en 2017

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres.

artículo científico publicado en 2009

The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+ T Cell Responses.

artículo científico publicado en 2016

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury

artículo científico publicado en 2015

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity

scientific article published on 01 June 2019

The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1

artículo científico publicado en 2016

The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia.

artículo científico publicado en 2017

The Receptor for Advanced Glycation Endproducts Does Not Contribute to Pathology in a Mouse Mesenteric Ischemia/Reperfusion-Induced Injury Model

artículo científico publicado en 2015

The Role of C5a Receptor Signaling in Endotoxin-Induced Miscarriage and Preterm Birth

artículo científico publicado en 2015

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

scientific article published on 01 December 2008

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

artículo científico publicado en 2019

The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

artículo científico publicado en 2020

The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization.

artículo científico publicado en 2013

The role of the complement system and the activation fragment C5a in the central nervous system

scientific article published on 11 September 2009

The role of the ribosomal protein S19 C-terminus in Gi protein-dependent alternative activation of p38 MAP kinase via the C5a receptor in HMC-1 cells

artículo científico publicado en 2010

Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration

artículo científico publicado en 2006

Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1 mouse model of amyotrophic lateral sclerosis

scholarly article by John D Lee et al published 19 February 2019 in Journal of Neuroinflammation

Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions

artículo científico publicado en 2016

Thrombin Differentially Modulates the Acute Inflammatory Response to <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> in Human Whole Blood

artículo científico publicado en 2022

Toll-like receptors in ischemia-reperfusion injury

artículo científico publicado en 2009

Transdermal Pharmacology of Small Molecule Cyclic C5a Antagonists

scientific article published on 01 January 2006

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

artículo científico publicado en 2009

The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding

artículo científico publicado en 2007