Lista de obras - José Martínez-González

3-Hydroxy-3-methylglutaryl-coenzyme-A synthase from Blattella germanica. Cloning, expression, developmental pattern and tissue expression

artículo científico publicado en 1993

A major role for RCAN1 in atherosclerosis progression

artículo científico publicado en 2013

A sudden increase in plasma epinephrine levels transiently enhances platelet deposition on severely damaged arterial wall--studies in a porcine model

scientific article published on 01 December 1999

Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes

artículo científico publicado en 2015

Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli.

artículo científico publicado en 2011

Atherogenic concentrations of native low-density lipoproteins down-regulate nitric-oxide-synthase mRNA and protein levels in endothelial cells

scientific article published on 01 March 1998

Biología celular y molecular de las lesiones ateroscleróticas

artículo científico publicado en 2001

Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle.

artículo científico publicado en 1994

Blood-borne tissue factor activity predicts major cerebrovascular events in patients undergoing carotid endarterectomy: results from a 1-year follow-up study.

artículo científico publicado en 2007

C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression

artículo científico publicado en 2008

CALU polymorphism A29809G affects calumenin availability involving vascular calcification

artículo científico publicado en 2015

CCL20 is increased in hypercholesterolemic subjects and is upregulated by LDL in vascular smooth muscle cells: role of NF-κB.

artículo científico publicado en 2011

Carotid plaque, stroke pathogenesis, and CRP: treatment of ischemic stroke.

scientific article published on February 2008

Carotid plaque, stroke pathogenesis, and CRP: treatment of ischemic stroke.

artículo científico publicado en 2007

Cells in Cardiovascular Disease: Using Diversity to Confront Adversity

artículo científico publicado en 2020

Cytochrome c oxidase subunit I from the cockroach Blattella germanica: cloning, developmental pattern and tissue expression

artículo científico publicado en 1994

Decreased pre-surgical CD34+/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients.

artículo científico publicado en 2012

Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.

artículo científico publicado en 2011

Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis †

scientific article published on 10 September 2020

Differential cholesteryl ester accumulation in two human vascular smooth muscle cell subpopulations exposed to aggregated LDL: effect of PDGF-stimulation and HMG-CoA reductase inhibition

scientific article published on 01 June 1999

Differential intracellular trafficking of von Willebrand factor (vWF) and vWF propeptide in porcine endothelial cells lacking Weibel–Palade bodies and in human endothelial cells

artículo científico publicado en 2003

Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics.

artículo científico publicado en 2016

EPC adhesion to arteries from diabetic and non-diabetic patients: effect of pioglitazone.

artículo científico publicado en 2009

Efecto temprano de las estatinas después de un infarto de miocardio. ¿Se debe a los efectos pleiotrópicos?

scientific article published on 01 March 2006

Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-γ)

scientific journal article

El receptor nuclear NOR-1 regula la activación de las células vasculares y el remodelado vascular en respuesta a estrés hemodinámico

artículo científico publicado en 2014

Emerging therapeutic strategies to enhance HDL function

artículo científico publicado en 2011

Endogenous Expression of C-Reactive Protein Is Increased in Active (Ulcerated Noncomplicated) Human Carotid Artery Plaques

scientific article published on 06 April 2006

Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis.

artículo científico publicado en 2016

Endothelial Krüppel-like factor 4 modulates pulmonary arterial hypertension

artículo científico publicado en 2014

Endothelium and vascular protection: an update

artículo científico publicado en 2002

Esterified Cholesterol Accumulation Induced by Aggregated LDL Uptake in Human Vascular Smooth Muscle Cells Is Reduced by HMG-CoA Reductase Inhibitors

scientific article published on 01 May 1998

Experimental and interventional dietary study in humans on the role of HDL fatty acid composition in PGI2 release and Cox-2 expression by VSMC.

artículo científico publicado en 2003

Expression and Cellular Localization of 15-Hydroxy-Prostaglandin-Dehydrogenase in Abdominal Aortic Aneurysm

artículo científico publicado en 2015

Fibulin-5 is up-regulated by hypoxia in endothelial cells through a hypoxia-inducible factor-1 (HIF-1α)-dependent mechanism. ⬇️

artículo científico publicado en 2010

HDL-Induced Prostacyclin Release in Smooth Muscle Cells Is Dependent on Cyclooxygenase-2 (Cox-2)

artículo científico publicado en 1997

HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia.

artículo científico publicado en 2011

Heterogeneity of smooth muscle cells in advanced human atherosclerotic plaques: intimal smooth muscle cells expressing a fibroblast surface protein are highly activated by platelet-released products.

artículo científico publicado en 2001

High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells

artículo científico publicado en 2004

Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells.

artículo científico publicado en 2015

HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration

artículo científico publicado en 2015

Human and porcine smooth muscle cells share similar proliferation dependence on the mevalonate pathway: implication for in vivo interventions in the porcine model

scientific article published on 01 November 1996

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

artículo científico publicado en 2011

Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells

artículo científico publicado en 2011

Imidazolineoxyl N-oxide induces COX-2 in endothelial cells: role of free radicals

artículo científico publicado en 2012

Inactivation of nuclear factor-Y inhibits vascular smooth muscle cell proliferation and neointima formation

artículo científico publicado en 2013

Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors

artículo científico publicado en 2016

Inflammation inhibits vascular fibulin-5 expression: Involvement of transcription factor SOX9

artículo científico publicado en 2016

Influence of statin use on endothelial function: from bench to clinics.

artículo científico publicado en 2007

Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB.

artículo científico publicado en 2004

LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism.

artículo científico publicado en 2001

LDL receptor-related protein mediates uptake of aggregated LDL in human vascular smooth muscle cells.

artículo científico

Left and right ventricle late remodeling following myocardial infarction in rats.

artículo científico publicado en 2013

Low density lipoproteins downregulate lysyl oxidase in vascular endothelial cells and the arterial wall.

artículo científico publicado en 2002

Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK.

artículo científico publicado en 2016

Lysyl oxidase (LOX) down-regulation by TNFα: A new mechanism underlying TNFα-induced endothelial dysfunction

artículo científico publicado en 2007

Lysyl oxidase (LOX) in vascular remodelling

artículo científico publicado en 2014

Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokines.

artículo científico publicado en 2008

Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II-induced hypertrophy

artículo científico publicado en 2017

Matrix metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation

artículo científico publicado en 2009

Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risks

artículo científico publicado en 2007

Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli.

artículo científico publicado en 2008

Mevalonate deprivation impairs IGF-I/insulin signaling in human vascular smooth muscle cells

artículo científico publicado en 1997

Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm.

artículo científico publicado en 2013

Modulation of ERG25 expression by LDL in vascular cells.

artículo científico publicado en 2003

Molecular cloning, developmental pattern and tissue expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase of the cockroach Blattella germanica.

artículo científico publicado en 1993

NOR-1 is involved in VEGF-induced endothelial cell growth.

artículo científico publicado en 2005

NOR-1 modulates the inflammatory response of vascular smooth muscle cells by preventing NFκB activation

artículo científico publicado en 2014

NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress

artículo científico publicado en 2016

NR4A receptors up-regulate the antiproteinase alpha-2 macroglobulin (A2M) and modulate MMP-2 and MMP-9 in vascular smooth muscle cells

artículo científico publicado en 2015

Neovascularización en arterias coronarias humanas con distintos grados de lesión

artículo científico publicado en 2003

Nestin(+) cells direct inflammatory cell migration in atherosclerosis.

artículo científico publicado en 2016

New challenges for a second-generation low-molecular-weight heparin: focus on bemiparin.

artículo científico publicado en 2010

New genetic association for the kinin system: the L-arginine connection. Insight: association of L-arginine levels and two loci in genes of the kallikrein-kinin system

artículo científico publicado en 2016

Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism

artículo científico publicado en 2008

Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury.

artículo científico publicado en 2013

Plasma profiling by a protein array approach identifies IGFBP-1 as a novel biomarker of abdominal aortic aneurysm.

artículo científico publicado en 2012

Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: Effect of simvastatin

artículo científico publicado en 2008

Reendotelización, engrosamiento intimal y remodelado vascular. ¿Un denominador común?

artículo científico publicado en 2000

Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases.

artículo científico publicado en 2008

Regulatory Effects of HDL on Smooth Muscle Cell Prostacyclin Release

artículo científico publicado en 1999

Retinoic acid induces PGI synthase expression in human endothelial cells.

artículo científico publicado en 2008

Small oxidative changes in atherogenic LDL concentrations irreversibly regulate adhesiveness of human endothelial cells: effect of the lazaroid U74500A

scientific article published on 01 April 2000

Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin

artículo científico publicado en 2009

Sustained long-term improvement of arterial endothelial function in heterozygous familial hypercholesterolemia patients treated with simvastatin.

artículo científico publicado en 2001

Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo

artículo científico publicado en 2012

Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia

artículo científico publicado en 2013

The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells.

artículo científico publicado en 2005

The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling

scientific article published on 21 November 2019

The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.

artículo científico publicado en 2016

The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats

artículo científico publicado en 2015

The nuclear receptor NOR-1 regulates the small muscle protein, X-linked (SMPX) and myotube differentiation.

artículo científico publicado en 2016

The nuclear receptor NOR-1/NR4A3 regulates the multifunctional glycoprotein vitronectin in human vascular smooth muscle cells.

artículo científico publicado en 2017

The response of smooth muscle cells to alpha-thrombin depends on its arterial origin: comparison among different species

artículo científico publicado en 1998

The unsaponifiable fraction of virgin olive oil in chylomicrons from men improves the balance between vasoprotective and prothrombotic factors released by endothelial cells

artículo científico publicado en 2004

Thrombin and protease-activated receptors (PARs) in atherothrombosis.

artículo científico publicado en 2008

Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth.

artículo científico publicado en 2005

Type II interleukin-1 receptor expression is reduced in monocytes/macrophages and atherosclerotic lesions

artículo científico publicado en 2011

Vascular lysyl oxidase over-expression alters extracellular matrix structure and induces oxidative stress

artículo científico publicado en 2017

[Development of coronary arteriosclerosis and its clinical complications]

artículo científico publicado en 1995

miR-146a targets Fos expression in human cardiac cells

artículo científico publicado en 2015

miR-17 and -20a Target the Neuron-Derived Orphan Receptor-1 (NOR-1) in Vascular Endothelial Cells

artículo científico publicado en 2015

Lista de obras de José Martínez-González

3-Hydroxy-3-methylglutaryl-coenzyme-A synthase from Blattella germanica. Cloning, expression, developmental pattern and tissue expression

A major role for RCAN1 in atherosclerosis progression

A sudden increase in plasma epinephrine levels transiently enhances platelet deposition on severely damaged arterial wall--studies in a porcine model

Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes

Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli.

Atherogenic concentrations of native low-density lipoproteins down-regulate nitric-oxide-synthase mRNA and protein levels in endothelial cells

Biología celular y molecular de las lesiones ateroscleróticas

Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle.

Blood-borne tissue factor activity predicts major cerebrovascular events in patients undergoing carotid endarterectomy: results from a 1-year follow-up study.

C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression

CALU polymorphism A29809G affects calumenin availability involving vascular calcification

CCL20 is increased in hypercholesterolemic subjects and is upregulated by LDL in vascular smooth muscle cells: role of NF-κB.

Carotid plaque, stroke pathogenesis, and CRP: treatment of ischemic stroke.

Carotid plaque, stroke pathogenesis, and CRP: treatment of ischemic stroke.

Cells in Cardiovascular Disease: Using Diversity to Confront Adversity

Cytochrome c oxidase subunit I from the cockroach Blattella germanica: cloning, developmental pattern and tissue expression

Decreased pre-surgical CD34+/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients.

Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.

Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis †

Differential cholesteryl ester accumulation in two human vascular smooth muscle cell subpopulations exposed to aggregated LDL: effect of PDGF-stimulation and HMG-CoA reductase inhibition

Differential intracellular trafficking of von Willebrand factor (vWF) and vWF propeptide in porcine endothelial cells lacking Weibel–Palade bodies and in human endothelial cells

Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics.

EPC adhesion to arteries from diabetic and non-diabetic patients: effect of pioglitazone.

Efecto temprano de las estatinas después de un infarto de miocardio. ¿Se debe a los efectos pleiotrópicos?

Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-γ)

El receptor nuclear NOR-1 regula la activación de las células vasculares y el remodelado vascular en respuesta a estrés hemodinámico

Emerging therapeutic strategies to enhance HDL function

Endogenous Expression of C-Reactive Protein Is Increased in Active (Ulcerated Noncomplicated) Human Carotid Artery Plaques

Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis.

Endothelial Krüppel-like factor 4 modulates pulmonary arterial hypertension

Endothelium and vascular protection: an update

Esterified Cholesterol Accumulation Induced by Aggregated LDL Uptake in Human Vascular Smooth Muscle Cells Is Reduced by HMG-CoA Reductase Inhibitors

Experimental and interventional dietary study in humans on the role of HDL fatty acid composition in PGI2 release and Cox-2 expression by VSMC.

Expression and Cellular Localization of 15-Hydroxy-Prostaglandin-Dehydrogenase in Abdominal Aortic Aneurysm

Fibulin-5 is up-regulated by hypoxia in endothelial cells through a hypoxia-inducible factor-1 (HIF-1α)-dependent mechanism. ⬇️

HDL-Induced Prostacyclin Release in Smooth Muscle Cells Is Dependent on Cyclooxygenase-2 (Cox-2)

HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia.

Heterogeneity of smooth muscle cells in advanced human atherosclerotic plaques: intimal smooth muscle cells expressing a fibroblast surface protein are highly activated by platelet-released products.

High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells

Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells.

HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration

Human and porcine smooth muscle cells share similar proliferation dependence on the mevalonate pathway: implication for in vivo interventions in the porcine model

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells

Imidazolineoxyl N-oxide induces COX-2 in endothelial cells: role of free radicals

Inactivation of nuclear factor-Y inhibits vascular smooth muscle cell proliferation and neointima formation

Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors

Inflammation inhibits vascular fibulin-5 expression: Involvement of transcription factor SOX9

Influence of statin use on endothelial function: from bench to clinics.

Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB.

LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism.

LDL receptor-related protein mediates uptake of aggregated LDL in human vascular smooth muscle cells.

Left and right ventricle late remodeling following myocardial infarction in rats.

Low density lipoproteins downregulate lysyl oxidase in vascular endothelial cells and the arterial wall.

Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK.

Lysyl oxidase (LOX) down-regulation by TNFα: A new mechanism underlying TNFα-induced endothelial dysfunction

Lysyl oxidase (LOX) in vascular remodelling

Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokines.

Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II-induced hypertrophy

Matrix metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation

Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risks

Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli.

Mevalonate deprivation impairs IGF-I/insulin signaling in human vascular smooth muscle cells

Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm.

Modulation of ERG25 expression by LDL in vascular cells.

Molecular cloning, developmental pattern and tissue expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase of the cockroach Blattella germanica.

NOR-1 is involved in VEGF-induced endothelial cell growth.

NOR-1 modulates the inflammatory response of vascular smooth muscle cells by preventing NFκB activation

NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress

NR4A receptors up-regulate the antiproteinase alpha-2 macroglobulin (A2M) and modulate MMP-2 and MMP-9 in vascular smooth muscle cells

Neovascularización en arterias coronarias humanas con distintos grados de lesión

Nestin(+) cells direct inflammatory cell migration in atherosclerosis.

New challenges for a second-generation low-molecular-weight heparin: focus on bemiparin.

New genetic association for the kinin system: the L-arginine connection. Insight: association of L-arginine levels and two loci in genes of the kallikrein-kinin system

Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism

Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury.

Plasma profiling by a protein array approach identifies IGFBP-1 as a novel biomarker of abdominal aortic aneurysm.

Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: Effect of simvastatin

Reendotelización, engrosamiento intimal y remodelado vascular. ¿Un denominador común?