Lista de obras - Diego Megías - Dominio Público Uruguay

A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka.

artículo científico publicado en 2011

A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis

artículo científico publicado en 2011

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

artículo científico publicado en 2015

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.

artículo científico publicado en 2016

Application of standard cell cultures and 3D in vitro tissue models as an effective tool in drug design and development.

artículo científico publicado en 2017

Assessing kinetics and recruitment of DNA repair factors using high content screens

artículo científico publicado en 2021

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

artículo científico publicado en 2018

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer.

scientific article published on 02 February 2017

CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions

artículo científico publicado en 2013

Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge.

artículo científico publicado en 2016

Combinatorial effects of splice variants modulate function of Aiolos

artículo científico publicado en 2007

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis.

artículo científico publicado en 2017

Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias

artículo científico publicado en 2021

Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing

artículo científico publicado en 2004

EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.

artículo científico publicado en 2015

Fra-2-expressing macrophages promote lung fibrosis in mice

scientific article published on 28 May 2019

Gasdermin-B promotes invasion and metastasis in breast cancer cells

artículo científico publicado en 2014

Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division

artículo científico publicado en 2022

Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.

artículo científico publicado en 2016

HCS Methodology for Helping in Lab Scale Image-Based Assays

scientific article published on 01 January 2019

High-Throughput Image-Based Screening to Identify Chemical Compounds Capable of Activating FOXO

artículo científico publicado en 2019

Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor

artículo científico publicado en 2009

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

artículo científico publicado en 2013

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

artículo científico publicado en 2017

Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways

artículo científico publicado en 2013

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

artículo científico publicado en 2014

In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias

artículo científico publicado en 2017

Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135

artículo científico publicado en 2020

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

artículo científico publicado en 2014

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

artículo científico publicado en 2016

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

scientific article published on 02 September 2019

Lysosomal trapping of palbociclib and its functional implications

artículo científico publicado en 2019

MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells

artículo científico publicado en 2008

MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.

artículo científico publicado en 2007

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism

artículo científico publicado en 2021

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.

artículo científico

Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

artículo científico publicado en 2015

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

artículo científico publicado en 2014

Novel lambda FRET spectral confocal microscopy imaging method

artículo científico publicado en 2009

PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection

artículo científico publicado en 2019

Podoplanin associates with CD44 to promote directional cell migration

artículo científico publicado en 2010

Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

artículo científico publicado en 2006

Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion.

artículo científico publicado en 2009

Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis.

artículo científico publicado en 2015

Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1.

artículo científico publicado en 2007

RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway

artículo científico publicado en 2014

Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms

scientific journal article

Reply: 'Comments on Stromal disrupting effects of nab-paclitaxel in pancreatic cancer'.

artículo científico publicado en 2014

Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

artículo científico publicado en 2013

Role of C/EBPβ transcription factor in adult hippocampal neurogenesis

artículo científico publicado en 2011

Role of bulge epidermal stem cells and TSLP signaling in psoriasis

scientific article published on 26 September 2019

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer

artículo científico publicado en 2015

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

artículo científico publicado en 2018

Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models

scientific article published on 08 August 2019

Screening protocol for the identification of modulators by immunofluorescent cell-based assay

artículo científico publicado en 2019

Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression

artículo científico publicado en 2010

Specific targeting of human inflamed endothelium and in situ vascular tissue transfection by the use of ultrasound contrast agents

artículo científico publicado en 2009

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

artículo científico publicado en 2017

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

artículo científico publicado en 2018

Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells

artículo científico publicado en 2009

The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.

artículo científico publicado en 2017

The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.

artículo científico publicado en 2011

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK ⬇️

artículo científico publicado el 14 de agosto de 2012

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

artículo científico publicado en 2015

Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.

artículo científico publicado en 2018

Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

scientific article published on 27 September 2019

Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis ⬇️

artículo científico publicado el 22 de agosto de 2012

Vitrification versus slow freezing of oocytes: effects on morphologic appearance, meiotic spindle configuration, and DNA damage

artículo científico publicado en 2010

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.

artículo científico publicado en 2017

c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis

artículo científico publicado en 2017

iMSRC: converting a standard automated microscope into an intelligent screening platform

artículo científico publicado en 2015

p120-catenin differentially regulates cell migration by Rho-dependent intracellular and secreted signals

artículo científico publicado en 2014

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors

artículo científico publicado en 2018

Lista de obras de Diego Megías

A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka.

A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.

Application of standard cell cultures and 3D in vitro tissue models as an effective tool in drug design and development.

Assessing kinetics and recruitment of DNA repair factors using high content screens

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer.

CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions

Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge.

Combinatorial effects of splice variants modulate function of Aiolos

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis.

Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias

Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing

EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.

Fra-2-expressing macrophages promote lung fibrosis in mice

Gasdermin-B promotes invasion and metastasis in breast cancer cells

Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division

Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.

HCS Methodology for Helping in Lab Scale Image-Based Assays

High-Throughput Image-Based Screening to Identify Chemical Compounds Capable of Activating FOXO

Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias

Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

Lysosomal trapping of palbociclib and its functional implications

MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells

MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.

Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

Novel lambda FRET spectral confocal microscopy imaging method

PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection

Podoplanin associates with CD44 to promote directional cell migration

Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion.

Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis.

Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1.

RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway

Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms

Reply: 'Comments on Stromal disrupting effects of nab-paclitaxel in pancreatic cancer'.

Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

Role of C/EBPβ transcription factor in adult hippocampal neurogenesis

Role of bulge epidermal stem cells and TSLP signaling in psoriasis

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models

Screening protocol for the identification of modulators by immunofluorescent cell-based assay

Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression

Specific targeting of human inflamed endothelium and in situ vascular tissue transfection by the use of ultrasound contrast agents

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells

The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.

The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK ⬇️

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.

Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis ⬇️

Vitrification versus slow freezing of oocytes: effects on morphologic appearance, meiotic spindle configuration, and DNA damage

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.

c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis

iMSRC: converting a standard automated microscope into an intelligent screening platform

p120-catenin differentially regulates cell migration by Rho-dependent intracellular and secreted signals

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors