Lista de obras - Nicole Déglon - Dominio Público Uruguay

A Gene Therapy Approach to Regulated Delivery of Erythropoietin as a Function of Oxygen Tension ⬇️

artículo científico publicado el 1 de noviembre de 1997

A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain

scientific article published on 04 December 2019

A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease

artículo científico publicado en 1998

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

artículo científico publicado en 2017

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

artículo científico publicado en 2013

AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington's disease.

artículo científico publicado en 2017

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.

artículo científico publicado en 2015

Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults.

artículo científico publicado en 2007

Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina.

artículo científico publicado en 2003

Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system

artículo científico publicado en 2016

Akt is altered in an animal model of Huntington's disease and in patients

artículo científico publicado en 2005

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

artículo científico publicado en 2008

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells

artículo científico publicado en 2014

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

artículo científico publicado en 2016

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

artículo científico publicado en 2008

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

artículo científico publicado en 2016

Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice

artículo científico publicado en 2015

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities.

artículo científico publicado en 2013

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease

artículo científico publicado en 2013

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity.

artículo científico publicado en 2006

CRISPR/Cas9-Mediated Genome Editing for Huntington’s Disease

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

artículo científico publicado en 2012

Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo

artículo científico publicado en 2012

Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

scientific article published on 01 February 2019

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

artículo científico publicado en 2006

Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

artículo científico publicado en 2003

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

artículo científico publicado en 2014

Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

artículo científico publicado en 2016

Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time

artículo científico publicado en 2003

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia.

artículo científico publicado en 2002

Development of Efficient AAV2/DJ-Based Viral Vectors to Selectively Downregulate the Expression of Neuronal or Astrocytic Target Proteins in the Rat Central Nervous System

scientific article published on 20 August 2019

Different tau species lead to heterogeneous tau pathology propagation and misfolding

scholarly article by Simon Dujardin et al published 29 November 2018 in Acta neuropathologica communications

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

artículo científico publicado en 2009

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

artículo científico publicado en 2016

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

artículo científico publicado en 2008

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

artículo científico publicado en 2002

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

artículo científico publicado en 2018

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

artículo científico publicado en 2008

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

artículo científico publicado en 2003

Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.

artículo científico publicado en 2012

Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

artículo científico publicado en 2013

Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors.

artículo científico publicado en 2000

Emerging technologies to study glial cells

artículo científico publicado en 2020

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

artículo científico publicado en 2004

Encapsulation of neurotrophic factor-releasing cells for the treatment of neurodegenerative diseases ⬇️

artículo científico publicado el 1 de enero de 1995

Engineered lentiviral vector targeting astrocytes in vivo

artículo científico publicado en 2009

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease.

artículo científico publicado en 2018

Erratum: Errata

scholarly article published in Nature Medicine

Evaluation of somatic cell variants deficient in glycosylphosphatidyl-inositol anchoring as candidates for genetic correction ⬇️

artículo científico publicado el 1 de noviembre de 1991

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

artículo científico publicado en 2007

Fatty acids regulate Thy-1 antigen mRNA stability in T lymphocyte precursors

artículo científico publicado en 1995

Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis.

artículo científico publicado en 2017

From huntingtin gene to Huntington’s disease-altering strategies

article

Gene silencing approaches for the treatment of Huntington's disease

artículo científico publicado en 2015

Gene transfer engineering for astrocyte-specific silencing in the CNS.

artículo científico publicado en 2015

Gene transfer into neurons from hippocampal slices: comparison of recombinant Semliki Forest Virus, adenovirus, adeno-associated virus, lentivirus, and measles virus.

artículo científico publicado en 2001

Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs

artículo científico publicado en 2020

Glucose metabolism links astroglial mitochondria to cannabinoid effects

scientific article published on 08 July 2020

Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

artículo científico publicado en 2001

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

artículo científico publicado en 2007

Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines

artículo científico publicado en 2018

Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution

artículo científico publicado en 2009

Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARgamma/STAT5 signaling pathway in macaques

artículo científico publicado en 2008

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

artículo científico publicado en 2018

Implication of the JNK pathway in a rat model of Huntington's disease

artículo científico publicado en 2008

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

artículo científico publicado en 2010

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

artículo científico publicado en 2006

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

artículo científico publicado en 1996

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

artículo científico publicado en 2006

Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg).

artículo científico publicado en 1991

Isolation of multipotent neural precursors residing in the cortex of the adult human brain.

artículo científico publicado en 2001

Lentiviral Vectors in Huntington’s Disease Research and Therapy

Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain

artículo científico publicado en 2013

Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level

scientific article published on 01 June 2020

Lentiviral vectors: a powerful tool to target astrocytes in vivo

artículo científico

Lentiviral-Mediated Gene Transfer of siRNAs for the Treatment of Huntington’s Disease ⬇️

artículo científico publicado el 1 de enero de 2013

Lentiviral-mediated RNA interference

artículo científico publicado en 2002

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

artículo científico publicado en 2002

Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

artículo científico publicado en 2005

Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice

artículo científico publicado en 2004

Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts

artículo científico publicado en 2002

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

artículo científico publicado en 2004

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

artículo científico publicado en 2014

Maximizing lentiviral vector gene transfer in the CNS

artículo científico publicado en 2020

Membrane mu poly(A) signal and 3' flanking sequences function as a transcription terminator for immunoglobulin-encoding genes

artículo científico publicado en 1992

Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts

artículo científico publicado en 2007

Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth.

artículo científico publicado en 2015

Minocycline in phenotypic models of Huntington's disease

artículo científico publicado en 2005

Mitochondria in Huntington's disease

artículo científico publicado en 2009

Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter. ⬇️

artículo científico publicado en 2011

Multi-level regulation of Thy-1 antigen expression in mouse T lymphomas

artículo científico publicado el 1 de enero de 1992

Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo.

artículo científico publicado en 2003

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

artículo científico publicado en 2014

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

artículo científico publicado en 2024

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

artículo científico publicado en 2007

Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.

artículo científico publicado en 2001

Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons

artículo científico publicado en 2002

Normal aging modulates the neurotoxicity of mutant huntingtin

artículo científico publicado en 2009

Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression

artículo científico publicado en 2011

Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy.

artículo científico publicado en 2003

Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology

artículo científico publicado en 2013

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease

scientific journal article

Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.

artículo científico publicado en 2009

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

artículo científico publicado en 2017

Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology

artículo científico publicado en 2003

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

artículo científico publicado en 2005

RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease

artículo científico publicado en 2014

Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF

artículo científico publicado en 1996

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.

artículo científico publicado en 2000

Restricted transgene expression in the brain with cell-type specific neuronal promoters

artículo científico publicado en 2012

Restricted transgene expression in the brain with cell-type specific neuronal promoters

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients

artículo científico publicado en 2013

Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV)

article

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Seizure suppression by adenosine-releasing cells is independent of seizure frequency

artículo científico publicado en 2002

Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

artículo científico publicado en 2010

Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice

artículo científico publicado en 2013

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

artículo científico publicado en 2008

Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo

artículo científico publicado en 2014

Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions.

artículo científico publicado en 2004

Sustained effects of nonallele-specific Huntingtin silencing

artículo científico publicado en 2009

Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease

scientific article published on 09 November 2020

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

scientific article published on 09 October 2019

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

artículo científico publicado en 2015

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

artículo científico publicado en 2017

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

artículo científico publicado en 2018

Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free “GeneSwitch” vector

article

Transplants of CNTF-producing Cells for the Treatment of Huntington's Disease

article

Vers un nouveau rôle du récepteur PPAR-γ dans le syndrome d’immunodéficience acquise et les hémopathies chez l’homme

Viral Vectors for in Vivo Gene Transfer

article

Viral-mediated overexpression of mutant huntingtin to model HD in various species

artículo científico

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

artículo científico publicado en 2002

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.

artículo científico publicado en 2017

Lista de obras de Nicole Déglon

A Gene Therapy Approach to Regulated Delivery of Erythropoietin as a Function of Oxygen Tension ⬇️

A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain

A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington's disease.

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.

Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults.

Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina.

Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system

Akt is altered in an animal model of Huntington's disease and in patients

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities.

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity.

CRISPR/Cas9-Mediated Genome Editing for Huntington’s Disease

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo

Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia.

Development of Efficient AAV2/DJ-Based Viral Vectors to Selectively Downregulate the Expression of Neuronal or Astrocytic Target Proteins in the Rat Central Nervous System

Different tau species lead to heterogeneous tau pathology propagation and misfolding

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.

Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors.

Emerging technologies to study glial cells

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

Encapsulation of neurotrophic factor-releasing cells for the treatment of neurodegenerative diseases ⬇️

Engineered lentiviral vector targeting astrocytes in vivo

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease.

Erratum: Errata

Evaluation of somatic cell variants deficient in glycosylphosphatidyl-inositol anchoring as candidates for genetic correction ⬇️

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

Fatty acids regulate Thy-1 antigen mRNA stability in T lymphocyte precursors

Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis.

From huntingtin gene to Huntington’s disease-altering strategies

Gene silencing approaches for the treatment of Huntington's disease

Gene transfer engineering for astrocyte-specific silencing in the CNS.

Gene transfer into neurons from hippocampal slices: comparison of recombinant Semliki Forest Virus, adenovirus, adeno-associated virus, lentivirus, and measles virus.

Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs

Glucose metabolism links astroglial mitochondria to cannabinoid effects

Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines

Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution

Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARgamma/STAT5 signaling pathway in macaques

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

Implication of the JNK pathway in a rat model of Huntington's disease

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg).

Isolation of multipotent neural precursors residing in the cortex of the adult human brain.

Lentiviral Vectors in Huntington’s Disease Research and Therapy

Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain

Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level

Lentiviral vectors: a powerful tool to target astrocytes in vivo

Lentiviral-Mediated Gene Transfer of siRNAs for the Treatment of Huntington’s Disease ⬇️

Lentiviral-mediated RNA interference

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease