Lista de obras - Lynne S Cox - Dominio Público Uruguay

A fluorescence-based exonuclease assay to characterize DmWRNexo, orthologue of human progeroid WRN exonuclease, and its application to other nucleases

artículo científico publicado en 2013

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

artículo científico publicado en 1995

Animal and human models to understand ageing.

artículo científico publicado en 2016

Asymmetry of DNA replication fork progression in Werner's syndrome

artículo científico publicado en 2002

Cell senescence: the future of ageing?

artículo científico publicado en 2008

Characterisation of a sexual stage-specific gene encoding ORC1 homologue in the human malaria parasite Plasmodium falciparum.

artículo científico publicado en 2003

Characterisation of the interaction between PCNA and Gadd45

artículo científico publicado en 1995

Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP).

artículo científico publicado en 2019

DNA replication in cell-free extracts from Xenopus eggs is prevented by disrupting nuclear envelope function

artículo científico publicado el 1 de enero de 1992

DNA replication occurs at discrete sites in pseudonuclei assembled from purified DNA in vitro.

artículo científico publicado en 1991

Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.

artículo científico publicado en 2004

DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease

artículo científico publicado en 2008

EDITORIAL. REGULATION OF APOPTOSIS BY Bcl-2 AND ITS RELATED PROTEINS: IMMUNOCHEMICAL CHALLENGES AND THERAPEUTIC IMPLICATIONS

artículo científico publicado en 1996

From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.

artículo científico publicado en 2007

Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins

artículo científico publicado en 2019

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity

artículo científico publicado en 2008

Identification of a second proliferating cell nuclear antigen in the human malarial pathogen Plasmodium falciparum.

artículo científico publicado en 2002

Intercellular Transfer of Mitochondria between Senescent Cells through Cytoskeleton-Supported Intercellular Bridges Requires mTOR and CDC42 Signalling

artículo científico publicado en 2021

Live fast, die young: new lessons in mammalian longevity.

artículo científico publicado en 2009

MDM2 and MDMX bind and stabilize the p53-related protein p73

artículo científico publicado en 1999

Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease

artículo científico publicado en 2007

Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1 ⬇️

artículo científico publicado el 1 de octubre de 1997

Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP).

artículo científico publicado en 2019

PCNA tightens its hold on the nucleus.

artículo científico publicado en 2015

Prospects for rejuvenation of aged tissue by telomerase reactivation.

artículo científico publicado en 2010

Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease

artículo científico publicado en 2012

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.

artículo científico publicado en 2016

Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.

artículo científico publicado en 2000

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence.

artículo científico publicado en 2017

Structural basis of the anti-ageing effects of polyphenolics: mitigation of oxidative stress

scientific article published on 10 August 2020

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.

artículo científico publicado en 2015

The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro

artículo científico publicado en 2012

The role of DNA exonucleases in protecting genome stability and their impact on ageing.

artículo científico publicado en 2011

The role of cellular senescence in ageing of the placenta

artículo científico publicado en 2017

Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

artículo científico publicado en 1995

Two Pathways for Base Excision Repair in Mammalian Cells

artículo científico publicado en 1996

Who binds wins: Competition for PCNA rings out cell-cycle changes

article

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

scholarly article by Hannah E Walters published in August 2018

Lista de obras de Lynne S Cox

A fluorescence-based exonuclease assay to characterize DmWRNexo, orthologue of human progeroid WRN exonuclease, and its application to other nucleases

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

Animal and human models to understand ageing.

Asymmetry of DNA replication fork progression in Werner's syndrome

Cell senescence: the future of ageing?

Characterisation of a sexual stage-specific gene encoding ORC1 homologue in the human malaria parasite Plasmodium falciparum.

Characterisation of the interaction between PCNA and Gadd45

Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP).

DNA replication in cell-free extracts from Xenopus eggs is prevented by disrupting nuclear envelope function

DNA replication occurs at discrete sites in pseudonuclei assembled from purified DNA in vitro.

Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.

DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease

EDITORIAL. REGULATION OF APOPTOSIS BY Bcl-2 AND ITS RELATED PROTEINS: IMMUNOCHEMICAL CHALLENGES AND THERAPEUTIC IMPLICATIONS

From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.

Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity

Identification of a second proliferating cell nuclear antigen in the human malarial pathogen Plasmodium falciparum.

Intercellular Transfer of Mitochondria between Senescent Cells through Cytoskeleton-Supported Intercellular Bridges Requires mTOR and CDC42 Signalling

Live fast, die young: new lessons in mammalian longevity.

MDM2 and MDMX bind and stabilize the p53-related protein p73

Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease

Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1 ⬇️

Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP).

PCNA tightens its hold on the nucleus.

Prospects for rejuvenation of aged tissue by telomerase reactivation.

Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.

Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence.

Structural basis of the anti-ageing effects of polyphenolics: mitigation of oxidative stress

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.

The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro

The role of DNA exonucleases in protecting genome stability and their impact on ageing.

The role of cellular senescence in ageing of the placenta

Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

Two Pathways for Base Excision Repair in Mammalian Cells

Who binds wins: Competition for PCNA rings out cell-cycle changes

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases