Lista de obras - Joris Deelen - Dominio Público Uruguay

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

artículo científico publicado en 2015

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

artículo científico publicado en 2011

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

artículo científico publicado en 2013

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

artículo científico publicado en 2016

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

artículo científico publicado en 2013

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

scientific article published on 15 August 2016

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

artículo científico publicado en 2016

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

artículo científico publicado en 2014

Biological interpretation of genome-wide association studies using predicted gene functions

artículo científico publicado en 2015

Blood lipids influence DNA methylation in circulating cells

artículo científico publicado en 2016

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

artículo científico publicado en 2015

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

artículo científico publicado en 2017

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

artículo científico publicado en 2012

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

artículo científico publicado en 2015

Disease variants alter transcription factor levels and methylation of their binding sites

artículo científico publicado en 2016

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene

artículo científico publicado en 2012

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

artículo científico publicado en 2016

Exome and whole genome sequencing in aging and longevity.

artículo científico

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

artículo científico publicado en 2014

Gene expression analysis of mTOR pathway: association with human longevity

artículo científico publicado en 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

artículo científico publicado en 2011

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

artículo científico publicado en 2018

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

artículo científico publicado en 2015

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

artículo científico publicado en 2018

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

artículo científico publicado en 2014

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

artículo científico publicado en 2011

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

artículo científico publicado en 2018

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

artículo científico publicado en 2013

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

artículo científico publicado en 2016

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

artículo científico publicado en 2016

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

artículo científico publicado en 2020

How to deal with the early GWAS data when imputing and combining different arrays is necessary

artículo científico publicado en 2011

IL7R gene expression network associates with human healthy ageing

artículo científico publicado en 2015

Identification of context-dependent expression quantitative trait loci in whole blood

artículo científico publicado en 2016

Identification of seven loci affecting mean telomere length and their association with disease

artículo científico publicado en 2013

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

artículo científico publicado en 2013

IgG glycosylation and DNA methylation are interconnected with smoking

artículo científico publicado en 2017

LDL cholesterol still a problem in old age? A Mendelian randomization study

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

artículo científico publicado en 2014

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

artículo científico publicado en 2014

Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms. ⬇️

artículo científico publicado en 2016

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

artículo científico publicado en 2016

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

artículo científico publicado en 2013

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

artículo científico publicado en 2020

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

artículo científico publicado en 2015

Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

artículo científico publicado en 2020

New genetic loci link adipose and insulin biology to body fat distribution

artículo científico publicado en 2015

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data

artículo científico publicado en 2013

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

artículo científico publicado en 2017

Novel loci and pathways significantly associated with longevity

artículo científico publicado en 2016

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Searching for the genetic key to a long and healthy life

scientific article published on 24 April 2020

Sex Differences in Genetic Associations With Longevity

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

artículo científico publicado en 2014

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

artículo científico publicado en 2017

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

artículo científico publicado en 2013

The MC1R Gene and Youthful Looks

artículo científico publicado en 2016

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

artículo científico publicado en 2016

The impact of low-frequency and rare variants on lipid levels

artículo científico publicado en 2015

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

artículo científico publicado en 2012

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

artículo científico publicado en 2016

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

artículo científico publicado en 2014

Lista de obras de Joris Deelen

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

A meta-analysis of genome-wide association studies identifies multiple longevity genes

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

Biological interpretation of genome-wide association studies using predicted gene functions

Blood lipids influence DNA methylation in circulating cells

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

Defining the role of common variation in the genomic and biological architecture of adult human height

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

Disease variants alter transcription factor levels and methylation of their binding sites

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

Exome and whole genome sequencing in aging and longevity.

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

Gene expression analysis of mTOR pathway: association with human longevity

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

How to deal with the early GWAS data when imputing and combining different arrays is necessary

IL7R gene expression network associates with human healthy ageing

Identification of context-dependent expression quantitative trait loci in whole blood

Identification of seven loci affecting mean telomere length and their association with disease

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

IgG glycosylation and DNA methylation are interconnected with smoking

LDL cholesterol still a problem in old age? A Mendelian randomization study

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms. ⬇️

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

New genetic loci link adipose and insulin biology to body fat distribution

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Novel loci and pathways significantly associated with longevity

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Searching for the genetic key to a long and healthy life

Sex Differences in Genetic Associations With Longevity

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

The MC1R Gene and Youthful Looks

The complex genetics of gait speed: genome-wide meta-analysis approach

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

The impact of low-frequency and rare variants on lipid levels

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk