Lista de obras - Leonardo Manzoni - Dominio Público Uruguay

4-Aminoproline-based arginine-glycine-aspartate integrin binders with exposed ligation points: practical in-solution synthesis, conjugation and binding affinity evaluation.

artículo científico publicado en 2009

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

artículo científico publicado en 2017

A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.

artículo científico publicado en 2011

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids

artículo científico publicado en 2008

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

artículo científico publicado en 2005

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

artículo científico publicado en 2015

Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.

artículo científico publicado en 2009

Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

artículo científico publicado en 2009

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

artículo científico publicado en 2015

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

artículo científico publicado en 2012

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

artículo científico publicado en 2009

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

artículo científico publicado en 2012

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

artículo científico publicado en 2016

Enhancement of the uptake and cytotoxic activity of doxorubicin in cancer cells by novel cRGD-semipeptide-anchoring liposomes.

artículo científico publicado en 2014

Froc: a new fluorous protective group for peptide and oligosaccharide synthesis

artículo científico publicado en 2006

Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

artículo científico publicado en 2005

Functionalized cyclic RGD peptidomimetics: conjugable ligands for αvβ3 receptor imaging.

artículo científico publicado en 2009

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

artículo científico publicado en 2012

Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors

artículo científico publicado en 2017

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

artículo científico publicado en 2018

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies

artículo científico publicado en 2017

MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction.

artículo científico publicado en 2013

Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.

artículo científico publicado en 2003

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

artículo científico publicado en 2016

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

artículo científico publicado en 2010

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

artículo científico publicado en 2010

Rapid synthesis of oligosaccharides using an anomeric fluorous silyl protecting group.

artículo científico publicado en 2003

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

artículo científico publicado en 2009

Regulation of HuR structure and function by dihydrotanshinone-I.

artículo científico publicado en 2017

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

artículo científico publicado en 2001

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

artículo científico publicado en 2009

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

artículo científico publicado en 2014

Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.

artículo científico publicado en 2012

Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag

scientific article published on 01 November 2004

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

artículo científico publicado en 2005

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

artículo científico publicado en 2008

Lista de obras de Leonardo Manzoni

4-Aminoproline-based arginine-glycine-aspartate integrin binders with exposed ligation points: practical in-solution synthesis, conjugation and binding affinity evaluation.

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.

Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

Enhancement of the uptake and cytotoxic activity of doxorubicin in cancer cells by novel cRGD-semipeptide-anchoring liposomes.

Froc: a new fluorous protective group for peptide and oligosaccharide synthesis

Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

Functionalized cyclic RGD peptidomimetics: conjugable ligands for αvβ3 receptor imaging.

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies

MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction.

Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

Rapid synthesis of oligosaccharides using an anomeric fluorous silyl protecting group.

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Regulation of HuR structure and function by dihydrotanshinone-I.

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.

Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles