Lista de obras - Daniele Lecis - Dominio Público Uruguay

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

artículo científico publicado en 2017

Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities.

artículo científico publicado en 2017

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

artículo científico publicado en 2013

Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

artículo científico publicado en 2005

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

artículo científico publicado en 2006

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

artículo científico publicado en 2019

DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.

artículo científico publicado en 2009

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

artículo científico publicado en 2009

Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10

artículo científico publicado en 2014

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

artículo científico publicado en 2012

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

artículo científico publicado en 2016

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells

artículo científico publicado en 2014

Expression quantitative trait analysis reveals fine germline transcript regulation in mouse lung tumors.

artículo científico publicado en 2016

Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency

artículo científico publicado en 2014

Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.

artículo científico publicado en 2019

Infiltrating mast cell-mediated stimulation of estrogen receptor activity in breast cancer cells promotes the luminal phenotype

scientific article published on 16 March 2020

Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.

artículo científico publicado en 2003

Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members

artículo científico publicado en 2016

MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner.

artículo científico publicado en 2018

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

artículo científico

Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells

scientific article published on 14 November 2018

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

artículo científico publicado en 2010

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

artículo científico publicado en 2010

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

artículo científico publicado en 2012

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

artículo científico publicado en 2009

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

artículo científico publicado en 2010

SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis

artículo científico publicado en 2021

SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.

artículo científico publicado en 2014

Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

artículo científico publicado en 2013

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

artículo científico publicado en 2013

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

artículo científico publicado en 2012

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

artículo científico publicado en 2009

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs

scientific article published on 16 August 2018

Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway

scientific article published on 26 November 2021

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases

artículo científico publicado en 2017

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

artículo científico publicado en 2014

Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells

artículo científico publicado en 2017

Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment

artículo científico publicado en 2019

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

artículo científico publicado en 2008

The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies

artículo científico publicado en 2015

The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage.

artículo científico publicado en 2009

When Failure Is Worse Than Giving Up: The Case of CTL

scientific article published on 01 April 2019

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.

artículo científico publicado en 2018

Lista de obras de Daniele Lecis

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities.

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells

Expression quantitative trait analysis reveals fine germline transcript regulation in mouse lung tumors.

Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency

Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.

Infiltrating mast cell-mediated stimulation of estrogen receptor activity in breast cancer cells promotes the luminal phenotype

Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.

Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members

MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner.

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis

SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.

Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs

Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells

Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies

The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage.

When Failure Is Worse Than Giving Up: The Case of CTL

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.