Lista de obras - Yosuke Demizu - Dominio Público Uruguay

A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool

artículo científico publicado en 2015

A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides

artículo científico publicado en 2015

A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products

artículo científico publicado en 2015

Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability.

artículo científico publicado en 2014

An extended planar C5 conformation and a 310-helical structure of peptide foldamer composed of diverse alpha-ethylated alpha,alpha-disubstituted alpha-amino acids

scientific article published on 01 July 2003

Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.

artículo científico publicado en 2007

Chiral centers in the side chains of alpha-amino acids control the helical screw sense of peptides

scientific article published on 01 October 2004

Conformational studies on peptides containing α,α-disubstituted α-amino acids: chiral cyclic α,α-disubstituted α-amino acid as an α-helical inducer

artículo científico publicado en 2011

Conformations of helical Aib peptides containing a pair of L-amino acid and D-amino acid

artículo científico publicado en 2012

Conformations of peptides containing a chiral cyclic α, α‐disubstituted α‐amino acid within the sequence of Aib residues ⬇️

artículo científico publicado el 1 de noviembre de 2010

Controlling 3(10)-helix and alpha-helix of short peptides in the solid state

scientific article published on 01 May 2007

Controlling the helical screw sense of peptides with C-terminal L-valine.

artículo científico publicado en 2010

De Novo Design of Cell-penetrating Foldamers

artículo científico publicado en 2020

Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives

artículo científico publicado en 2018

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.

artículo científico publicado en 2011

Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton

artículo científico publicado en 2018

Design and synthesis of novel selective estrogen receptor degradation inducers based on the diphenylheptane skeleton

scientific article published on 08 December 2016

Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.

artículo científico publicado en 2013

Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands ⬇️

artículo científico publicado el 17 de agosto de 2011

Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives.

artículo científico publicado en 2015

Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives.

artículo científico publicado en 2015

Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

artículo científico publicado en 2019

Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence

artículo científico publicado en 2019

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

artículo científico publicado en 2016

Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins

scientific article published on 16 October 2019

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.

artículo científico publicado en 2016

Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins.

artículo científico publicado en 2017

Development of a peptide-based inducer of nuclear receptors degradation

artículo científico publicado en 2016

Development of a peptide-based inducer of protein degradation targeting NOTCH1.

artículo científico publicado en 2017

Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells.

artículo científico publicado en 2017

Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.

artículo científico publicado en 2014

Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic α,α-disubstituted α-amino acid residues

artículo científico publicado en 2017

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters.

artículo científico publicado en 2017

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

artículo científico publicado en 2013

Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions.

artículo científico publicado en 2013

Diastereomeric Right- and Left-Handed Helical Structures with Fourteen (R)-Chiral Centers

artículo científico publicado en 2017

Direct electrochemical alpha-cyanation of N-protected cyclic amines.

artículo científico publicado en 2008

Effect of one D-Leu residue on right-handed helical -L-Leu-Aib- peptides in the crystal state

scientific article published on 21 February 2011

Effects of D-Leu residues on the helical secondary structures of L-Leu-based nonapeptides

artículo científico publicado en 2015

Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton

artículo científico publicado en 2015

Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic.

artículo científico publicado en 2017

Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence

artículo científico publicado en 2018

Front Cover: Recent Advances in PROTAC Technology Toward New Therapeutic Modalities (Chem. Biodiversity 11/2022)

artículo científico publicado en 2022

Helical foldamer containing a combination of cyclopentane-1,2-diamine and 2,2-dimethylmalonic acid

artículo científico publicado en 2013

Helical peptide-foldamers having a chiral five-membered ring amino acid with two azido functional groups

artículo científico publicado en 2014

Helical-screw directions of diastereoisomeric cyclic alpha-amino acid oligomers.

artículo científico publicado en 2009

Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator

artículo científico publicado en 2016

Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis

scientific article published on 01 January 2011

Inhibition of β-amyloid-induced neurotoxicity by planar analogues of procyanidin B3

artículo científico publicado en 2019

Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium

artículo científico publicado en 2013

Left-Handed Helix of Three-Membered Ring Amino Acid Homopeptide Interrupted by an N-H···Ethereal O-Type Hydrogen Bond

scientific article published on 30 November 2018

Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: synthetic application to chiral seven-membered-ring alpha,alpha-disubstituted alpha-amino acid

scientific article published on 22 August 2007

Low pH-triggering changes in peptide secondary structures

artículo científico publicado en 2017

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

artículo científico publicado en 2016

Monoallylation of 1,2-diols by Pd/Sn bimetallic catalysis

scientific article published on 27 January 2012

NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells

artículo científico publicado en 2014

Oligopeptides with equal amounts of L- and D-amino acids may prefer a helix screw sense.

artículo científico publicado en 2013

One-handed helical screw direction of homopeptide foldamer exclusively induced by cyclic α-amino acid side-chain chiral centers

artículo científico publicado en 2012

PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA.

artículo científico publicado en 2017

Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage.

artículo científico publicado en 2016

Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids

artículo científico publicado en 2016

Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides.

artículo científico publicado en 2015

Preorganized Cyclic α,α-Disubstituted α-Amino Acids Bearing Functionalized Side Chains That Act as Peptide-Helix Inducers

artículo científico publicado en 2017

Rational Design and Synthesis of Post-Functionalizable Peptide Foldamers as Helical Templates.

artículo científico publicado en 2017

Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling

artículo científico publicado en 2020

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

artículo científico publicado en 2019

Regioselective protection of sugars catalyzed by dimethyltin dichloride

scientific article published on 10 October 2008

Screw-sense control of helical oligopeptides containing equal amounts of L- and D-amino acids

artículo científico publicado en 2011

Side-chain chiral centers of amino acid and helical-screw handedness of its peptides

scientific article published on 01 August 2005

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

artículo científico publicado en 2017

Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives.

artículo científico publicado en 2018

Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon

artículo científico publicado en 2018

Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.

artículo científico publicado en 2015

Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors

artículo científico publicado en 2015

Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents

artículo científico publicado en 2015

Synthesis and Resolution of Substituted [5]Carbohelicenes

artículo científico publicado en 2015

Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives

artículo científico publicado en 2006

Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents ⬇️

artículo científico publicado el 3 de julio de 2013

Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator

artículo científico publicado en 2016

Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators.

artículo científico publicado en 2015

Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication

artículo científico publicado en 2006

Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptides

scientific article published on 01 November 2016

Tamoxifen and Fulvestrant Hybrids Showed Potency as Selective Estrogen Receptor Down-Regulators.

artículo científico publicado en 2016

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.

artículo científico publicado en 2016

The side-chain hydroxy groups of a cyclic α,α-disubstituted α-amino acid promote oligopeptide 310 -helix packing in the crystalline state.

artículo científico publicado en 2016

Three-dimensional structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state

artículo científico publicado en 2010

Topological Study of the Structures of Heterochiral Peptides Containing Equal Amounts of l-Leu and d-Leu

artículo científico publicado en 2015

Twisted structure of a cyclic hexapeptide containing a combination of alternating L-Leu-D-Leu-Aib segments

artículo científico publicado en 2012

β-PNA: peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone

artículo científico publicado en 2011

Lista de obras de Yosuke Demizu

A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool

A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides

A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products

Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability.

An extended planar C5 conformation and a 310-helical structure of peptide foldamer composed of diverse alpha-ethylated alpha,alpha-disubstituted alpha-amino acids

Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.

Chiral centers in the side chains of alpha-amino acids control the helical screw sense of peptides

Conformational studies on peptides containing α,α-disubstituted α-amino acids: chiral cyclic α,α-disubstituted α-amino acid as an α-helical inducer

Conformations of helical Aib peptides containing a pair of L-amino acid and D-amino acid

Conformations of peptides containing a chiral cyclic α, α‐disubstituted α‐amino acid within the sequence of Aib residues ⬇️

Controlling 3(10)-helix and alpha-helix of short peptides in the solid state

Controlling the helical screw sense of peptides with C-terminal L-valine.

De Novo Design of Cell-penetrating Foldamers

Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.

Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton

Design and synthesis of novel selective estrogen receptor degradation inducers based on the diphenylheptane skeleton

Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.

Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands ⬇️

Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives.

Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives.

Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.

Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins.

Development of a peptide-based inducer of nuclear receptors degradation

Development of a peptide-based inducer of protein degradation targeting NOTCH1.

Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells.

Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.

Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic α,α-disubstituted α-amino acid residues

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters.

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions.

Diastereomeric Right- and Left-Handed Helical Structures with Fourteen (R)-Chiral Centers

Direct electrochemical alpha-cyanation of N-protected cyclic amines.

Effect of one D-Leu residue on right-handed helical -L-Leu-Aib- peptides in the crystal state

Effects of D-Leu residues on the helical secondary structures of L-Leu-based nonapeptides

Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton

Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic.

Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence

Front Cover: Recent Advances in PROTAC Technology Toward New Therapeutic Modalities (Chem. Biodiversity 11/2022)

Helical foldamer containing a combination of cyclopentane-1,2-diamine and 2,2-dimethylmalonic acid

Helical peptide-foldamers having a chiral five-membered ring amino acid with two azido functional groups

Helical-screw directions of diastereoisomeric cyclic alpha-amino acid oligomers.

Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator

Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis

Inhibition of β-amyloid-induced neurotoxicity by planar analogues of procyanidin B3

Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium

Left-Handed Helix of Three-Membered Ring Amino Acid Homopeptide Interrupted by an N-H···Ethereal O-Type Hydrogen Bond

Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: synthetic application to chiral seven-membered-ring alpha,alpha-disubstituted alpha-amino acid

Low pH-triggering changes in peptide secondary structures

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

Monoallylation of 1,2-diols by Pd/Sn bimetallic catalysis

NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells

Oligopeptides with equal amounts of L- and D-amino acids may prefer a helix screw sense.

One-handed helical screw direction of homopeptide foldamer exclusively induced by cyclic α-amino acid side-chain chiral centers

PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA.

Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage.

Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids

Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides.

Preorganized Cyclic α,α-Disubstituted α-Amino Acids Bearing Functionalized Side Chains That Act as Peptide-Helix Inducers

Rational Design and Synthesis of Post-Functionalizable Peptide Foldamers as Helical Templates.

Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

Regioselective protection of sugars catalyzed by dimethyltin dichloride

Screw-sense control of helical oligopeptides containing equal amounts of L- and D-amino acids

Side-chain chiral centers of amino acid and helical-screw handedness of its peptides

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives.

Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon

Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.

Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors

Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents

Synthesis and Resolution of Substituted [5]Carbohelicenes

Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives

Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents ⬇️

Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator