Lista de obras - Cornelia Prehn - Dominio Público Uruguay

12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study

artículo científico publicado en 2016

A genome-wide perspective of genetic variation in human metabolism

artículo científico publicado en 2009

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

article

A network-based conditional genetic association analysis of the human metabolome

artículo científico publicado en 2018

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

article

A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance

artículo científico publicado en 2015

Acylcarnitine profiles in serum and muscle of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation

artículo científico publicado en 2018

Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies

article published in 2019

Alcohol-induced metabolomic differences in humans

artículo científico publicado en 2013

Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk

artículo científico publicado en 2015

Alterations of the acylcarnitine profiles in blood serum and in muscle from periparturient cows with normal or elevated body condition

artículo científico publicado en 2020

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques.

artículo científico publicado en 2018

Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes

artículo científico publicado en 2015

Assay Tools for Metabolomics

Association of Atopic Dermatitis with Cardiovascular Risk Factors and Diseases

artículo científico publicado en 2016

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

artículo científico publicado en 2013

Associations of anthropometric markers with serum metabolites using a targeted metabolomics approach: results of the EPIC-potsdam study

artículo científico publicado en 2016

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice

artículo científico publicado en 2016

Biogenic amines: Concentrations in serum and skeletal muscle from late pregnancy until early lactation in dairy cows with high versus normal body condition score

artículo científico publicado en 2019

Body fat free mass is associated with the serum metabolite profile in a population-based study

artículo científico publicado en 2012

Changes in the serum metabolite profile in obese children with weight loss

artículo científico publicado en 2014

Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass

artículo científico publicado en 2012

Childhood obesity is associated with changes in the serum metabolite profile

artículo científico publicado en 2012

Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.

artículo científico publicado en 2018

Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland--involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1.

artículo científico publicado en 2011

Circulating glutamate concentration as a biomarker of visceral obesity and associated metabolic alterations

scientific article published on 06 November 2018

Circulating steroid levels as correlates of adipose tissue phenotype in premenopausal women

scientific article published on 11 May 2018

Comparative analysis of plasma metabolomics response to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk allele

article

Comparison of metabolite networks from four German population-based studies

article

Cord Blood Lysophosphatidylcholine 16: 1 is Positively Associated with Birth Weight

artículo científico publicado en 2018

Correction to: A network-based conditional genetic association analysis of the human metabolome

artículo científico publicado en 2019

Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism

artículo científico publicado en 2021

Cortisol-related metabolic alterations assessed by mass spectrometry assay in patients with Cushing's syndrome

artículo científico publicado en 2017

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

artículo científico publicado en 2012

Development of an (S)-1-{2-[Tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] Carba Analogue Inhibitor for Murine γ-Aminobutyric Acid Transporter Type 4

article

Differences between human plasma and serum metabolite profiles

artículo científico publicado en 2011

Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis

artículo científico publicado en 2012

Discovery of sexual dimorphisms in metabolic and genetic biomarkers

artículo científico publicado en 2011

Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis

artículo científico publicado en 2017

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes

artículo científico publicado en 2015

Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study

artículo científico publicado en 2013

Endocrinology Meets Metabolomics: Achievements, Pitfalls, and Challenges.

artículo científico

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.

artículo científico publicado en 2018

Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study

artículo científico publicado en 2014

Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation

article

Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo.

artículo científico publicado en 2018

Familial resemblance for serum metabolite concentrations

artículo científico publicado en 2013

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

artículo científico publicado en 2018

Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice

artículo científico publicado en 2017

Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes

artículo científico publicado en 2017

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

artículo científico publicado en 2015

Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium

artículo científico publicado en 2015

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

artículo científico publicado en 2013

High-throughput extraction and quantification method for targeted metabolomics in murine tissues.

artículo científico publicado en 2017

Human metabolic individuality in biomedical and pharmaceutical research

artículo científico publicado en 2011

Human serum metabolic profiles are age dependent

artículo científico publicado en 2012

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach

artículo científico publicado en 2012

Immediate reduction of serum citrulline but no change of steroid profile after initiation of metformin in individuals with type 2 diabetes

artículo científico publicado en 2017

Impact of maternal smoking associated lyso-phosphatidylcholine 20:3 on offspring brain development

artículo científico publicado en 2020

Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers

artículo científico publicado en 2017

Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up

artículo científico publicado en 2014

Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction

artículo científico publicado en 2020

Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: comparison with other steroid metabolizing enzymes.

artículo científico publicado en 2005

Innovations in phenotyping of mouse models in the German Mouse Clinic

artículo científico publicado en 2012

Instability of personal human metabotype is linked to all-cause mortality.

artículo científico publicado en 2018

Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington's disease peripheral blood samples

artículo científico publicado en 2016

Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma

artículo científico publicado en 2013

Intergenerational Metabolomic Analysis of Mothers with a History of Gestational Diabetes Mellitus and Their Offspring

artículo científico publicado en 2020

Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.

artículo científico publicado en 2016

International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis

scientific article published on 08 November 2019

Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

artículo científico publicado en 2014

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

artículo científico publicado en 2005

LC-MS/MS-Based Metabolomics for Cell Cultures

artículo científico publicado en 2019

Lactation is associated with altered metabolomic signatures in women with gestational diabetes

artículo científico publicado en 2016

Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study

artículo científico publicado en 2014

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse

artículo científico publicado en 2015

Long-Term Stability of Human Plasma Metabolites during Storage at -80 °C.

artículo científico publicado en 2017

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.

artículo científico publicado en 2018

Mammalian target of rapamycin signaling and ubiquitin-proteasome-related gene expression in skeletal muscle of dairy cows with high or normal body condition score around calving

scientific article published on 03 October 2019

Mendelian Randomization Study on Amino Acid Metabolism Suggests Tyrosine as Causal Trait for Type 2 Diabetes

scientific article published on 19 December 2020

Metabolic impact of pheochromocytoma/paraganglioma: targeted metabolomics in patients before and after tumor removal

scientific article published on 01 December 2019

Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.

artículo científico publicado en 2015

Metabolite Shifts Induced by Marathon Race Competition Differ between Athletes Based on Level of Fitness and Performance: A Substudy of the Enzy-MagIC Study

scientific article published on 01 March 2020

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

artículo científico publicado en 2017

Metabolites associate with kidney function decline and incident chronic kidney disease in the general population

artículo científico publicado en 2013

Metabolome profiling in skeletal muscle to characterize metabolic alterations in over-conditioned cows during the periparturient period

scientific article published on 31 January 2020

Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus

artículo científico publicado en 2017

Metabolomic profiles in individuals with negative affectivity and social inhibition: a population-based study of Type D personality

artículo científico publicado en 2012

Metabolomics meets machine learning: Longitudinal metabolite profiling in serum of normal versus overconditioned cows and pathway analysis

scientific article published on 20 September 2019

Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake

artículo científico publicado en 2014

Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children

Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema

artículo científico publicado en 2015

Mild maternal hyperglycemia in INS C93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring

artículo científico publicado en 2019

Models including plasma levels of sphingomyelins and phosphatidylcholines as diagnostic and prognostic biomarkers of endometrial cancer

artículo científico publicado en 2018

Mouse Age Matters: How Age Affects the Murine Plasma Metabolome

scientific article published on 19 November 2020

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse phenotyping

artículo científico publicado en 2010

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus

scientific article published on 04 June 2019

Network based conditional genome wide association analysis of human metabolomics

Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation

artículo científico publicado en 2019

Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype

scholarly article by Markus Rotter published in August 2018

Nonadditive Effects of Genes in Human Metabolomics

artículo científico publicado en 2015

Novel biomarkers for pre-diabetes identified by metabolomics

artículo científico publicado en 2012

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

artículo científico publicado en 2018

Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study.

artículo científico publicado en 2015

Plasma and Serum Metabolite Association Networks: Comparability within and between Studies Using NMR and MS Profiling

artículo científico publicado en 2017

Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146

artículo científico publicado en 2013

Pleiotropic functions for transcription factor zscan10.

artículo científico publicado en 2014

Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice

artículo científico

Postprandial metabolite profiles associated with type 2 diabetes clearly stratify individuals with impaired fasting glucose

artículo científico publicado en 2017

Pre-analytical sample quality: metabolite ratios as an intrinsic marker for prolonged room temperature exposure of serum samples

artículo científico publicado en 2015

Preservation of metabolic flexibility in skeletal muscle by a combined use of n-3 PUFA and rosiglitazone in dietary obese mice

artículo científico publicado en 2012

Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics

article published in 2011

Proteasome activity and expression of mammalian target of rapamycin signaling factors in skeletal muscle of dairy cows supplemented with conjugated linoleic acids during early lactation

scientific article published on 15 January 2020

Rapamycin extends murine lifespan but has limited effects on aging

artículo científico publicado en 2013

Recent advances in 17beta-hydroxysteroid dehydrogenases

artículo científico publicado en 2009

Reliability of serum metabolite concentrations over a 4-month period using a targeted metabolomic approach ⬇️

artículo científico publicado en 2011

Removing the bottlenecks of cell culture metabolomics: fast normalization procedure, correlation of metabolites to cell number, and impact of the cell harvesting method

artículo científico publicado en 2016

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

artículo científico publicado en 2011

Schizophrenia shows a unique metabolomics signature in plasma

artículo científico publicado en 2012

Serum and plasma amino acids as markers of prediabetes, insulin resistance, and incident diabetes

artículo científico publicado en 2017

Serum metabolite concentrations and decreased GFR in the general population

artículo científico publicado en 2012

Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts

artículo científico publicado en 2017

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes

artículo científico publicado en 2012

Stability of targeted metabolite profiles of urine samples under different storage conditions

artículo científico publicado en 2016

Systemic first-line phenotyping

artículo científico

Targeted Metabolomics of Dried Blood Spot Extracts

Targeted metabolomics identifies reliable and stable metabolites in human serum and plasma samples

artículo científico publicado en 2014

Targeted metabolomics profiles are strongly correlated with nutritional patterns in women

artículo científico publicado en 2012

Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells

artículo científico publicado en 2013

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

artículo científico publicado en 2016

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

artículo científico publicado en 2009

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes

artículo científico publicado en 2017

The dynamic range of the human metabolome revealed by challenges

artículo científico publicado en 2012

The human metabolic profile reflects macro- and micronutrient intake distinctly according to fasting time

scientific article published in Scientific Reports

The liver-alpha cell axis associates with liver fat and insulin resistance: a validation study in women with non-steatotic liver fat levels

artículo científico publicado en 2020

Treatment with beta-blockers is associated with lower levels of Lp-PLA2 and suPAR in carotid plaques

artículo científico publicado en 2013

Type 2 diabetes is associated with postprandial amino acid measures

artículo científico publicado en 2015

Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam

artículo científico publicado en 2013

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in mice

artículo científico publicado en 2019

Lista de obras de Cornelia Prehn

12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study

A genome-wide perspective of genetic variation in human metabolism

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

A network-based conditional genetic association analysis of the human metabolome

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance

Acylcarnitine profiles in serum and muscle of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation

Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies

Alcohol-induced metabolomic differences in humans

Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk

Alterations of the acylcarnitine profiles in blood serum and in muscle from periparturient cows with normal or elevated body condition

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques.

Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes

Assay Tools for Metabolomics

Association of Atopic Dermatitis with Cardiovascular Risk Factors and Diseases

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

Associations of anthropometric markers with serum metabolites using a targeted metabolomics approach: results of the EPIC-potsdam study

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice

Biogenic amines: Concentrations in serum and skeletal muscle from late pregnancy until early lactation in dairy cows with high versus normal body condition score

Body fat free mass is associated with the serum metabolite profile in a population-based study

Changes in the serum metabolite profile in obese children with weight loss

Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass

Childhood obesity is associated with changes in the serum metabolite profile

Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.

Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland--involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1.

Circulating glutamate concentration as a biomarker of visceral obesity and associated metabolic alterations

Circulating steroid levels as correlates of adipose tissue phenotype in premenopausal women

Comparative analysis of plasma metabolomics response to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk allele

Comparison of metabolite networks from four German population-based studies

Cord Blood Lysophosphatidylcholine 16: 1 is Positively Associated with Birth Weight

Correction to: A network-based conditional genetic association analysis of the human metabolome

Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism

Cortisol-related metabolic alterations assessed by mass spectrometry assay in patients with Cushing's syndrome

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

Development of an (S)-1-{2-[Tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] Carba Analogue Inhibitor for Murine γ-Aminobutyric Acid Transporter Type 4

Differences between human plasma and serum metabolite profiles

Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis

Discovery of sexual dimorphisms in metabolic and genetic biomarkers

Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes

Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study

Endocrinology Meets Metabolomics: Achievements, Pitfalls, and Challenges.

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.

Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study

Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation

Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo.

Familial resemblance for serum metabolite concentrations

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice

Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

High-throughput extraction and quantification method for targeted metabolomics in murine tissues.

Human metabolic individuality in biomedical and pharmaceutical research

Human serum metabolic profiles are age dependent

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach

Immediate reduction of serum citrulline but no change of steroid profile after initiation of metformin in individuals with type 2 diabetes

Impact of maternal smoking associated lyso-phosphatidylcholine 20:3 on offspring brain development

Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers

Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up

Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction

Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: comparison with other steroid metabolizing enzymes.

Innovations in phenotyping of mouse models in the German Mouse Clinic

Instability of personal human metabotype is linked to all-cause mortality.

Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington's disease peripheral blood samples

Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma

Intergenerational Metabolomic Analysis of Mothers with a History of Gestational Diabetes Mellitus and Their Offspring

Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.

International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis

Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

LC-MS/MS-Based Metabolomics for Cell Cultures

Lactation is associated with altered metabolomic signatures in women with gestational diabetes

Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse

Long-Term Stability of Human Plasma Metabolites during Storage at -80 °C.

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.