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Lista de obras de Hermann-Georg Holzhütter

2,3-Biphosphoglycerate, inorganic phosphate, pH and hemoglobin concentration in chronic renal failure of man

scientific article published on 01 January 1981

A Study on UV Filter Chemicals from Annex VII of European Union Directive 76/768/EEC, in the In Vitro 3T3 NRU Phototoxicity Test.

artículo científico publicado en 1998

A compartment model to calculate time-dependent concentration profiles of topically applied chemical compounds in the anterior compartments of the rabbit eye.

artículo científico publicado en 2001

A computational analysis of protein interactions in metabolic networks reveals novel enzyme pairs potentially involved in metabolic channeling

artículo científico publicado en 2007

A computer assisted method to control the steady state of an ATP-regenerating assay.

artículo científico publicado en 1989

A conceptual mathematical model of the dynamic self-organisation of distinct cellular organelles

artículo científico publicado en 2009

A hypothetical model of cargo-selective rab recruitment during organelle maturation

artículo científico publicado en 2012

A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes

artículo científico publicado en 1987

A kinetic model for the interaction of nitric oxide with a mammalian lipoxygenase

artículo científico publicado en 1997

A kinetic model of phosphofructokinase from Plasmodium berghei. Influence of ATP and fructose-6-phosphate

artículo científico publicado en 1988

A kinetic model of vertebrate 20S proteasome accounting for the generation of major proteolytic fragments from oligomeric peptide substrates

artículo científico publicado en 2000

A mathematical model for the cell age-dependent decline of creatine in human cell cells

artículo científico publicado en 1984

A mathematical model to study short-term regulation of mitochondrial energy transduction.

artículo científico publicado en 1985

A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism

artículo científico publicado en 2018

A new method of parameter estimation from progress curves.

artículo científico publicado en 1984

A study of anoxia in rat hepatocytes

scientific article published on 01 January 1994

A theoretical approach to the evolution and structural design of enzymatic networks: linear enzymatic chains, branched pathways and glycolysis of erythrocytes.

artículo científico publicado en 1987

A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20 S proteasome.

artículo científico publicado en 1999

A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis

artículo científico publicado en 2017

ATP-dependence of proteolysis in the pulp of rabbit molar teeth

artículo científico publicado el 1 de enero de 1991

An estimate on the effect of point mutation and natural selection on the rate of amino acid replacement in proteins.

artículo científico publicado en 1984

Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis

artículo científico publicado en 2010

Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test

artículo científico publicado en 2013

Assessment of proteasomal cleavage probabilities from kinetic analysis of time-dependent product formation

artículo científico publicado en 2002

Balance of glucose utilization in rabbit reticulocytes.

artículo científico publicado en 1981

Both lysine-clusters of the NH2-terminal prion-protein fragment PrP23-110 are essential for t-PA mediated plasminogen activation

artículo científico publicado en 2004

CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases

artículo científico publicado en 2021

Calculation of kinetic parameters of a reversible enzymatic reaction in states of maximal activity.

artículo científico publicado en 1990

CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism

artículo científico publicado en 2012

Characterization of Lipid and Lipid Droplet Metabolism in Human HCC.

artículo científico publicado en 2019

Characterizing the N-terminal processing motif of MHC class I ligands

artículo científico publicado en 2008

Combining bioinformatics resources for the structural modelling of eukaryotic metabolic networks

artículo científico publicado en 2005

Compartmental analysis: theoretical aspects and application

artículo científico publicado en 1985

Composition of metabolic flux distributions by functionally interpretable minimal flux modes (MinModes).

artículo científico publicado en 2006

Computational analysis of protein-protein interactions in metabolic networks of Escherichia coli and yeast.

artículo científico publicado en 2007

Computational design of reduced metabolic networks

artículo científico publicado en 2004

Computational lipidology: predicting lipoprotein density profiles in human blood plasma

artículo científico publicado en 2008

Computer aided optimization of carbon atom labeling for tracer experiments.

artículo científico publicado en 2008

Computer simulations suggest a key role of membranous nanodomains in biliary lipid secretion

artículo científico publicado en 2015

Correction: The importance of membrane microdomains for bile salt-dependent biliary lipid secretion (doi:10.1242/jcs.211524)

scientific article published on 19 March 2018

Corrigendum to "Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species"

scholarly article published in International Journal of Cell Biology

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

scholarly article by Astrid Borchert published in September 2018

CySBML: a Cytoscape plugin for SBML

scientific article published on 05 July 2012

Dermal and inhalation acute toxic class methods: test procedures and biometric evaluations for the Globally Harmonized Classification System

artículo científico publicado en 2003

Dual role of oxygen during lipoxygenase reactions

artículo científico publicado en 2005

Dynamic Metabolic Zonation of the Hepatic Glucose Metabolism Is Accomplished by Sinusoidal Plasma Gradients of Nutrients and Hormones

EEC/COLIPA project on in vitro phototoxicity testing: First results obtained with a Balb/c 3T3 cell phototoxicity assay ⬇️

artículo científico publicado el 1 de agosto de 1994

Effects of reactive oxygen species on eicosanoid metabolism in human endothelial cells ⬇️

artículo científico publicado el 1 de marzo de 1992

Efficiency and design of simple metabolic systems

artículo científico publicado en 1985

Enzymatic features of the glucose metabolism in tumor cells

artículo científico publicado en 2011

Enzyme maintenance effort as criterion for the characterization of alternative pathways and length distribution of isofunctional enzymes.

artículo científico publicado en 2011

Estimation of metabolic flux rates in liver purine catabolism of tumour-bearing mice by computer simulation of radioactive tracer experiments

artículo científico publicado en 1994

Estimation of steady-state flux rates in metabolic systems by computer simulations of radioactive tracer experiments.

artículo científico publicado en 1993

Evaluation of 41 candidate gene variants for obesity in the EPIC-Potsdam cohort by multi-locus stepwise regression

artículo científico publicado en 2013

Evidence for the existence of a non-catalytic modifier site of peptide hydrolysis by the 20 S proteasome

artículo científico publicado en 2000

Experience with the particulate prostaglandin endoperoxide synthase assay for testing non-steroidal antiinflammatory drugs.

artículo científico publicado en 1991

FASIMU: flexible software for flux-balance computation series in large metabolic networks

artículo científico publicado en 2011

Finding one's way in proteomics: a protein species nomenclature

artículo científico publicado en 2009

Fluxviz - Cytoscape plug-in for visualization of flux distributions in networks

artículo científico publicado en 2010

HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology.

artículo científico publicado en 2018

Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit.

artículo científico publicado en 2003

How an inhibitor of the HIV-I protease modulates proteasome activity

artículo científico publicado en 1999

Human T cell responses to endogenously presented HLA-A*0201 restricted peptides of Simian virus 40 large T antigen

artículo científico publicado en 2001

IRAG working group 2. CAM-based assays. Interagency Regulatory Alternatives Group

scientific article published on 01 January 1997

Identification and characteristics of a novel mitochondrial 5'-nucleotidase in rat liver.

artículo científico publicado en 1989

Identification and characteristics of a novel mitochondrial ATPase in rat liver

scientific article published on 01 July 1987

Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases

scientific article published on October 2001

Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.

artículo científico publicado en 2003

In vitro phototoxicity testing: development and validation of a new concentration response analysis software and biostatistical analyses related to the use of various prediction models.

artículo científico publicado en 2002

Inactivation of 15-lipoxygenases by acetylenic fatty acids

artículo científico publicado el 1 de enero de 1991

Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks

artículo científico publicado en 2007

Influence of erythropoietin treatment on 2,3-bisphosphoglycerate and O2-affinity of red blood cells in children with renal anemia

artículo científico publicado en 1990

Infrared spectroscopic ellipsometry (IRSE) and X-ray photoelectron spectroscopy (XPS) monitoring the preparation of maleimide-functionalized surfaces: from Au towards Si (111)

Interpretation of non-invasive breath tests using (13)C-labeled substrates--a preliminary report with (13)C-methacetin

artículo científico publicado en 2009

Interpretation of the inotropic effect of 2,3-butanedione monoxime on the isometric twitch of guinea-pig papillary muscle

artículo científico publicado en 1994

Interrelations between glycolysis and the hexose monophosphate shunt in erythrocytes as studied on the basis of a mathematical model

artículo científico publicado en 1988

Joint effect of unlinked genotypes: application to type 2 diabetes in the EPIC-Potsdam case-cohort study.

artículo científico publicado en 2015

Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

artículo científico publicado en 2012

Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28.

artículo científico publicado en 2000

Kinetic hybrid models composed of mechanistic and simplified enzymatic rate laws--a promising method for speeding up the kinetic modelling of complex metabolic networks

artículo científico publicado en 2009

Kinetic model of glucose-6-phosphate dehydrogenase from red blood cells. Parameter estimation from progress curves and simulation of regulatory properties

artículo científico publicado en 1986

Kinetic modeling of human hepatic glucose metabolism in type 2 diabetes mellitus predicts higher risk of hypoglycemic events in rigorous insulin therapy

artículo científico publicado en 2012

MAPPP: MHC class I antigenic peptide processing prediction.

artículo científico publicado en 2003

METANNOGEN: compiling features of biochemical reactions needed for the reconstruction of metabolic networks

artículo científico publicado en 2007

Macrophage cholesteryl ester hydrolases and hormone-sensitive lipase prefer specifically oxidized cholesteryl esters as substrates over their non-oxidized counterparts

artículo científico publicado en 2000

Mathematical Modeling of Cellular Metabolism

artículo científico publicado en 2016

Mathematical analysis of enzymic reaction systems using optimization principles

artículo científico publicado en 1991

Mathematical model of pyruvate kinase of chicken erythrocytes.

artículo científico publicado en 1983

Mathematical modelling of energy and redox metabolism of G6PD-deficient erythrocytes

artículo científico publicado en 1990

Mathematical modelling of metabolic pathways affected by an enzyme deficiency.

artículo científico publicado en 1990

Mathematical modelling of metabolic pathways affected by an enzyme deficiency. A mathematical model of glycolysis in normal and pyruvate-kinase-deficient red blood cells.

artículo científico publicado en 1985

Mathematical modelling of metabolic pathways affected by an enzyme deficiency. Energy and redox metabolism of glucose-6-phosphate-dehydrogenase-deficient erythrocytes

artículo científico publicado en 1989

Mathematical modelling of the purine metabolism of the rat liver.

artículo científico publicado en 1990

Metabolic Consequences of TGFb Stimulation in CulturedPrimary Mouse Hepatocytes Screened from Transcript Data with ModeScore

artículo científico publicado en 2012

Metabolic gradients as key regulators in zonation of tumor energy metabolism: a tissue-scale model-based study

artículo científico publicado en 2013

Metannogen: annotation of biological reaction networks

artículo científico

Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach

artículo científico publicado en 2014

Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics

artículo científico publicado en 2008

Modelling the reaction mechanism of the reticulocyte lipoxygenase

artículo científico publicado en 1987

Models for the regulation of purine metabolism in rat hepatocytes: evaluation of tracer kinetic experiments

artículo científico publicado en 1997

Modern biostatistical methods for assessing in vitro/in vivo correlation of severely eye irritating chemicals in a validation study of in vitro alternatives to the Draize eye test

artículo científico publicado en 1995

Molecular and cellular regulation of pyruvate kinase in red blood cells.

artículo científico publicado en 1984

Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels

artículo científico publicado en 2007

Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis

artículo científico publicado en 2012

Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism

artículo científico publicado en 2012

Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species.

artículo científico publicado en 1996

Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the active site

artículo científico publicado en 1998

Oxidation of a methionine residue in subtilisin-type proteinases by the hydrogen peroxide/borate system--an active site-directed reaction.

artículo científico publicado en 1988

Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network

artículo científico publicado en 2012

Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients

artículo científico publicado en 2015

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome.

artículo científico publicado en 2009

Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices

scholarly article by Nikolaus Berndt et al published October 2018 in Archives of Toxicology

Prediction of temporal gene expression. Metabolic opimization by re-distribution of enzyme activities.

artículo científico publicado en 2002

Pruning genome-scale metabolic models to consistent ad functionem networks

artículo científico publicado en 2007

Pyruvate utilization of rabbit reticulocytes--a compartmental study.

artículo científico publicado en 1990

Quantification of pathways of glucose utilization and balance of energy metabolism of rabbit reticulocytes.

artículo científico publicado en 1982

Quantifying the contribution of defective ribosomal products to antigen production: a model-based computational analysis

artículo científico publicado en 2005

Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism

artículo científico publicado en 2012

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

artículo científico publicado en 2015

Rapid degradation of solid-phase bound peptides by the 20S proteasome

artículo científico publicado en 2013

Rapid flip-flop of phospholipids in endoplasmic reticulum membranes studied by a stopped-flow approach

artículo científico publicado en 2000

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

artículo científico publicado en 2013

Red cell creatine in steady state and stimulated erythropoiesis.

artículo científico publicado en 1983

Red cell creatine in term and preterm, adequate and small for gestational age newborns after normal pregnancy or risk conditions. I. Statistical analysis of creatine in various groups of newborns

artículo científico publicado en 1983

Regulation of liver metabolism by the endosomal GTPase Rab5.

artículo científico publicado en 2015

Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione

artículo científico publicado en 2017

SEE: structured representation of scientific evidence in the biomedical domain using Semantic Web techniques

artículo científico publicado en 2014

SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry.

artículo científico publicado en 1990

Sequential metabolic phases as a means to optimize cellular output in a constant environment

artículo científico publicado en 2015

Statistical planning and analysis considerations in the evaluation of in vitro alternatives to whole animal use for eye irritation testing

artículo científico publicado en 1997

Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110.

artículo científico publicado en 2003

Stochastic simulation of hemagglutinin-mediated fusion pore formation

artículo científico publicado en 2001

Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure.

artículo científico publicado en 2005

The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team.

artículo científico publicado en 1998

The ECVAM Prevalidation Study on the Use of EpiDerm for Skin Corrosivity Testing.

artículo científico publicado en 2000

The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test.

artículo científico publicado en 1998

The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity

artículo científico publicado en 2017

The energy metabolism of pyruvate kinase deficient red blood cells.

artículo científico publicado en 1983

The generalized flux-minimization method and its application to metabolic networks affected by enzyme deficiencies

artículo científico publicado en 2005

The high energy demand of neuronal cells caused by passive leak currents is not a waste of energy

artículo científico publicado en 2013

The importance of membrane microdomains for bile salt-dependent biliary lipid secretion

artículo científico publicado en 2018

The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model

artículo científico publicado en 2011

The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere.

artículo científico publicado en 1999

The mechanism of inactivation of lipoxygenases by acetylenic fatty acids

artículo científico publicado en 1984

The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks

artículo científico publicado en 2004

The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes.

artículo científico publicado en 1999

The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling

artículo científico publicado en 2016

The speciation of the proteome

artículo científico publicado en 2008

The stability and robustness of metabolic states: identifying stabilizing sites in metabolic networks

artículo científico publicado en 2007

The structure of metabolic systems: a theoretical approach

artículo científico publicado en 1990

The use of progress curves for the estimation of inactivation rate constants of enzymes

scientific article published on 01 January 1985

The virtual liver: a multidisciplinary, multilevel challenge for systems biology.

artículo científico publicado en 2012

The virtual liver: state of the art and future perspectives

artículo científico publicado en 2014

Transitions of hepatic purine metabolism of Ehrlich ascites tumor bearing mice in different phases of tumor growth.

artículo científico publicado en 1994

Uncovering metabolic objectives pursued by changes of enzyme levels

artículo científico publicado en 2009

Use of mathematical models for predicting the metabolic effect of large-scale enzyme activity alterations. Application to enzyme deficiencies of red blood cells

artículo científico publicado en 1995

[Immunologic determination of glucose-6-phosphate dehydrogenase concentration of red blood cells of G6PD defect carriers]

scientific article published on 01 January 1985

[Phosphorus-31 magnetic resonance spectroscopy of the heart. New perspectives and development trends]

artículo científico publicado en 1991

[Results of the first phase of the ECVAM project "prevalidation and validation of three in vitro embryotoxicity tests"]

artículo científico publicado en 1998

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