Lista de obras - Feixiong Cheng - Dominio Público Uruguay

A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data

article

A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types

artículo científico publicado en 2015

A component overlapping attribute clustering (COAC) algorithm for single-cell RNA sequencing data analysis and potential pathobiological implications

artículo científico publicado en 2019

A cross-cancer differential co-expression network reveals microRNA-regulated oncogenic functional modules

artículo científico publicado en 2015

A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

artículo científico publicado en 2020

A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes.

artículo científico

Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes

artículo científico publicado en 2015

Adverse drug events: database construction and in silico prediction

artículo científico publicado en 2013

AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer's drug discovery

artículo científico publicado en 2021

Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease

artículo científico publicado en 2022

Autoimmune Cardiotoxicity of Cancer Immunotherapy

artículo científico publicado en 2016

Biomarker-based drug safety assessment in the age of systems pharmacology: from foundational to regulatory science

artículo científico publicado en 2015

Cardiac risk stratification in cancer patients: A longitudinal patient-patient network analysis

artículo científico publicado en 2021

Classification of cytochrome P450 inhibitors and noninhibitors using combined classifiers

artículo científico publicado en 2011

Computational Insights into Ligand Selectivity of Estrogen Receptors from Pharmacophore Modeling.

artículo científico publicado en 2011

Computational models to predict endocrine-disrupting chemical binding with androgen or oestrogen receptors.

artículo científico publicado en 2014

Computational prediction of microRNA networks incorporating environmental toxicity and disease etiology

artículo científico publicado en 2014

Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer

scientific article published on 18 April 2019

Correction: Investigation of Indazole Unbinding Pathways in CYP2E1 by Molecular Dynamics Simulations.

artículo científico publicado en 2012

Deep Learning-Based Prediction of Drug-Induced Cardiotoxicity

artículo científico publicado en 2019

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.

artículo científico publicado en 2017

Drug Repurposing: New Treatments for Zika Virus Infection?

artículo científico publicado en 2016

Entropy-based Consensus Clustering for Patient Stratification

artículo científico publicado en 2017

Estimation of ADME properties with substructure pattern recognition.

artículo científico publicado en 2010

Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer

artículo científico publicado en 2017

FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

artículo científico publicado en 2015

Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach

artículo científico publicado en 2014

Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing

scientific article published on 13 July 2020

Heterogeneous DNA methylation contributes to tumorigenesis through inducing the loss of coexpression connectivity in colorectal cancer

artículo científico publicado en 2014

In Silico Insights into Protein-protein Interaction Disruptive Mutations in the PCSK9-LDLR complex

scientific article published on 25 February 2020

In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers.

artículo científico publicado en 2018

In silico ADMET prediction: recent advances, current challenges and future trends

artículo científico

In silico Prediction of Drug Induced Liver Toxicity Using Substructure Pattern Recognition Method

artículo científico publicado en 2016

In silico assessment of chemical biodegradability

artículo científico publicado en 2012

In silico polypharmacology of natural products

artículo científico publicado en 2017

In silico prediction of chemical Ames mutagenicity.

artículo científico publicado en 2012

In silico prediction of chemical acute oral toxicity using multi-classification methods.

artículo científico publicado en 2014

In silico prediction of chemical mechanism of action via an improved network-based inference method

artículo científico publicado en 2016

In silico prediction of chemical toxicity on avian species using chemical category approaches.

artículo científico publicado en 2014

Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

artículo científico publicado en 2020

Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era.

artículo científico

Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.

artículo científico publicado en 2010

Investigating cellular network heterogeneity and modularity in cancer: a network entropy and unbalanced motif approach

artículo científico publicado en 2016

Machine learning-based prediction of drug-drug interactions by integrating drug phenotypic, therapeutic, chemical, and genomic properties

artículo científico publicado en 2014

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

scientific article published on 16 April 2020

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

artículo científico publicado en 2021

Network-based Prediction of Drug-Target Interactions using an Arbitrary-Order Proximity Embedded Deep Forest

scientific article published on 23 January 2020

Network-based identification of microRNAs as potential pharmacogenomic biomarkers for anticancer drugs

artículo científico publicado en 2016

Network-based prediction of drug combinations

article

PTEN Mutations Trigger Resistance to Immunotherapy

artículo científico publicado en 2019

Pharmacophore modeling of human adenosine receptor A(₂A) antagonists.

artículo científico publicado en 2010

Phosphorylation of PLCγ1 by EphA2 receptor tyrosine kinase promotes tumor growth in lung cancer

artículo científico publicado en 2020

Prediction of chemical-protein interactions network with weighted network-based inference method

artículo científico publicado en 2012

Prediction of chemical-protein interactions: multitarget-QSAR versus computational chemogenomic methods.

artículo científico publicado en 2012

Prediction of drug-target interactions and drug repositioning via network-based inference

artículo científico publicado en 2012

Prediction of human genes and diseases targeted by xenobiotics using predictive toxicogenomic-derived models (PTDMs).

artículo científico publicado en 2013

Prediction of polypharmacological profiles of drugs by the integration of chemical, side effect, and therapeutic space

artículo científico publicado en 2013

Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes

artículo científico publicado en 2016

Quantitative and Systems Pharmacology. 1. In Silico Prediction of Drug-Target Interactions of Natural Products Enables New Targeted Cancer Therapy

artículo científico publicado en 2017

Quantitative network mapping of the human kinome interactome reveals new clues for rational kinase inhibitor discovery and individualized cancer therapy

artículo científico publicado en 2014

Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from non-coding genome findings

artículo científico publicado en 2022

Regulation rewiring analysis reveals mutual regulation between STAT1 and miR-155-5p in tumor immunosurveillance in seven major cancers

artículo científico publicado en 2015

Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

article

SDTNBI: an integrated network and chemoinformatics tool for systematic prediction of drug-target interactions and drug repositioning

artículo científico publicado en 2016

SGDriver: a novel structural genomics-based approach to prioritize cancer related and potentially druggable somatic mutations.

artículo científico publicado en 2015

Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA.

artículo científico publicado en 2017

SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

artículo científico publicado en 2015

Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome

artículo científico publicado en 2014

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

artículo científico publicado en 2016

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

artículo científico publicado en 2020

Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Cancer Types Using a Structural Genomics-based Approach

artículo científico publicado en 2015

Systematic dissection of dysregulated transcription factor-miRNA feed-forward loops across tumor types

scientific article published on 09 December 2015

Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis

artículo científico publicado en 2016

Systems Pharmacology-Based Discovery of Natural Products for Precision Oncology Through Targeting Cancer Mutated Genes.

artículo científico publicado en 2017

Target identification among known drugs by deep learning from heterogeneous networks

artículo científico publicado en 2020

Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery

artículo científico publicado en 2017

Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer

artículo científico publicado en 2016

Unbinding pathways of GW4064 from human farnesoid X receptor as revealed by molecular dynamics simulations.

artículo científico publicado en 2012

admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties

artículo científico publicado en 2012

ccmGDB: a database for cancer cell metabolism genes

artículo científico publicado en 2015

deepDR: a network-based deep learning approach to in silico drug repositioning

scientific article published on 01 December 2019

iDrug: Integration of drug repositioning and drug-target prediction via cross-network embedding

scientific article published on 15 July 2020

Lista de obras de Feixiong Cheng

A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data

A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types

A component overlapping attribute clustering (COAC) algorithm for single-cell RNA sequencing data analysis and potential pathobiological implications

A cross-cancer differential co-expression network reveals microRNA-regulated oncogenic functional modules

A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes.

Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes

Adverse drug events: database construction and in silico prediction

AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer's drug discovery

Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease

Autoimmune Cardiotoxicity of Cancer Immunotherapy

Biomarker-based drug safety assessment in the age of systems pharmacology: from foundational to regulatory science

Cardiac risk stratification in cancer patients: A longitudinal patient-patient network analysis

Classification of cytochrome P450 inhibitors and noninhibitors using combined classifiers

Computational Insights into Ligand Selectivity of Estrogen Receptors from Pharmacophore Modeling.

Computational models to predict endocrine-disrupting chemical binding with androgen or oestrogen receptors.

Computational prediction of microRNA networks incorporating environmental toxicity and disease etiology

Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer

Correction: Investigation of Indazole Unbinding Pathways in CYP2E1 by Molecular Dynamics Simulations.

Deep Learning-Based Prediction of Drug-Induced Cardiotoxicity

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.

Drug Repurposing: New Treatments for Zika Virus Infection?

Entropy-based Consensus Clustering for Patient Stratification

Estimation of ADME properties with substructure pattern recognition.

Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer

FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach

Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing

Heterogeneous DNA methylation contributes to tumorigenesis through inducing the loss of coexpression connectivity in colorectal cancer

In Silico Insights into Protein-protein Interaction Disruptive Mutations in the PCSK9-LDLR complex

In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers.

In silico ADMET prediction: recent advances, current challenges and future trends

In silico Prediction of Drug Induced Liver Toxicity Using Substructure Pattern Recognition Method

In silico assessment of chemical biodegradability

In silico polypharmacology of natural products

In silico prediction of chemical Ames mutagenicity.

In silico prediction of chemical acute oral toxicity using multi-classification methods.

In silico prediction of chemical mechanism of action via an improved network-based inference method

In silico prediction of chemical toxicity on avian species using chemical category approaches.

Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era.

Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.

Investigating cellular network heterogeneity and modularity in cancer: a network entropy and unbalanced motif approach

Machine learning-based prediction of drug-drug interactions by integrating drug phenotypic, therapeutic, chemical, and genomic properties

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

Network-based Prediction of Drug-Target Interactions using an Arbitrary-Order Proximity Embedded Deep Forest

Network-based identification of microRNAs as potential pharmacogenomic biomarkers for anticancer drugs

Network-based prediction of drug combinations

PTEN Mutations Trigger Resistance to Immunotherapy

Pharmacophore modeling of human adenosine receptor A(₂A) antagonists.

Phosphorylation of PLCγ1 by EphA2 receptor tyrosine kinase promotes tumor growth in lung cancer

Prediction of chemical-protein interactions network with weighted network-based inference method

Prediction of chemical-protein interactions: multitarget-QSAR versus computational chemogenomic methods.

Prediction of drug-target interactions and drug repositioning via network-based inference

Prediction of human genes and diseases targeted by xenobiotics using predictive toxicogenomic-derived models (PTDMs).

Prediction of polypharmacological profiles of drugs by the integration of chemical, side effect, and therapeutic space

Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes

Quantitative and Systems Pharmacology. 1. In Silico Prediction of Drug-Target Interactions of Natural Products Enables New Targeted Cancer Therapy

Quantitative network mapping of the human kinome interactome reveals new clues for rational kinase inhibitor discovery and individualized cancer therapy

Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from non-coding genome findings

Regulation rewiring analysis reveals mutual regulation between STAT1 and miR-155-5p in tumor immunosurveillance in seven major cancers

Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

SDTNBI: an integrated network and chemoinformatics tool for systematic prediction of drug-target interactions and drug repositioning

SGDriver: a novel structural genomics-based approach to prioritize cancer related and potentially druggable somatic mutations.

Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA.

SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Cancer Types Using a Structural Genomics-based Approach

Systematic dissection of dysregulated transcription factor-miRNA feed-forward loops across tumor types

Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis

Systems Pharmacology-Based Discovery of Natural Products for Precision Oncology Through Targeting Cancer Mutated Genes.

Target identification among known drugs by deep learning from heterogeneous networks

Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery

Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer

Unbinding pathways of GW4064 from human farnesoid X receptor as revealed by molecular dynamics simulations.

admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties