Lista de obras - Nico Ghilardi - Dominio Público Uruguay

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

artículo científico publicado en 2013

A mouse knockout library for secreted and transmembrane proteins.

artículo científico publicado en 2010

A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5

artículo científico publicado en 2002

A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors

artículo científico publicado en 2013

A single-base deletion in the thrombopoietin (TPO) gene causes familial essential thrombocythemia through a mechanism of more efficient translation of TPO mRNA

artículo científico publicado en 1999

Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression

artículo científico publicado en 2016

Bystanders not so innocent after all

artículo científico publicado en 2012

CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens

artículo científico publicado en 2006

Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice

artículo científico publicado en 2004

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells

artículo científico publicado en 2008

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

artículo científico publicado en 2012

Discovery of GDC-0853, a Potent, Selective, and Non-Covalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development

artículo científico publicado en 2018

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

scientific article published on 04 April 2019

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

artículo científico publicado en 2005

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q

artículo científico publicado en 2011

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis

artículo científico publicado en 2009

Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene

scientific article published on 01 November 1999

Hereditary thrombocythaemia is a genetically heterogeneous disorder: exclusion of TPO and MPL in two families with hereditary thrombocythaemia

scientific article published on 01 July 2000

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota.

artículo científico publicado en 2014

IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available

artículo científico publicado en 2005

IL-23 is required for protection against systemic infection with Listeria monocytogenes

artículo científico publicado en 2009

IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice

artículo científico publicado en 2016

IL-27 promotes T cell-dependent colitis through multiple mechanisms ⬇️

artículo científico publicado en 2010

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

artículo científico publicado en 2003

IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice

artículo científico publicado en 2004

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. ⬇️

artículo científico publicado en 2010

IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung

artículo científico publicado en 2007

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

artículo científico publicado en 2013

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

artículo científico publicado en 2017

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors

artículo científico publicado en 2012

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

artículo científico publicado en 2015

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

artículo científico publicado en 2009

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

artículo científico publicado en 2006

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

artículo científico publicado en 2006

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

artículo científico publicado en 2015

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

artículo científico publicado en 2008

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

artículo científico publicado en 2003

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism.

artículo científico publicado en 2013

Lead identification of novel and selective TYK2 inhibitors

artículo científico publicado en 2013

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

artículo científico publicado en 2013

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

artículo científico publicado en 2018

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.

artículo científico publicado en 2018

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1.

artículo científico publicado en 2009

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice.

artículo científico publicado en 2016

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

artículo científico publicado en 2013

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice.

artículo científico publicado en 2011

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

artículo científico publicado en 2014

Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.

artículo científico publicado en 1999

Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31.

artículo científico publicado en 2007

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

artículo científico publicado en 2018

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

artículo científico publicado en 2012

T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection

artículo científico publicado en 2017

Targeting the development and effector functions of TH17 cells.

scientific article published on December 2007

The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections

artículo científico publicado en 2013

The biology and therapeutic potential of interleukin 27.

artículo científico publicado en 2007

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

scientific article published on 02 June 2020

The role of IL-22 in intestinal health and disease

scientific article published on 13 February 2020

Thrombopoietin production is inhibited by a translational mechanism.

artículo científico publicado en 1998

Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages

artículo científico publicado en 2014

Lista de obras de Nico Ghilardi

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

A mouse knockout library for secreted and transmembrane proteins.

A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5

A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors

A single-base deletion in the thrombopoietin (TPO) gene causes familial essential thrombocythemia through a mechanism of more efficient translation of TPO mRNA

Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression

Bystanders not so innocent after all

CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens

Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

Discovery of GDC-0853, a Potent, Selective, and Non-Covalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis

Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene

Hereditary thrombocythaemia is a genetically heterogeneous disorder: exclusion of TPO and MPL in two families with hereditary thrombocythaemia

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota.

IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available

IL-23 is required for protection against systemic infection with Listeria monocytogenes

IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice

IL-27 promotes T cell-dependent colitis through multiple mechanisms ⬇️

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. ⬇️

IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism.

Lead identification of novel and selective TYK2 inhibitors

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1.

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice.

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice.

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.

Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31.

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection

Targeting the development and effector functions of TH17 cells.

The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections

The biology and therapeutic potential of interleukin 27.

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

The role of IL-22 in intestinal health and disease

Thrombopoietin production is inhibited by a translational mechanism.

Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages