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A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia

scientific article published on 29 September 2020

Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization.

artículo científico publicado en 2013

Acute lymphoblastic leukemia: monitoring minimal residual disease as a therapeutic principle

artículo científico publicado en 2012

Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies

scientific article published on 22 March 2012

Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis

artículo científico publicado en 2016

An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse

artículo científico publicado en 2022

Blinatumomab for Acute Lymphoblastic Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

artículo científico publicado en 2019

Blinatumomab for minimal residual disease in adults with B-precursor acute lymphoblastic leukemia

artículo científico publicado en 2018

Blinatumomab treatment of older adults with relapsed/refractory B-precursor acute lymphoblastic leukemia: Results from 2 phase 2 studies

artículo científico publicado en 2016

Blinatumomab vs historic standard-of-care treatment for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukaemia

artículo científico publicado en 2020

CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy

artículo científico publicado en 2008

Changes in clinical laboratory parameters and pharmacodynamic markers in response to blinatumomab treatment of patients with relapsed/refractory ALL

artículo científico

Chemoimmunotherapy in acute lymphoblastic leukemia

artículo científico publicado en 2011

Clinical applications and safety evaluation of the new CD19 specific T-cell engager antibody construct blinatumomab

artículo científico

Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia

artículo científico publicado en 2009

Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia.

artículo científico publicado en 2005

Comparison of chimerism and minimal residual disease monitoring for relapse prediction after allogeneic stem cell transplantation for adult acute lymphoblastic leukemia

artículo científico publicado en 2014

Comparison of minimal residual disease levels in bone marrow and peripheral blood in adult acute lymphoblastic leukemia

artículo científico publicado en 2019

Complete Hematologic and Molecular Response in Adult Patients With Relapsed/Refractory Philadelphia Chromosome-Positive B-Precursor Acute Lymphoblastic Leukemia Following Treatment With Blinatumomab: Results From a Phase II, Single-Arm, Multicenter S

article

Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2020

Developing a European network for adult ALL

scientific article published on 01 January 2004

Diagnosis, Prognostic Factors and Assessment of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel

artículo científico publicado en 2024

Dose-intensive chemotherapy including rituximab is highly effective but toxic in human immunodeficiency virus-infected patients with Burkitt lymphoma/leukemia: parallel study of 81 patients

artículo científico publicado en 2014

Early Thymic Progenitor Leukemia (ETP-ALL) in Adults: A Distinct Molecular Entity, ⬇️

artículo científico publicado en 2011

Early prediction of response in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib

artículo científico publicado en 2003

Efficacy and safety analysis by age cohort of inotuzumab ozogamicin in patients with relapsed or refractory acute lymphoblastic leukemia enrolled in INO-VATE.

artículo científico publicado en 2018

Efficacy of inotuzumab ozogamicin in patients with Philadelphia chromosome-positive relapsed/refractory acute lymphoblastic leukemia

scientific article published on 24 November 2020

Erroneous class switching and false VDJ recombination: molecular dissection of t(8;14)/MYC-IGH translocations in Burkitt-type lymphoblastic leukemia/B-cell lymphoma

artículo científico publicado en 2013

Expression of interleukin 15 in primary adult acute lymphoblastic leukemia.

artículo científico publicado en 2010

FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors

artículo científico publicado en 2013

Focus on academic multicenter trials: impact of the German drug law on hematological/oncological therapy optimization trials

artículo científico

Genomic Profiling Reveals Gain of Mutations in Histone Methylation Regulators in Relapsed Adult B Cell Precursor ALL ⬇️

artículo científico publicado en 2015

Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group

artículo científico publicado en 2014

Hematopoietic stem cell involvement in BCR-ABL1-positive ALL as potential mechanism of resistance to blinatumomab therapy.

artículo científico publicado en 2017

High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia.

artículo científico publicado en 2010

High Survival Rate in Adult Burkitt’s Lymphoma/Leukemia and Diffuse Large B-Cell Lymphoma with Mediastinal Involvement. ⬇️

artículo científico publicado en 2007

High cure rates in Burkitt lymphoma and leukemia: a Northern Italy Leukemia Group study of the German short intensive rituximab-chemotherapy program.

artículo científico publicado en 2013

High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults.

artículo científico publicado en 2006

High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation

artículo científico publicado en 2011

How I treat older patients with ALL.

artículo científico publicado en 2013

Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab

artículo científico

Improved Outcome in High Risk and Very High Risk ALL by Risk Adapted SCT and in Standard Risk ALL by Intensive Chemotherapy in 713 Adult ALL Patients Treated According to the Prospective GMALL Study 07/2003. ⬇️

artículo científico publicado en 2007

Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial

artículo científico publicado en 2014

Inclusion and response criteria for clinical trials in relapsed/refractory acute lymphoblastic leukemia and usefulness of historical control trials

artículo científico publicado en 2017

Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia

artículo científico publicado en 2016

Inotuzumab ozogamicin versus standard of care in relapsed or refractory acute lymphoblastic leukemia: Final report and long-term survival follow-up from the randomized, phase 3 INO-VATE study

artículo científico publicado en 2019

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

artículo científico publicado en 2019

International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia

artículo científico publicado en 2016

Involvement of the MLL gene in adult T-lymphoblastic leukemia

artículo científico publicado en 2012

Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis.

artículo científico publicado en 2002

Leukemia research in Germany: the Competence Network Acute and Chronic Leukemias

artículo científico

Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma

artículo científico publicado en 2010

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

scholarly article by Alva Rani James et al published 14 January 2019 in Journal of Hematology & Oncology

Long-Term Outcomes after Blinatumomab Treatment: Follow-up of a Phase 2 Study in Patients (Pts) with Minimal Residual Disease (MRD) Positive B-Cell Precursor Acute Lymphoblastic Leukemia (ALL) ⬇️

scholarly article

Long-Term Results of Allogeneic Stem Cell Transplantation in Adult Ph- Negative High-Risk Acute Lymphoblastic Leukemia

artículo científico publicado en 2022

Long-term relapse-free survival in a phase 2 study of blinatumomab for the treatment of patients with minimal residual disease in B-lineage acute lymphoblastic leukemia

artículo científico publicado en 2017

Long-term survival and T-cell kinetics in relapsed/refractory ALL patients who achieved MRD response after blinatumomab treatment

artículo científico publicado en 2015

Long-term survival of patients with relapsed/refractory acute lymphoblastic leukemia treated with blinatumomab

artículo científico publicado en 2020

Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute lymphoblastic leukemia

artículo científico publicado en 2017

Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome

artículo científico publicado en 2007

Low Expression Of BCL11B Predicts Poor Overall Survival In Adult Standard Risk T-ALL ⬇️

scholarly article

Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients

artículo científico publicado en 2014

Lymphatic neoplasias in young patients

artículo científico publicado en 2011

Management of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel

artículo científico publicado en 2024

Minimal residual disease level predicts outcome in adults with Ph-negative B-precursor acute lymphoblastic leukemia

scientific article published on 01 December 2019

Molecular analysis of the t(2;8)/MYC-IGK translocation in high-grade lymphoma/leukemia by long-distance inverse PCR.

artículo científico publicado en 2011

Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials

artículo científico publicado en 2006

Molecular response with blinatumomab in relapsed/refractory B-cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2019

Multi-Genomics of Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Reveals Three Distinct Genetic Clusters Characterized By Different Alterations ⬇️

scholarly article

Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia

artículo científico publicado en 2009

Mutational spectrum of adult T-ALL

artículo científico publicado en 2015

NUP214-ABL1 in adult T-ALL: the GMALL study group experience.

artículo científico publicado en 2006

Next-Generation Sequencing and Real-Time Quantitative PCR For Quantification Of Low-Level Minimal Residual Disease In Acute Lymphoblastic Leukemia Of Adults ⬇️

scholarly article

Non-Functional ("haploinsufficient"), but Not Dominant Negative Clonal IKZF1 Deletions Confer an Adverse Prognosis in Adult BCR-ABL-Negative Acute Lymphoblastic Leukemia ⬇️

artículo científico publicado en 2015

Novel antibody-based therapy for acute lymphoblastic leukaemia

artículo científico publicado en 2006

Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia

artículo científico publicado en 2002

Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation.

artículo científico publicado en 2012

Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia.

artículo científico publicado en 2011

PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2019

Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia

artículo científico publicado en 2014

Philadelphia-Like Acute Lymphoblastic Leukemia in Adults

artículo científico publicado en 2017

Prognostic implications of cytogenetics in adults with acute lymphoblastic leukemia treated with inotuzumab ozogamicin

artículo científico publicado en 2019

Randomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia.

artículo científico publicado en 2017

Risk-adapted treatment according to minimal residual disease in adult ALL.

artículo científico publicado en 2002

Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

artículo científico publicado en 2014

Subclonal IKZF1 Deletions Indicate a Multiclonal Evolution In BCR-ABL1-Positive B-Cell Precursor ALL ⬇️

artículo científico publicado en 2013

Successful Subtype Oriented Treatment Strategies in Adult T-All; Results of 744 Patients Treated in Three Consecutive GMALL Studies. ⬇️

scholarly article

T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity?

artículo científico publicado en 2009

Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia

artículo científico publicado en 2002

Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.

artículo científico publicado en 2011

The European LeukemiaNet: achievements and perspectives

artículo científico publicado en 2010

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group

artículo científico publicado en 2009

The role of high-dose cytarabine in induction therapy for adult ALL.

artículo científico publicado en 2002

The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia.

artículo científico publicado en 2010

Toxic non-resorptive internal hydrocephalus as a result of haemorrhagic ventriculitis during induction chemotherapy of Bcr-Abl positive acute lymphoblastic leukaemia.

artículo científico publicado en 2009

Transplantation in adults with relapsed/refractory acute lymphoblastic leukemia who are treated with blinatumomab from a phase 3 study

artículo científico publicado en 2019

Treatment of adult acute lymphoblastic leukemia

artículo científico publicado en 2006

Treatment of adult acute lymphoblastic leukemia

artículo científico publicado en 2009

Treatment of older patients with acute lymphoblastic leukemia.

artículo científico publicado en 2016

Treatment with monoclonal antibodies in acute lymphoblastic leukemia: current knowledge and future prospects

artículo científico publicado en 2003

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

artículo científico publicado en 2013

Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome

artículo científico publicado en 2009

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