Lista de obras - Christoph Herwig - Dominio Público Uruguay

A Novel Application for Low Frequency Electrochemical Impedance Spectroscopy as an Online Process Monitoring Tool for Viable Cell Concentrations.

artículo científico publicado en 2016

A combination of HPLC and automated data analysis for monitoring the efficiency of high-pressure homogenization

artículo científico publicado en 2017

A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cells ⬇️

artículo científico publicado en 2016

A dynamic fed batch strategy for a Pichia pastoris mixed feed system to increase process understanding

artículo científico publicado en 2012

A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris ⬇️

artículo científico publicado el 3 de marzo de 2011

A dynamic method for the investigation of induced state metabolic capacities as a function of temperature

artículo científico publicado en 2013

A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains.

artículo científico publicado en 2011

A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis.

artículo científico publicado en 2014

A novel method for fast and statistically verified morphological characterization of filamentous fungi.

artículo científico publicado en 2012

A novel method to recover inclusion body protein from recombinant E. coli fed-batch processes based on phage ΦX174-derived lysis protein E.

artículo científico publicado en 2017

A novel toolbox for E. coli lysis monitoring

artículo científico publicado en 2016

A rapid method for the differentiation of yeast cells grown under carbon and nitrogen-limited conditions by means of partial least squares discriminant analysis employing infrared micro-spectroscopic data of entire yeast cells

artículo científico publicado en 2012

A robust feeding strategy to maintain set-point glucose in mammalian fed-batch cultures when input parameters have a large error

artículo científico publicado en 2017

Advanced Development Strategies for Biopharmaceutical Cell Culture Processes.

artículo científico

An Integrated Downstream Process Development Strategy along QbD Principles

artículo científico publicado en 2014

An automated data-driven DSP development approach for glycoproteins from yeast

artículo científico

At-line determination of spore inoculum quality in Penicillium chrysogenum bioprocesses

artículo científico publicado en 2016

At-line determining spore germination of Penicillium chrysogenum bioprocesses in complex media

artículo científico publicado en 2016

Automatic feed phase identification in multivariate bioprocess profiles by sequential binary classification.

artículo científico publicado en 2017

Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria

article

Bioprocess development workflow: Transferable physiological knowledge instead of technological correlations

artículo científico publicado en 2016

Bioprocess monitoring: minimizing sample matrix effects for total protein quantification with bicinchoninic acid assay

artículo científico publicado en 2016

Combining Protein and Strain Engineering for the Production of Glyco-Engineered Horseradish Peroxidase C1A in Pichia pastoris.

artículo científico publicado en 2015

Combining light microscopy, dielectric spectroscopy, MALDI intact cell mass spectrometry, FTIR spectromicroscopy and multivariate data mining for morphological and physiological bioprocess characterization of filamentous organisms

artículo científico publicado en 2012

Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process.

artículo científico publicado en 2015

Comparison of Fiber Optic and Conduit Attenuated Total Reflection (ATR) Fourier Transform Infrared (FT-IR) Setup for In-Line Fermentation Monitoring.

artículo científico publicado en 2016

Determination of a dynamic feeding strategy for recombinant Pichia pastoris strains

artículo científico publicado en 2014

Determination of carbohydrates present in Saccharomyces cerevisiae using mid-infrared spectroscopy and partial least squares regression.

artículo científico publicado en 2013

Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase

artículo científico publicado en 2015

Dynamics in bioprocess development for Pichia pastoris.

artículo científico publicado en 2014

Effect of post-induction substrate oscillation on recombinant alkaline phosphatase production expressed in Escherichia coli.

artículo científico publicado en 2011

Effects of temperature shifts and oscillations on recombinant protein production expressed in Escherichia coli

artículo científico publicado en 2013

Essential prerequisites for successful bioprocess development of biological CH4 production from CO2 and H2.

artículo científico

Examining the freezing process of an intermediate bulk containing an industrially relevant protein.

artículo científico publicado en 2015

Fed-Batch Production of Bacterial Ghosts Using Dielectric Spectroscopy for Dynamic Process Control.

artículo científico publicado en 2016

Generation of PHB from Spent Sulfite Liquor Using Halophilic Microorganisms

artículo científico publicado en 2015

Glyco-variant library of the versatile enzyme horseradish peroxidase

artículo científico publicado en 2014

High throughput inclusion body sizing: Nano particle tracking analysis

artículo científico publicado en 2017

How to Determine Interdependencies of Glucose and Lactose Uptake Rates for Heterologous Protein Production with E. coli

artículo científico publicado en 2017

Identification of lipophilic bioproduct portfolio from bioreactor samples of extreme halophilic archaea with HPLC-MS/MS.

artículo científico publicado en 2014

Impact of Glycerol as Carbon Source onto Specific Sugar and Inducer Uptake Rates and Inclusion Body Productivity in E. coli BL21(DE3).

artículo científico publicado en 2017

Inclusion Body Bead Size in Controlled by Physiological Feeding

Information Processing: Rate-Based Investigation of Cell Physiological Changes along Design Space Development.

artículo científico publicado en 2012

Intact cell mass spectrometry as a progress tracking tool for batch and fed-batch fermentation processes

artículo científico publicado en 2014

Integrated Process Modeling-A Process Validation Life Cycle Companion

artículo científico publicado en 2017

Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes

artículo científico publicado en 2016

Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut(+) strain using a two-compartment scale-down system

scientific article published on 03 May 2013

Knockout of an endogenous mannosyltransferase increases the homogeneity of glycoproteins produced in Pichia pastoris.

artículo científico publicado en 2013

Know-how and know-why in biochemical engineering ⬇️

artículo científico publicado el 1 de agosto de 2003

Knowledge management in the QbD paradigm: manufacturing of biotech therapeutics.

artículo científico

Mechanistic platform knowledge of concomitant sugar uptake in Escherichia coli BL21(DE3) strains

artículo científico publicado en 2017

Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness

artículo científico publicado en 2016

Method for assessing the impact of emission gasses on physiology and productivity in biological methanogenesis

artículo científico publicado en 2013

Microbials for the production of monoclonal antibodies and antibody fragments.

artículo científico publicado en 2014

Model-Based Methods in the Biopharmaceutical Process Lifecycle

artículo científico publicado en 2017

Model-based analysis on the relationship of signal quality to real-time extraction of information in bioprocesses.

artículo científico publicado en 2011

Morphological analysis of the filamentous fungus Penicillium chrysogenum using flow cytometry-the fast alternative to microscopic image analysis

artículo científico publicado en 2017

Multi-analyte quantification in bioprocesses by Fourier-transform-infrared spectroscopy by partial least squares regression and multivariate curve resolution

artículo científico publicado en 2013

Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production.

artículo científico publicado en 2015

Multivariate Monitoring Workflow for Formulation, Fill and Finish Processes

artículo científico publicado en 2020

Observability analysis of biochemical process models as a valuable tool for the development of mechanistic soft sensors.

artículo científico publicado en 2015

Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control

artículo científico publicado en 2020

Optimization of sample preparation for intact cell mass spectrometry (matrix-assisted laser desorption/ionization linear time-of-flight mass spectrometry) of endophytic Xylaria

artículo científico publicado en 2018

Optimizing cofactor availability for the production of recombinant heme peroxidase in Pichia pastoris

artículo científico publicado en 2015

Photosynthetic poly-β-hydroxybutyrate accumulation in unicellular cyanobacterium Synechocystis sp. PCC 6714.

artículo científico publicado en 2017

Physiological capacities decline during induced bioprocesses leading to substrate accumulation.

artículo científico publicado en 2017

Physiological description of multivariate interdependencies between process parameters, morphology and physiology during fed-batch penicillin production

artículo científico publicado en 2014

Prediction of filamentous process performance attributes by CSL quality assessment using mid-infrared spectroscopy and chemometrics.

artículo científico publicado en 2017

Predictive Monitoring of Shake Flask Cultures with Online Estimated Growth Models

artículo científico publicado en 2021

Production and purification of the multifunctional enzyme horseradish peroxidase.

artículo científico

Production of Active Recombinant Hyaluronidase Inclusion Bodies from Apis mellifera in E. coli Bl21(DE3) and characterization by FT-IR Spectroscopy

artículo científico publicado en 2020

Production strategies for active heme-containing peroxidases from E. coli inclusion bodies - a review.

artículo científico publicado en 2016

Propagation of measurement accuracy to biomass soft-sensor estimation and control quality.

artículo científico publicado en 2016

Purification and basic biochemical characterization of 19 recombinant plant peroxidase isoenzymes produced in Pichia pastoris.

artículo científico publicado en 2013

Purification of a recombinant plant peroxidase produced in Pichia pastoris by a simple 2-step strategy

article by Oliver Spadiut et al published 28 September 2012 in Protein Expression and Purification

Quantification of cell lysis during CHO bioprocesses: Impact on cell count, growth kinetics and productivity.

artículo científico publicado en 2015

Quantitative CPP Evaluation from Risk Assessment Using Integrated Process Modeling

scientific article published on 13 December 2019

Quantitative analysis of the regulation scheme of invertase expression in Saccharomyces cerevisiae.

artículo científico publicado en 2001

Quantitative comparison of dynamic physiological feeding profiles for recombinant protein production with Pichia pastoris

artículo científico publicado en 2013

Radial line-scans as representative sampling strategy in dried-droplet laser ablation of liquid samples deposited on pre-cut filter paper disks

artículo científico publicado en 2014

Reagent-free monitoring of multiple clinically relevant parameters in human blood plasma using a mid-infrared quantum cascade laser based sensor system.

artículo científico publicado en 2013

Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes.

artículo científico publicado en 2012

Recombinant protein expression in Pichia pastoris strains with an engineered methanol utilization pathway

artículo científico publicado en 2012

Risk-based Process Development of Biosimilars as Part of the Quality by Design Paradigm.

artículo científico publicado en 2013

Role of Knowledge Management in Development and Lifecycle Management of Biopharmaceuticals

artículo científico publicado en 2016

Science-based bioprocess design for filamentous fungi.

artículo científico publicado en 2012

Soft Sensor-Based Monitoring and Efficient Control Strategies of Biomass Concentration for Continuous Cultures of Haloferax mediterranei and Their Application to an Industrial Production Chain

scientific article published on 04 December 2019

Soft sensor for monitoring biomass subpopulations in mammalian cell culture processes

artículo científico

Stoichiometric and kinetic analysis of extreme halophilic Archaea on various substrates in a corrosion resistant bioreactor.

artículo científico publicado en 2013

Substrate oscillations boost recombinant protein release from Escherichia coli

artículo científico publicado en 2013

Switching industrial production processes from complex to defined media: method development and case study using the example of Penicillium chrysogenum.

artículo científico publicado en 2012

Teaching an old pET new tricks: tuning of inclusion body formation and properties by a mixed feed system in E. coli

artículo científico publicado en 2017

The filamentous fungal pellet-relationship between morphology and productivity.

artículo científico publicado en 2018

The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion.

artículo científico publicado en 2017

Toward a Noninvasive, Label-Free Screening Method for Determining Spore Inoculum Quality of Penicillium chrysogenum Using Raman Spectroscopy

artículo científico publicado en 2017

Tunable recombinant protein expression in E. coli: enabler for continuous processing?

artículo científico publicado en 2016

Tunable recombinant protein expression in E. coli: promoter systems and genetic constraints

artículo científico publicado en 2016

Tunable recombinant protein expression with E. coli in a mixed-feed environment.

artículo científico publicado en 2013

Ultrasound-enhanced attenuated total reflection mid-infrared spectroscopy in-line probe: acquisition of cell spectra in a bioreactor

artículo científico publicado en 2015

Universal Capacitance Model for Real-Time Biomass in Cell Culture.

artículo científico publicado en 2015

Workflow for Criticality Assessment Applied in Biopharmaceutical Process Validation Stage 1.

artículo científico publicado en 2017

Workflow for Target-Oriented Parametrization of an Enhanced Mechanistic Cell Culture Model.

artículo científico publicado en 2017

Workflow for multi-analyte bioprocess monitoring demonstrated on inline NIR spectroscopy of P. chrysogenum fermentation.

artículo científico publicado en 2016

Lista de obras de Christoph Herwig

A Novel Application for Low Frequency Electrochemical Impedance Spectroscopy as an Online Process Monitoring Tool for Viable Cell Concentrations.

A combination of HPLC and automated data analysis for monitoring the efficiency of high-pressure homogenization

A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cells ⬇️

A dynamic fed batch strategy for a Pichia pastoris mixed feed system to increase process understanding

A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris ⬇️

A dynamic method for the investigation of induced state metabolic capacities as a function of temperature

A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains.

A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis.

A novel method for fast and statistically verified morphological characterization of filamentous fungi.

A novel method to recover inclusion body protein from recombinant E. coli fed-batch processes based on phage ΦX174-derived lysis protein E.

A novel toolbox for E. coli lysis monitoring

A rapid method for the differentiation of yeast cells grown under carbon and nitrogen-limited conditions by means of partial least squares discriminant analysis employing infrared micro-spectroscopic data of entire yeast cells

A robust feeding strategy to maintain set-point glucose in mammalian fed-batch cultures when input parameters have a large error

Advanced Development Strategies for Biopharmaceutical Cell Culture Processes.

An Integrated Downstream Process Development Strategy along QbD Principles

An automated data-driven DSP development approach for glycoproteins from yeast

At-line determination of spore inoculum quality in Penicillium chrysogenum bioprocesses

At-line determining spore germination of Penicillium chrysogenum bioprocesses in complex media

Automatic feed phase identification in multivariate bioprocess profiles by sequential binary classification.

Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria

Bioprocess development workflow: Transferable physiological knowledge instead of technological correlations

Bioprocess monitoring: minimizing sample matrix effects for total protein quantification with bicinchoninic acid assay

Combining Protein and Strain Engineering for the Production of Glyco-Engineered Horseradish Peroxidase C1A in Pichia pastoris.

Combining light microscopy, dielectric spectroscopy, MALDI intact cell mass spectrometry, FTIR spectromicroscopy and multivariate data mining for morphological and physiological bioprocess characterization of filamentous organisms

Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process.

Comparison of Fiber Optic and Conduit Attenuated Total Reflection (ATR) Fourier Transform Infrared (FT-IR) Setup for In-Line Fermentation Monitoring.

Determination of a dynamic feeding strategy for recombinant Pichia pastoris strains

Determination of carbohydrates present in Saccharomyces cerevisiae using mid-infrared spectroscopy and partial least squares regression.

Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase

Dynamics in bioprocess development for Pichia pastoris.

Effect of post-induction substrate oscillation on recombinant alkaline phosphatase production expressed in Escherichia coli.

Effects of temperature shifts and oscillations on recombinant protein production expressed in Escherichia coli

Essential prerequisites for successful bioprocess development of biological CH4 production from CO2 and H2.

Examining the freezing process of an intermediate bulk containing an industrially relevant protein.

Fed-Batch Production of Bacterial Ghosts Using Dielectric Spectroscopy for Dynamic Process Control.

Generation of PHB from Spent Sulfite Liquor Using Halophilic Microorganisms

Glyco-variant library of the versatile enzyme horseradish peroxidase

High throughput inclusion body sizing: Nano particle tracking analysis

How to Determine Interdependencies of Glucose and Lactose Uptake Rates for Heterologous Protein Production with E. coli

Identification of lipophilic bioproduct portfolio from bioreactor samples of extreme halophilic archaea with HPLC-MS/MS.

Impact of Glycerol as Carbon Source onto Specific Sugar and Inducer Uptake Rates and Inclusion Body Productivity in E. coli BL21(DE3).

Inclusion Body Bead Size in Controlled by Physiological Feeding

Information Processing: Rate-Based Investigation of Cell Physiological Changes along Design Space Development.

Intact cell mass spectrometry as a progress tracking tool for batch and fed-batch fermentation processes

Integrated Process Modeling-A Process Validation Life Cycle Companion

Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes

Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut(+) strain using a two-compartment scale-down system

Knockout of an endogenous mannosyltransferase increases the homogeneity of glycoproteins produced in Pichia pastoris.

Know-how and know-why in biochemical engineering ⬇️

Knowledge management in the QbD paradigm: manufacturing of biotech therapeutics.

Mechanistic platform knowledge of concomitant sugar uptake in Escherichia coli BL21(DE3) strains

Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness

Method for assessing the impact of emission gasses on physiology and productivity in biological methanogenesis

Microbials for the production of monoclonal antibodies and antibody fragments.

Model-Based Methods in the Biopharmaceutical Process Lifecycle

Model-based analysis on the relationship of signal quality to real-time extraction of information in bioprocesses.

Morphological analysis of the filamentous fungus Penicillium chrysogenum using flow cytometry-the fast alternative to microscopic image analysis

Multi-analyte quantification in bioprocesses by Fourier-transform-infrared spectroscopy by partial least squares regression and multivariate curve resolution

Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production.

Multivariate Monitoring Workflow for Formulation, Fill and Finish Processes

Observability analysis of biochemical process models as a valuable tool for the development of mechanistic soft sensors.

Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control

Optimization of sample preparation for intact cell mass spectrometry (matrix-assisted laser desorption/ionization linear time-of-flight mass spectrometry) of endophytic Xylaria

Optimizing cofactor availability for the production of recombinant heme peroxidase in Pichia pastoris

Photosynthetic poly-β-hydroxybutyrate accumulation in unicellular cyanobacterium Synechocystis sp. PCC 6714.

Physiological capacities decline during induced bioprocesses leading to substrate accumulation.

Physiological description of multivariate interdependencies between process parameters, morphology and physiology during fed-batch penicillin production

Prediction of filamentous process performance attributes by CSL quality assessment using mid-infrared spectroscopy and chemometrics.

Predictive Monitoring of Shake Flask Cultures with Online Estimated Growth Models

Production and purification of the multifunctional enzyme horseradish peroxidase.

Production of Active Recombinant Hyaluronidase Inclusion Bodies from Apis mellifera in E. coli Bl21(DE3) and characterization by FT-IR Spectroscopy

Production strategies for active heme-containing peroxidases from E. coli inclusion bodies - a review.

Propagation of measurement accuracy to biomass soft-sensor estimation and control quality.

Purification and basic biochemical characterization of 19 recombinant plant peroxidase isoenzymes produced in Pichia pastoris.

Purification of a recombinant plant peroxidase produced in Pichia pastoris by a simple 2-step strategy

Quantification of cell lysis during CHO bioprocesses: Impact on cell count, growth kinetics and productivity.

Quantitative CPP Evaluation from Risk Assessment Using Integrated Process Modeling

Quantitative analysis of the regulation scheme of invertase expression in Saccharomyces cerevisiae.

Quantitative comparison of dynamic physiological feeding profiles for recombinant protein production with Pichia pastoris