Lista de obras - Bob van de Water - Dominio Público Uruguay

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

artículo científico publicado en 2016

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

artículo científico publicado en 2014

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

artículo científico publicado en 2014

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens

artículo científico publicado en 2014

A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response

artículo científico

A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.

artículo científico publicado en 2013

A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen

artículo científico publicado en 2014

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

artículo científico publicado en 2015

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

artículo científico publicado en 2015

An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis

artículo científico publicado en 2007

An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse

artículo científico publicado en 2009

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

artículo científico publicado en 2015

Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells

artículo científico publicado en 2010

Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation

artículo científico publicado en 2007

Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening

artículo científico publicado en 2012

Automated whole animal bio-imaging assay for human cancer dissemination

artículo científico publicado en 2012

Cellular stress responses and molecular mechanisms of nephrotoxicity

artículo científico publicado en 2005

Cellular-signaling pathways unveil the carcinogenic potential of chemicals

artículo científico

Cross-talk between integrins and oncogenes modulates chemosensitivity

artículo científico publicado en 2009

Current approaches and future role of high content imaging in safety sciences and drug discovery

artículo científico publicado en 2014

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

artículo científico publicado en 2011

Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells

artículo científico publicado en 2002

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes ⬇️

artículo científico publicado el 19 de mayo de 2011

Elucidation of Signaling Pathways from Large-Scale Phosphoproteomic Data Using Protein Interaction Networks

artículo científico publicado en 2016

Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure

artículo científico publicado en 2011

Epac-Rap signaling reduces oxidative stress in the tubular epithelium

artículo científico publicado en 2014

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation

artículo científico publicado en 2014

Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury

scientific journal article

Focal Adhesion Kinase Signaling Mediates Acute Renal Injury Induced by Ischemia/Reperfusion ⬇️

artículo científico publicado el 5 de octubre de 2011

Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells

scientific journal article

Focal adhesion kinase: a potential target in cancer therapy

artículo científico publicado en 2006

Functional screening with a live cell imaging-based random cell migration assay

artículo científico publicado en 2011

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells

artículo científico publicado en 2011

Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis

artículo científico publicado en 2005

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

artículo científico publicado en 2016

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

artículo científico publicado en 2016

Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells

artículo científico publicado en 2013

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

artículo científico publicado en 2017

Integrins uncouple Src-induced morphological and oncogenic transformation

artículo científico publicado en 2008

Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice.

artículo científico publicado en 2009

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/⁺WAPCre mouse model

artículo científico publicado en 2015

Pathways of proximal tubular cell death in bismuth nephrotoxicity

artículo científico publicado en 2002

Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling

artículo científico publicado en 2005

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

artículo científico publicado en 2014

Phospho-proteomic analysis of cellular signaling

artículo científico publicado en 2006

Protein kinase C mediates cisplatin-induced loss of adherens junctions followed by apoptosis of renal proximal tubular epithelial cells

artículo científico publicado en 2004

Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells

scientific journal article

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment

artículo científico publicado en 2014

Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation

artículo científico publicado en 2005

Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment

artículo científico publicado en 2011

Silencing of doublecortin-like (DCL) results in decreased mitochondrial activity and delayed neuroblastoma tumor growth

artículo científico publicado en 2013

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury

artículo científico publicado en 2017

Stem cell-derived systems in toxicology assessment

artículo científico publicado en 2015

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells

artículo científico publicado en 2013

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells

artículo científico publicado en 2012

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals ⬇️

artículo científico publicado el 14 de octubre de 2011

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

artículo científico publicado en 2015

The membrane attack complex of complement induces caspase activation and apoptosis

artículo científico publicado en 2002

The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch

artículo científico publicado en 2013

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

artículo científico publicado en 2009

Toxicogenomics directory of chemically exposed human hepatocytes

artículo científico publicado en 2014

Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

artículo científico publicado en 2015

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

artículo científico publicado en 2015

Tumor-induced remote ECM network orientation steers angiogenesis

artículo científico publicado en 2016

Two-photon intravital multicolor imaging combined with inducible gene expression to distinguish metastatic behavior of breast cancer cells in vivo

artículo científico publicado en 2011

Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo

artículo científico publicado en 2011

Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues

artículo científico publicado en 2014

Unraveling DNA damage response-signaling networks through systems approaches

artículo científico

Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death

artículo científico publicado en 2014

cAMP signalling protects proximal tubular epithelial cells from cisplatin‐induced apoptosis via activation of Epac ⬇️

artículo científico publicado el 1 de febrero de 2012

Lista de obras de Bob van de Water

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens

A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response

A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.

A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis

An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells

Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation

Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening

Automated whole animal bio-imaging assay for human cancer dissemination

Cellular stress responses and molecular mechanisms of nephrotoxicity

Cellular-signaling pathways unveil the carcinogenic potential of chemicals

Cross-talk between integrins and oncogenes modulates chemosensitivity

Current approaches and future role of high content imaging in safety sciences and drug discovery

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes ⬇️

Elucidation of Signaling Pathways from Large-Scale Phosphoproteomic Data Using Protein Interaction Networks

Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure

Epac-Rap signaling reduces oxidative stress in the tubular epithelium

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation

Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury

Focal Adhesion Kinase Signaling Mediates Acute Renal Injury Induced by Ischemia/Reperfusion ⬇️

Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells

Focal adhesion kinase: a potential target in cancer therapy

Functional screening with a live cell imaging-based random cell migration assay

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells

Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

Integrins uncouple Src-induced morphological and oncogenic transformation

Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice.

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/⁺WAPCre mouse model

Pathways of proximal tubular cell death in bismuth nephrotoxicity

Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

Phospho-proteomic analysis of cellular signaling

Protein kinase C mediates cisplatin-induced loss of adherens junctions followed by apoptosis of renal proximal tubular epithelial cells

Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment

Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation

Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment

Silencing of doublecortin-like (DCL) results in decreased mitochondrial activity and delayed neuroblastoma tumor growth

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury

Stem cell-derived systems in toxicology assessment

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals ⬇️

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

The membrane attack complex of complement induces caspase activation and apoptosis

The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

Toxicogenomics directory of chemically exposed human hepatocytes

Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

Tumor-induced remote ECM network orientation steers angiogenesis

Two-photon intravital multicolor imaging combined with inducible gene expression to distinguish metastatic behavior of breast cancer cells in vivo

Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo

Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues

Unraveling DNA damage response-signaling networks through systems approaches

Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death

cAMP signalling protects proximal tubular epithelial cells from cisplatin‐induced apoptosis via activation of Epac ⬇️