Lista de obras - Le Deley - Dominio Público Uruguay

A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial

artículo científico publicado en 2018

A double-blind placebo-controlled randomized phase II trial assessing the activity and safety of regorafenib in non-adipocytic sarcoma patients previously treated with both chemotherapy and pazopanib

artículo científico publicado en 2020

A new approach to integrate toxicity grade and repeated treatment cycles in the analysis and reporting of phase I dose-finding trials.

artículo científico publicado en 2014

Anthracyclines, mitoxantrone, radiotherapy, and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer.

artículo científico publicado en 2006

Bayesian survival analysis in clinical trials: What methods are used in practice?

artículo científico publicado en 2016

Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E.W.I.N.G group

artículo científico publicado en 2016

Central nervous system involvement in anaplastic large cell lymphoma in childhood: results from a multicentre European and Japanese study

artículo científico publicado en 2013

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite

artículo científico publicado en 2015

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial

scientific article published on 12 January 2016

Clinical analysis and prognostic significance of haemophagocytic lymphohistiocytosis-associated anaplastic large cell lymphoma in children.

artículo científico publicado en 2014

Clinicopathologic prognostic factors in childhood atypical teratoid and rhabdoid tumor of the central nervous system ⬇️

artículo científico publicado el 16 de diciembre de 2011

Concomitant chemo-radiotherapy and local dose of radiation as risk factors for second malignant neoplasms after solid cancer in childhood: a case-control study

artículo científico

Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial

artículo científico publicado en 2014

Dose-finding approach for dose escalation with overdose control considering incomplete observations

artículo científico publicado en 2011

Dose-finding designs in pediatric phase I clinical trials: Comparison by simulations in a realistic timeline framework ⬇️

artículo científico publicado el 13 de abril de 2012

Dose-finding designs using a novel quasi-continuous endpoint for multiple toxicities

artículo científico publicado en 2013

EPT-01DOSE-FINDING STUDY OF VINBLASTINE IN COMBINATION WITH NILOTINIB IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH REFRACTORY OR RECURRENT LOW-GRADE GLIOMA: RESULTS OF THE ITCC/SIOPE-BRAIN VINILO PHASE I TRIAL (NCT01887522).

artículo científico publicado en 2016

Effect of a misspecification of response rates on type I and type II errors, in a phase II Simon design

artículo científico publicado en 2011

Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma

Equal access to innovative therapies and precision cancer care

artículo científico publicado en 2016

Factors associated with success of image-guided tumour biopsies: Results from a prospective molecular triage study (MOSCATO-01).

artículo científico publicado en 2016

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations

artículo científico publicado en 2014

Hematopoietic stem cell transplantation in relapsed ALK+ anaplastic large cell lymphoma in children and adolescents: a study on behalf of the SFCE and SFGM-TC.

artículo científico publicado en 2015

High cumulative rate of secondary leukemia after continuous etoposide treatment for solid tumors in children and young adults

artículo científico publicado en 2005

High-Throughput Genomics and Clinical Outcome in Hard-to-Treat Advanced Cancers: Results of the MOSCATO 01 Trial

artículo científico publicado en 2017

Identification of single nucleotide polymorphisms of the PI3K-AKT-mTOR pathway as a risk factor of central nervous system metastasis in metastatic breast cancer

artículo científico publicado en 2017

Impact of early palliative care on overall survival of patients with metastatic upper gastrointestinal cancers treated with first-line chemotherapy: a randomised phase III trial

artículo científico publicado en 2018

Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: secondary analysis of the Euro-Ewing99-R1 trial

artículo científico publicado en 2015

Impact of the methotrexate administration dose on the need for intrathecal treatment in children and adolescents with anaplastic large-cell lymphoma: results of a randomized trial of the EICNHL Group

artículo científico publicado en 2009

Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

artículo científico publicado en 2010

Investigating the heterogeneity of alkylating agents' efficacy and toxicity between sexes: A systematic review and meta-analysis of randomized trials comparing cyclophosphamide and ifosfamide (MAIAGE study).

artículo científico publicado en 2017

Limited stage I disease is not necessarily indicative of an excellent prognosis in childhood anaplastic large cell lymphoma.

artículo científico publicado en 2011

Long-term results of the combination of the N7 induction chemotherapy and the busulfan-melphalan high dose chemotherapy

artículo científico publicado en 2013

Multicenter randomized trial of chewing gum for preventing oral mucositis in children receiving chemotherapy

artículo científico publicado en 2007

Neuro-meningeal relapse in anaplastic large-cell lymphoma: incidence, risk factors and prognosis - a report from the European intergroup for childhood non-Hodgkin lymphoma

artículo científico publicado en 2020

New drugs for children and adolescents with cancer: the need for novel development pathways.

artículo científico publicado en 2013

New insights into the evaluation of randomized controlled trials for rare diseases over a long-term research horizon: a simulation study

artículo científico publicado en 2016

Non-Hodgkin Lymphoma in Children and Adolescents: Progress Through Effective Collaboration, Current Knowledge, and Challenges Ahead

artículo científico publicado en 2015

Once weekly paclitaxel associated with a fixed dose of oral metronomic cyclophosphamide: a dose-finding phase 1 trial

artículo científico publicado en 2018

Operating characteristics of two independent sample design in phase I trials in paediatric oncology.

artículo científico publicado en 2010

Paediatric anaplastic large cell lymphoma with leukaemic presentation in children: a report of nine French cases

artículo científico publicado en 2014

Phase I study of temsirolimus in combination with cetuximab in patients with advanced solid tumours.

artículo científico publicado en 2017

Phase I study of topotecan in combination with temozolomide (TOTEM) in relapsed or refractory paediatric solid tumours

artículo científico publicado en 2010

Phase I trial of bortezomib daily dose: safety, pharmacokinetic profile, biological effects and early clinical evaluation in patients with advanced solid tumors

artículo científico publicado en 2017

Phase II study of temozolomide in combination with topotecan (TOTEM) in relapsed or refractory neuroblastoma: a European Innovative Therapies for Children with Cancer-SIOP-European Neuroblastoma study.

artículo científico publicado en 2013

Phase II, Open-Label, Randomized, Multicenter Trial (HERBY) of Bevacizumab in Pediatric Patients With Newly Diagnosed High-Grade Glioma.

artículo científico publicado en 2018

Phase-II trials in osteosarcoma recurrences: A systematic review of past experience

artículo científico publicado en 2017

Population analysis of erlotinib in adults and children reveals pharmacokinetic characteristics as the main factor explaining tolerance particularities in children.

artículo científico publicado en 2011

Postoperative chemotherapy without irradiation for ependymoma in children under 5 years of age: a multicenter trial of the French Society of Pediatric Oncology.

artículo científico publicado en 2001

Postoperative radiotherapy in the management of adult soft tissue sarcoma of the extremities: results with two different total dose, fractionation, and overall treatment time schedules

scientific article published on 01 July 1999

Prediction of fluid responsiveness by a continuous non-invasive assessment of arterial pressure in critically ill patients: comparison with four other dynamic indices

artículo científico publicado en 2012

Primary cutaneous and subcutaneous Ewing sarcoma.

artículo científico publicado en 2015

Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.

artículo científico publicado en 2010

Prognostic and predictive factors for angiosarcoma patients receiving paclitaxel once weekly plus or minus bevacizumab: an ancillary study derived from a randomized clinical trial

scientific article published on 11 October 2018

Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study

artículo científico publicado en 2007

Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study

artículo científico publicado en 2011

Prognostic value of circulating VEGFR2+ bone marrow-derived progenitor cells in patients with advanced cancer

artículo científico publicado en 2012

Progression-free survival in children with optic pathway tumors: dependence on age and the quality of the response to chemotherapy--results of the first French prospective study for the French Society of Pediatric Oncology

artículo científico publicado en 2003

Pure and mixed fibrolamellar hepatocellular carcinomas differ in natural history and prognosis after complete surgical resection

artículo científico

RECIST response and variation of circulating tumour cells in phase 1 trials: A prospective multicentric study

artículo científico publicado en 2017

Relapses of childhood anaplastic large-cell lymphoma: Treatment results in a series of 41 children - a report from the French Society of Pediatric Oncology

article

Relationship between the brain radiation dose for the treatment of childhood cancer and the risk of long-term cerebrovascular mortality

scientific article published on 01 May 2011

Results of API-AI based regimen in osteosarcoma adult patients included in the French OS2006/Sarcome-09 study

scientific article published on 19 July 2019

Results of a multicenter phase I dose-finding trial of hyperthermic intraperitoneal cisplatin after neoadjuvant chemotherapy and complete cytoreductive surgery and followed by maintenance bevacizumab in initially unresectable ovarian cancer.

artículo científico publicado en 2016

Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study.

artículo científico publicado en 2017

Risk of Subsequent Leukemia After a Solid Tumor in Childhood: Impact of Bone Marrow Radiation Therapy and Chemotherapy

artículo científico publicado en 2015

Risk of secondary leukemia after a solid tumor in childhood according to the dose of epipodophyllotoxins and anthracyclines: a case-control study by the Société Française d'Oncologie Pédiatrique.

artículo científico publicado en 2003

Role of radiation dose in the risk of secondary leukemia after a solid tumor in childhood treated between 1980 and 1999.

artículo científico publicado en 2010

Role of radiotherapy and chemotherapy in the risk of secondary leukaemia after a solid tumour in childhood

scientific article published on 11 September 2006

SAE: an R package for early stopping rules in clinical trials

artículo científico publicado en 2011

SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients

artículo científico publicado en 2007

Safety assessment of intensive induction therapy in childhood anaplastic large cell lymphoma: Report of the ALCL99 randomised trial

artículo científico publicado en 2011

Taking the long view: how to design a series of Phase III trials to maximize cumulative therapeutic benefit ⬇️

artículo científico publicado el 8 de mayo de 2012

Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer (ITCC) European Consortium.

artículo científico publicado en 2009

Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children.

artículo científico publicado en 2005

Variations in the breast reconstruction rate in France: A nationwide study of 19,466 patients based on the French medico-administrative database

scientific article published on 06 August 2018

Vinblastine in children and adolescents with high-risk anaplastic large-cell lymphoma: results of the randomized ALCL99-vinblastine trial

artículo científico publicado en 2010

Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial

artículo científico publicado en 2016

[Neoadjuvant treatment in osteosarcomas]

scientific article published on 01 November 2006

[Parents' opinions of pediatric oncology day hospitals]

artículo científico publicado en 2000

[The role of the expansion cohort in phase I trials in oncology: guidelines of the phase I HUB]

scientific article published on 02 January 2015

Lista de obras de Le Deley

A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial

A double-blind placebo-controlled randomized phase II trial assessing the activity and safety of regorafenib in non-adipocytic sarcoma patients previously treated with both chemotherapy and pazopanib

A new approach to integrate toxicity grade and repeated treatment cycles in the analysis and reporting of phase I dose-finding trials.

Anthracyclines, mitoxantrone, radiotherapy, and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer.

Bayesian survival analysis in clinical trials: What methods are used in practice?

Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E.W.I.N.G group

Central nervous system involvement in anaplastic large cell lymphoma in childhood: results from a multicentre European and Japanese study

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial

Clinical analysis and prognostic significance of haemophagocytic lymphohistiocytosis-associated anaplastic large cell lymphoma in children.

Clinicopathologic prognostic factors in childhood atypical teratoid and rhabdoid tumor of the central nervous system ⬇️

Concomitant chemo-radiotherapy and local dose of radiation as risk factors for second malignant neoplasms after solid cancer in childhood: a case-control study

Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial

Dose-finding approach for dose escalation with overdose control considering incomplete observations

Dose-finding designs in pediatric phase I clinical trials: Comparison by simulations in a realistic timeline framework ⬇️

Dose-finding designs using a novel quasi-continuous endpoint for multiple toxicities

EPT-01DOSE-FINDING STUDY OF VINBLASTINE IN COMBINATION WITH NILOTINIB IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH REFRACTORY OR RECURRENT LOW-GRADE GLIOMA: RESULTS OF THE ITCC/SIOPE-BRAIN VINILO PHASE I TRIAL (NCT01887522).

Effect of a misspecification of response rates on type I and type II errors, in a phase II Simon design

Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma

Equal access to innovative therapies and precision cancer care

Factors associated with success of image-guided tumour biopsies: Results from a prospective molecular triage study (MOSCATO-01).

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations

Hematopoietic stem cell transplantation in relapsed ALK+ anaplastic large cell lymphoma in children and adolescents: a study on behalf of the SFCE and SFGM-TC.

High cumulative rate of secondary leukemia after continuous etoposide treatment for solid tumors in children and young adults

High-Throughput Genomics and Clinical Outcome in Hard-to-Treat Advanced Cancers: Results of the MOSCATO 01 Trial

Identification of single nucleotide polymorphisms of the PI3K-AKT-mTOR pathway as a risk factor of central nervous system metastasis in metastatic breast cancer

Impact of early palliative care on overall survival of patients with metastatic upper gastrointestinal cancers treated with first-line chemotherapy: a randomised phase III trial

Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: secondary analysis of the Euro-Ewing99-R1 trial

Impact of the methotrexate administration dose on the need for intrathecal treatment in children and adolescents with anaplastic large-cell lymphoma: results of a randomized trial of the EICNHL Group

Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

Investigating the heterogeneity of alkylating agents' efficacy and toxicity between sexes: A systematic review and meta-analysis of randomized trials comparing cyclophosphamide and ifosfamide (MAIAGE study).

Limited stage I disease is not necessarily indicative of an excellent prognosis in childhood anaplastic large cell lymphoma.

Long-term results of the combination of the N7 induction chemotherapy and the busulfan-melphalan high dose chemotherapy

Multicenter randomized trial of chewing gum for preventing oral mucositis in children receiving chemotherapy

Neuro-meningeal relapse in anaplastic large-cell lymphoma: incidence, risk factors and prognosis - a report from the European intergroup for childhood non-Hodgkin lymphoma

New drugs for children and adolescents with cancer: the need for novel development pathways.

New insights into the evaluation of randomized controlled trials for rare diseases over a long-term research horizon: a simulation study

Non-Hodgkin Lymphoma in Children and Adolescents: Progress Through Effective Collaboration, Current Knowledge, and Challenges Ahead

Once weekly paclitaxel associated with a fixed dose of oral metronomic cyclophosphamide: a dose-finding phase 1 trial

Operating characteristics of two independent sample design in phase I trials in paediatric oncology.

Paediatric anaplastic large cell lymphoma with leukaemic presentation in children: a report of nine French cases

Phase I study of temsirolimus in combination with cetuximab in patients with advanced solid tumours.

Phase I study of topotecan in combination with temozolomide (TOTEM) in relapsed or refractory paediatric solid tumours

Phase I trial of bortezomib daily dose: safety, pharmacokinetic profile, biological effects and early clinical evaluation in patients with advanced solid tumors

Phase II study of temozolomide in combination with topotecan (TOTEM) in relapsed or refractory neuroblastoma: a European Innovative Therapies for Children with Cancer-SIOP-European Neuroblastoma study.

Phase II, Open-Label, Randomized, Multicenter Trial (HERBY) of Bevacizumab in Pediatric Patients With Newly Diagnosed High-Grade Glioma.

Phase-II trials in osteosarcoma recurrences: A systematic review of past experience

Population analysis of erlotinib in adults and children reveals pharmacokinetic characteristics as the main factor explaining tolerance particularities in children.

Postoperative chemotherapy without irradiation for ependymoma in children under 5 years of age: a multicenter trial of the French Society of Pediatric Oncology.

Postoperative radiotherapy in the management of adult soft tissue sarcoma of the extremities: results with two different total dose, fractionation, and overall treatment time schedules

Prediction of fluid responsiveness by a continuous non-invasive assessment of arterial pressure in critically ill patients: comparison with four other dynamic indices

Primary cutaneous and subcutaneous Ewing sarcoma.

Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.

Prognostic and predictive factors for angiosarcoma patients receiving paclitaxel once weekly plus or minus bevacizumab: an ancillary study derived from a randomized clinical trial

Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study

Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study

Prognostic value of circulating VEGFR2+ bone marrow-derived progenitor cells in patients with advanced cancer

Progression-free survival in children with optic pathway tumors: dependence on age and the quality of the response to chemotherapy--results of the first French prospective study for the French Society of Pediatric Oncology

Pure and mixed fibrolamellar hepatocellular carcinomas differ in natural history and prognosis after complete surgical resection

RECIST response and variation of circulating tumour cells in phase 1 trials: A prospective multicentric study

Relapses of childhood anaplastic large-cell lymphoma: Treatment results in a series of 41 children - a report from the French Society of Pediatric Oncology

Relationship between the brain radiation dose for the treatment of childhood cancer and the risk of long-term cerebrovascular mortality

Results of API-AI based regimen in osteosarcoma adult patients included in the French OS2006/Sarcome-09 study

Results of a multicenter phase I dose-finding trial of hyperthermic intraperitoneal cisplatin after neoadjuvant chemotherapy and complete cytoreductive surgery and followed by maintenance bevacizumab in initially unresectable ovarian cancer.

Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study.

Risk of Subsequent Leukemia After a Solid Tumor in Childhood: Impact of Bone Marrow Radiation Therapy and Chemotherapy

Risk of secondary leukemia after a solid tumor in childhood according to the dose of epipodophyllotoxins and anthracyclines: a case-control study by the Société Française d'Oncologie Pédiatrique.

Role of radiation dose in the risk of secondary leukemia after a solid tumor in childhood treated between 1980 and 1999.

Role of radiotherapy and chemotherapy in the risk of secondary leukaemia after a solid tumour in childhood

SAE: an R package for early stopping rules in clinical trials

SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients

Safety assessment of intensive induction therapy in childhood anaplastic large cell lymphoma: Report of the ALCL99 randomised trial

Taking the long view: how to design a series of Phase III trials to maximize cumulative therapeutic benefit ⬇️

Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer (ITCC) European Consortium.

Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children.

Variations in the breast reconstruction rate in France: A nationwide study of 19,466 patients based on the French medico-administrative database

Vinblastine in children and adolescents with high-risk anaplastic large-cell lymphoma: results of the randomized ALCL99-vinblastine trial

Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial

[Neoadjuvant treatment in osteosarcomas]