Lista de obras -

A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor

artículo científico publicado en 2002

A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor

artículo científico publicado en 2003

A receptor fusion protein for the inhibition of murine oncostatin M ⬇️

artículo científico publicado el 11 de enero de 2011

Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms

artículo científico publicado en 2014

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.

artículo científico publicado en 2003

An essential role for gp130 in neointima formation following arterial injury

scientific journal article

Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy

artículo científico publicado en 2015

Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery

artículo científico publicado en 2015

Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.

artículo científico publicado en 2014

Assessing the Intracellular Integrity of Phosphine-Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling

artículo científico publicado en 2016

Barttin modulates trafficking and function of ClC-K channels

artículo científico publicado en 2006

Biological Activation of Bioinert Medical High Performance Oxide Ceramics by Hydrolytically Stable Immobilization of c(RGDyK) and BMP-2

article

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts

artículo científico publicado en 2012

Bow to your partner for signaling

artículo científico publicado en 2005

CLCN2 variants in idiopathic generalized epilepsy

artículo científico publicado en 2009

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis

artículo científico publicado en 2014

Characterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical function

artículo científico publicado en 2013

Characterization of cyclin L1 as an immobile component of the splicing factor compartment

artículo científico publicado en 2007

Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors

artículo científico publicado en 2004

Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins

artículo científico publicado en 2006

Consequences of the disease-related L78R mutation for dimerization and activity of STAT3

artículo científico publicado en 2014

Corrigendum: Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-<i>in-Silico</i> Approach Combining <i>In Vitro</i> Experiments and Machine Learning

artículo científico publicado en 2020

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma

artículo científico publicado en 2018

Cytokines and inflammation

artículo científico publicado en 2012

DDX6 recruits translational silenced human reticulocyte 15-lipoxygenase mRNA to RNP granules

artículo científico publicado en 2010

Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1)

scientific article published on 01 July 2009

Development of platelets during steady state and inflammation

artículo científico publicado en 2017

Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells

artículo científico publicado en 2005

Directed covalent immobilization of fluorescently labeled cytokines

artículo científico publicado en 2011

Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3 nuclear trafficking

artículo científico publicado en 2016

Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain

artículo científico publicado en 2013

Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62.

artículo científico publicado en 2012

Dynamics and non-canonical aspects of JAK/STAT signalling

artículo científico

Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

artículo científico publicado en 2017

Fluorescent SNAP-tag galectin fusion proteins as novel tools in glycobiology.

artículo científico publicado en 2013

Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism

artículo científico publicado en 2018

Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells

artículo científico publicado en 2004

Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer

scientific article published on 15 November 2005

Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells

artículo científico publicado en 2020

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

artículo científico publicado en 2018

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

artículo científico publicado en 2017

Gp130-dependent signaling in the podocyte

Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning

artículo científico publicado en 2018

Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis.

artículo científico publicado en 2004

Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy

artículo científico publicado en 2004

Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies

artículo científico publicado en 2014

Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

artículo científico publicado en 2016

JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation

article

Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase

artículo científico publicado en 2004

Latent MMP-9 is bound to TIMP-1 before secretion

artículo científico publicado en 2007

Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis

artículo científico publicado en 2003

Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling

artículo científico publicado en 2013

MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis

artículo científico publicado en 2015

Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes

artículo científico publicado en 2007

Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

artículo científico publicado en 2003

Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis

scientific article published on 19 August 2013

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis

artículo científico publicado en 2019

Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors

artículo científico publicado en 2008

Nuclear translocation of STAT3 and NF-κB are independent of each other but NF-κB supports expression and activation of STAT3.

artículo científico publicado en 2017

Nucleocytoplasmic Shuttling of STATs. A Target for Intervention?

artículo científico publicado en 2019

Nucleocytoplasmic shuttling of persistently activated STAT3.

artículo científico publicado en 2007

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.

artículo científico publicado en 2018

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

artículo científico publicado en 2017

Plasticity and cross-talk of interleukin 6-type cytokines

artículo científico

Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury

artículo científico publicado en 2010

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

artículo científico publicado en 2003

Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo

artículo científico publicado en 2020

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

artículo científico publicado en 2016

Real time analysis of STAT3 nucleocytoplasmic shuttling

artículo científico publicado en 2003

Receptor fusion proteins for the inhibition of cytokines ⬇️

artículo científico publicado el 29 de septiembre de 2011

Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

artículo científico publicado en 2009

Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis

artículo científico publicado en 2020

STAT3 is enriched in nuclear bodies

artículo científico publicado en 2003

Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes

artículo científico publicado en 2015

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

artículo científico publicado en 2010

Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction

artículo científico publicado en 2015

Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling

artículo científico publicado en 2019

Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies

artículo científico publicado en 2017

Telomere shortening in enterocytes of patients with uncontrolled acute intestinal graft-versus-host disease

artículo científico publicado en 2015

The Cytokine Receptor gp130: Faithfully Promiscuous ⬇️

artículo científico publicado el 23 de septiembre de 2003

The Impact of Plasma-Derived Microvesicles From a Femoral Fracture Animal Model on Osteoblast Function

artículo científico publicado en 2020

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3.

artículo científico publicado en 2011

The role of the carboxyl terminus in ClC chloride channel function

artículo científico publicado en 2004

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling ⬇️

artículo científico publicado el 1 de marzo de 2004

The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum

artículo científico publicado en 2016

Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis

artículo científico publicado en 2006

Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation ⬇️

artículo científico publicado el 16 de noviembre de 2012

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

scientific article published on 19 September 2019

Lista de obras de

A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor

A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor

A receptor fusion protein for the inhibition of murine oncostatin M ⬇️

Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.

An essential role for gp130 in neointima formation following arterial injury

Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy

Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery

Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.

Assessing the Intracellular Integrity of Phosphine-Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling

Barttin modulates trafficking and function of ClC-K channels

Biological Activation of Bioinert Medical High Performance Oxide Ceramics by Hydrolytically Stable Immobilization of c(RGDyK) and BMP-2

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts

Bow to your partner for signaling

CLCN2 variants in idiopathic generalized epilepsy

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis

Characterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical function

Characterization of cyclin L1 as an immobile component of the splicing factor compartment

Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors

Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins

Consequences of the disease-related L78R mutation for dimerization and activity of STAT3

Corrigendum: Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-<i>in-Silico</i> Approach Combining <i>In Vitro</i> Experiments and Machine Learning

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma

Cytokines and inflammation

DDX6 recruits translational silenced human reticulocyte 15-lipoxygenase mRNA to RNP granules

Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1)

Development of platelets during steady state and inflammation

Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells

Directed covalent immobilization of fluorescently labeled cytokines

Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3 nuclear trafficking

Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain

Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62.

Dynamics and non-canonical aspects of JAK/STAT signalling

Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

Fluorescent SNAP-tag galectin fusion proteins as novel tools in glycobiology.

Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism

Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells

Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer

Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Gp130-dependent signaling in the podocyte

Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning

Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis.

Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy

Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies

Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation

Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase

Latent MMP-9 is bound to TIMP-1 before secretion

Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis

Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling

MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis

Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes

Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis

Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors

Nuclear translocation of STAT3 and NF-κB are independent of each other but NF-κB supports expression and activation of STAT3.

Nucleocytoplasmic Shuttling of STATs. A Target for Intervention?

Nucleocytoplasmic shuttling of persistently activated STAT3.

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

Plasticity and cross-talk of interleukin 6-type cytokines

Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

Real time analysis of STAT3 nucleocytoplasmic shuttling

Receptor fusion proteins for the inhibition of cytokines ⬇️

Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis

STAT3 is enriched in nuclear bodies

Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction

Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling

Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies

Telomere shortening in enterocytes of patients with uncontrolled acute intestinal graft-versus-host disease