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A Murine Model of K-RAS and β-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor

artículo científico publicado en 2015

A delicate balance: TGF-beta and the tumor microenvironment

artículo científico publicado en 2007

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance

artículo científico publicado en 1990

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling

artículo científico publicado en 2007

ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to bone

artículo científico publicado en 2014

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

artículo científico publicado en 2008

Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer

scientific article published on 18 May 2009

Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro

artículo científico publicado en 2004

Active and latent forms of transforming growth factor beta activity in synovial effusions

artículo científico publicado en 1989

Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation

artículo científico publicado en 2005

Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.

artículo científico publicado en 2015

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

artículo científico publicado en 2006

Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts ⬇️

artículo científico publicado el 7 de julio de 2011

Analysis of transforming growth factor β receptor expression and signaling in higher grade meningiomas

artículo científico publicado en 2010

Antagonistic effects of TGFbeta1 and BMP-6 on skin keratinocyte differentiation

artículo científico publicado en 2001

Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis

artículo científico publicado en 2014

BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation

artículo científico publicado en 2014

Benzo(A)pyrene metabolism and blast transformation in peripheral blood mononuclear cells from smoking and nonsmoking populations and lung cancer patients ⬇️

artículo científico publicado el 1 de enero de 1978

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequences ⬇️

artículo científico publicado el 1 de julio de 1991

Biomarker Tests for Molecularly Targeted Therapies--The Key to Unlocking Precision Medicine

artículo científico publicado en 2016

Biomarker Tests for Molecularly Targeted Therapies: Laying the Foundation and Fulfilling the Dream

artículo científico publicado en 2016

Blocking CXCLs-CXCR2 axis in tumor-stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment

article by Makoto Sano et al published 18 January 2019 in Oncogenesis

Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion

artículo científico publicado en 2013

Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma

artículo científico publicado en 2015

Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs

scientific article published on 08 December 2019

Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptorin Vivo

scientific article published in Journal of Biological Chemistry

Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor

artículo científico publicado en 1995

Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2.

artículo científico publicado en 1989

Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma

artículo científico publicado en 2014

Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones

scientific journal article

Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects

scientific journal article

Conditional inactivation of the TGF-beta type II receptor using Cre:Lox

artículo científico publicado en 2002

Covalent binding of benzo[a]pyrene metabolites to DNA, RNA and chromatin proteins in the AKR mouse embryo cell-line ⬇️

artículo científico publicado el 1 de abril de 1981

Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties.

artículo científico publicado en 2012

Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis

artículo científico publicado en 2015

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

artículo científico publicado en 2014

Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells

artículo científico publicado en 2017

Differential expression of genes encoding TGFs β1, β2, and β3 during murine palate formation ⬇️

artículo científico publicado el 1 de octubre de 1990

Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators.

artículo científico publicado en 2011

Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling

artículo científico publicado en 2006

Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis

scientific journal article

Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia

artículo científico publicado en 2007

Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis

artículo científico publicado en 2007

Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells

artículo científico publicado en 2007

Erlotinib Prolongs Survival in Pancreatic Cancer by Blocking Gemcitabine-Induced MAPK Signals ⬇️

artículo científico publicado el 1 de abril de 2013

Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis ⬇️

artículo científico publicado el 20 de octubre de 1997

Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product

artículo científico publicado en 1991

Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli

artículo científico publicado en 2000

Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss

artículo científico publicado en 2016

Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors

artículo científico publicado en 2017

GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma

artículo científico publicado en 2009

Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis

artículo científico publicado en 2009

Genomic and proteomic analysis of mammary tumors arising in transgenic mice

artículo científico publicado en 2005

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

artículo científico publicado en 2016

Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung

artículo científico publicado en 2010

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor ⬇️

artículo científico publicado el 9 de noviembre de 1984

Growth factors in the tumorigenicity of a brain tumor cell line.

artículo científico publicado en 1989

Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion

artículo científico publicado en 1987

Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling

artículo científico publicado en 1998

Identification of an interferon-gamma-responsive element of a class II major histocompatibility gene in rat type 1 astrocytes.

artículo científico publicado en 1991

Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1

artículo científico publicado en 2008

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development

artículo científico publicado en 1991

Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy.

artículo científico publicado en 2005

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1 ⬇️

artículo científico publicado el 1 de diciembre de 2003

Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro

artículo científico publicado en 2004

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity

artículo científico publicado en 1986

Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells

artículo científico publicado en 1988

Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling

artículo científico publicado en 2001

Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences

artículo científico publicado en 2011

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma ⬇️

artículo científico publicado el 19 de septiembre de 2011

Inhibition of BMP signaling suppresses metastasis in mammary cancer

artículo científico publicado en 2014

Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression.

artículo científico publicado en 2007

Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

artículo científico publicado en 2017

Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha

artículo científico publicado en 1995

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

artículo científico publicado en 1999

Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo

artículo científico publicado en 2005

Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk.

artículo científico publicado en 2012

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

artículo científico publicado en 2005

Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression

artículo científico publicado en 2011

Mammary tumor suppression by transforming growth factor beta 1 transgene expression

artículo científico publicado en 1995

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

artículo científico publicado en 1990

Meharry Medical College-Vanderbilt-Ingram Cancer Center partnership: its history and role in cancer health disparities research

artículo científico publicado en 2010

Microdialysis combined with proteomics for protein identification in breast tumor microenvironment in vivo

artículo científico publicado en 2010

Modulation of transforming growth factor type beta action by activated ras and c-myc

artículo científico publicado en 1987

Myeloid cell-derived TGF-beta signaling regulates ECM deposition in mammary carcinoma via adenosine-dependent mechanisms

scientific article published on 20 April 2020

Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis.

artículo científico publicado en 2006

Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching

artículo científico publicado en 1999

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

artículo científico publicado en 1995

PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses

artículo científico publicado en 2016

Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians

artículo científico publicado en 2012

Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor

artículo científico publicado en 2017

Polyadenylylated RNA complementary to a mouse retrovirus-like multigene family is rapidly and specifically induced by epidermal growth factor stimulation of quiescent cells ⬇️

artículo científico publicado el 1 de diciembre de 1982

Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice

artículo científico publicado en 2005

Prostate cancer cells lose their sensitivity to TGFβI growth inhibition with tumor progression ⬇️

artículo científico publicado el 1 de noviembre de 1995

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium

artículo científico publicado en 1988

Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts

artículo científico publicado en 2010

Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells

artículo científico publicado en 2002

Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection.

artículo científico publicado en 2016

Regulation of intestinal epithelial cell growth by transforming growth factor type beta

artículo científico publicado en 1989

Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-beta

artículo científico publicado en 1988

Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors

artículo científico publicado en 2014

STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

artículo científico publicado en 2000

Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen

artículo científico publicado en 2000

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta

artículo científico publicado en 1988

Serum contains a platelet-derived transforming growth factor

artículo científico publicado en 1982

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.

artículo científico publicado en 2015

Signal transduction by transforming growth factor-β: A cooperative paradigm with extensive negative regulation

artículo científico publicado en 1998

Signaling pathways regulating TC21-induced tumorigenesis

artículo científico publicado en 2007

Signaling to the epithelium is not sufficient to mediate all of the effects of transforming growth factor β and bone morphogenetic protein 4 on murine embryonic lung development ⬇️

artículo científico publicado el 1 de noviembre de 2001

Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth

artículo científico publicado en 2015

Some characteristics of a Ca2+ dependent ATPase activity associated with a group of erythrocyte membrane proteins which form fibrils

artículo científico publicado en 1970

Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair.

artículo científico publicado en 1993

Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets ⬇️

artículo científico publicado el 1 de noviembre de 1984

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta

artículo científico publicado en 1987

Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas

artículo científico publicado en 2013

Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells

artículo científico publicado en 1999

TGF beta 1 and TGF beta 2 are potential growth regulators for low-grade and malignant gliomas in vitro: evidence in support of an autocrine hypothesis

artículo científico publicado en 1991

TGF- Biology in Mammary Development and Breast Cancer ⬇️

artículo científico publicado el 1 de enero de 2011

TGF-beta and cancer

artículo científico publicado en 2005

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression

artículo científico publicado en 2010

TGF-beta helps cells fly solo

artículo científico publicado en 2009

TGF-beta in mammary development and neoplasia

artículo científico publicado en 1996

TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution

artículo científico publicado en 2009

TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung

artículo científico publicado en 2008

TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis.

artículo científico publicado en 2010

TGF-beta signaling is essential for joint morphogenesis.

artículo científico publicado en 2007

TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest

artículo científico publicado en 2003

TGF-β Receptor II Loss Promotes Mammary Carcinoma Progression by Th17-Dependent Mechanisms ⬇️

artículo científico publicado el 1 de octubre de 2011

TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment

artículo científico publicado en 2017

TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions

artículo científico publicado en 2015

TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis

artículo científico publicado en 2010

Telomeric associations and consistent growth factor overexpression detected in giant cell tumor of bone ⬇️

artículo científico publicado el 15 de octubre de 1991

Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development

scientific journal article

The Discovery and Early Days of TGF-β: A Historical Perspective

artículo científico publicado en 2016

The binding of benzo(alpha)pyrene and N-methyl-N'-nitro-N-nitrosoguanidine to subnuclear fractions of AKR mouse embryo cells in culture

artículo científico publicado en 1977

The cell biology of transforming growth factor beta

artículo científico

The impact of bone morphogenetic protein 4 (BMP4) on breast cancer metastasis in a mouse xenograft model

artículo científico publicado en 2016

The loss of TGF-beta signaling promotes prostate cancer metastasis

artículo científico publicado en 2003

The roles of TGFβ in the tumour microenvironment

artículo científico publicado en 2013

Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.

artículo científico publicado en 2013

Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis

artículo científico publicado en 2007

Transforming growth factor beta (TGF-beta) and inflammation in cancer

artículo científico publicado en 2009

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation

artículo científico publicado en 1990

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane ⬇️

artículo científico publicado el 1 de agosto de 1990

Transforming growth factor beta mimetics: discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamic acid, a biaryl hydroxamate inhibitor of histone deacetylase

artículo científico publicado en 2002

Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.

artículo científico

Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer

artículo científico publicado en 2004

Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer.

artículo científico publicado en 2014

Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line

artículo científico publicado en 2003

Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?

artículo científico publicado en 2008

Transforming growth factor regulation of keratinocyte growth.

artículo científico publicado en 1993

Transforming growth factor type beta can act as a potent competence factor for AKR-2B cells

scientific article published on 01 October 1987

Transforming growth factor type beta in normal human urine

artículo científico publicado en 1987

Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells

artículo científico publicado en 2008

Transforming growth factor-beta activity in sheep lung lymph during the development of pulmonary hypertension

artículo científico publicado en 1990

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts

artículo científico publicado en 1987

Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment

artículo científico publicado en 2008

Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion

artículo científico publicado en 2008

Transforming growth factor-beta. A family of growth regulatory peptides

artículo científico publicado en 1990

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

artículo científico publicado en 2001

Transforming growth factors and the regulation of cell proliferation

artículo científico publicado en 1990

Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation ⬇️

artículo científico publicado el 1 de octubre de 2003

Tumor necrosis factor alpha response elements in the HLA-DRA promoter: identification of a tumor necrosis factor alpha-induced DNA-protein complex in astrocytes ⬇️

artículo científico publicado el 1 de diciembre de 1992

Tumor-stroma interactions

artículo científico publicado en 2005

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

artículo científico publicado en 2006

Turn Off the IDO: Will Clinical Trials Be Successful? ⬇️

artículo científico publicado el 1 de agosto de 2012

Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

artículo científico publicado en 1988

Type beta transforming growth factor/growth inhibitor stimulates entry of monolayer cultures of AKR-2B cells into S phase after a prolonged prereplicative interval

scientific article published on June 1985

TβRIII Expression in Human Breast Cancer Stroma and the Role of Soluble TβRIII in Breast Cancer Associated Fibroblasts

artículo científico publicado en 2016

Under pressure: stromal fibroblasts change their ways

scientific article published on 01 December 2005

Variation of microsomal mixed function oxidase(s) and human lung cancer

scientific article published on 01 March 1980

p120-catenin is essential for terminal end bud function and mammary morphogenesis ⬇️

artículo científico publicado el 29 de marzo de 2012

β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors

artículo científico publicado en 2011

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