Lista de obras - Yuk Y. Sham - Dominio Público Uruguay

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase ⬇️

artículo científico publicado el 7 de marzo de 2011

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

artículo científico publicado en 2012

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase ⬇️

artículo científico publicado el 18 de febrero de 2011

A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.

artículo científico publicado en 2011

A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription

artículo científico publicado en 2006

A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

artículo científico publicado en 2014

A universal method for the preparation of covalent protein-DNA conjugates for use in creating protein nanostructures

artículo científico publicado en 2007

All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions

artículo científico publicado en 2017

An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules

artículo científico publicado en 2018

Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases

artículo científico publicado en 2016

CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy

scientific article published on 17 October 2019

Can 5-methylcytosine analogues with extended alkyl side chains guide DNA methylation?

artículo científico publicado en 2018

Cell permeable vanX inhibitors as vancomycin re-sensitizing agents

artículo científico publicado en 2014

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization

artículo científico publicado en 2017

Design and synthesis of sulfoximine based inhibitors for HIV-1 protease.

artículo científico publicado en 2008

Design, asymmetric synthesis, and evaluation of pseudosymmetric sulfoximine inhibitors against HIV-1 protease

scientific article published on 21 January 2010

Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation

scientific article published on 01 March 2007

Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor

artículo científico publicado en 2017

Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.

artículo científico publicado en 2015

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

artículo científico publicado en 2010

Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system.

artículo científico publicado en 2005

Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity

artículo científico publicado en 2007

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

artículo científico publicado en 2015

Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation

artículo científico publicado en 2018

Modeling and Simulation of GAT1: A Mechanistic Investigation of the GABA Transport Process

Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues

artículo científico publicado en 2014

Mosquito salivary allergen Aed a 3: cloning, comprehensive molecular analysis, and clinical evaluation

artículo científico publicado en 2015

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

artículo científico publicado en 2018

Mutations in the amino terminus of herpes simplex virus type 1 gL can reduce cell-cell fusion without affecting gH/gL trafficking.

artículo científico publicado en 2013

N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase

artículo científico publicado en 2011

Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

artículo científico publicado en 2010

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

scientific article published on 01 September 2019

Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level

scientific article published on 05 November 2004

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search

artículo científico publicado en 2014

Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines

artículo científico publicado en 2013

The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli

artículo científico publicado en 2017

Thermal unfolding molecular dynamics simulation of Escherichia coli dihydrofolate reductase: thermal stability of protein domains and unfolding pathway

artículo científico publicado en 2002

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility.

artículo científico publicado en 2018

Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis

scientific journal article

pH-Dependent Transport of Pemetrexed by Breast Cancer Resistance Protein ⬇️

artículo científico publicado el 31 de mayo de 2011

pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.

artículo científico publicado en 2012

Lista de obras de Yuk Y. Sham

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase ⬇️

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase ⬇️

A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.

A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription

A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

A universal method for the preparation of covalent protein-DNA conjugates for use in creating protein nanostructures

All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions

An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules

Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases

CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy

Can 5-methylcytosine analogues with extended alkyl side chains guide DNA methylation?

Cell permeable vanX inhibitors as vancomycin re-sensitizing agents

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization

Design and synthesis of sulfoximine based inhibitors for HIV-1 protease.

Design, asymmetric synthesis, and evaluation of pseudosymmetric sulfoximine inhibitors against HIV-1 protease

Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation

Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor

Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system.

Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation

Modeling and Simulation of GAT1: A Mechanistic Investigation of the GABA Transport Process

Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues

Mosquito salivary allergen Aed a 3: cloning, comprehensive molecular analysis, and clinical evaluation

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

Mutations in the amino terminus of herpes simplex virus type 1 gL can reduce cell-cell fusion without affecting gH/gL trafficking.

N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase

Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search

Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines

The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli

Thermal unfolding molecular dynamics simulation of Escherichia coli dihydrofolate reductase: thermal stability of protein domains and unfolding pathway

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility.

Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis

pH-Dependent Transport of Pemetrexed by Breast Cancer Resistance Protein ⬇️

pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.