Lista de obras - Denis Servent - Dominio Público Uruguay

A snake toxin as a theranostic agent for the type 2 vasopressin receptor

artículo científico publicado en 2020

A synthetic weak neurotoxin binds with low affinity to Torpedo and chicken alpha7 nicotinic acetylcholine receptors.

artículo científico publicado en 2002

Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study

artículo científico publicado en 2006

Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins

artículo científico publicado en 2017

Antigen stability controls antigen presentation

scientific article published on 10 September 2004

Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors

artículo científico publicado en 1999

Characterization of a novel Conus bandanus conopeptide belonging to the M-superfamily containing bromotryptophan.

artículo científico publicado en 2014

Chelate oxorhenium to assemble new integrin antagonists.

artículo científico publicado en 2011

Chemical synthesis of MT1 and MT7 muscarinic toxins: critical role of Arg-34 in their interaction with M1 muscarinic receptor.

artículo científico publicado en 2003

Critical role of peptidic toxins in the functional and structural analysis of nicotinic acetylcholine receptors

artículo científico publicado en 2005

Crystallization of recombinant green mamba ρ-Da1a toxin during a lyophilization procedure and its structure determination

artículo científico publicado en 2013

Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors

artículo científico publicado en 2017

Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity.

artículo científico publicado en 2006

Development of novel therapeutic strategies for lung cancer: targeting the cholinergic system.

artículo científico publicado en 2006

Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states

artículo científico publicado en 2008

Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches.

artículo científico publicado en 2018

Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry

artículo científico publicado en 2017

Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides

artículo científico publicado en 2017

Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors

artículo científico publicado en 2012

Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor

artículo científico publicado en 2002

From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei

scientific article published on 09 April 2019

Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors

artículo científico publicado en 1998

G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors.

artículo científico publicado en 2011

Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

artículo científico publicado en 2017

High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli.

artículo científico publicado en 2013

High-throughput production of two disulphide-bridge toxins.

artículo científico publicado en 2014

How do snake curaremimetic toxins discriminate between nicotinic acetylcholine receptor subtypes

artículo científico publicado en 1998

How three-finger-fold toxins interact with various cholinergic receptors

artículo científico publicado en 2006

Identification and functional characterization of a novel α-conotoxin (EIIA) from Conus ermineus

artículo científico publicado en 2013

Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors.

artículo científico publicado en 2010

Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7.

artículo científico publicado en 2006

Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor

artículo científico publicado en 2013

Influence of MT7 toxin on the oligomerization state of the M1 muscarinic receptor.

artículo científico publicado en 2010

Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment

artículo científico publicado en 2009

Interaction of protein ligands with receptor fragments. On the residues of curaremimetic toxins that recognize fragments 128-142 and 185-199 of the alpha-subunit of the nicotinic acetylcholine receptor

artículo científico publicado en 1994

Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor.

artículo científico publicado en 2009

Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition

artículo científico publicado en 2015

Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α1(2)βγδ nAChRs.

artículo científico publicado en 2015

Mass-spectrometry-based method for screening of new peptide ligands for G-protein-coupled receptors

artículo científico publicado en 2015

Minimal conformation of the alpha-conotoxin ImI for the alpha7 neuronal nicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies

artículo científico publicado en 1999

Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors

artículo científico publicado en 2000

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor

artículo científico publicado en 2000

Molecular exploration of the α(1A)-adrenoceptor orthosteric site: binding site definition for epinephrine, HEAT and prazosin

artículo científico publicado en 2014

Motions and structural variability within toxins: Implication for their use as scaffolds for protein engineering

artículo científico publicado en 2003

Multiple enzymatic pathways involved in the metabolism of glyceryl trinitrate in Phanerochaete chrysosporium ⬇️

artículo científico publicado el 1 de junio de 1992

Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: implications on lung carcinogenesis.

artículo científico publicado en 2008

Muscarinic toxins.

artículo científico publicado en 2011

Neonicotinoid binding, toxicity and expression of nicotinic acetylcholine receptor subunits in the aphid Acyrthosiphon pisum

artículo científico publicado en 2014

New α-adrenergic property for synthetic MTβ and CM-3 three-finger fold toxins from black mamba.

artículo científico publicado en 2013

Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: involvement of cytochrome P-450

artículo científico publicado en 1989

Nitric oxide, a biological effector. Electron paramagnetic resonance detection of nitrosyl-iron-protein complexes in whole cells.

artículo científico publicado en 1991

Nitroglycerin metabolism by Phanerochaete chrysosporium: evidence for nitric oxide and nitrite formation

scientific article published on 01 July 1991

Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor

scientific article published on 01 September 1997

Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor

artículo científico publicado en 2013

Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: subsequent formation of nitric oxide

artículo científico publicado en 1993

Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension

artículo científico publicado en 2012

Pharmacological characterization of zinc and copper interaction with the human alpha(1A)-adrenoceptor

artículo científico publicado en 2011

Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins

artículo científico publicado en 2014

Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors.

artículo científico publicado en 2018

Relative spatial position of a snake neurotoxin and the reduced disulfide bond alpha (Cys192-Cys193) at the alpha gamma interface of the nicotinic acetylcholine receptor

artículo científico publicado en 2000

Resistance to D-tubocurarine of the rat diaphragm as compared to a limb muscle: influence of quantal transmitter release and nicotinic acetylcholine receptors.

artículo científico publicado en 2009

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia.

artículo científico publicado en 2017

Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation

artículo científico publicado en 2008

Site-directed disulfide reduction using an affinity reagent: application on the nicotinic acetylcholine receptor

artículo científico publicado en 1995

Special Issue on "Toxins: New targets and new functions"

artículo científico publicado en 2016

Special Issue on "freshwater and marine toxins"

artículo científico publicado en 2014

Special issue on «Toxins: from threats to benefits»

artículo científico publicado en 2013

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

artículo científico publicado en 2010

Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor

artículo científico publicado en 2011

Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.

artículo científico publicado en 2015

Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na<sub>V</sub>1.7/Na<sub>V</sub>1.6 Selectivity Ratios

artículo científico publicado en 2021

Targeting alpha7-nicotinic receptor for the treatment of pleural mesothelioma.

artículo científico publicado en 2008

The Cloning and Characterization of a Three-Finger Toxin Homolog (NXH8) from the Coralsnake Micrurus corallinus That Interacts with Skeletal Muscle Nicotinic Acetylcholine Receptors

artículo científico publicado en 2024

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors

scientific article published on 24 August 2016

The European FP7 Venomics Project

artículo científico publicado en 2014

The Neurotoxic Effect of 13,19-Didesmethyl and 13-Desmethyl Spirolide C Phycotoxins Is Mainly Mediated by Nicotinic Rather Than Muscarinic Acetylcholine Receptors.

artículo científico publicado en 2015

The Repellent DEET Potentiates Carbamate Effects via Insect Muscarinic Receptor Interactions: An Alternative Strategy to Control Insect Vector-Borne Diseases

artículo científico publicado en 2015

The marine phycotoxin gymnodimine targets muscular and neuronal nicotinic acetylcholine receptor subtypes with high affinity.

artículo científico publicado en 2008

The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions.

artículo científico publicado en 2017

Total Synthesis of Pinnatoxins A and G and Revision of the Mode of Action of Pinnatoxin A ⬇️

artículo científico publicado el 17 de junio de 2011

Variability among the sites by which curaremimetic toxins bind to torpedo acetylcholine receptor, as revealed by identification of the functional residues of alpha-cobratoxin

artículo científico publicado en 1999

α9-containing nicotinic acetylcholine receptors and the modulation of pain.

artículo científico publicado en 2017

Lista de obras de Denis Servent

A snake toxin as a theranostic agent for the type 2 vasopressin receptor

A synthetic weak neurotoxin binds with low affinity to Torpedo and chicken alpha7 nicotinic acetylcholine receptors.

Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study

Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins

Antigen stability controls antigen presentation

Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors

Characterization of a novel Conus bandanus conopeptide belonging to the M-superfamily containing bromotryptophan.

Chelate oxorhenium to assemble new integrin antagonists.

Chemical synthesis of MT1 and MT7 muscarinic toxins: critical role of Arg-34 in their interaction with M1 muscarinic receptor.

Critical role of peptidic toxins in the functional and structural analysis of nicotinic acetylcholine receptors

Crystallization of recombinant green mamba ρ-Da1a toxin during a lyophilization procedure and its structure determination

Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors

Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity.

Development of novel therapeutic strategies for lung cancer: targeting the cholinergic system.

Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states

Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches.

Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry

Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides

Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors

Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor

From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei

Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors

G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors.

Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli.

High-throughput production of two disulphide-bridge toxins.

How do snake curaremimetic toxins discriminate between nicotinic acetylcholine receptor subtypes

How three-finger-fold toxins interact with various cholinergic receptors

Identification and functional characterization of a novel α-conotoxin (EIIA) from Conus ermineus

Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors.

Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7.

Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor

Influence of MT7 toxin on the oligomerization state of the M1 muscarinic receptor.

Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment

Interaction of protein ligands with receptor fragments. On the residues of curaremimetic toxins that recognize fragments 128-142 and 185-199 of the alpha-subunit of the nicotinic acetylcholine receptor

Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor.

Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition

Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α1(2)βγδ nAChRs.

Mass-spectrometry-based method for screening of new peptide ligands for G-protein-coupled receptors

Minimal conformation of the alpha-conotoxin ImI for the alpha7 neuronal nicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies

Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor

Molecular exploration of the α(1A)-adrenoceptor orthosteric site: binding site definition for epinephrine, HEAT and prazosin

Motions and structural variability within toxins: Implication for their use as scaffolds for protein engineering

Multiple enzymatic pathways involved in the metabolism of glyceryl trinitrate in Phanerochaete chrysosporium ⬇️

Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: implications on lung carcinogenesis.

Muscarinic toxins.

Neonicotinoid binding, toxicity and expression of nicotinic acetylcholine receptor subunits in the aphid Acyrthosiphon pisum

New α-adrenergic property for synthetic MTβ and CM-3 three-finger fold toxins from black mamba.

Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: involvement of cytochrome P-450

Nitric oxide, a biological effector. Electron paramagnetic resonance detection of nitrosyl-iron-protein complexes in whole cells.

Nitroglycerin metabolism by Phanerochaete chrysosporium: evidence for nitric oxide and nitrite formation

Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor

Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor

Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: subsequent formation of nitric oxide

Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension

Pharmacological characterization of zinc and copper interaction with the human alpha(1A)-adrenoceptor

Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins

Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors.

Relative spatial position of a snake neurotoxin and the reduced disulfide bond alpha (Cys192-Cys193) at the alpha gamma interface of the nicotinic acetylcholine receptor

Resistance to D-tubocurarine of the rat diaphragm as compared to a limb muscle: influence of quantal transmitter release and nicotinic acetylcholine receptors.

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia.

Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation

Site-directed disulfide reduction using an affinity reagent: application on the nicotinic acetylcholine receptor

Special Issue on "Toxins: New targets and new functions"

Special Issue on "freshwater and marine toxins"

Special issue on «Toxins: from threats to benefits»

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor

Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.

Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na<sub>V</sub>1.7/Na<sub>V</sub>1.6 Selectivity Ratios

Targeting alpha7-nicotinic receptor for the treatment of pleural mesothelioma.

The Cloning and Characterization of a Three-Finger Toxin Homolog (NXH8) from the Coralsnake Micrurus corallinus That Interacts with Skeletal Muscle Nicotinic Acetylcholine Receptors

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors

The European FP7 Venomics Project

The Neurotoxic Effect of 13,19-Didesmethyl and 13-Desmethyl Spirolide C Phycotoxins Is Mainly Mediated by Nicotinic Rather Than Muscarinic Acetylcholine Receptors.

The Repellent DEET Potentiates Carbamate Effects via Insect Muscarinic Receptor Interactions: An Alternative Strategy to Control Insect Vector-Borne Diseases

The marine phycotoxin gymnodimine targets muscular and neuronal nicotinic acetylcholine receptor subtypes with high affinity.

The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions.