Lista de obras - Anton Bespalov - Dominio Público Uruguay

A case study of foliglurax, the first clinical mGluR4 PAM for symptomatic treatment of Parkinson's disease: Translational gaps or a failing industry innovation model?

artículo científico publicado en 2020

AMPA receptor antagonists reverse effects of extended habit training on signaled food approach responding in rats

artículo científico publicado en 2007

Agonist and antagonist effects of cytisine in vivo

artículo científico publicado en 2015

Antidepressant Treatment in Anxiety Disorders ⬇️

artículo científico publicado el 1 de enero de 2010

Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests.

artículo científico publicado en 2006

Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval

scientific article published on 01 May 2000

Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.

artículo científico publicado en 2005

Be positive about negatives-recommendations for the publication of negative (or null) results

artículo científico publicado en 2019

Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression

artículo científico publicado en 2008

Behavioral effects of MK-801 in morphine-dependent and non-dependent mice

scientific article published on 01 January 1996

Blinding and Randomization

artículo científico publicado en 2020

Blockade of glycine transporter 1 by SSR-504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner

artículo científico publicado en 2011

Classical conditioning of electrical self-stimulation of ventral tegmental area to brief visual stimuli in rats

artículo científico publicado en 1996

Competitive and noncompetitive NMDA antagonist effects in rats trained to discriminate lever-press counts.

artículo científico publicado en 2001

Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration

artículo científico publicado en 2003

Decrement in operant performance produced by NMDA receptor antagonists in the rat: tolerance and cross-tolerance.

artículo científico publicado en 2000

Development of disease-modifying treatment of schizophrenia

artículo científico

Development of novel therapy of schizophrenia in children and adolescents.

artículo científico publicado en 2014

Differential effects of nitric oxide synthase inhibitor, 7-nitroindazole, on discriminative stimulus and somatic effects of naloxone in morphine-dependent rats.

artículo científico publicado en 1999

Double dissociation of the effects of haloperidol and the dopamine D3 receptor antagonist ABT-127 on acquisition vs. expression of cocaine-conditioned activity in rats.

artículo científico publicado en 2010

Drug Tolerance: A Known Unknown in Translational Neuroscience.

artículo científico publicado en 2016

Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats.

artículo científico publicado en 2005

Editorial for special issue on mGluRs and cognition

artículo científico publicado en 2010

Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice.

artículo científico publicado en 2005

Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients

artículo científico publicado en 2007

Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration

artículo científico publicado en 2006

Effects of NMDA receptor antagonists on cocaine-conditioned motor activity in rats.

artículo científico publicado en 2000

Effects of NMDA receptor channel blockers, MK-801 and memantine, on locomotor activity and tolerance to delay of reward in Wistar-Kyoto and spontaneously hypertensive rats.

artículo científico publicado en 2004

Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats.

artículo científico publicado en 2010

Effects of abused drugs on thresholds and breaking points of intracranial self-stimulation in rats

artículo científico publicado en 1999

Effects of calcium channel blockers on behaviors induced by the N-methyl-D-aspartate receptor antagonist, dizocilpine, in rats

artículo científico publicado en 1999

Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain

artículo científico publicado en 2004

Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats

artículo científico publicado en 2007

Effects of memantine on estrogen-dependent acute tolerance to the morphine analgesia in female rats

artículo científico publicado en 2006

Effects of morphine on formalin-induced nociception in rats.

artículo científico publicado en 2003

Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice.

artículo científico publicado en 2005

Effects of short-acting NMDA receptor antagonist MRZ 2/576 on morphine tolerance development in mice

artículo científico publicado en 2000

Enhanced brain penetration of hexamethonium in complexes with derivatives of fullerene C60.

artículo científico publicado en 2016

Enhancing quality in preclinical data: Of hot science and cool quality

artículo científico publicado en 2020

Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in rats.

artículo científico publicado en 2004

Excitatory amino acid receptor antagonist kynurenic acid attenuates rewarding potential of morphine

scientific article published on 01 November 1994

Facilitation of aggressive and sexual behaviors by saccharin deprivation in rats.

artículo científico publicado en 2004

Facilitation of electrical brain self-stimulation behavior by abused solvents.

artículo científico publicado en 2003

Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets

artículo científico publicado en 2016

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies

artículo científico publicado en 2010

Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?

artículo científico publicado en 2009

Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs

artículo científico publicado en 2006

Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex.

artículo científico publicado en 2014

Improving Transparency and Scientific Rigor in Academic Publishing

Improving target assessment in biomedical research: the GOT-IT recommendations

artículo científico publicado en 2020

Improving transparency and scientific rigor in academic publishing

scientific article published on 02 December 2018

Improving transparency and scientific rigor in academic publishing

In search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence behind the mTor activation hypothesis

Industry is more alarmed about reproducibility than academia

scientific article published on 01 November 2018

Interaction of blockers of ionotropic NMDA receptors and metabotropic glutamate receptors in a working memory test in rats.

artículo científico publicado en 2010

Interactions Between N-Methyl-?-Aspartate Receptor Antagonists and the Discriminative Stimulus Effects of Morphine in Rats ⬇️

artículo científico publicado el 1 de junio de 1998

Intraaccumbens administration of NMDA receptor antagonist (+/-)-CPP prevents locomotor activation conditioned by morphine and amphetamine in rats

artículo científico publicado en 1996

Intravenous self-administration of abused solvents and anesthetics in mice.

artículo científico publicado en 2004

Introduction to the EQIPD quality system

artículo científico publicado en 2021

Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer's disease.

artículo científico publicado en 2015

Lack of depression-like effects of saccharin deprivation in rats: forced swim test, differential reinforcement of low rates and intracranial self-stimulation procedures.

artículo científico publicado en 2003

Lacking quality in research: Is behavioral neuroscience affected more than other areas of biomedical science?

artículo científico publicado en 2017

Low-affinity NMDA receptor channel blockers inhibit acquisition of intravenous morphine self-administration in naive mice

artículo científico publicado en 1999

Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists

artículo científico publicado en 2006

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

artículo científico publicado en 2013

Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy

artículo científico publicado en 2018

Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats.

artículo científico publicado en 2005

Morphine Tolerance and Dependence in Mice with History of Repeated Exposures to NMDA Receptor Channel Blockers

scientific article published on 01 August 1999

Morphine-induced Straub tail reaction in mice treated with serotonergic compounds.

artículo científico publicado en 2016

Motor impairment produced by ethanol and site-selective NMDA receptor antagonists in mice: tolerance and cross-tolerance

artículo científico publicado en 2000

NMDA receptor antagonists prevent conditioned activation of intracranial self-stimulation in rats

artículo científico publicado en 1997

Naltrexone for heroin dependence treatment in St. Petersburg, Russia

artículo científico publicado en 2004

Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia.

artículo científico publicado en 2006

Novel reinforcement learning paradigm based on response patterning under interval schedules of reinforcement.

artículo científico publicado en 2017

Opioid-NMDA receptor interactions may clarify conditioned (associative) components of opioid analgesic tolerance.

artículo científico publicado en 2001

Place conditioning of mice with the NMDA receptor antagonists, eliprodil and dizocilpine

artículo científico publicado en 1998

Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity

artículo científico publicado en 2017

Preclinical models of muscle spasticity: valuable tools in the development of novel treatment for neurological diseases and conditions.

artículo científico publicado en 2016

Pretreatment with morphine potentiates naloxone-conditioned place aversion in mice: effects of NMDA receptor antagonists

artículo científico publicado en 2000

Prolongation of morphine analgesia by competitive NMDA receptor antagonist D-CPPene (SDZ EAA 494) in rats.

artículo científico publicado en 1998

Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals

Short-acting NMDA receptor antagonist MRZ 2/576 produces prolonged suppression of morphine withdrawal in mice

artículo científico publicado en 2000

Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment

artículo científico publicado en 2007

Subchronic morphine increases amphetamine-induced potentiation of brain stimulation reward: reversal by DNQX.

artículo científico publicado en 1995

THE USE OF SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR 5 AGONISTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS SUCH AS ALZHEIMER'S DISEASE AND LYSOSOMAL STORAGE DISEASES SUCH AS NIEMANN-PICK C DISEASE

artículo científico publicado en 2014

Targeting Glycine Reuptake in Alcohol Seeking and Relapse.

artículo científico publicado en 2018

The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile.

artículo científico publicado en 2015

The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats

artículo científico publicado en 2004

The effects of PDE10 inhibition on attentional set-shifting do not depend on the activation of dopamine D1 receptors.

artículo científico publicado en 2016

The expression of both amphetamine-conditioned place preference and pentylenetetrazol-conditioned place aversion is attenuated by the NMDA receptor antagonist (+/-)-CPP.

artículo científico publicado en 1996

The preclinical data forum network: A new ECNP initiative to improve data quality and robustness for (preclinical) neuroscience.

artículo científico publicado en 2015

Theoretical Model to Explain Excess of Quasiparticles in Superconductors ⬇️

artículo científico publicado en 2016

Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene

artículo científico publicado en 2017

mGlu1 receptor as a drug target for treatment of substance use disorders: time to gather stones together?

artículo científico publicado en 2017

mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats.

artículo científico publicado en 2006

Lista de obras de Anton Bespalov

A case study of foliglurax, the first clinical mGluR4 PAM for symptomatic treatment of Parkinson's disease: Translational gaps or a failing industry innovation model?

AMPA receptor antagonists reverse effects of extended habit training on signaled food approach responding in rats

Agonist and antagonist effects of cytisine in vivo

Antidepressant Treatment in Anxiety Disorders ⬇️

Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests.

Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval

Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.

Be positive about negatives-recommendations for the publication of negative (or null) results

Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression

Behavioral effects of MK-801 in morphine-dependent and non-dependent mice

Blinding and Randomization

Blockade of glycine transporter 1 by SSR-504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner

Classical conditioning of electrical self-stimulation of ventral tegmental area to brief visual stimuli in rats

Competitive and noncompetitive NMDA antagonist effects in rats trained to discriminate lever-press counts.

Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration

Decrement in operant performance produced by NMDA receptor antagonists in the rat: tolerance and cross-tolerance.

Development of disease-modifying treatment of schizophrenia

Development of novel therapy of schizophrenia in children and adolescents.

Differential effects of nitric oxide synthase inhibitor, 7-nitroindazole, on discriminative stimulus and somatic effects of naloxone in morphine-dependent rats.

Double dissociation of the effects of haloperidol and the dopamine D3 receptor antagonist ABT-127 on acquisition vs. expression of cocaine-conditioned activity in rats.

Drug Tolerance: A Known Unknown in Translational Neuroscience.

Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats.

Editorial for special issue on mGluRs and cognition

Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice.

Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients

Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration

Effects of NMDA receptor antagonists on cocaine-conditioned motor activity in rats.

Effects of NMDA receptor channel blockers, MK-801 and memantine, on locomotor activity and tolerance to delay of reward in Wistar-Kyoto and spontaneously hypertensive rats.

Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats.

Effects of abused drugs on thresholds and breaking points of intracranial self-stimulation in rats

Effects of calcium channel blockers on behaviors induced by the N-methyl-D-aspartate receptor antagonist, dizocilpine, in rats

Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain

Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats

Effects of memantine on estrogen-dependent acute tolerance to the morphine analgesia in female rats

Effects of morphine on formalin-induced nociception in rats.

Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice.

Effects of short-acting NMDA receptor antagonist MRZ 2/576 on morphine tolerance development in mice

Enhanced brain penetration of hexamethonium in complexes with derivatives of fullerene C60.

Enhancing quality in preclinical data: Of hot science and cool quality

Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in rats.

Excitatory amino acid receptor antagonist kynurenic acid attenuates rewarding potential of morphine

Facilitation of aggressive and sexual behaviors by saccharin deprivation in rats.

Facilitation of electrical brain self-stimulation behavior by abused solvents.

Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies

Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?

Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs

Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex.

Improving Transparency and Scientific Rigor in Academic Publishing

Improving target assessment in biomedical research: the GOT-IT recommendations

Improving transparency and scientific rigor in academic publishing

Improving transparency and scientific rigor in academic publishing

Improving transparency and scientific rigor in academic publishing

In search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence behind the mTor activation hypothesis

Industry is more alarmed about reproducibility than academia

Interaction of blockers of ionotropic NMDA receptors and metabotropic glutamate receptors in a working memory test in rats.

Interactions Between N-Methyl-?-Aspartate Receptor Antagonists and the Discriminative Stimulus Effects of Morphine in Rats ⬇️

Intraaccumbens administration of NMDA receptor antagonist (+/-)-CPP prevents locomotor activation conditioned by morphine and amphetamine in rats

Intravenous self-administration of abused solvents and anesthetics in mice.

Introduction to the EQIPD quality system

Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer's disease.

Lack of depression-like effects of saccharin deprivation in rats: forced swim test, differential reinforcement of low rates and intracranial self-stimulation procedures.

Lacking quality in research: Is behavioral neuroscience affected more than other areas of biomedical science?

Low-affinity NMDA receptor channel blockers inhibit acquisition of intravenous morphine self-administration in naive mice

Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy

Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats.

Morphine Tolerance and Dependence in Mice with History of Repeated Exposures to NMDA Receptor Channel Blockers

Morphine-induced Straub tail reaction in mice treated with serotonergic compounds.

Motor impairment produced by ethanol and site-selective NMDA receptor antagonists in mice: tolerance and cross-tolerance

NMDA receptor antagonists prevent conditioned activation of intracranial self-stimulation in rats

Naltrexone for heroin dependence treatment in St. Petersburg, Russia

Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia.

Novel reinforcement learning paradigm based on response patterning under interval schedules of reinforcement.

Opioid-NMDA receptor interactions may clarify conditioned (associative) components of opioid analgesic tolerance.

Place conditioning of mice with the NMDA receptor antagonists, eliprodil and dizocilpine

Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity

Preclinical models of muscle spasticity: valuable tools in the development of novel treatment for neurological diseases and conditions.