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Lista de obras de Isabel Fabregat

2-[18F]FDG PET/CT as a Predictor of Microvascular Invasion and High Histological Grade in Patients with Hepatocellular Carcinoma

artículo científico publicado en 2021

A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells

scientific article published on 04 August 2014

A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins

artículo científico publicado en 2014

Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism

artículo científico publicado en 2007

Altered TGF-β endocytic trafficking contributes to the increased signaling in Marfan syndrome

artículo científico publicado en 2017

Apoptosis Induced by Transforming Growth Factor- in Fetal Hepatocyte Primary Cultures

artículo científico publicado en 1996

Apoptotic Response to TGF-$beta; in Fetal Hepatocytes Depends upon Their State of Differentiation

scientific article published on 01 November 1999

Apoptotic action of E2F1 requires glycogen synthase kinase 3-beta activity in PC12 cells

artículo científico publicado en 2007

Autocrine production of TGF-β confers resistance to apoptosis after an epithelial–mesenchymal transition process in hepatocytes: Role of EGF receptor ligands

artículo científico publicado en 2006

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells

artículo científico publicado en 2013

BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation

artículo científico publicado en 2015

BMPS and liver: more questions than answers

artículo científico

Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC-induced cholestatic liver injury.

artículo científico publicado en 2018

Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC

scientific article published on 18 October 2019

Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.

artículo científico publicado en 2014

Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1.

artículo científico publicado en 2016

Cell fusion reprogramming leads to a specific hepatic expression pattern during mouse bone marrow derived hepatocyte formation in vivo.

artículo científico publicado en 2012

Changes in rat liver gene expression induced by thioacetamide: protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism

scientific article published on 01 March 1996

Citrate synthase of Tetrahymena pyriformis: Evolutionary and regulatory aspects

scientific article published on 01 February 1983

Clathrin switches transforming growth factor-β role to pro-tumorigenic in liver cancer

scientific article published on 25 September 2019

Correction: Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II.

artículo científico publicado en 2013

Cross-Talk Between TGF-β and NADPH Oxidases During Liver Fibrosis and Hepatocarcinogenesis

artículo científico publicado en 2015

Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture.

artículo científico publicado en 1997

Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro

artículo científico publicado en 2008

Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II.

artículo científico publicado en 2013

Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.

artículo científico publicado en 2006

Differential proliferative response of cultured fetal and regenerating hepatocytes to growth factors and hormones

artículo científico publicado en 1992

Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.

artículo científico publicado en 2010

Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis.

artículo científico publicado en 2015

Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition

scientific article published on 26 August 2019

Dysregulation of apoptosis in hepatocellular carcinoma cells

artículo científico publicado en 2009

EGF blocks NADPH oxidase activation by TGF-beta in fetal rat hepatocytes, impairing oxidative stress, and cell death.

artículo científico publicado en 2006

EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells.

artículo científico publicado en 2011

Editorial Special Issue TGF-beta/BMP Signaling Pathway

artículo científico publicado en 2020

Effects of growth and differentiation factors on the epithelial-mesenchymal transition in cultured neonatal rat hepatocytes

scientific journal article

Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase

artículo científico publicado en 2005

Epidermal Growth Factor Impairs the Cytochrome C/Caspase-3 Apoptotic Pathway Induced by Transforming Growth Factorβ in Rat Fetal Hepatocytes Via a Phosphoinositide 3-Kinase–Dependent Pathway

artículo científico publicado en 2000

Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture

article

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

artículo científico publicado en 2017

Exploring liver physiology, pathology, TGF-β, EMT, stemness and new developments in liver cancer.

artículo científico publicado en 2017

Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture.

artículo científico publicado en 2000

Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression.

artículo científico publicado en 2018

Genetically modified animal models recapitulating molecular events altered in human hepatocarcinogenesis

artículo científico publicado en 2009

Glucocorticoid receptor down-Regulates c-jun amino terminal kinases induced by tumor necrosis factor ? in fetal rat hepatocyte primary cultures

article

Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells.

artículo científico publicado en 2010

Growth factor- and cytokine-driven pathways governing liver stemness and differentiation ⬇️

artículo científico publicado el 7 de noviembre de 2010

Growth stimulation of rat fetal hepatocytes in response to hepatocyte growth factor: modulation of c-myc and c-fos expression

artículo científico publicado el 15 de diciembre de 1992

HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.

artículo científico publicado en 2015

Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion

artículo científico publicado en 2006

Hepatocyte growth factor up-regulates met expression in rat fetal hepatocytes in primary culture

scientific journal article

Hormonal regulation of malic enzyme expression in primary cultures of foetal brown adipocytes

article

Hybrid polymeric-protein nano-carriers (HPPNC) for targeted delivery of TGFβ inhibitors to hepatocellular carcinoma cells

artículo científico publicado en 2017

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.

artículo científico publicado en 2004

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

artículo científico publicado en 2013

Inhibition of fatty acid biosynthesis by bezafibrate in different rat cells

artículo científico publicado en 1989

Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion

artículo científico publicado en 2008

Interaction with protein SH groups could be involved in adriamycin cardiotoxicity ⬇️

artículo científico publicado el 1 de diciembre de 1984

Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes

scientific journal article

Isolation and characterization of a putative liver progenitor population after treatment of fetal rat hepatocytes with TGF-beta

scientific journal article

Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells.

artículo científico publicado en 2011

Lack of aminoacids in mouse hepatocytes in culture induces the selection of preneoplastic cells

artículo científico publicado en 2012

Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation

scientific journal article

Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.

artículo científico publicado en 2003

Mechanisms regulating cell membrane localization of the chemokine receptor CXCR4 in human hepatocarcinoma cells.

artículo científico publicado en 2015

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes

artículo científico publicado en 2003

Mouse hepatic oval cells require Met-dependent PI3K to impair TGF-β-induced oxidative stress and apoptosis

artículo científico publicado en 2013

NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice

artículo científico publicado en 2020

NADPH oxidase NOX1 controls autocrine growth of liver tumor cells through up-regulation of the epidermal growth factor receptor pathway

artículo científico publicado en 2010

NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.

artículo científico publicado en 2012

New Insights into the Crossroads between EMT and Stemness in the Context of Cancer

artículo científico publicado en 2016

Noradrenergic modulation of albumin expression in growth-stimulated adult rat hepatocytes in primary culture

article

Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.

artículo científico publicado en 2009

Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells.

artículo científico publicado en 2013

Paradoxical role of the NADPH oxidase NOX4 in early preneoplastic stages of hepatocytes induced by amino acid deprivation

artículo científico publicado en 2019

Phorbol esters down-regulate alpha-fetoprotein gene expression without affecting growth in fetal hepatocytes in primary culture.

artículo científico publicado en 1998

Polμ deficiency increases resistance to oxidative damage and delays liver aging

artículo científico publicado en 2014

Possible involvement of NADPH requirement in regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenase levels in rat liver

artículo científico publicado en 1990

Precocious induction of malic enzyme by nutritional and hormonal factors in rat foetal hepatocyte primary cultures

article

Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes

artículo científico publicado en 2012

ROS production is essential for the apoptotic function of E2F1 in pheochromocytoma and neuroblastoma cell lines

artículo científico publicado en 2012

Rates of lipogenesis in fetal hepatocytes in suspension and in primary culture: hormonal effects

artículo científico publicado en 1989

Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes.

artículo científico publicado en 2001

Reciprocal regulation of NADPH oxidases and the cyclooxygenase-2 pathway

artículo científico publicado en 2011

Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm.

artículo científico publicado en 2018

Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones

artículo científico publicado el 1 de julio de 1992

Regulation of gene expression by interleukin-6 in fetal rat hepatocyte primary cultures: Role of epidermal growth factor and dexamethasone

article

Regulation of gene expression by interleukin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone

scientific article published on 01 December 1995

Resistance to TGF-beta-induced apoptosis in regenerating hepatocytes

artículo científico publicado en 2004

Resminostat induces changes in epithelial plasticity of hepatocellular carcinoma cells and sensitizes them to sorafenib-induced apoptosis.

artículo científico publicado en 2017

Revisiting the liver: from development to regeneration - what we ought to know!

artículo científico publicado en 2018

Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta

artículo científico publicado en 2009

Role of NADPH oxidases in the redox biology of liver fibrosis

artículo científico publicado en 2015

Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.

artículo científico publicado en 2017

Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma

artículo científico

Short-chain ceramide regulates hepatic methionine adenosyltransferase expression.

artículo científico publicado en 2001

Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes

artículo científico publicado en 1987

Snail blocks the cell cycle and confers resistance to cell death

scientific journal article

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

artículo científico publicado en 2017

Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes

artículo científico publicado en 2010

Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli.

artículo científico publicado en 2012

Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes

artículo científico publicado en 2004

Study of the inhibition produced by adriamycin against specific enzymes in the rat heart

artículo científico publicado en 1982

Survival and apoptosis: a dysregulated balance in liver cancer

artículo científico publicado en 2007

Syndecan-2 expression increases serum-withdrawal-induced apoptosis, mediated by re-distribution of Fas into lipid rafts, in stably transfected Swiss 3T3 cells

artículo científico publicado en 2006

TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells

artículo científico publicado en 2007

TGF-beta signaling in cancer treatment

artículo científico

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.

artículo científico publicado en 2018

TGF-β signalling and liver disease.

artículo científico publicado en 2016

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men

artículo científico publicado en 2016

The NADPH consumption regulates the NADPH-producing pathways (pentose phosphate cycle and malic enzyme) in rat adipocytes

scientific article published on 01 March 1987

The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression

artículo científico publicado en 2014

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination.

artículo científico publicado en 2016

The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells ⬇️

artículo científico publicado el 26 de enero de 2011

The TGF-β pathway: a pharmacological target in hepatocellular carcinoma?

artículo científico publicado en 2017

The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes

artículo científico publicado en 2002

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

scientific journal article

The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells.

artículo científico publicado en 2017

The pentose phosphate cycle is regulated by NADPHNADP ratio in rat liver

scientific article published on 01 January 1985

The rationale for targeting TGF-β in chronic liver diseases.

artículo científico publicado en 2016

The role of NADPH in the regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in rat adipose tissue

artículo científico publicado en 1991

The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells.

artículo científico publicado en 2011

The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

artículo científico publicado en 2011

Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis

artículo científico publicado en 2018

Transforming growth factor ? modulates growth and differentiation of fetal hepatocytes in primary culture

artículo científico publicado en 1995

Transforming growth factor-beta (TGF-beta) and EGF promote cord-like structures that indicate terminal differentiation of fetal hepatocytes in primary culture.

artículo científico publicado en 1998

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes

artículo científico publicado en 2004

Transforming growth factor-β-induced plasticity causes a migratory stemness phenotype in hepatocellular carcinoma.

artículo científico publicado en 2017

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

scientific journal article

Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.

artículo científico publicado en 2015

Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells.

artículo científico publicado en 2003

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a neuropeptide antagonist, blocks binding, Ca2(+)-mobilizing, and mitogenic effects of endothelin and vasoactive intestinal contractor in mouse 3T3 cells.

artículo científico publicado en 1990

c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition and Regulates Cell Phenotypic Switch.

artículo científico publicado en 2019

c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver

artículo científico publicado en 2005

cIAP-1, but not XIAP, is cleaved by caspases during the apoptosis induced by TGF-beta in fetal rat hepatocytes

artículo científico publicado en 2002

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