Lista de obras - Simon J Arthur - Dominio Público Uruguay

A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages

artículo científico publicado en 2017

A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs

artículo científico publicado en 2004

A second binding site revealed by C-terminal truncation of calpain small subunit, a penta-EF-hand protein

artículo científico publicado en 2003

Active site residues in m-calpain: identification by site-directed mutagenesis.

artículo científico publicado en 1995

Autolysis, Ca2+Requirement, and Heterodimer Stability in m-Calpain

artículo científico publicado en 1997

C-terminal phosphorylation controls the stability and function of p27kip1

artículo científico publicado en 2006

CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling

artículo científico publicado en 2014

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

artículo científico publicado en 2006

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

artículo científico publicado en 2016

Characterization of the cellular action of the MSK inhibitor SB-747651A.

artículo científico publicado en 2012

Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays.

artículo científico publicado en 2011

Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.

artículo científico publicado en 2013

Crystallization and X-ray crystallographic analysis of m-calpain, a Ca2+-dependent protease

artículo científico publicado en 1999

Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers

artículo científico publicado en 2013

Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases

artículo científico publicado en 2017

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation ⬇️

artículo científico publicado en 2016

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

scientific article published in Nature Communications

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

scientific journal article

ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis

artículo científico publicado en 2010

ERK5 regulation in naïve T-cell activation and survival.

artículo científico publicado en 2008

Evaluation of Approaches to Generation of Tissue-specific Knock-in Mice

artículo científico publicado en 2006

Evidence of p38γ and p38δ involvement in cell transformation processes

artículo científico publicado en 2011

Experience recruits MSK1 to expand the dynamic range of synapses and enhance cognition

artículo científico publicado en 2020

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

artículo científico publicado en 2005

Generation of a conditional CREB Ser133Ala knockin mouse

artículo científico publicado en 2009

Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen- and stress-activated kinase-1.

artículo científico publicado en 2007

IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages.

artículo científico publicado en 2013

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

artículo científico publicado en 2012

Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.

artículo científico publicado en 2010

Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback

artículo científico publicado en 2012

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

artículo científico publicado en 2016

Investigation of the interaction of m-calpain with phospholipids: calpain-phospholipid interactions

artículo científico publicado en 1996

Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

artículo científico publicado en 2012

MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2.

artículo científico publicado en 2005

MAPK activation by radio waves.

artículo científico publicado en 2007

MSK activation and physiological roles

artículo científico publicado en 2008

MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription.

artículo científico publicado en 2007

MSK1 activity is controlled by multiple phosphorylation sites.

artículo científico publicado en 2005

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

artículo científico publicado en 2002

MSK1 regulates homeostatic and experience-dependent synaptic plasticity.

artículo científico publicado en 2012

MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

artículo científico publicado en 2010

MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins

artículo científico publicado en 2017

MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.

artículo científico publicado en 2005

Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver.

artículo científico publicado en 2012

Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.

artículo científico publicado en 2011

Mitogen and stress response kinase-1 (MSK1) mediates excitotoxic induced death of hippocampal neurones.

artículo científico publicado en 2003

Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus

artículo científico publicado en 2017

Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.

artículo científico publicado en 2004

Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock

artículo científico publicado en 2012

Mitogen-activated protein kinases in innate immunity ⬇️

artículo científico publicado el 19 de agosto de 2013

Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.

artículo científico publicado en 2006

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.

artículo científico publicado en 2012

Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.

artículo científico publicado en 2005

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

artículo científico publicado en 2012

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

artículo científico publicado en 2011

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

artículo científico publicado en 2001

Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

artículo científico publicado en 2006

Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

artículo científico publicado en 2011

Post-translational control of Nur77

artículo científico publicado en 2006

Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

artículo científico publicado en 2006

RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

artículo científico publicado en 2013

Regulation of miRNA transcription in macrophages in response to Candida albicans

artículo científico publicado en 2010

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.

artículo científico publicado en 2011

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

artículo científico publicado en 2017

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. ⬇️

artículo científico publicado en 2018

Selective kinase inhibitors as tools for neuroscience research.

artículo científico

Signaling downstream of p38 in psoriasis.

artículo científico publicado en 2006

Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changes

artículo científico publicado el 1 de julio de 1997

Structure of the mouse calpain small subunit gene

artículo científico publicado en 1998

Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases ⬇️

artículo científico publicado el 28 de septiembre de 2012

Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome

artículo científico publicado en 2016

The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development

artículo científico publicado en 2016

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells

artículo científico publicado en 2019

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

artículo científico publicado en 2012

The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory.

artículo científico publicado en 2017

The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen ⬇️

artículo científico publicado en 2017

The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells

artículo científico publicado en 2003

The nuclear kinase mitogen- and stress-activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation.

artículo científico publicado en 2007

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

artículo científico publicado en 2010

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

artículo científico publicado en 2005

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

artículo científico publicado en 2000

The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.

artículo científico publicado en 2010

The selectivity of protein kinase inhibitors: a further update

artículo científico publicado en 2007

Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.

artículo científico publicado en 2013

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

artículo científico publicado en 2013

m -Calpain subunits remain associated in the presence of calcium

artículo científico publicado en 1998

m-Calpain is required for preimplantation embryonic development in mice.

artículo científico publicado en 2006

p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.

artículo científico publicado en 2009

p38α and p38β mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons.

artículo científico publicado en 2011

p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

artículo científico publicado en 2012

Lista de obras de Simon J Arthur

A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages

A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs

A second binding site revealed by C-terminal truncation of calpain small subunit, a penta-EF-hand protein

Active site residues in m-calpain: identification by site-directed mutagenesis.

Autolysis, Ca2+Requirement, and Heterodimer Stability in m-Calpain

C-terminal phosphorylation controls the stability and function of p27kip1

CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

Characterization of the cellular action of the MSK inhibitor SB-747651A.

Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays.

Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.

Crystallization and X-ray crystallographic analysis of m-calpain, a Ca2+-dependent protease

Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers

Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation ⬇️

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis

ERK5 regulation in naïve T-cell activation and survival.

Evaluation of Approaches to Generation of Tissue-specific Knock-in Mice

Evidence of p38γ and p38δ involvement in cell transformation processes

Experience recruits MSK1 to expand the dynamic range of synapses and enhance cognition

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

Generation of a conditional CREB Ser133Ala knockin mouse

Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen- and stress-activated kinase-1.

IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages.

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.

Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

Investigation of the interaction of m-calpain with phospholipids: calpain-phospholipid interactions

Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2.

MAPK activation by radio waves.

MSK activation and physiological roles

MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription.

MSK1 activity is controlled by multiple phosphorylation sites.

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

MSK1 regulates homeostatic and experience-dependent synaptic plasticity.

MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins

MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.

Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver.

Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.

Mitogen and stress response kinase-1 (MSK1) mediates excitotoxic induced death of hippocampal neurones.

Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus

Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.

Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock

Mitogen-activated protein kinases in innate immunity ⬇️

Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.

Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

Post-translational control of Nur77

Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

Regulation of miRNA transcription in macrophages in response to Candida albicans

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. ⬇️

Selective kinase inhibitors as tools for neuroscience research.

Signaling downstream of p38 in psoriasis.

Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changes

Structure of the mouse calpain small subunit gene

Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases ⬇️

Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome

The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory.

The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen ⬇️

The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells

The nuclear kinase mitogen- and stress-activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation.

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice