Lista de obras - Stephen B. Duffull - Dominio Público Uruguay

100 years of modelling ligand-receptor binding and response: A focus on GPCRs

scientific article published on 28 February 2020

A Bayesian approach for population pharmacokinetic modelling of sirolimus.

artículo científico publicado en 2006

A Bayesian dose-individualization method for warfarin

artículo científico publicado en 2013

A Framework for Simplification of Quantitative Systems Pharmacology Models in Clinical Pharmacology

artículo científico publicado en 2020

A Joint Model for Vitamin K-Dependent Clotting Factors and Anticoagulation Proteins

artículo científico publicado en 2017

A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics

artículo científico publicado en 2016

A Population Pharmacokinetic Model for 51Cr EDTA to Estimate Renal Function.

artículo científico publicado en 2016

A Review of the Methods and Associated Mathematical Models Used in the Measurement of Fat-Free Mass.

artículo científico publicado en 2018

A comprehensive model for the humoral coagulation network in humans.

artículo científico publicado en 2009

A d-optimal designed population pharmacokinetic study of oral itraconazole in adult cystic fibrosis patients

artículo científico publicado en 2006

A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose

artículo científico publicado en 2011

A factor VII-based method for the prediction of anticoagulant response to warfarin

artículo científico publicado en 2018

A framework for quantifying the influence of adherence and dose individualization

artículo científico publicado en 2015

A general empirical model for renal drug handling in pharmacokinetic analyses.

artículo científico publicado en 2017

A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies

artículo científico publicado en 2012

A general model for cell death and biomarker release from injured tissues

artículo científico publicado en 2020

A generalisation of T-optimality for discriminating between competing models with an application to pharmacokinetic studies

artículo científico publicado en 2012

A learning-based approach for performing an in-depth literature search using MEDLINE.

artículo científico publicado en 2010

A minimal model to describe short-term haemodynamic changes of the cardiovascular system

artículo científico publicado en 2020

A model for venom-induced consumptive coagulopathy in snake bite

artículo científico publicado en 2008

A model-based meta-analysis of the influence of factors that impact adherence to medications

artículo científico publicado en 2014

A pharmacokinetic model for the glycation of albumin.

artículo científico publicado en 2012

A pharmacokinetic simulation model for ivabradine in healthy volunteers

scientific article published on 01 January 2000

A philosophical framework for pharmacy in the 21st century guided by ethical principles

artículo científico publicado en 2017

A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin's or Hodgkin's lymphoma.

artículo científico publicado en 2009

A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells

artículo científico publicado en 2013

A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics

artículo científico publicado en 2013

A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin

artículo científico publicado en 2009

A reduction in between subject variability is not mandatory for selecting a new covariate

artículo científico publicado en 2012

A robust design for identification of the Parasite Clearance Estimator

artículo científico publicado en 2013

A semi-mechanistic red blood cell survival model provides some insight into red blood cell destruction mechanisms.

artículo científico publicado en 2013

A sequential Bayesian algorithm for dose individualisation of carboplatin

artículo científico publicado en 1997

A standard weight descriptor for dose adjustment in the obese patient

artículo científico publicado en 2004

A statistical model for red blood cell survival

artículo científico publicado en 2010

A suggested approach to once‐daily aminoglycoside dosing ⬇️

artículo científico publicado el 1 de junio de 1995

A systematic review and meta-analysis of pharmacist-led fee-for-services medication review

artículo científico publicado en 2014

Activated Charcoal Decreases the Risk of QT Prolongation After Citalopram Overdose

scientific article published on 23 August 2007

Adaptive Bayesian compound designs for dose finding studies

Adaptive optimal design for bridging studies with an application to population pharmacokinetic studies.

artículo científico publicado en 2012

Adverse drug reactions

artículo científico publicado en 1990

Aminoglycoside dosage regimens after therapeutic drug monitoring

scientific article published on 01 January 2002

Aminoglycosides in hemodialysis patients: is the current practice of post dialysis dosing appropriate?

artículo científico publicado en 2009

Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes

artículo científico publicado en 2010

An Evaluation of a Factor Xa-Based Clotting Time Test for Enoxaparin: A Proof-of-Concept Study.

artículo científico publicado en 2017

An In Silico Knockout Model for Gastrointestinal Absorption Using a Systems Pharmacology Approach - Development and Application for Ketones.

artículo científico publicado en 2016

An approach for identifiability of population pharmacokinetic-pharmacodynamic models

artículo científico publicado en 2013

An evaluation of the operational model when applied to quantify functional selectivity

artículo científico publicado en 2018

An extended interval dosing method for gentamicin in neonates

artículo científico publicado en 2001

An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine.

artículo científico publicado en 2001

An intact model for quantifying functional selectivity

artículo científico publicado en 2019

Analysis of population pharmacokinetic data using NONMEM and WinBUGS.

artículo científico publicado en 2005

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

artículo científico publicado en 2008

Another case of high gentamicin clearance and volume of distribution in a patient with high output ileostomy

artículo científico publicado en 1998

Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review

artículo científico publicado en 2015

An Extension of Janmahasatian's Fat-Free Mass Model for Universal Application Across Populations of Different Ethnicities

scientific article published on 22 March 2020

Application of Adaptive DP-optimality to Design a Pilot Study for a Clotting Time Test for Enoxaparin

artículo científico publicado en 2015

Application of pharmacokinetic-pharmacodynamic modeling in management of QT abnormalities after citalopram overdose. Reply to A. Manini

Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose

artículo científico publicado en 2006

Assessing risk of a prolonged QT interval-a survey of emergency physicians

artículo científico publicado en 2008

Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models.

artículo científico publicado en 2017

Assessment of markers of glycaemic control in diabetic patients with chronic kidney disease using continuous glucose monitoring

artículo científico publicado en 2012

Assessment of the relationship between methotrexate polyglutamates in red blood cells and clinical response in patients commencing methotrexate for rheumatoid arthritis

artículo científico publicado en 2014

Authors' Reply to Friesen: "An Extension of Janmahasatian's Fat-Free Mass Model for Universal Application Across Populations of Different Ethnicities"

artículo científico publicado en 2020

Automated Scale Reduction of Nonlinear QSP Models With an Illustrative Application to a Bone Biology System

artículo científico publicado en 2018

Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems

scientific article published on 21 June 2019

Basic Pharmacokinetics and Pharmacodynamics, an Integrated Textbook and Computer Simulations

artículo científico publicado en 2012

Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods

Between-subject variability: should high be the new normal?

artículo científico publicado en 2014

Caution when lean body weight is used as a size descriptor for obese subjects

artículo científico publicado en 2002

Choosing the Allometric Exponent in Covariate Model Building

artículo científico publicado en 2019

Clinical decision-making: An essential skill for 21st century pharmacy practice

artículo científico publicado en 2018

Clinical pharmacokinetics and dose optimisation of carboplatin.

artículo científico publicado en 1997

Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types

artículo científico publicado en 2014

Comparison of robust criteria for D-optimal designs

artículo científico publicado en 2012

Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers

artículo científico publicado en 2009

Comparison of two Bayesian approaches to dose-individualization for once-daily aminoglycoside regimens

artículo científico publicado en 1997

Compound optimal design criteria for nonlinear models.

artículo científico publicado en 2008

Concepts for Critical Appraisal of an Original Research Paper

article

Correction: Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome.

artículo científico publicado en 2010

Current enoxaparin dosing guidelines have dubious credibility.

artículo científico publicado en 2010

Dabigatran: rational dose individualisation and monitoring guidance is needed

artículo científico publicado en 2012

Defining Target Vancomycin Trough Concentrations for Treating Staphylococcus aureus Infection in Infants Aged 0 to 90 Days

scientific article published on 10 June 2019

Design Of Clinical Pharmacology Trials

artículo científico publicado en 2001

Design of experiments for bivariate binary responses modelled by Copula functions

article

Design of pharmacokinetic studies for latent covariates

artículo científico publicado en 2011

Designs to balance cost and success rate for an early phase clinical study

scientific article published on 23 February 2016

Deterministic identifiability of population pharmacokinetic and pharmacokinetic-pharmacodynamic models

artículo científico publicado en 2017

Development and evaluation of a prototype of a novel clotting time test to monitor enoxaparin

artículo científico publicado en 2011

Development and implementation of the population Fisher information matrix for the evaluation of population pharmacokinetic designs.

artículo científico publicado en 2001

Development of a Parsimonious Design for Optimal Classification of Exclusive Breastfeeding

artículo científico publicado en 2019

Development of a Semimechanistic Model to Describe the Pharmacokinetics of Gentamicin in Patients Receiving Hemodialysis

article

Development of a bayesian forecasting method for warfarin dose individualization

artículo científico publicado en 2011

Development of a dosage strategy in patients receiving enoxaparin by continuous intravenous infusion using modelling and simulation

artículo científico publicado en 2006

Development of a dosing strategy for enoxaparin in obese patients

artículo científico publicado en 2003

Development of a general method of limited sampling for the determination of AUC for a drug that displays two-compartment pharmacokinetics

article

Development of a nonlinear hierarchical model to describe the disposition of deuterium in mother-infant pairs to assess exclusive breastfeeding practice

artículo científico publicado en 2018

Development of a population pharmacokinetic-pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients

artículo científico publicado en 2016

Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

article

Development of a sufficient design for estimation of fluconazole pharmacokinetics in people with HIV infection.

artículo científico publicado en 2008

Dose- and exposure-response to ketamine in depression

artículo científico publicado en 2011

Dosing in obesity: a simple solution to a big problem.

artículo científico publicado en 2007

Dosing of gentamicin in patients with end-stage renal disease receiving hemodialysis.

artículo científico publicado en 2006

Effect of Australian elapid venoms on blood coagulation: Australian Snakebite Project (ASP-17).

artículo científico publicado en 2012

Efficacies of different vancomycin dosing regimens against Staphylococcus aureus determined with a dynamic in vitro model.

artículo científico publicado en 1994

Enhanced gentamicin clearance associated with ileostomy fluid loss

scientific article published on 01 April 1997

Estimating risk from underpowered, but statistically significant, studies: was APPROVe on TARGET?

artículo científico publicado en 2010

Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel

artículo científico publicado en 2005

Evaluating Lean Liver Volume as a Potential Scaler for in vitro-in vivo Extrapolation of Drug Clearance in Obesity using the model drug antipyrine

artículo científico publicado en 2020

Evaluating the Relationship Between Lean Liver Volume and Fat-Free Mass

scientific article published on 01 April 2020

Evaluation of Approaches to Deal with Low-Frequency Nuisance Covariates in Population Pharmacokinetic Analyses.

artículo científico publicado en 2015

Evaluation of Assumptions Underpinning Pharmacometric Models

scientific article published on 05 August 2019

Evaluation of designs for renal drug studies based on the EMA and FDA guidelines for drugs that are predominantly secreted

artículo científico publicado en 2020

Evaluation of graphical diagnostics for assessing goodness of fit of logistic regression models

artículo científico publicado en 2010

Evaluation of red blood cell labelling methods based on a statistical model for red blood cell survival.

artículo científico publicado en 2011

Evaluation of the Pre-Posterior Distribution of Optimized Sampling Times for the Design of Pharmacokinetic Studies

artículo científico publicado en 2012

Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling

scientific article published on 15 April 2020

Evidence for the changing regimens of acetylcysteine

artículo científico publicado en 2015

Experience of once-daily aminoglycoside dosing using a target area under the concentration-time curve

scientific article published on 01 June 1995

Experience with heparin dosing at Christchurch Hospital

artículo científico publicado en 1998

Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations.

artículo científico publicado en 2017

Exposure response - getting the dose right

artículo científico publicado en 2009

Failure of antivenom to improve recovery in Australian snakebite coagulopathy.

artículo científico publicado en 2009

Fluoxetine distribution in human milk

scientific article published on 01 November 1996

Free mycophenolic acid should be monitored in renal transplant recipients with hypoalbuminemia.

artículo científico publicado en 2004

GFR may not accurately predict aspects of proximal tubule drug handling

scientific article published on 20 August 2014

General practitioners' perceptions of pharmacists' new services in New Zealand

artículo científico publicado en 2012

General practitioners' views of pharmacists' current and potential contributions to medication review and prescribing in New Zealand

artículo científico

How vancomycin is used in Australasia - A survey

artículo científico publicado en 1993

Idiosyncratic drug-induced haematological abnormalities. Incidence, pathogenesis, management and avoidance.

artículo científico publicado en 1994

Impact of anticholinergic discontinuation on cognitive outcomes in older people: a systematic review.

artículo científico publicado en 2014

Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria

artículo científico publicado en 2007

In reply

Incidence and risk factors of major bleeding following major orthopaedic surgery with fondaparinux thromboprophylaxis. A time-to-event analysis

artículo científico publicado en 2018

Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome

artículo científico publicado en 2010

Individualized compared with conventional dosing of enoxaparin

artículo científico publicado en 2007

Individualized dosing of enoxaparin for subjects with renal impairment is superior to conventional dosing at achieving therapeutic concentrations

artículo científico publicado en 2010

Influence of Genotype on Warfarin Maintenance Dose Predictions Produced Using a Bayesian Dose Individualization Tool.

artículo científico publicado en 2016

Interaction between amiodarone and phenytoin

artículo científico publicado en 1991

Interpreting population pharmacokinetic-pharmacodynamic analyses - a clinical viewpoint.

artículo científico publicado en 2011

Introduction to pharmacokinetics in clinical toxicology

artículo científico publicado en 2012

Investigating myotoxicity following Australian red-bellied black snake (Pseudechis porphyriacus) envenomation

artículo científico publicado en 2021

Is the dose of dabigatran really more predictable than warfarin?

artículo científico publicado en 2013

Is the ideal anticoagulant a myth?

artículo científico publicado en 2012

Kinetic-pharmacodynamic model for drugs with non-linear elimination: Parameterisation matters

artículo científico publicado en 2020

Lack of effect of tart cherry concentrate dose on serum urate in people with gout

artículo científico publicado en 2019

Lean body mass normalizes the effect of obesity on renal function.

artículo científico publicado en 2008

Measuring the Development of Therapeutic-Decision-Making Skills by Practicing Pharmacists Undertaking a University-Based Postgraduate Clinical Qualification at Distance

scientific article published on 11 May 2020

Methanol and ethylene glycol acute poisonings - predictors of mortality

artículo científico publicado en 2011

Methods and software tools for design evaluation in population pharmacokinetics-pharmacodynamics studies.

artículo científico publicado en 2015

Methods for Predicting Warfarin Dose Requirements.

artículo científico publicado en 2015

Methods of robust design of nonlinear models with an application to pharmacokinetics

artículo científico publicado en 2010

Methods to Account for Inaccuracies in the Dosing History When Performing Population Pharmacokinetic Analysis

artículo científico publicado en 2008

Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors

scientific article published on 21 May 2019

Modeling and stimulation for clinical trial design involving a categorical response: a phase II case study with naratriptan

artículo científico publicado en 2001

Modeling red blood cell survival data

artículo científico publicado en 2011

Modelling the occurrence and severity of enoxaparin-induced bleeding and bruising events

artículo científico publicado en 2009

Myocardial infarction and type II diabetes--preferential treatment for high risk patients?

artículo científico publicado en 2002

Once-daily aminoglycoside therapy: potential ototoxicity

scientific article published on 01 April 1997

Optimal Design of Pharmacokinetic–Pharmacodynamic Studies

Optimal crossover designs for logistic regression models in pharmacodynamics.

artículo científico publicado en 2006

Optimal design criteria for discrimination and estimation in nonlinear models.

artículo científico publicado en 2009

Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients

artículo científico publicado en 2005

Optimal design of a population pharmacodynamic experiment for ivabradine

artículo científico publicado en 2001

Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

artículo científico publicado en 2011

Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria

artículo científico publicado en 2012

Optimal designs for studying bioimpedance

scientific article published on 31 October 2007

Optimal dosing of enoxaparin in overweight and obese children

Parameterisation affects identifiability of population models.

artículo científico publicado en 2013

Paroxetine in human milk

artículo científico publicado en 1999

Pharmacists' performance of clinical interventions during adherence support medication reviews

artículo científico

Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID-19

artículo científico publicado en 2020

Pharmacokinetic software for the health sciences: choosing the right package for teaching purposes

artículo científico publicado en 2001

Pharmacokinetic-Pharmacodynamic Model for the Effect of l-Arginine on Endothelial Function in Patients with Moderately Severe Falciparum Malaria

artículo científico publicado en 2015

Pharmacokinetic-pharmacodynamic modelling of QT interval prolongation following citalopram overdoses

artículo científico publicado en 2006

Pharmacokinetics and efficacy of rectal versus oral sustained-release morphine in cancer patients.

artículo científico publicado en 1992

Pharmacokinetics of L-arginine in adults with moderately severe malaria

artículo científico publicado en 2008

Pharmacokinetics of Snake Venom.

artículo científico publicado en 2018

Pharmacokinetics of gentamicin in 957 patients with varying renal function dosed once daily.

artículo científico publicado en 1999

Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal.

artículo científico publicado en 2007

Pharmacometrics and Systems Pharmacology 2030

scientific article published on 23 November 2019

Pharmacometrics in Australasia-Twenty Years of Population Approach Group of Australia and New Zealand

artículo científico publicado en 2019

Population analysis of once-daily dosing of gentamicin in patients with neutropenia

artículo científico publicado en 1998

Population pharmacokinetic analysis of mycophenolic acid in renal transplant recipients following oral administration of mycophenolate mofetil

artículo científico publicado en 2003

Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal

artículo científico publicado en 2012

Population pharmacokinetics of <i>Pseudechis porphyriacus</i> (red-bellied black snake) venom in snakebite patients

artículo científico publicado en 2021

Population pharmacokinetics of intramuscular droperidol in acutely agitated patients

artículo científico publicado en 2016

Population pharmacokinetics of ivermectin for the treatment of scabies in Indigenous Australian children

artículo científico publicado en 2020

Population pharmacokinetics of melphalan in patients with multiple myeloma undergoing high dose therapy.

artículo científico publicado en 2010

Population pharmacokinetics of mycophenolic acid during the first week after renal transplantation

artículo científico publicado en 2005

Potential Issues With Virtual Populations When Applied to Nonlinear Quantitative Systems Pharmacology Models

scientific article published on 24 September 2020

Predicting allopurinol response in patients with gout

artículo científico publicado en 2015

Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose

artículo científico publicado en 2013

Prediction of Fat-Free Mass in Children

artículo científico publicado en 2015

Prediction of drug loss from PVC infusion bags.

artículo científico publicado en 1991

Prediction of torsade de pointes from the QT interval: analysis of a case series of amisulpride overdoses

artículo científico publicado en 2011

Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal

artículo científico publicado en 2008

Prospective evaluation of a D-optimal designed population pharmacokinetic study.

artículo científico publicado en 2003

Prospective evaluation of a model for the prediction of milk:plasma drug concentrations from physicochemical characteristics

artículo científico publicado en 1992

Quantification of lean bodyweight

artículo científico publicado en 2005

Quantification of the Forgiveness of Drugs to Imperfect Adherence

artículo científico publicado en 2015

Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal.

artículo científico publicado en 2009

Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations

artículo científico publicado en 2008

Red blood cell survival in long-term dialysis patients.

artículo científico publicado en 2011

Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria

artículo científico publicado en 2009

Relationships between sirolimus dosing, concentration and outcomes in renal transplant recipients

artículo científico publicado en 2005

Relationships of tacrolimus pharmacokinetic measures and adverse outcomes in stable adult liver transplant recipients

artículo científico publicado en 2006

Reply to Dr. Mégarbane et al. regarding “Pharmacokinetic/pharmacodynamic modelling of cardiac toxicity in venlafaxine overdose”

article

Reply to the editor of Journal of Pharmacokinetics and Pharmacodynamics

Response to “Influence of Lean Body Weight on Anticancer Drug Clearance”

Retrospective examination of selected outcomes of Medicines Use Review (MUR) services in New Zealand.

artículo científico

Reusing Smaller Versions of Large Models: A Case Example of Reuse of a Simplified Bone Model

scientific article published on 27 August 2019

Revisiting the Pharmacology of Unfractionated Heparin

artículo científico publicado en 2019

Routine plasma anti-Xa monitoring is required for low-molecular-weight heparins.

artículo científico publicado en 2010

Safety profile of L-arginine infusion in moderately severe falciparum malaria

artículo científico publicado en 2008

Sampling times for monitoring tacrolimus in stable adult liver transplant recipients.

artículo científico publicado en 2004

Scale reduction of a systems coagulation model with an application to modeling pharmacokinetic-pharmacodynamic data

artículo científico publicado en 2014

Selection and Qualification of Simplified QSP Models When Using Model Order Reduction Techniques.

artículo científico publicado en 2017

SimPharm: How pharmacy students made meaning of a clinical case differently in paper- and simulation-based workshops

article

Simplification of a pharmacokinetic model for red blood cell methotrexate disposition

artículo científico publicado en 2015

Simultaneous versus sequential optimal design for pharmacokinetic-pharmacodynamic models with FO and FOCE considerations

artículo científico publicado en 2009

Single or multiple daily doses of aminoglycosides. Exposure to aminoglycosides should be monitored during treatment

artículo científico publicado en 1996

Some Considerations on the Design of Population Pharmacokinetic Studies

artículo científico publicado en 2005

Students' perceptions of playing a serious game intended to enhance therapeutic decision-making in a pharmacy curriculum

artículo científico publicado en 2020

Studying drugs in human milk: time to unify the approach.

artículo científico publicado en 2002

Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose

artículo científico publicado en 2020

Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteers

artículo científico publicado en 2007

Terfenadine ineffective in the prophylaxis of exercise-induced pruritus

artículo científico publicado en 1992

The Influence of Haemostatic System Maturation on the Dose-Response Relationship of Unfractionated Heparin

artículo científico publicado en 2020

The Influence of Patient Characteristics on Anticholinergic Events in Older People

artículo científico publicado en 2015

The Influence of the Different Disposition Characteristics of Snake Toxins on the Pharmacokinetics of Snake Venom

artículo científico publicado en 2020

The Population Pharmacokinetics of D-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate.

scientific article published on 18 February 2016

The effect of body weight on dalteparin pharmacokinetics. A preliminary study

artículo científico publicado en 2000

The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose

artículo científico publicado en 2011

The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose.

artículo científico publicado en 2009

The influence of dosing time, variable compliance and circadian low-density lipoprotein production on the effect of simvastatin: simulations from a pharmacokinetic-pharmacodynamic model.

artículo científico publicado en 2011

The intact nephron hypothesis as a model for renal drug handling

article

The pharmacokinetics of meropenem and piperacillin-tazobactam during sustained low efficiency haemodiafiltration (SLED-HDF)

scientific article published on 09 December 2019

The pharmacokinetics of methanol in the presence of ethanol: a case study

artículo científico publicado en 2011

The pharmacokinetics of sertraline in overdose and the effect of activated charcoal.

artículo científico publicado en 2015

The pharmacometrician's dilemma: the tension between mechanistic and empirical approaches in mathematical modelling and simulation - a continuation of the age-old dispute between rationalism and empiricism?

artículo científico publicado en 2016

The population pharmacokinetics of allopurinol and oxypurinol in patients with gout

artículo científico publicado en 2013

The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach

artículo científico publicado en 2005

The propagation of between-subject variability from dose to response

artículo científico publicado en 2020

The relevance of gluten in pharmaceutical products

artículo científico publicado en 1993

The time course of drug effects.

artículo científico publicado en 2009

The use of a change in gentamicin clearance as an early predictor of gentamicin-induced nephrotoxicity

artículo científico publicado en 2003

The use of simulated annealing for finding optimal population designs.

artículo científico publicado en 2002

Therapeutic decision-making in primary care pharmacy practice

scientific article published on 10 April 2020

The Association between Metformin Therapy and Lactic Acidosis

artículo científico publicado en 2019

Towards optimal design of anti-malarial pharmacokinetic studies

artículo científico publicado en 2009

Twice- and Thrice-daily Cephalexin Dosing for Staphylococcus aureus Infections in Children

artículo científico publicado en 2020

Understanding probability and exposure in paracetamol overdose risk assessment

artículo científico publicado en 2013

Understanding the association between metformin plasma concentrations and lactate

artículo científico publicado en 2020

Understanding the process of clinical judgement for pharmacists when making clinical decisions

scientific article published on 10 August 2018

Understanding the time course of pharmacological effect: a PKPD approach

artículo científico publicado en 2011

Using Disease Progression Models as a Tool to Detect Drug Effect

scientific article published on 16 May 2007

Vancomycin toxicity. What is the evidence for dose dependency?

artículo científico publicado en 1994

Warfarin Dosing Algorithms Underpredict Dose Requirements in Patients Requiring ≥7 mg Daily: A Systematic Review and Meta-analysis

artículo científico publicado en 2017

What do we learn from repeated population analyses?

artículo científico publicado en 2015

What free services do pharmacists offer? Investigating the provision of unfunded pharmacy services in community pharmacies

artículo científico publicado en 2020

What is the best size descriptor to use for pharmacokinetic studies in the obese?

artículo científico publicado en 2004

What is the best way to deliver therapeutics and who decides?

artículo científico publicado en 2013

When is research clinical advice? Interpreting an exploratory study of paracetamol overdose.

artículo científico publicado en 2013

Lista de obras de Stephen B. Duffull

100 years of modelling ligand-receptor binding and response: A focus on GPCRs

A Bayesian approach for population pharmacokinetic modelling of sirolimus.

A Bayesian dose-individualization method for warfarin

A Framework for Simplification of Quantitative Systems Pharmacology Models in Clinical Pharmacology

A Joint Model for Vitamin K-Dependent Clotting Factors and Anticoagulation Proteins

A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics

A Population Pharmacokinetic Model for 51Cr EDTA to Estimate Renal Function.

A Review of the Methods and Associated Mathematical Models Used in the Measurement of Fat-Free Mass.

A comprehensive model for the humoral coagulation network in humans.

A d-optimal designed population pharmacokinetic study of oral itraconazole in adult cystic fibrosis patients

A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose

A factor VII-based method for the prediction of anticoagulant response to warfarin

A framework for quantifying the influence of adherence and dose individualization

A general empirical model for renal drug handling in pharmacokinetic analyses.

A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies

A general model for cell death and biomarker release from injured tissues

A generalisation of T-optimality for discriminating between competing models with an application to pharmacokinetic studies

A learning-based approach for performing an in-depth literature search using MEDLINE.

A minimal model to describe short-term haemodynamic changes of the cardiovascular system

A model for venom-induced consumptive coagulopathy in snake bite

A model-based meta-analysis of the influence of factors that impact adherence to medications

A pharmacokinetic model for the glycation of albumin.

A pharmacokinetic simulation model for ivabradine in healthy volunteers

A philosophical framework for pharmacy in the 21st century guided by ethical principles

A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin's or Hodgkin's lymphoma.

A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells

A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics

A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin

A reduction in between subject variability is not mandatory for selecting a new covariate

A robust design for identification of the Parasite Clearance Estimator

A semi-mechanistic red blood cell survival model provides some insight into red blood cell destruction mechanisms.

A sequential Bayesian algorithm for dose individualisation of carboplatin

A standard weight descriptor for dose adjustment in the obese patient

A statistical model for red blood cell survival

A suggested approach to once‐daily aminoglycoside dosing ⬇️

A systematic review and meta-analysis of pharmacist-led fee-for-services medication review

Activated Charcoal Decreases the Risk of QT Prolongation After Citalopram Overdose

Adaptive Bayesian compound designs for dose finding studies

Adaptive optimal design for bridging studies with an application to population pharmacokinetic studies.

Adverse drug reactions

Aminoglycoside dosage regimens after therapeutic drug monitoring

Aminoglycosides in hemodialysis patients: is the current practice of post dialysis dosing appropriate?

Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes

An Evaluation of a Factor Xa-Based Clotting Time Test for Enoxaparin: A Proof-of-Concept Study.

An In Silico Knockout Model for Gastrointestinal Absorption Using a Systems Pharmacology Approach - Development and Application for Ketones.

An approach for identifiability of population pharmacokinetic-pharmacodynamic models

An evaluation of the operational model when applied to quantify functional selectivity

An extended interval dosing method for gentamicin in neonates

An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine.

An intact model for quantifying functional selectivity

Analysis of population pharmacokinetic data using NONMEM and WinBUGS.

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

Another case of high gentamicin clearance and volume of distribution in a patient with high output ileostomy

Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review

An Extension of Janmahasatian's Fat-Free Mass Model for Universal Application Across Populations of Different Ethnicities

Application of Adaptive DP-optimality to Design a Pilot Study for a Clotting Time Test for Enoxaparin

Application of pharmacokinetic-pharmacodynamic modeling in management of QT abnormalities after citalopram overdose. Reply to A. Manini

Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose

Assessing risk of a prolonged QT interval-a survey of emergency physicians

Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models.

Assessment of markers of glycaemic control in diabetic patients with chronic kidney disease using continuous glucose monitoring

Assessment of the relationship between methotrexate polyglutamates in red blood cells and clinical response in patients commencing methotrexate for rheumatoid arthritis

Authors' Reply to Friesen: "An Extension of Janmahasatian's Fat-Free Mass Model for Universal Application Across Populations of Different Ethnicities"

Automated Scale Reduction of Nonlinear QSP Models With an Illustrative Application to a Bone Biology System

Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems

Basic Pharmacokinetics and Pharmacodynamics, an Integrated Textbook and Computer Simulations

Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods

Between-subject variability: should high be the new normal?

Caution when lean body weight is used as a size descriptor for obese subjects

Choosing the Allometric Exponent in Covariate Model Building

Clinical decision-making: An essential skill for 21st century pharmacy practice

Clinical pharmacokinetics and dose optimisation of carboplatin.

Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types

Comparison of robust criteria for D-optimal designs

Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers

Comparison of two Bayesian approaches to dose-individualization for once-daily aminoglycoside regimens

Compound optimal design criteria for nonlinear models.

Concepts for Critical Appraisal of an Original Research Paper

Correction: Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome.