Filtros de búsqueda

Lista de obras de William D. Lubell

1,3,5-Tri- and 1,3,4,5-tetra-substituted 1,4-diazepin-2-one solid-phase synthesis.

artículo científico publicado en 2008

1,3,5-trisubstituted 1,4-diazepin-2-ones

artículo científico publicado en 2007

1,4-Diazepinone and pyrrolodiazepinone syntheses via homoallylic ketones from cascade addition of vinyl Grignard reagent to alpha-aminoacyl-beta-amino esters

scientific article published on 01 August 2006

2-vinylpyrroles and pyrrolo[3,2-d]pyrimidines from direct addition of aldehydes to 4-amino-pyrrole-2-carboxylate derivatives

scientific article published on 31 January 2008

4-Vinylproline

scientific article published on 11 October 2018

4-alkoxy- and 4-amino-2,2'-bipyrrole synthesis

artículo científico publicado en 2006

9-(4-Bromophenyl)-9-fluorenyl as a safety-catch nitrogen protecting group

artículo científico publicado en 2006

A critical role of interleukin-1 in preterm labor.

artículo científico publicado en 2015

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway

artículo científico publicado en 2010

Adiponectin has a pivotal role in the cardioprotective effect of CP-3(iv), a selective CD36 azapeptide ligand, after transient coronary artery occlusion in mice

artículo científico publicado en 2017

Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of Their N-Acetyl N'-Methylamides

artículo científico publicado en 1999

Amino acid-azetidine chimeras: synthesis of enantiopure 3-substituted azetidine-2-carboxylic acids.

artículo científico publicado en 2005

An Olefination Entry for the Synthesis of Enantiopure α,ω-Diaminodicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids ⬇️

artículo científico publicado el 16 de octubre de 1998

An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration

artículo científico publicado en 2020

An effective new synthesis of 4-aminopyrrole-2-carboxylates

scientific article published on 01 July 2002

Analysis of N-amino-imidazolin-2-one peptide turn mimic 4-position substituent effects on conformation by X-ray crystallography

artículo científico publicado en 2014

Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny

scientific article published in Scientific Reports

Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice

artículo científico publicado en 2017

Application of N-Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo

scientific article published on 15 November 2019

Application of constrained aza-valine analogs for Smac mimicry

scientific article published on 01 May 2016

Applications of γ,δ-Unsaturated Ketones Synthesized by Copper-Catalyzed Cascade Addition of Vinyl Grignard Reagents to Esters

article

Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice

scientific article published on 06 July 2020

Author Correction: Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny

artículo científico publicado en 2020

Aza-1,2,3-triazole-3-alanine synthesis via copper-catalyzed 1,3-dipolar cycloaddition on aza-progargylglycine.

artículo científico publicado en 2010

Aza-amino acid scan for rapid identification of secondary structure based on the application of N-Boc-aza(1)-dipeptides in peptide synthesis

artículo científico publicado en 2004

Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands.

artículo científico publicado en 2017

Aza-amino acid scanning of secondary structure suited for solid-phase peptide synthesis with fmoc chemistry and aza-amino acids with heteroatomic side chains

artículo científico publicado en 2005

Aza-scanning of the potent melanocortin receptor agonist Ac-His-D-Phe-Arg-Trp-NH

artículo científico publicado en 2006

Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications.

artículo científico publicado en 2017

Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a.

artículo científico publicado en 2012

Azapeptides and their therapeutic potential.

artículo científico

Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization

artículo científico publicado en 2018

Azopeptides: Synthesis and Pericyclic Chemistry

artículo científico publicado en 2015

Benzophenone semicarbazone protection strategy for synthesis of aza-glycine containing aza-peptides

artículo científico publicado en 2008

Beta,beta-disubstituted C- and N-vinylindoles from one-step condensations of aldehydes and indole derivatives.

artículo científico publicado en 2009

Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila.

artículo científico publicado en 2017

Bis(pyrrol-2-yl)arylenes from the tandem bidirectional addition of vinyl Grignard reagent to aryl diesters.

artículo científico publicado en 2005

CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits.

artículo científico publicado en 2010

Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor

artículo científico publicado en 2007

Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates

artículo científico publicado en 2015

Cinnamoyl inhibitors of tissue transglutaminase.

artículo científico publicado en 2008

Conformationally constrained dipeptide surrogates with aromatic side-chains: synthesis of 4-aryl indolizidin-9-one amino acids by conjugate addition to a common alpha,omega-diaminoazelate enone intermediate.

artículo científico publicado en 2004

Conjugated 4-methoxybipyrrole thiophene azomethines: synthesis, opto-electronic properties, and crystallographic characterization

artículo científico publicado en 2011

Copper-catalyzed N-arylation of semicarbazones for the synthesis of aza-arylglycine-containing aza-peptides.

artículo científico publicado en 2010

Crystal structure analyses of azasulfuryltripeptides reveal potential for γ-turn mimicry

scientific article published on 01 September 2015

Cyclic Aza-peptide Integrin Ligand Synthesis and Biological Activity

artículo científico publicado en 2012

Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics

artículo científico publicado en 2019

De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo

artículo científico publicado en 2015

Deazapurine solid-phase synthesis: combinatorial synthesis of a library of N3,N5,C6-trisubstituted pyrrolo[3,2-d]pyrimidine derivatives on cross-linked polystyrene bearing a cysteamine linker

artículo científico publicado en 2005

Deazapurine solid-phase synthesis: construction of 3-substituted pyrrolo[3,2-d]pyrimidine-6-carboxylates on cross-linked polystyrene bearing a cysteamine linker

artículo científico publicado en 2005

Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells.

artículo científico publicado en 2014

Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics.

artículo científico publicado en 2017

Design, synthesis, and application of azabicyclo[X.Y.0]alkanone amino acids as constrained dipeptide surrogates and peptide mimics

artículo científico publicado en 2005

Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics.

artículo científico publicado en 2014

Development of a novel noncompetitive antagonist of IL-1 receptor

scientific article published on 01 May 2008

Diastereoselective Pictet-Spengler approach for the synthesis of pyrrolo[3,2-e][1,4]diazepin-2-one peptide turn mimics

artículo científico publicado en 2008

Diversity-Oriented Syntheses of β-Substituted α-Amino γ-Lactam Peptide Mimics with Constrained Backbone and Side Chain Residues

scientific article published on 19 September 2018

Diversity-Oriented Synthesis of Cyclic Azapeptides by A3 -Macrocyclization Provides High-Affinity CD36-Modulating Peptidomimetics.

artículo científico publicado en 2017

Diversity-oriented synthesis of azapeptides with basic amino acid residues: aza-lysine, aza-ornithine, and aza-arginine.

artículo científico publicado en 2014

Diversity-oriented synthesis of functionalized pyrrolo[3,2-d]pyrimidines with variation of the pyrimidine ring nitrogen substituents.

artículo científico publicado en 2003

Dynamic Chirality in the Mechanism of Action of Allosteric CD36 Modulators of Macrophage-Driven Inflammation

scientific article published on 13 December 2019

Effect of sequence on peptide geometry in 5-tert-butylprolyl type VI beta-turn mimics.

artículo científico publicado en 2002

Efficient synthesis of enantiopure pyrrolizidinone amino acid

artículo científico publicado en 2003

Examination of structural characteristics of the potent oxytocin antagonists [dPen1,Pen6]-OT and [dPen1,Pen6, 5-tBuPro7]-OT by NMR, Raman, CD spectroscopy and molecular modeling

artículo científico publicado en 2005

Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using β-amino γ-lactams

artículo científico publicado en 2011

Examination of the potential for adaptive chirality of the nitrogen chiral center in aza-aspartame.

artículo científico publicado en 2013

Exploring relationships between mimic configuration, peptide conformation and biological activity in indolizidin-2-one amino acid analogs of gramicidin S

artículo científico publicado en 2002

Exploring side-chain diversity by submonomer solid-phase aza-peptide synthesis

artículo científico publicado en 2009

Fluorometric assay for tissue transglutaminase-mediated transamidation activity.

artículo científico publicado en 2009

From macrocycle dipeptide lactams to azabicyclo[X.Y.0]alkanone amino acids: a transannular cyclization route for peptide mimic synthesis

artículo científico publicado en 2006

Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides

artículo científico publicado en 2019

Heumann Indole Flow Chemistry Process

scientific article published on 08 August 2019

Homoserine-derived cyclic sulfamidate as chiral educt for the diversity-oriented synthesis of lactam-bridged dipeptides

artículo científico publicado en 2005

Immunometabolic modulation of retinal inflammation by CD36 ligand

artículo científico publicado en 2019

Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators.

artículo científico publicado en 2017

Insertion of multiple alpha-amino gamma-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns.

artículo científico publicado en 2010

Insight into Transannular Cyclization Reactions To Synthesize Azabicyclo[X.Y.Z]alkanone Amino Acid Derivatives from 8-, 9-, and 10-Membered Macrocyclic Dipeptide Lactams

artículo científico publicado en 2015

Interleukin-1 Receptor Modulation Using β-Substituted α-Amino-γ-Lactam Peptides From Solid-Phase Synthesis and Diversification

artículo científico publicado en 2020

Interleukin-1 and ischemic brain injury in the newborn: development of a small molecule inhibitor of IL-1 receptor

artículo científico publicado en 2008

Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor

scientific article published on 19 June 2015

Isolated α-turn and incipient γ-helix

artículo científico publicado en 2019

Large structural modification with conserved conformation: analysis of delta(3)-fused aryl prolines in model beta-turns.

artículo científico publicado en 2004

Microglia and interleukin-1β in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A.

artículo científico publicado en 2013

Microwave-assisted synthesis of rhodamine fluorescent tags

artículo científico publicado en 2009

Mimicry of peptide backbone geometry and heteroatomic side-chain functionality: synthesis of enantiopure indolizidin-2-one amino acids possessing alcohol, acid, and azide functional groups.

artículo científico publicado en 2001

Mimics of peptide turn backbone and side-chain geometry by a general approach for modifying azabicyclo[5.3.0]alkanone amino acids

artículo científico publicado en 2011

Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors.

artículo científico publicado en 2011

Multicomponent diversity-oriented synthesis of aza-lysine-peptide mimics

artículo científico publicado en 2013

N-(9-(9-phenylfluorenyl))homoserine-derived cyclic sulfamidates: novel chiral educts for the synthesis of enantiopure gamma-substituted alpha-amino acids

scientific article published on 01 September 2001

N-Amino-imidazolin-2-one peptide mimic synthesis and conformational analysis.

artículo científico publicado en 2012

N-Aminosulfamide peptide mimic synthesis by alkylation of aza-sulfurylglycinyl peptides

scientific article published on 13 February 2012

N-aminoimidazolidin-2-one peptidomimetics

artículo científico publicado en 2014

Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth

artículo científico publicado en 2015

One-pot synthesis of homoallylic ketones from the addition of vinyl grignard reagent to carboxylic esters

artículo científico publicado en 2003

Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry: Conception of Prostaglandin F2α Receptor Allosteric Modulators That Delay Preterm Birth

scientific article published on 23 April 2019

Peptide Chemistry ⬇️

artículo científico publicado el 7 de septiembre de 2012

Peptide chemistry

Peptide scanning for studying structure-activity relationships in drug discovery

artículo científico

Peptides in Paris

article

Peptides of life teaching peptide science and art in elementary school.

artículo científico publicado en 2009

Peptidomimetic Synthesis by Way of Diastereoselective Iodoacetoxylation and Transannular Amidation of 7-9-Membered Lactams

artículo científico publicado en 2017

Photoacoustic FTIR Spectroscopy, a Nondestructive Method for Sensitive Analysis of Solid-Phase Organic Chemistry ⬇️

artículo científico publicado el 15 de noviembre de 1996

Photolabeling of tissue transglutaminase reveals the binding mode of potent cinnamoyl inhibitors.

artículo científico publicado en 2009

Poly (vinyl alcohol)-graft-poly (ethylene glycol) supported hydroxyproline: synthesis and application in the enantioselective aldol condensation.

artículo científico publicado en 2009

Poly(vinyl alcohol)-graft-poly(ethylene glycol) resins and their use in solid-phase synthesis and supported TEMPO catalysis

artículo científico publicado en 2007

Poly-(Prophi[Ch(OAc)CH2]Aib)3 a protected trimer of Pro-Aib hydroxyethylene isosteres.

artículo científico publicado en 2009

Portraits of the pioneers of the American Peptide Society

artículo científico publicado en 2009

Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides

artículo científico publicado en 2009

Preface

Preparation, characterization, and application of poly(vinyl alcohol)-graft-poly(ethylene glycol) resins: novel polymer matrices for solid-phase synthesis.

artículo científico publicado en 2007

Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands

article

Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist

artículo científico publicado en 2002

Pyrrole protection

article

Pyrrolo[3,2-e][1,4]diazepin-2-one synthesis: a head-to-head comparison of soluble versus insoluble supports

artículo científico publicado en 2011

Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure.

artículo científico publicado en 2012

Reversible and competitive cinnamoyl triazole inhibitors of tissue transglutaminase.

artículo científico publicado en 2008

Rho signaling pathway targeted to promote spinal cord repair.

artículo científico publicado en 2002

Rigid Dipeptide Mimics: Synthesis of Enantiopure 5- and 7-Benzyl and 5,7-Dibenzyl Indolizidinone Amino Acids via Enolization and Alkylation of δ-Oxo α,ω-Di-[N-(9-(9-phenylfluorenyl))amino]azelate Esters ⬇️

artículo científico publicado el 21 de agosto de 1998

Rigid dipeptide mimics: synthesis of enantiopure C6-functionalized pyrrolizidinone amino acids

artículo científico publicado en 2007

SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis

artículo científico publicado en 2002

Selective tert-butyl ester deprotection in the presence of acid labile protecting groups with use of ZnBr2.

artículo científico publicado en 2004

Serine as chiral educt for the practical synthesis of enantiopure N-protected beta-hydroxyvaline

artículo científico publicado en 2003

Site-specific protein propargylation using tissue transglutaminase.

artículo científico publicado en 2012

Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity

artículo científico publicado en 2010

Solid-Phase Azopeptide Diels-Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation

scientific article published on 26 April 2019

Solid-phase synthesis of 1,3,5-trisubstituted 1,4-diazepin-2-one peptide mimic.

artículo científico publicado en 2009

Solid-phase synthesis of 3-aminopyrrole-2,5-dicarboxylate analogues

artículo científico publicado en 2006

Solid-phase synthesis of C-terminal azapeptides

artículo científico publicado en 2014

Solution-phase submonomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-DKP synthesis.

artículo científico publicado en 2010

Stereo- and Regiochemical Transannular Cyclization of a Common Hexahydro-1H-azonine to Afford Three Different Indolizidinone Dipeptide Mimetics

artículo científico publicado en 2019

Structure-activity analysis of the growth hormone secretagogue GHRP-6 by alpha- and beta-amino gamma-lactam positional scanning

scientific article published on 01 January 2010

Structure-activity relationships of GHRP-6 azapeptide ligands of the CD36 scavenger receptor by solid-phase submonomer azapeptide synthesis

artículo científico publicado en 2011

Structure-activity study of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH2.

artículo científico publicado en 2004

Surfactant Mediated Cationic and Anionic Suspension Polymerization of PEG-Based Resins in Silicon Oil: Beaded SPOCC 1500 and POEPOP 1500.

artículo científico publicado en 2001

Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36)

artículo científico publicado en 2020

Synthesis and alkylation of Aza-Gly-Pro building blocks of peptidomimetic libraries for developing prostaglandin F2α receptor modulators as therapeutics to inhibit preterm labor.

artículo científico publicado en 2015

Synthesis and alkylation of aza-glycinyl dipeptide building blocks.

artículo científico publicado en 2013

Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters.

artículo científico publicado en 2004

Synthesis and peptide coupling of protected pyrrolylalanine.

artículo científico publicado en 2009

Synthesis and pharmacology of new enantiopure delta(3)-4-arylkainoids

artículo científico publicado en 2000

Synthesis of a new pi-deficient phenylalanine derivative from a common 1,4-diketone intermediate and study of the influence of aromatic density on prolyl amide isomer population.

artículo científico publicado en 2007

Synthesis of enantiopure 7-[3-azidopyl]indolizidin-2-one amino acid. A constrained mimic of the peptide backbone geometry and heteroatomic side-chain functionality of the ala-lys dipeptide.

artículo científico publicado en 2001

Synthesis of fused heteroarylprolines and pyrrolopyrroles

artículo científico publicado en 2004

Synthesis of protected 2-pyrrolylalanine for peptide chemistry and examination of its influence on prolyl amide isomer equilibrium

artículo científico publicado en 2012

Synthesis of pyrrolo[3,2-e] [1,4]diazepin-2-ones as potential gamma-turn mimetics

artículo científico publicado en 2009

Systematic study of the synthesis of macrocyclic dipeptide beta-turn mimics possessing 8-, 9-, and 10- membered rings by ring-closing metathesis

artículo científico publicado en 2005

THG113: a novel selective FP antagonist that delays preterm labor

artículo científico publicado en 2002

Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.

artículo científico publicado en 2011

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress

artículo científico publicado en 2021

Thoughts on Meldal and Hirschmann

artículo científico publicado en 2010

Three-step solution-phase combinatorial access to 1,2-disubstituted and 1,2,5-trisubstituted pyrroles from carboxylic esters.

artículo científico publicado en 2004

Unsymmetric electronic push-pull bipyrroles - synthesis, spectroelectrochemical, and photophysical investigation

artículo científico publicado en 2009

Urotensin II((4-11)) Azasulfuryl Peptides: Synthesis and Biological Activity

artículo científico publicado en 2016

Urotensin core mimics that modulate the biological activity of urotensin-II related peptide but not urotensin-II.

artículo científico publicado en 2017

Use of Steric Interactions To Control Peptide Turn Geometry. Synthesis of Type VI beta-Turn Mimics with 5-tert-Butylproline.

artículo científico publicado en 1999

X-ray structure analysis reveals β-turn mimicry by N-amino-imidazolidin-2-ones

artículo científico publicado en 2015

alpha-Amino-beta-hydroxy-gamma-lactam for constraining peptide Ser and Thr residue conformation.

artículo científico publicado en 2010

γ-Turn Mimicry with Benzodiazepinones and Pyrrolobenzodiazepinones Synthesized from a Common Amino Ketone Intermediate

artículo científico publicado en 2015

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda