Lista de obras - Mark W Richards - Dominio Público Uruguay

A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation

artículo científico publicado en 2010

A closed conformation of the Caenorhabditis elegans separase-securin complex ⬇️

artículo científico publicado en 2016

A moving target: structure and disorder in pursuit of Myc inhibitors ⬇️

artículo científico publicado en 2017

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain ⬇️

artículo científico publicado en 2016

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

artículo científico publicado en 2009

Ca2+ channel beta-subunits: structural insights AID our understanding

artículo científico publicado en 2004

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches ⬇️

artículo científico publicado en 2017

Combined inhibition of Aurora-A and ATR kinase results in regression of <i>MYCN</i>-amplified neuroblastoma

artículo científico publicado en 2021

Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding

artículo científico publicado en 2013

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

artículo científico publicado en 2014

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

artículo científico publicado en 2010

Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer ⬇️

artículo científico publicado en 2016

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex. ⬇️

artículo científico publicado en 2017

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression

artículo científico publicado en 2015

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

artículo científico publicado en 2009

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

artículo científico publicado en 2015

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

artículo científico publicado en 2015

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

scientific article published on 13 August 2019

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release ⬇️

artículo científico publicado en 2018

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix ⬇️

artículo científico publicado en 2018

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding

artículo científico publicado en 2015

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs ⬇️

artículo científico publicado en 2016

Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma

artículo científico publicado en 2020

Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels

artículo científico publicado en 2006

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors ⬇️

artículo científico publicado en 2016

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

artículo científico publicado en 2010

The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation.

artículo científico publicado en 2007

The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function

artículo científico publicado en 2006

Lista de obras de Mark W Richards

A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation

A closed conformation of the Caenorhabditis elegans separase-securin complex ⬇️

A moving target: structure and disorder in pursuit of Myc inhibitors ⬇️

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain ⬇️

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

Ca2+ channel beta-subunits: structural insights AID our understanding

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches ⬇️

Combined inhibition of Aurora-A and ATR kinase results in regression of <i>MYCN</i>-amplified neuroblastoma

Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer ⬇️

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex. ⬇️

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release ⬇️

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix ⬇️

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs ⬇️

Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma

Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors ⬇️

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation.

The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function