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Lista de obras de Tiziano Tuccinardi

1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors

scientific article published on 04 February 2020

1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors

artículo científico publicado en 2005

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

artículo científico publicado en 2015

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

artículo científico publicado en 2007

A Guide to PIN1 Function and Mutations Across Cancers

artículo científico publicado en 2018

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

artículo científico publicado en 2016

A Virtual Screening Study of the 18 kDa Translocator Protein using Pharmacophore Models Combined with 3D-QSAR Studies

artículo científico publicado en 2009

A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs

artículo científico publicado en 2005

A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).

artículo científico publicado en 2017

A theoretical study to investigate D2DAR/D4DAR selectivity: receptor modeling and molecular docking of dopaminergic ligands.

artículo científico publicado en 2006

Adenosine receptor ligands in clinical trials

artículo científico publicado en 2010

Adenosine receptor ligands: where are we, and where are we going?

artículo científico publicado en 2010

Adenosine receptor modelling. A1/A2a selectivity

artículo científico publicado en 2006

Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides

artículo científico publicado en 2006

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

scientific article published on 21 October 2020

Analysis of Human Carbonic Anhydrase II: Docking Reliability and Receptor-Based 3D-QSAR Study

article

Antibacterial and ATP Synthesis Modulating Compounds from Salvia tingitana

scientific article published on 17 March 2020

Antibacterial and Hypoglycemic Diterpenoids from Salvia chamaedryoides

artículo científico publicado en 2017

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells.

artículo científico publicado en 2018

Application of MM-PBSA Methods in Virtual Screening

artículo científico publicado en 2020

Application of a FLAP-consensus docking mixed strategy for the identification of new fatty acid amide hydrolase inhibitors.

artículo científico publicado en 2015

Ask the experts: focus on computational chemistry

artículo científico publicado en 2011

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

scientific article published on 29 August 2013

Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.

artículo científico publicado en 2017

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

artículo científico publicado en 2018

Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy.

artículo científico publicado en 2017

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

scientific article published on 30 June 2018

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

scientific article published on 31 December 2018

CDK inhibitors: from the bench to clinical trials.

artículo científico publicado en 2010

Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools

artículo científico publicado en 2020

Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis

artículo científico publicado en 2006

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

artículo científico publicado en 2017

Computational Studies of Epidermal Growth Factor Receptor: Docking Reliability, Three-Dimensional Quantitative Structure−Activity Relationship Analysis, and Virtual Screening Studies

article

Computational approaches for the identification and optimization of Src family kinases inhibitors

artículo científico

Computational approaches on angiotensin receptors and their ligands: recent developments and results.

artículo científico publicado en 2007

Computational studies on translocator protein (TSPO) and its ligands.

artículo científico

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

artículo científico publicado en 2019

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

artículo científico

Construction and validation of a RET TK catalytic domain by homology modeling

artículo científico publicado en 2007

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

scientific article published on 21 December 2018

Correction to Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

artículo científico publicado en 2017

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.

artículo científico publicado en 2016

Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists

artículo científico publicado en 2008

Design, Synthesis, Biological Evaluation, and NMR Studies of a New Series of Arylsulfones As Selective and Potent Matrix Metalloproteinase-12 Inhibitors

article by Elisa Nuti et al published 22 October 2009 in Journal of Medicinal Chemistry

Design, Synthesis, and Evaluation of GLUT Inhibitors.

artículo científico publicado en 2018

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)

artículo científico publicado en 2018

Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors

scientific article published on 27 July 2006

Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists

artículo científico publicado en 2006

Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors

scientific article published on 31 May 2007

Development and validation of a docking-based virtual screening platform for the identification of new lactate dehydrogenase inhibitors.

artículo científico publicado en 2015

Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors.

artículo científico publicado en 2018

Development of a cheminformatics platform for selectivity analyses of carbonic anhydrase inhibitors

artículo científico publicado en 2020

Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors

article

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

artículo científico publicado en 2017

Different binding modes of structurally diverse ligands for human D3DAR.

artículo científico publicado en 2010

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

scientific article published on 18 June 2018

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

artículo científico publicado en 2018

Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists

artículo científico publicado en 2013

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

artículo científico publicado en 2020

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

artículo científico publicado en 2011

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

artículo científico publicado en 2020

Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models

artículo científico publicado en 2016

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 16 August 2018

Docking-based virtual screening: recent developments.

artículo científico publicado en 2009

Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator

artículo científico publicado en 2016

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.

artículo científico publicado en 2008

Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

artículo científico publicado en 2013

Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies

artículo científico publicado en 2019

Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis

artículo científico publicado en 2013

Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies ⬇️

artículo científico publicado en 2019

Extensive consensus docking evaluation for ligand pose prediction and virtual screening studies

artículo científico publicado en 2014

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

scientific article published on 20 February 2019

Former Foodstuff Products in Tenebrio Molitor Rearing: Effects on Growth, Chemical Composition, Microbiological Load, and Antioxidant Status

artículo científico publicado en 2019

Growth performances, chemical composition, and microbiological loads of mealworm reared with brewery spent grains and bread leftovers

artículo científico publicado en 2022

Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic hCA II and membrane-bound hCA IX isoforms.

artículo científico publicado en 2017

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

artículo científico publicado en 2015

Homology Modeling and Receptor-Based 3D-QSAR Study of Carbonic Anhydrase IX

artículo científico publicado en 2007

Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds

scientific article published on 13 February 2017

Human carbonyl reductase 1 as efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation.

artículo científico publicado en 2016

Identification and characterization of a new reversible MAGL inhibitor

artículo científico publicado en 2014

Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach

artículo científico publicado en 2015

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

artículo científico publicado en 2013

Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

artículo científico publicado en 2018

Immune-modulation and properties of absorption and blood brain barrier permeability of 1,8-naphthyridine derivatives

artículo científico publicado en 2013

Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15.

artículo científico publicado en 2017

Indoles and related compounds as cannabinoid ligands

artículo científico publicado en 2008

Inhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds

artículo científico publicado en 2016

Interaction of anticancer reduced Schiff base coumarin derivatives with human serum albumin investigated by fluorescence quenching and molecular modeling.

artículo científico publicado en 2013

Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins

artículo científico publicado en 2014

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies

scientific article published on 21 June 2011

Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder

artículo científico publicado en 2012

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer

scientific article published on 08 May 2018

Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.

artículo científico publicado en 2017

Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors

artículo científico publicado en 2007

Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays

scientific article published on 01 May 2019

Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system

scientific article published on 17 October 2019

Molecular modeling of adenosine receptors: new results and trends.

artículo científico publicado en 2008

Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta

artículo científico publicado en 2008

Multitemplate Alignment Method for the Development of a Reliable 3D-QSAR Model for the Analysis of MMP3 Inhibitors

article

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

artículo científico publicado en 2011

N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity

artículo científico publicado en 2015

N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis

article

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

scientific article published on 06 June 2019

New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists

artículo científico publicado en 2007

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

artículo científico publicado en 2018

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

scientific article published on 01 December 2019

New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo

artículo científico publicado en 2009

New tris(hydroxypyridinones) as iron and aluminium sequestering agents: synthesis, complexation and in vivo studies

artículo científico publicado en 2010

Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.

artículo científico publicado en 2011

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII ⬇️

artículo científico

Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation

artículo científico publicado en 2011

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

artículo científico publicado en 2019

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

artículo científico publicado en 2013

Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.

artículo científico publicado en 2006

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.

artículo científico publicado en 2015

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system

artículo científico publicado en 2018

Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases.

artículo científico publicado en 2017

Probing the 'bipolar' nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms

artículo científico publicado en 2015

Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists: Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

article

Protein kinases: docking and homology modeling reliability.

artículo científico publicado en 2010

Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH)

artículo científico publicado en 2015

Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII

scientific article published on 28 April 2016

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines

scientific article published on 15 February 2019

Rational Development of MAGL Inhibitors

artículo científico publicado en 2018

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.

artículo científico publicado en 2012

Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists

artículo científico publicado en 2009

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

artículo científico publicado en 2014

Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies.

artículo científico publicado en 2016

Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.

artículo científico publicado en 2012

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

artículo científico publicado en 2015

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

artículo científico publicado en 2011

Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct

artículo científico publicado en 2019

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

artículo científico publicado en 2016

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

artículo científico publicado en 2009

Structure-Based Virtual Screening: Identification of Novel CB2 Receptor Ligands

Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists

artículo científico publicado en 2008

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors

artículo científico publicado en 2015

Study of the binding interaction between fluorinated matrix metalloproteinase inhibitors and Human Serum Albumin

artículo científico publicado en 2014

Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives

artículo científico publicado en 2004

Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: developments in understanding the receptor stereoselectivity.

artículo científico publicado en 2011

Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model

artículo científico publicado en 2008

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

artículo científico publicado en 2019

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

artículo científico publicado en 2015

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists

artículo científico publicado en 2016

Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes

scientific article published on 01 August 2006

Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

artículo científico publicado en 2006

Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties

artículo científico publicado en 2010

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

artículo científico publicado en 2011

Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones

artículo científico publicado en 2008

Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor

artículo científico publicado en 2014

The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation

scientific article published on 21 November 2019

The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine

artículo científico publicado en 2019

The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

artículo científico publicado en 2015

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel

artículo científico publicado en 2019

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

scientific article published on 21 August 2019

The influence of Echinacea purpurea leaf microbiota on chicoric acid level

scientific article published on 26 July 2019

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

artículo científico publicado en 2017

Three-Dimensional Interactions Analysis of the Anticancer Target c-Src Kinase with Its Inhibitors

artículo científico publicado en 2020

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects

scientific article published on 29 January 2019

α-Glucosidase and α-Amylase Inhibitors from Arcytophyllum thymifolium.

artículo científico publicado en 2016

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