Lista de obras - Roger Hunter - Dominio Público Uruguay

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

artículo científico publicado en 2017

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.

artículo científico publicado en 2011

Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy

artículo científico publicado en 2013

C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors

artículo científico publicado en 2008

Catalytic enantioselective acyl transfer: the case for 4-PPY with a C-3 carboxamide peptide auxiliary based on synthesis and modelling studies

artículo científico publicado en 2016

Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with Plasmodium falciparum Multidrug Resistance-Associated Protein and Lipids

scientific article published on 24 September 2018

Chemoselective room temperature E1cB N-N cleavage of oxazolidinone hydrazides from enantioselective aldehyde α-hydrazination: synthesis of (+)-1,4-dideoxyallonojirimycin.

artículo científico publicado en 2016

Current developments in the synthesis and biological activity of HIV-1 double-drug inhibitors.

artículo científico publicado en 2007

Garlic-derived anticancer agents: structure and biological activity of ajoene.

artículo científico publicado en 2010

Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum

artículo científico publicado en 2017

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.

artículo científico publicado en 2016

In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles

artículo científico publicado en 2013

Inclusion of the allicin mimicS-p-tolylt-butylthiosulphinate in β-cyclodextrin

Inexpensive, one-pot synthesis of unsymmetrical disulfides using 1-chlorobenzotriazole

artículo científico publicado en 2006

Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols

artículo científico publicado en 2009

Modification, crosslinking and reactive electrospinning of a thermoplastic medical polyurethane for vascular graft applications.

artículo científico publicado en 2010

Preparation and structure of an air stable sodium cyanoborate salt

Preparation, Thermal Behaviour and Solid-state Structures of Inclusion Complexes of Permethylated-β-cyclodextrin with the Garlic-derived Antithrombotics (E)- and (Z)-Ajoene

Quaternized α,α'-Amino Acids via Curtius Rearrangement of Substituted Malonate-Imidazolidinones

artículo científico publicado en 2017

Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

artículo científico publicado en 2011

Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum

artículo científico publicado en 2016

Solution chemistry of 1,15-bis(N,N-dimethyl)-5,11-dioxo-8-(N-benzyl)-1,4,8,12,15-pentaazapentadecane with metal ions of biological interest-Insights toward active metal ion containing therapeutics and diagnostic agents

artículo científico publicado en 2006

Stereoselective formation of quaternary stereogenic centers via alkylation of α-substituted malonate-imidazolidinones.

artículo científico publicado en 2014

Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

artículo científico publicado en 2000

Structure–activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells ⬇️

artículo científico publicado el 11 de febrero de 2012

Synthesis and anti-prion activity evaluation of aminoquinoline analogues

artículo científico publicado en 2010

Synthesis of (+)-Tacamonine via Stereoselective Radical Cyclization

scientific article published on 24 October 2019

Synthesis of 2-deoxy-2-C-alkylglucosides of myo-inositol as possible inhibitors of a N-deacetylase enzyme in the biosynthesis of mycothiol.

artículo científico publicado en 2003

Technetium-99m labelling of bis-oxime ligands

artículo científico publicado en 1994

The Mechanism of the Amidases: MUTATING THE GLUTAMATE ADJACENT TO THE CATALYTIC TRIAD INACTIVATES THE ENZYME DUE TO SUBSTRATE MISPOSITIONING

artículo científico publicado en 2013

The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS.

artículo científico publicado en 2016

The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells.

artículo científico publicado en 2015

Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent.

artículo científico publicado en 2005

Unsymmetrical Organotrisulfide Formation via Low-Temperature Disulfanyl Anion Transfer to an Organothiosulfonate

scientific article published on 18 February 2019

[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor

artículo científico publicado en 2007

[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase.

artículo científico publicado en 2010

Lista de obras de Roger Hunter

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.

Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy

C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors

Catalytic enantioselective acyl transfer: the case for 4-PPY with a C-3 carboxamide peptide auxiliary based on synthesis and modelling studies

Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with Plasmodium falciparum Multidrug Resistance-Associated Protein and Lipids

Chemoselective room temperature E1cB N-N cleavage of oxazolidinone hydrazides from enantioselective aldehyde α-hydrazination: synthesis of (+)-1,4-dideoxyallonojirimycin.

Current developments in the synthesis and biological activity of HIV-1 double-drug inhibitors.

Garlic-derived anticancer agents: structure and biological activity of ajoene.

Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.

In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles

Inclusion of the allicin mimicS-p-tolylt-butylthiosulphinate in β-cyclodextrin

Inexpensive, one-pot synthesis of unsymmetrical disulfides using 1-chlorobenzotriazole

Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols

Modification, crosslinking and reactive electrospinning of a thermoplastic medical polyurethane for vascular graft applications.

Preparation and structure of an air stable sodium cyanoborate salt

Preparation, Thermal Behaviour and Solid-state Structures of Inclusion Complexes of Permethylated-β-cyclodextrin with the Garlic-derived Antithrombotics (E)- and (Z)-Ajoene

Quaternized α,α'-Amino Acids via Curtius Rearrangement of Substituted Malonate-Imidazolidinones

Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum

Solution chemistry of 1,15-bis(N,N-dimethyl)-5,11-dioxo-8-(N-benzyl)-1,4,8,12,15-pentaazapentadecane with metal ions of biological interest-Insights toward active metal ion containing therapeutics and diagnostic agents

Stereoselective formation of quaternary stereogenic centers via alkylation of α-substituted malonate-imidazolidinones.

Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

Structure–activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells ⬇️

Synthesis and anti-prion activity evaluation of aminoquinoline analogues

Synthesis of (+)-Tacamonine via Stereoselective Radical Cyclization

Synthesis of 2-deoxy-2-C-alkylglucosides of myo-inositol as possible inhibitors of a N-deacetylase enzyme in the biosynthesis of mycothiol.

Technetium-99m labelling of bis-oxime ligands

The Mechanism of the Amidases: MUTATING THE GLUTAMATE ADJACENT TO THE CATALYTIC TRIAD INACTIVATES THE ENZYME DUE TO SUBSTRATE MISPOSITIONING

The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS.

The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells.

Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent.

Unsymmetrical Organotrisulfide Formation via Low-Temperature Disulfanyl Anion Transfer to an Organothiosulfonate

[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor

[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase.