Lista de obras - James E. Dunford - Dominio Público Uruguay

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

artículo científico publicado en 2019

Activation of multiple protein kinases by interleukin-1.

artículo científico publicado en 1995

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

artículo científico publicado en 2013

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

artículo científico publicado en 2019

CMT3 alters mitochondrial function in murine osteoclast lineage cells.

artículo científico publicado en 2007

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells

artículo científico publicado en 2011

Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes

artículo científico publicado en 2007

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

scientific article published on 07 December 2018

Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.

artículo científico publicado en 2008

Differences between bisphosphonates in binding affinities for hydroxyapatite.

artículo científico publicado en 2010

Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes

artículo científico publicado en 1998

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

artículo científico publicado en 2018

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

artículo científico publicado en 2015

Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types

artículo científico publicado en 2018

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates.

artículo científico publicado en 2017

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

artículo científico publicado en 2001

Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors.

artículo científico publicado en 2004

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

artículo científico publicado en 2006

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

artículo científico publicado en 2017

Modulation of osteoclastogenesis by fatty acids

artículo científico publicado en 2008

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

artículo científico publicado en 2011

Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition.

artículo científico publicado en 2010

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

artículo científico publicado en 2012

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

artículo científico publicado en 2008

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

artículo científico publicado en 2001

Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.

artículo científico publicado en 2014

Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.

artículo científico publicado en 2010

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

artículo científico publicado en 2008

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

artículo científico publicado en 2017

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

artículo científico publicado en 2006

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma

artículo científico publicado en 2019

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

artículo científico

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

artículo científico publicado en 2006

The relationship between the chemistry and biological activity of the bisphosphonates.

scientific article published on 09 April 2011

Lista de obras de James E. Dunford

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

Activation of multiple protein kinases by interleukin-1.

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

CMT3 alters mitochondrial function in murine osteoclast lineage cells.

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells

Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.

Differences between bisphosphonates in binding affinities for hydroxyapatite.

Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates.

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors.

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

Modulation of osteoclastogenesis by fatty acids

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition.

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.

Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

The relationship between the chemistry and biological activity of the bisphosphonates.