1,1,1-Trichloro-4,4-diethoxy-3-buten-2-one and its Trichloroacetylacetate Derivatives: Synthesis and Applications in Regiospecific Preparation of Azoles

1,1-Difluoro-3-aryl(heteroaryl)-1H-pyrido[1,2-c][1,3,5,2]oxadiazaborinin-9-ium-1-uides: synthesis; structure; and photophysical, electrochemical, and BSA-binding studies

13C NMR Chemical Shift Substituent Effects: Empirical Substituent Effects in β-Alcoxyvinyl Halomethylketones

13C NMR Chemical Shifts Substituent Effects of (E)- and (Z)-N-ethyl-N-Methylamides

13C NMR Chemical Shifts of β-Alkoxyvinyl Ketones: III✠-Empirical Substituent Effects in 1-Alkylamino-6-Ethoxy-1,5-Hexadien-3,4-Diones and 1,6-bis(Alkylamino)-1,5-Hexadien-3,4-diones

15N NMR spectroscopy of 3-substituted 5-trichloromethyl-1,2-dimethyl-1H-pyrazolium chlorides

1H and13C NMR Chemical Shifts and N-Substituent Effects of Some Unsymmetrically N,N-Disubstituted Acetamides

2-Trifluoroacetyl-1-methoxycycloalkenes: A convenient precursor for the synthesis of geminated polymethylene trifluoromethyl substituted heterocycles

4-Alkoxy-1,1,1-Trichloro-3-Alken-2-ones: Preparation and Applications in Heterocyclic Synthesis

5-Halomethyl-5-Hydroxy-4,5-Dihydroisoxazoles: Synthesis and 13C, 17O,15N, 19F NMR Spectroscopy

5-Trifluoromethyl-1,2-dimethyl-1H-pyrazolium chlorides: synthesis and , , and NMR chemical shifts

A CONVENIENT SYNTHESIS OF 4-TRICHLOROMETHYL-PYRIMIDIN-2-YLAMINE DERIVATIVES

A Convenient Method to Obtain 4,5-Dihydro-1H-Methylpyrazoles by A Ring Transformation Reaction

A Convenient Preparation of 4-Methyl- and 4-Phenylseleno-1,1,1-trihalo-3-alken-2-ones and their Usefulness in the Synthesis of 3-Trihalomethylisoselenazoles

article published in 2002

A Convenient Synthesis of 5- and 6-Substituted 2-Phenyl-3H-pyrimidin-4-ones

A convenient method for the synthesis of 2-trichloromethyl-4-p-substituted-phenyl-3h-1,5-benzodiazepines

A convenient one-pot synthesis of 5-carboxyisoxazoles: trichloromethyl group as a carboxyl group precursor

article published in 2000

A convenient two-step synthesis of 6-methylenesubstituted-4-trichloromethyl-2-methylsulfanyl pyrimidines

article by Nilo Zanatta et al published January 2006 in Tetrahedron Letters

A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.

artículo científico publicado en 2013

A pyrazolyl-thiazole derivative causes antinociception in mice

artículo científico publicado en 2006

A simple one-pot synthesis of 3-alkoxy-3-cyanocarboxylic acids: a rapid entry to new GABA derivatives

A solvent-free synthesis of beta-enamino trihalomethyl ketones

A telescoped protocol for the synthesis of new pyrrolo [3,4-d]pyridazinones by cascade reactions

ANRORC rearrangement in tetrahydro-2H-chromenones. Synthesis and structural assignment by NMR, MS, X-ray and DFT calculations of 2-[3(5)-trifluoromethyl-1H-pyrazol-4-yl)arylmethyl]cyclohexenones and derivatives

Activity of 4,5-dihydro-1H-pyrazoles against Mycobacterium tuberculosis and nontuberculous mycobacteria

artículo científico publicado en 2014

Alpha 2-adrenoceptors and 5-HT receptors mediate the antinociceptive effect of new pyrazolines, but not of dipyrone

artículo científico publicado en 2004

An E-factor minimized solvent-free protocol for the preparation of 4,5-dihydro-5-(trifluoromethyl)-1H-pyrazoles

An Efficient Synthesis of Oxa- and Aza-Condensed Tetrahydropyridines from Cyclic Enones

An Efficient Two-Step Synthesis of New 5-Substituted-1H-tetrazoles of Biological Interest

An efficient and regioselective synthesis of 1,1′-oxalylbis[3-(alkyl/aryl/heteroaryl)-5-(trihalomethyl)-1H-pyrazoles] from 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones

An efficient solvent-free synthesis of NH-pyrazoles from β-dimethylaminovinylketones and hydrazine on grinding

An efficient synthesis of 1-cyanoacetyl-5-halomethyl-4,5-dihydro-1H-pyrazoles in ionic liquid

An ionic liquid as reaction medium for the synthesis of halo-containing β-enaminones at room temperature

Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice

artículo científico publicado en 2012

Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues

artículo científico publicado en 2005

Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.

artículo científico publicado en 2008

Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain

artículo científico publicado en 2014

Antinociceptive effect of a novel tosylpyrazole compound in mice.

artículo científico publicado en 2008

Antinociceptive effect of novel pyrazolines in mice.

artículo científico publicado en 2004

Antinociceptive effect of novel trihalomethyl-substituted pyrazoline methyl esters in formalin and hot-plate tests in mice.

artículo científico publicado en 2007

Antioxidant potential of new pyrazoline derivatives to prevent oxidative damage

artículo científico publicado en 2008

Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats.

artículo científico publicado en 2010

Antitumoral activity of a trichloromethyl pyrimidine analogue: molecular cross-talk between intrinsic and extrinsic apoptosis

artículo científico publicado en 2014

Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1, 5-benzodiazepine hydrogen sulfate in mice

artículo científico publicado en 2000

Application of 4-Alkoxy-1,1,1-trifluoro[chloro]alk-3-en-2-ones as Selective Protecting Groups of Amino Acids

Brominated Trihalomethylenones as Versatile Precursors to 3-Ethoxy, -Formyl, -Azidomethyl, -Triazolyl, and 3-Aminomethyl Pyrazoles

Chelating effect of novel pyrimidines in a model of aluminum intoxication

artículo científico publicado en 2005

Chemo- and regioselective reactions of 5-bromo enones/enaminones with pyrazoles

scientific article published on 01 February 2019

Chemoselective Synthesis of 1-Substituted 4-Amino-2-(trifluoromethyl)-1H-pyrroles through the Heterocyclization Reaction of 4-Methoxy-5-bromo-1,1,1-trifluoropent-3-en-2-ones with Amines

scientific article published on 30 November 2015

Chemoselective fluorination of 2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones using DAST

Comparative Study of the Chemoselectivity and Yields of the Synthesis ofN-Alkyl-4-(trihalomethyl)-1H-pyrimidin-2-ones

article published in 2008

Comparative Study of the Regioselectivity and Reaction Media for the Synthesis of 1-tert-Butyl-3(5)-trifluoromethyl-1H-pyrazoles

Competition between the donor and acceptor hydrogen bonds of the threads in the formation of [2]rotaxanes by clipping reaction

article

Conformer Distribution in Rotaxanes Containing Nonsymmetric Threads: A Systematic Approach

Convenient One-Pot Synthesis of N-Substituted 3-Trifluoroacetyl Pyrroles

Convenient synthesis of 3-aminomethylenedihydrofuran-2-ones

Convenient synthesis of furan-3-carboxylic acid and derivatives

Convergent procedure for the synthesis of trifluoromethyl-containing N-(pyridinyl-triazolyl)pyrimidin-2-amines

Convergent synthesis and cruzain inhibitory activity of novel 2-(N'-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines

artículo científico publicado en 2008

Correction to Antitumoral Activity of a Trichloromethyl Pyrimidine Analogue: Molecular Cross-Talk between Intrinsic and Extrinsic Apoptosis

article

Cover Feature: Conformer Distribution in Rotaxanes Containing Nonsymmetric Threads: A Systematic Approach (Eur. J. Org. Chem. 36/2018)

Cyanoacetylazoles and salicylic aldehydes promoting the synthesis of new trifluoromethyl-substituted azolecarbonyl-2H-chromen-2-ones through the Knoevenagel condensation reaction

Cycloaromatization Reaction of 4-Alkoxy-1,1,1-trifluoroalk-3-en-2-ones with 2,6-Diaminotoluene: The Unexpected Regioselective Synthesis of 2,4,7,8-Tetrasubstituted Quinolines

DAST promotes the synthesis of new 5-(trifluoromethyl)-3-(1,1-difluoroethan-2-yl)-1H-pyrazoles

Deep eutectic solvent mediated synthesis of thiomethyltriazolo[1,5- a ]pyrimidines

Design and Synthesis of Novel TrichloromethylatedN-Azolylmethyl-1H-pyrimidin-2-ones and RelatedN-Methylenaminones

Design and microwave-assisted synthesis of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles: novel agents with analgesic and anti-inflammatory properties

artículo científico publicado en 2007

Eco-friendly synthesis and antioxidant activity of new trifluoromethyl-substituted N-(pyrimidin-2-yl)benzo[d]thiazol-2-amines and some N-derivatives

Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats

artículo científico publicado en 2009

Effect of carbonyl substituents on the barrier to rotation inN-ethyl-N-methylamides

Effect of slight structural changes on the gelation properties of N-phenylstearamide supramolecular gels

artículo científico publicado en 2018

Effects per se of organic solvents in the cerebral acetylcholinesterase of rats

artículo científico publicado en 2005

Efficient Syntheses of Ethyl 2-Methylthio- and Ethyl 2-Benzylthio-6-methyl(aryl)pyrimidine-4-carboxylates and Their Carboxylic Acid Derivatives

Efficient Synthesis of (1,2,3-Triazol-1-yl)methylpyrimidines from 5-Bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one

Efficient and highly regioselective synthesis of ethyl 1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylates under ultrasound irradiation

artículo científico publicado en 2010

Efficient entry to trifluoromethyl substituted chromanes from oxidative aromatization of tetrahydro-2H-chromen-5(6H)-ones using iodine/alcohol with conventional and microwave methods

article published in 2012

Efficient microwave-assisted synthesis of 1-aryl-4-dimethylamino methyleno-pyrrolidine-2,3,5-triones

Efficient synthesis and dehydration reaction of trichloromethylated 2-(3-phenyl-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl)-4-aryl-5-alkylthiazoles

Efficient synthesis of new 1-[Alkyl(aryl)]-5-(3,3,3-trihalo-2-oxopropylidene)pyrrolidin-2-ones

Efficient synthetic access to novel N-(Pyrimidinyl)-N-(1H-benzo[d]imidazolyl)amines in an aqueous medium

Energetic and topological approach for characterization of supramolecular clusters in organic crystals

scholarly article in RSC Advances, vol. 4 no. 84, 2014

Enol ethers and acetals: acylation with dichloroacetyl, acetyl and benzoyl chloride in ionic liquid medium

Evaluation of the synthesis of 1-(pentafluorophenyl)-4,5-dihydro-1H-pyrazoles using green metrics

Experimental and calculated structural parameters of 5-trihalomethyl-4,5-dihydro-1H-pyrazole derivatives, novel analgesic agents

Facile Synthesis and Structural Characterization by NMR, ESI-MS/MS and DFT Calculations of New (E)-6-[2-Ferrocenylalkylidenehydrazino]nicotinic Hydrazides and Their (E)-Ferrocenyl-pyrazolyl-pyridine Heterocyclic System

General method for dehydration, intramolecular cyclization, and fluorination of trifluoromethyl-1H-pyrazoles using DAST

General pathway for a convenient one-pot synthesis of trifluoromethyl-containing 2-amino-7-alkyl(aryl/heteroaryl)-1,8-naphthyridines and fused cycloalkane analogues

HALOACETYLATED ENOL ETHERS. XVII.1* A CONVENIENT SYNTHESIS OF 5-TRICHLOROMETHYL-1,2-DIMETHYL- 1H-PYRAZOLIUM CHLORIDES

Haloacetylated Compounds: Solvent Effects on the 17O Nmr Chemical Shifts of 1,1,1-Trichloro-4-Methoxy-3-Alken-2-Ones

Haloacetylated Enol Ethers, 19: Synthesis of 3-(2-Thienyl)- and 3-(2-Furyl)-5-trihalomethyl Substituted Azoles

Haloacetylated enol ethers 10. Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide. Synthesis of new trifluoromethyl 4,5-dihydro-1H-1-pyrazolethiocarboxyamides

Haloacetylated enol ethers: 12 [18]. Regiospecific synthesis and structural determination of stable 5-hydroxy-1H-pyrazolines

Haloacetylated enol ethers: 18

Highly Chemoselective Synthesis of 6-Alkoxy-1-alkyl(aryl)-3-trifluoroacetyl-1,4,5,6-tetrahydropyridines and 1-Alkyl(aryl)-6-amino-3-trifluoroacetyl-1,4,5,6-tetrahydropyridines

Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3H)-ones

Highly regioselective synthesis of novel 1,4'-bipyrazoles

How Mechanical and Chemical Features Affect the Green Synthesis of 1H-Pyrazoles in a Ball Mill

Hypothermic and antipyretic effects of 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamides in mice

artículo científico publicado en 2002

Improved One-Pot Synthesis of 1-Aryl-3-trifluoroacetyl-1H-pyrroles under Swern Oxidation

Indium(III) bromide catalyzed one-pot synthesis of trichloromethylated tetrahydropyrimidinones

Influence of bulky and halogen substituents on crystal packing of pyrazolo[1,5-a]pyrimidines

Inhibitory effect of novel pyrimidines on ATP and ADP hydrolysis in synaptosomes from rat cerebral cortex

artículo científico publicado en 2003

Insights on conformation in the solid state: a case study – s-cis and/or s-trans crystallization of 5(3)-aryl-3(5)-carboxyethyl-1-tert-butylpyrazoles

Intramolecular cyclization of N-propargylic β-enaminones catalyzed by silver

Ionic Liquids Promoted the C-Acylation of Acetals in Solvent-free Conditions

Ionic Liquids in Heterocyclic Synthesis

scientific article published on 01 June 2008

Ionic liquid and Lewis acid combination in the synthesis of novel (E)-1-(benzylideneamino)-3-cyano-6-(trifluoromethyl)-1H-2-pyridones

Ionic liquid as catalyst in the synthesis of N-alkyl trifluoromethyl pyrazoles

Ionic liquid effects on the reaction of β-enaminones and tert-butylhydrazine and applications for the synthesis of pyrazoles

Ionic liquid promoted cyclocondensation reactions to the formation of isoxazoles, pyrazoles and pyrimidines

Ionic liquid/HCl catalyzed synthesis of 4-(trifluoromethyl)-2(1H)-pyrimidinones

MOLECULAR STRUCTURE OF HETEROCYCLES:17O NMR CHEMICAL SHIFTS: TORSION ANGLE RELATIONSHIPS IN 3-ALKYL SUBSTITUTED 4,5-DIHYDROISOXAZOLES AND ISOXAZOLES†

Microwave assisted synthesis of 5-hydroxy-5-trichloromethyl-4,5-dihydroisoxazoles

Microwave-Assisted Regiospecific Synthesis of 2-Trifluoromethyl-7- Trihalomethylated Pyrazolo[1,5-a]Pyrimidines

Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles

Microwave-assisted synthesis of 5-trichloromethyl substituted 1-phenyl-1H-pyrazoles and 1,2-dimethylpyrazolium chlorides

Microwave-assisted synthesis of novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole methyl esters under solvent free conditions

Molecular Structure of Heterocycles: 2#NMR Spectroscopy, X- ray Diffraction, and Semiempirical MO Calculations of 5-Bromo-4, 6-dimethoxy-4-trichloromethyl-hexahydropyrimidin-2-one

Molecular Structure of Heterocycles: 4# NMR Spectroscopy, X-Ray Diffraction, and Semiempirical Mo Calculations of 3-Phenyl-5-Hydroxy- 5-Trichloromethyl-4,5-Dihydro-FH-Pyrazole-1-Carboxyamide

N- and C-Acylation in β-Enamino Ketones: Structural Effects on Regiocontrol

New 2-(aryl/heteroaryl)-6-(morpholin-4-yl/pyrrolidin-1-yl)-(4-trifluoromethyl)quinolines: synthesis via Buchwald–Hartwig amination, photophysics, and biomolecular binding properties

New 4-fluoroalkyl substituted N-phenylpyrazoles: Synthesis promoted by DAST and multinuclear NMR analysis

New Pyrazolyl-Nicotinic Acids, Methyl Esters, and 1,3,4-Oxadiazolyl-pyrazolyl-pyridine Tricyclic Scaffold Derivatives from 6-Hydrazinylnicotinic Acid Hydrazide Hydrate

New benzodiazepines alter acetylcholinesterase and ATPDase activities

artículo científico publicado en 2000

New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs

New regioselective synthesis of polyfunctionalized 3-ferrocenyl-1 H -pyrroles under microwave irradiation

New solventless and metal-free synthesis of the antiepileptic drug 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide (Rufinamide) and analogues

New strategy for the regioselective synthesis of 1-phenyl-3-trifluoromethyl-1H-pyrazoles

New succinyl-spaced pyrazoles: Regioselective synthesis of 1,4-bis[5-(trichloromethyl)-1H-pyrazol-1-yl]butane-1,4-diones

New trifluoromethyl-containing (E)-N′-arylidene-[3-alkyl(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-1-yl]carbohydrazides: Synthesis, crystal structure and antimicrobial/antioxidant activity

Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides

artículo científico publicado en 2017

One-Pot Synthesis of a New Series of 3-Alkoxy-5-hydroxy-5-trifluoromethylpyrrolidin-2-ones from 1,1,1-Trifluoro-4-alkoxyalk-3-en-2-ones

One-pot synthesis of aryl and heteroaroyl-substituted hydroxypyrazolines from the reactions of β-alkoxyvinyl trichloromethyl ketones with heteroarylhydrazides

One‐Pot Synthesis of Pyrazole‐5(3)‐carboxyamides

Organoallylaluminum reagents promote easy access to trihalomethyl triazolyl homoallylic alcohols analogous to rufinamide

article by Helio G Bonacorso et al published April 2014 in Tetrahedron Letters

Polymorphism in an 18-membered macrocycle: an energetic and topological approach to understand the supramolecular structure

Preparation and crystal structure determination of adducts of copper(II) chloride with 3-aryl-1-(imino-pyridin-2-yl-methyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazoles

Promotion of 1,3-dipolar cycloaddition between azides and β-enaminones by deep eutectic solvents

Proposal for crystallization of 3-amino-4-halo-5-methylisoxazoles: an energetic and topological approach

article published in 2015

Pyrazole synthesis under microwave irradiation and solvent-free conditions

article published in 2010

REACTIONS OF β-ALKOXYVINYL TRIFLUOROMETHYL KETONES. THE SYNTHESIS OFN-[1-ARYL-3-OXO-4,4,4-TRIFLUORO-1-BUTEN-1-YL]-o-PHENYLENEDIAMINES AND 4-ARYL-2-TRIFLUOROMETHYL-3H-1,5-BENZODIAZEPINES

Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide

Reactions of β-methoxyvinyl trifluoromethyl ketones with 2-pyridinecarboxamidrazone

Regiochemistry of cyclocondensation reactions in the synthesis of polyazaheterocycles.

scientific article published on 10 February 2017

Regioselective synthesis and characterization of new 3-aryl-7-trifluoromethyl-[1,2,4]triazolo[4,3-a]pyrimidines

Regioselective synthesis and through-space 13C–19F spin–spin coupling NMR of new tetracyclic 3-(trifluoromethyl)-spiro(chromen[4,3-c]pyrazole-4,1′-cycloalkanes)

Regioselective synthesis, biological evaluation, and molecular docking of dihydropyrimidin-4-ols as acetylcholinesterase inhibitors.

artículo científico publicado en 2017

Regioselectively Controlled Synthesis of N-Substituted (Trifluoromethyl)pyrimidin-2(1H)-ones

artículo científico publicado en 2016

Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice

artículo científico publicado en 2015

Regiospecific Allylic Mono- and Dibromination of 4-Methoxy-1,1,1-trihalo-3-alken-2-ones and 5-Methoxy-1,1,1,2,2-pentafluoro-4-hexen-2-one, and their Applications to the Synthesis of Heterocycles

Regiospecific Bromination of 2-Phenyl-3H-pyrimidin-4-ones

Regiospecific Synthesis of 4-Alkoxy and 4-Amino Substituted 2-Trifluoromethyl Pyrroles

scientific article published on 01 September 2006

Regiospecific acylation of acetals. A convenient method to obtain β-methoxyvinyl trichloromethyl ketones

Regiospecific synthesis of 1,2-bis(azolyl)ethanes

Regiospecific synthesis of 3H-pyrido[2,3-b][1,4]diazepin-4(5H)-onesviahaloform reaction with the isolation ofN3-[3-oxo-4,4,4-trichloroalk-1-en-1-yl]-2,3-diaminopyridine intermediates

Regiospecific synthesis of new non-condensed heteropolycyclic systems from beta-heteroaryl-beta-methoxyvinyl trihalomethyl ketones

Regiospecific synthesis of polyfluorinated heterocycles

Resourceful synthesis of pyrazolo[1,5-a]pyrimidines under ultrasound irradiation

artículo científico publicado en 2013

SYNTHESIS OF 3-METHYLISOXAZOLE- 5-CARBOXAMIDES AND 5-[(1H-PYRAZOL-1-YL)CARBONYL]- 3-METHYLISOXAZOLES

SYNTHESIS OF SOME N-[1-ALKYL(ARYL)- 3-OXO-4,4,4-TRICHLORO(TRIFLUORO)- 1-BUTEN-1-YL]-o-AMINOPHENOLS AND o-PHENYLENEDIAMINES AS POTENTIAL ANTICANCER AGENTS

Sequential one-pot three-step synthesis of polysubstituted 4-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazole systems

scholarly article in RSC Advances, vol. 7 no. 69, 2017

Simplified Approach to the Regiospecific Synthesis of Trichloromethylpyrazolines Using Microwave Irradiation

Solvent effects on the 17O NMR chemical shifts of 4-dimethylsulfoximide-1,1,1-trifluoro-3-alken-2-ones

Solvent-free route to β-enamino dichloromethyl ketones and application in the synthesis of novel 5-dichloromethyl-1H-pyrazoles

Sonochemical heating profile for solvents and ionic liquid doped solvents, and their application in the N -alkylation of pyrazoles

artículo científico publicado en 2016

Straightforward and Regiospecific Synthesis of Pyrazole-5-carboxylates from Unsymmetrical Enaminodiketones

Straightforward method for regioselective reduction of 3-acyl-substituted 2-(trifluoromethyl)-2H-chromen-5-one and chromane scaffolds in NaBH4/ethanol medium

Straightforward microwave-assisted synthesis of 1-carboxymethyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles under solvent-free conditions

Structural investigations of 5-hydroxy-4,5-dihydroisoxazoles

Succinic acid dihydrazide: a convenient N,N-double block for the synthesis of symmetrical and non-symmetrical succinyl-bis[5-trifluoro(chloro)methyl-1H-pyrazoles]

Supramolecular structure of enaminones in solid-state

Synergic Effects of Ionic Liquid and Microwave Irradiation in Promoting Trifluoromethylpyrazole Synthesis

Synthesis and Characterization of Some Novel 2-(Trifluoromethyl)pyrimido[1,2-a]benzimidazoles and Pyrimido[1,2-a]benzimidazol-2H)-ones of Biological Interest

Synthesis and antimicrobial activity of new (4,4,4-trihalo-3-oxo-but-1-enyl)-carbamic acid ethyl esters, (4,4,4-trihalo-3-hydroxy-butyl)-carbamic acid ethyl esters, and 2-oxo-6-trihalomethyl-[1,3]oxazinane-3-carboxylic acid ethyl esters

artículo científico publicado en 2006

Synthesis and antinociceptive activity of new 2-substituted 4-(trifluoromethyl)-5,6-dihydrobenzo[ h ]quinazolines

artículo científico publicado en 2016

Synthesis and cytotoxic activity evaluation of some novel 1-(3-(aryl-4,5-dihydroisoxazol-5-yl)methyl)-4-trihalomethyl-1H-pyrimidin-2-ones in human cancer cells

artículo científico publicado en 2015

Synthesis and in vitro antimycobacterial activity of 3-substituted 5-hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-1-(isonicotinoyl) pyrazoles

artículo científico publicado en 2008

Synthesis and structural study of N-methyl-2-methylthiopyrimidine derivatives from trihalomethylated enones

Synthesis of 1,1,1-trichloro[fluoro]-3-alken-2-ones using ionic liquids

Synthesis of 1-Arylethyl-2-arylethylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines and Related Compounds with Potential Cell Efflux Pump Inhibition

Synthesis of 1H-1,2,3-triazoles—Rufinamide analogs by 1,3-dipolar cycloaddition and eletrocyclization reactions of trifluoroacetyl enolethers under thermal solventless conditions

Synthesis of Alkyl-, Aryl- and Heteroaryl-Substituted 2-[3-Oxo-2,3-dihydro-1H-pyrazol-2-yl]-6(4)-trifluoromethylpyrimidines from β-Alkoxyvinyl Trifluoromethyl Ketones

Synthesis of Ethyl Pyrimidine-4-carboxylates from Unsymmetrical Enamino Diketones and Their Application in the First Synthesis of Pyrimido[4,5-d]pyridazin-8(7H)-ones

Synthesis of N-Pyrrolyl(furanyl)-Substituted Piperazines, 1,4-Dizepanes, and 1,4-Diazocanes

scientific article published on 01 July 2019

Synthesis of N-substituted 6-trifluoromethyl-1,3-oxazinanes

Synthesis of New Fluorine-Containing 1,2,3,4-Tetrahydroacridines

Synthesis of Novel 3-Amino-5-trifluoromethylazoles: A Convenient Method of Obtaining N-(Azol-3-yl)amines

Synthesis of Tetrahydro‐2(1H)quinazolinones, Cyclopenta[d]‐2(1H)pyrimidinones, and Their Thioxo Analogs from 2‐Trifluoroacetyl‐1‐methoxycycloalkenes

Synthesis of new 1,1′-carbonyl-bis[3-aryl(heteroaryl)-5-(trihalomethyl)-1H-pyrazoles] and trifluoromethyl derivatives through ring-opening reactions

Synthesis of new fluorine-containing dihydrobenzo[c]acridines from trifluoroacetyl dihydronaphthalene and substituted anilines

Synthesis of new halo-containing acetylenes and their application to the synthesis of azoles

Synthesis of novel trifluoromethylated β-acetal-diols and their application to the synthesis of 3-ethoxy-5-hydroxy-5-trifluoromethyl-pyrrolidin-2-one

Synthesis of pyrazolo[1,5-a]quinoxalin-4(5H)-ones via one-pot amidation/N-arylation reactions under transition metal-free conditions

artículo científico publicado en 2016

Synthesis of tetra-substituted 5-trifluoromethylpyrazoles via sequential halogenation/palladium-catalyzed C–C and C–N cross-coupling

artículo científico publicado en 2016

Synthesis of the omega-brominated alpha-trifluoroacetylcycloalkanones and their isoxazole derivatives

Synthesis of β-enaminones by ionic liquid catalysis: A one-pot condensation under solvent-free conditions

Synthesis, 11B- and 19F NMR spectroscopy, and optical and electrochemical properties of novel 9-aryl-3-(aryl/heteroaryl)-1,1-difluoro-7-(trifluoromethyl)-1H-[1,3,5,2]oxadiazaborinino[3,4-a][1,8]naphthyridin-11-ium-1-uide complexes

Synthesis, 17O NMR spectroscopy and structure of 2-trifluoroacetyl-1-methoxycycloalkenes

Synthesis, Crystal Structure, and Supramolecular Understanding of 1,3,5-Tris(1-phenyl-1H-pyrazol-5-yl)benzenes.

artículo científico publicado en 2017

Synthesis, Structure Elucidation, Antioxidant and Antimicrobial Activity of Novel 2-(5-Trifluoromethyl-1H-pyrazol-1-yl)-5-(5-trihalomethyl-1H-pyrazol-1-yl-1-carbonyl)pyridines

Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides

artículo científico publicado en 2007

Synthesis, biological evaluation and molecular docking study of 7-amine-spiro[chromeno[4,3-b]quinoline-6,1′-cycloalkanes] as new tacrine hybrids

Synthesis, effect of substituents on the regiochemistry and equilibrium studies of tetrazolo[1,5-a]pyrimidine/2-azidopyrimidines

artículo científico publicado en 2017

Synthesis, screening for antiacetylcholinesterase activity and binding mode prediction of a new series of [3-(disubstituted-phosphate)-4,4,4-trifluoro-butyl]-carbamic acid ethyl esters

The Efficient One-Step Synthesis of Protected 6-Alkyl(aryl)-2-acetylamino-4(3H)-pyrimidinones

The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model

artículo científico publicado en 2013

The first application of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones in a three-component condensation protocol for the synthesis of 3-acyl-4-aryl-2-(trifluoromethyl)-2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones

The first synthesis of dihydro-3H-pyrido[2,3-b][1,4]diazepinols and a new alternative approach for diazepinone analogues

The regiospecific ω-bromination of 2-trichloroacetylcycloalkanones

The unexpected cyclization routes of N,N′-bis(oxotrifluoroalkenyl)-1,3-phenylenediamines in polyphosphoric acid medium

Trifluoroacetylation of unsymmetrical ketone acetals. A convenient route to obtain alkyl side chain trifluoromethylated heterocycles

Trifluoromethyl-containing pyrazolinyl (p-tolyl) sulfones: The synthesis and structure of promising antimicrobial agents

Two-photon absorption properties of BODIPY-like compounds based on BF2-naphthyridine complexes

artículo científico publicado en 2019

Ultrasound irradiation promotes the synthesis of new 1,2,4-triazolo[1,5-a]pyrimidine

artículo científico publicado en 2013

Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors

artículo científico publicado en 2008

Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and β-enamino trihalomethyl ketones in water

artículo científico publicado en 2005

Ultrasound promoted the synthesis of N-propargylic β-enaminones

scientific article published on 02 July 2011

Unexpected Metal-Free Fluorination and Oxidation at the C-4 Position of Pyrazoles Promoted by Selectfluor

Update 1 of: Ionic Liquids in Heterocyclic Synthesis

artículo científico publicado en 2014

X-ray structure, semi-empirical MO calculations and π-electron delocalization of 1-cyanoacetyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles

β-Alkoxyvinyl trichloromethyl ketones as N-heterocyclic acylating agent. A new access to 5H-thiazolo[3,2-a]pyrimidin-5-ones