Lista de obras - Agatha Bastida - Dominio Público Uruguay

6-O-Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine

A Molecular Modeling Approach to Identify Novel Inhibitors of the Major Facilitator Superfamily of Efflux Pump Transporters

artículo científico publicado en 2019

A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer.

artículo científico

A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.

artículo científico publicado en 2005

A thorough experimental study of CH/π interactions in water: quantitative structure-stability relationships for carbohydrate/aromatic complexes

artículo científico

Aryl Sulfotransferase from Haliangium ochraceum : A Versatile Tool for the Sulfation of Small Molecules

Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

scientific article published on 01 November 2018

Biocatalyst engineering exerts a dramatic effect on selectivity of hydrolysis catalyzed by immobilized lipases in aqueous medium

article published in 2001

C-terminal truncation of alpha 1,6-fucosyltransferase from Rhizobium sp. does not annul the transferase activity of the enzyme

artículo científico publicado en 2002

Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design

artículo científico publicado en 2013

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

artículo científico publicado en 2010

Effect of immiscible organic solvents on activity/stability of native chymotrypsin and immobilized-stabilized derivatives

artículo científico publicado en 1992

Enzymes in the synthesis of bioactive compounds: the prodigious decades

artículo científico publicado en 2004

Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance

artículo científico publicado en 2006

Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders.

artículo científico publicado en 2016

From kinase to cyclase: an unusual example of catalytic promiscuity modulated by metal switching

artículo científico publicado en 2009

Fully Dispersed and Covalently Attached Chymotrypsin Derivatives as Industrial Catalysts in Biphasic Systems

Immobilization-stabilization of α-chymotrypsin by covalent attachment to aldehyde-agarose gels

artículo científico publicado en 1991

In Vivo Chaperone-Assisted Folding of α-1,6-Fucosyltransferase from Rhizobium sp

artículo científico publicado en 2003

Inhibition-Disruption of Candida glabrata Biofilms: Symmetrical Selenoesters as Potential Anti-Biofilm Agents

scientific article published on 09 December 2019

Microfluidic Reactors Based on Rechargeable Catalytic Porous Supports: Heterogeneous Enzymatic Catalysis via Reversible Host-Guest Interactions

artículo científico publicado en 2016

Modulating weak interactions for molecular recognition: a dynamic combinatorial analysis for assessing the contribution of electrostatics to the stability of CH-π bonds in water

artículo científico publicado en 2015

Modulation of lipase properties in macro-aqueous systems by controlled enzyme immobilization: enantioselective hydrolysis of a chiral ester by immobilized Pseudomonas lipase

artículo científico publicado en 2001

Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase

artículo científico publicado en 2005

Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex

artículo científico publicado en 2012

NMR-based analysis of aminoglycoside recognition by the resistance enzyme ANT(4'): the pattern of OH/NH3(+) substitution determines the preferred antibiotic binding mode and is critical for drug inactivation.

artículo científico publicado en 2008

Overcoming Aminoglycoside Enzymatic Resistance: Design of Novel Antibiotics and Inhibitors.

artículo científico publicado en 2018

Preparation of activated supports containing low pK amino groups. A new tool for protein immobilization via the carboxyl coupling method

artículo científico publicado en 1993

Reactivation strategies by unfolding/refolding of chymotrypsin derivatives after inactivation by organic solvents

artículo científico publicado en 1997

Regioselective enzymatic hydrolysis of acetylated pyranoses and pyranosides using immobilised lipases. An easy chemoenzymatic synthesis of alpha- and beta-D-glucopyranose acetates bearing a free secondary C-4 hydroxyl group

artículo científico publicado en 2002

Regioselective hydrolysis of peracetylated alpha-D-glycopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis.

artículo científico publicado en 1999

Rescue of the streptomycin antibiotic activity by using streptidine as a "decoy acceptor" for the aminoglycoside-inactivating enzyme adenyl transferase.

artículo científico publicado en 2007

Role of aromatic rings in the molecular recognition of aminoglycoside antibiotics: implications for drug design.

artículo científico publicado en 2010

Role of conserved salt bridges in homeodomain stability and DNA binding

artículo científico publicado en 2009

Selective modification of the 3''-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains

artículo científico publicado en 2016

Structure / Activity Relationship of Carba- and C-Fucopyranosides as Inhibitors of an α 1,6-Fucosyltransferase by Molecular Modeling and Kinetic Studies

Structure-based design of highly crowded ribostamycin/kanamycin hybrids as a new family of antibiotics.

artículo científico publicado en 2010

Studies on the conformational features of neomycin-B and its molecular recognition by RNA and bacterial defense proteins

artículo científico publicado en 2008

Syntheses of pharmaceutical oligosaccharides catalyzed by immobilized-stabilized derivatives of different β-galactosidases

Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition

scientific article published on 02 August 2019

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease

artículo científico publicado en 2011

Synthesis, inhibition properties, and theoretical study of the new nanomolar trehalase inhibitor 1-thiatrehazolin: towards a structural understanding of trehazolin inhibition

artículo científico publicado en 2005

Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics

artículo científico publicado en 2018

The Unusual Nucleotide Recognition Properties of the Resistance Enzyme ANT(4′): Inorganic Tri/Polyphosphate as a Substrate for Aminoglycoside Inactivation

artículo científico publicado en 2010

The pattern of distribution of amino groups modulates the structure and dynamics of natural aminoglycosides: implications for RNA recognition.

artículo científico

Theoretical Studies on Mechanism of Inactivation of Kanamycin A by 4'-O-Nucleotidyltransferase

artículo científico publicado en 2018

Lista de obras de Agatha Bastida

6-O-Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine

A Molecular Modeling Approach to Identify Novel Inhibitors of the Major Facilitator Superfamily of Efflux Pump Transporters

A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer.

A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.

A thorough experimental study of CH/π interactions in water: quantitative structure-stability relationships for carbohydrate/aromatic complexes

Aryl Sulfotransferase from Haliangium ochraceum : A Versatile Tool for the Sulfation of Small Molecules

Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

Biocatalyst engineering exerts a dramatic effect on selectivity of hydrolysis catalyzed by immobilized lipases in aqueous medium

C-terminal truncation of alpha 1,6-fucosyltransferase from Rhizobium sp. does not annul the transferase activity of the enzyme

Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

Effect of immiscible organic solvents on activity/stability of native chymotrypsin and immobilized-stabilized derivatives

Enzymes in the synthesis of bioactive compounds: the prodigious decades

Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance

Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders.

From kinase to cyclase: an unusual example of catalytic promiscuity modulated by metal switching

Fully Dispersed and Covalently Attached Chymotrypsin Derivatives as Industrial Catalysts in Biphasic Systems

Immobilization-stabilization of α-chymotrypsin by covalent attachment to aldehyde-agarose gels

In Vivo Chaperone-Assisted Folding of α-1,6-Fucosyltransferase from Rhizobium sp

Inhibition-Disruption of Candida glabrata Biofilms: Symmetrical Selenoesters as Potential Anti-Biofilm Agents

Microfluidic Reactors Based on Rechargeable Catalytic Porous Supports: Heterogeneous Enzymatic Catalysis via Reversible Host-Guest Interactions

Modulating weak interactions for molecular recognition: a dynamic combinatorial analysis for assessing the contribution of electrostatics to the stability of CH-π bonds in water

Modulation of lipase properties in macro-aqueous systems by controlled enzyme immobilization: enantioselective hydrolysis of a chiral ester by immobilized Pseudomonas lipase

Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase

Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex

NMR-based analysis of aminoglycoside recognition by the resistance enzyme ANT(4'): the pattern of OH/NH3(+) substitution determines the preferred antibiotic binding mode and is critical for drug inactivation.

Overcoming Aminoglycoside Enzymatic Resistance: Design of Novel Antibiotics and Inhibitors.

Preparation of activated supports containing low pK amino groups. A new tool for protein immobilization via the carboxyl coupling method

Reactivation strategies by unfolding/refolding of chymotrypsin derivatives after inactivation by organic solvents

Regioselective enzymatic hydrolysis of acetylated pyranoses and pyranosides using immobilised lipases. An easy chemoenzymatic synthesis of alpha- and beta-D-glucopyranose acetates bearing a free secondary C-4 hydroxyl group

Regioselective hydrolysis of peracetylated alpha-D-glycopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis.

Rescue of the streptomycin antibiotic activity by using streptidine as a "decoy acceptor" for the aminoglycoside-inactivating enzyme adenyl transferase.

Role of aromatic rings in the molecular recognition of aminoglycoside antibiotics: implications for drug design.

Role of conserved salt bridges in homeodomain stability and DNA binding

Selective modification of the 3''-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains

Structure / Activity Relationship of Carba- and C-Fucopyranosides as Inhibitors of an α 1,6-Fucosyltransferase by Molecular Modeling and Kinetic Studies

Structure-based design of highly crowded ribostamycin/kanamycin hybrids as a new family of antibiotics.

Studies on the conformational features of neomycin-B and its molecular recognition by RNA and bacterial defense proteins

Syntheses of pharmaceutical oligosaccharides catalyzed by immobilized-stabilized derivatives of different β-galactosidases

Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease

Synthesis, inhibition properties, and theoretical study of the new nanomolar trehalase inhibitor 1-thiatrehazolin: towards a structural understanding of trehazolin inhibition

Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics

The Unusual Nucleotide Recognition Properties of the Resistance Enzyme ANT(4′): Inorganic Tri/Polyphosphate as a Substrate for Aminoglycoside Inactivation

The pattern of distribution of amino groups modulates the structure and dynamics of natural aminoglycosides: implications for RNA recognition.

Theoretical Studies on Mechanism of Inactivation of Kanamycin A by 4'-O-Nucleotidyltransferase