Lista de obras - Yuemao Shen - Dominio Público Uruguay

17-ABAG, a novel geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition

artículo científico publicado en 2015

17-DMCHAG, a new geldanamycin derivative, inhibits prostate cancer cells through Hsp90 inhibition and survivin downregulation

artículo científico publicado en 2015

3-Acetonyl-3-hydroxyoxindole: a new inducer of systemic acquired resistance in plants.

artículo científico publicado en 2008

4-Hydroxybenzoic acid is a diffusible factor that connects metabolic shikimate pathway to the biosynthesis of a unique antifungal metabolite in Lysobacter enzymogenes

artículo científico publicado en 2017

8-Deoxy-Rifamycin Derivatives from Amycolatopsis mediterranei S699 ΔrifT Strain

artículo científico publicado en 2020

A Single-Component Flavoenzyme Catalyzed Regioselective Halogenation of Pyrone in the Biosynthesis of Venemycins

scientific article published on 04 December 2019

A new cyclic peptide from the marine fungal strain Aspergillus sp. AF119

scientific article published on 13 December 2011

A new dihydroisocoumarin from the strain Aspergillus sp. CMM, an endophytic fungus of Cephalotaxus mannii

artículo científico publicado en 2008

A new macrolide antibiotic with antitumor activity produced by Streptomyces sp. CS, a commensal microbe of Maytenus hookeri ⬇️

artículo científico publicado en 2003

A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum.

artículo científico publicado en 2004

A novel p-terphenyl derivative inducing cell-cycle arrest and apoptosis in MDA-MB-435 cells through topoisomerase inhibition.

artículo científico publicado en 2013

Activation of a Cryptic Gene Cluster in Lysobacter enzymogenes Reveals a Module/Domain Portable Mechanism of Nonribosomal Peptide Synthetases in the Biosynthesis of Pyrrolopyrazines. ⬇️

artículo científico publicado en 2017

Alteramide B is a microtubule antagonist of inhibiting Candida albicans

artículo científico publicado en 2016

Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA.

artículo científico publicado en 2017

Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.

artículo científico publicado en 2008

Anti-Angiogenic Therapy: Strategies to Develop Potent VEGFR-2 Tyrosine Kinase Inhibitors and Future Prospect.

artículo científico publicado en 2016

Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

article

Bioactive natural products from Lysobacter.

artículo científico publicado en 2012

Biosynthesis of 3,5-AHBA-derived natural products.

artículo científico publicado en 2011

Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes

artículo científico publicado en 2010

Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes.

artículo científico publicado en 2013

CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles

artículo científico publicado en 2014

Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy

artículo científico publicado en 2020

Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification.

artículo científico publicado en 2017

Chemical Constituents of the Endophytic Fungal StrainPhomopsis sp. NXZ-05 ofCamptotheca acuminata

artículo científico publicado en 2007

Chemical and genetic diversity of Ligularia vellerea in Yunnan, China

artículo científico publicado en 2008

Chemical constitutes from endophytic Streptomyces sp. W5 isolated from Trewia nudiflora L. ⬇️

scientific article published on 24 March 2010

Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.

artículo científico publicado en 2011

Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum

artículo científico publicado en 2015

Correction: Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation

artículo científico publicado en 2019

Cytosporone B is an agonist for nuclear orphan receptor Nur77.

artículo científico publicado en 2008

Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium

artículo científico publicado en 2013

Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818.

artículo científico publicado en 2017

Deacetylmycoepoxydiene is an agonist of Rac1, and simultaneously induces autophagy and apoptosis.

artículo científico publicado en 2018

Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents.

artículo científico publicado en 2015

Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents

artículo científico publicado en 2014

Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors.

artículo científico publicado en 2016

Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.

artículo científico publicado en 2014

Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors

artículo científico publicado en 2017

Direct Regulation of Extracellular Chitinase Production by the Transcription Factor LeClp in Lysobacter enzymogenes OH11.

artículo científico publicado en 2016

Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches

artículo científico publicado en 2018

Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors

artículo científico publicado en 2014

Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors

artículo científico publicado en 2014

Diversities within genotypes, bioactivity and biosynthetic genes of endophytic actinomycetes isolated from three pharmaceutical plants.

artículo científico publicado en 2009

Diversity of Polyketide Chains Achieved by Deleting the Tailoring Genes in the Biosynthesis of Ansatrienins

artículo científico publicado en 2017

Enhanced Heterologous Spinosad Production from a 79-kb Synthetic Multioperon Assembly

scientific article published on 09 January 2019

Expression of the Clifednamide Biosynthetic Pathway in Streptomyces Generates 27,28-seco-Derivatives

scientific article published on 11 September 2020

Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF

artículo científico publicado en 2013

Five unusual natural carbohydrates from Actinosynnema pretiosum

scientific article published on 19 December 2008

Fusaric acid modulates Type Three Secretion System of Salmonella enterica serovar Typhimurium

artículo científico publicado en 2014

Gambogic acid activates AMP-activated protein kinase in mammalian cells

artículo científico publicado en 2012

Guanacastane-type diterpenoids from Coprinus plicatilis

artículo científico publicado en 2013

Guanacastane-type diterpenoids with cytotoxic activity from Coprinus plicatilis

artículo científico publicado en 2012

HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis

artículo científico publicado en 2016

Heterocyclic Aromatic N-Oxidation in the Biosynthesis of Phenazine Antibiotics from Lysobacter antibioticus.

artículo científico publicado en 2016

Heterologous Expression Guides Identification of the Biosynthetic Gene Cluster of Chuangxinmycin, an Indole Alkaloid Antibiotic.

artículo científico publicado en 2018

Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029.

artículo científico publicado en 2017

High diversity of Ligularia dictyoneura in chemical composition and DNA sequence

artículo científico publicado en 2007

Identification and Characterization of the Anti-Methicillin-Resistant Staphylococcus aureus WAP-8294A2 Biosynthetic Gene Cluster from Lysobacter enzymogenes OH11 ⬇️

artículo científico publicado el 19 de septiembre de 2011

Identification and characterization of the cuevaene A biosynthetic gene cluster in streptomyces sp. LZ35.

artículo científico publicado en 2013

Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22

scientific article published on 12 April 2019

Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B

scientific article published on 13 October 2020

Identification of the Bacterial Maytansinoid Gene Cluster asc Provides Insights into the Post-PKS Modifications of Ansacarbamitocin Biosynthesis

scientific article published on 12 July 2019

Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.

artículo científico publicado en 2005

Inhibitory effects of Mycoepoxydiene on macrophage foam cell formation and atherosclerosis in ApoE-deficient mice

artículo científico publicado en 2015

Introduction of the AAL-toxin polyketide synthase gene ALT1 into FUM1-disrupted Fusarium verticillioides produces metabolites with the fumonisin methylation pattern.

artículo científico publicado en 2009

Isoflavone diglycosides from Glycosmis pentaphylla

artículo científico publicado en 2006

Isolation of 11,12- seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain

scientific article published on 04 February 2019

Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF.

artículo científico publicado en 2014

Juanlimycins A and B, Ansamycin Macrodilactams from Streptomyces sp.

artículo científico publicado en 2014

Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium

artículo científico publicado en 2016

Ligustrazine derivatives. Part 6: design, synthesis and evaluation of novel ligustrazinyl acylguanidine derivatives as potential cardiovascular agents

artículo científico publicado en 2012

Ligustrazine derivatives. Part 8: design, synthesis, and preliminary biological evaluation of novel Ligustrazinyl amides as cardiovascular agents

artículo científico publicado en 2014

Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the suppression of TRAF6 polyubiquitination [corrected]

artículo científico publicado en 2012

Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice

artículo científico publicado en 2012

Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways.

artículo científico publicado en 2012

Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.

artículo científico publicado en 2010

Nam7 Hydroxylase Is Responsible for the Formation of the Naphthalenic Ring in the Biosynthesis of Neoansamycins.

artículo científico publicado en 2017

New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066. ⬇️

artículo científico publicado en 2017

OX4 Is an NADPH-Dependent Dehydrogenase Catalyzing an Extended Michael Addition Reaction To Form the Six-Membered Ring in the Antifungal HSAF

scientific article published on 03 May 2019

Optimization of genome shuffling for high-yield production of the antitumor deacetylmycoepoxydiene in an endophytic fungus of mangrove plants

artículo científico publicado en 2016

PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization.

artículo científico publicado en 2018

Para-aminobenzoic acid (PABA) synthase enhances thermotolerance of mushroom Agaricus bisporus

artículo científico publicado en 2014

Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp. A123

artículo científico publicado en 2014

Phytotoxic Metabolites Isolated from Aspergillus sp., an Endophytic Fungus of Crassula arborescens ⬇️

Protoplast mutation and genome shuffling induce the endophytic fungus Tubercularia sp. TF5 to produce new compounds

artículo científico publicado en 2010

Recent advances in the boric acid/boronate-based fluorescent probes for detection of hydrogen peroxide

Secondary metabolites of Tubercularia sp. TF5, an endophytic fungal strain of Taxus mairei

artículo científico publicado en 2009

Secondary metabolites ofPyrenochaetasp. B36, an endophytic fungus fromAnnona squamosaL.

artículo científico publicado en 2011

Species diversity, distribution, and genetic structure of endophytic and epiphytic Trichoderma associated with banana roots

artículo científico publicado en 2010

Structural basis of GPBAR activation and bile acid recognition

artículo científico publicado en 2020

Synthesis of aryl-substituted naphthalenoids as potent topoisomerase inhibitors

artículo científico publicado en 2014

Synthesis, biological evaluation and modeling studies of terphenyl topoisomerase IIα inhibitors as anticancer agents

artículo científico publicado en 2015

Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A-E

artículo científico publicado en 2018

Targeted Discovery of Pentaketide Ansamycin Aminoansamycins A-G

scientific article published on 16 September 2019

Targeted Discovery of the Polyene Macrolide Hexacosalactone A from Streptomyces by Reporter-Guided Selection of Fermentation Media

artículo científico publicado en 2021

The HSP90 inhibitor 17-PAG effectively inhibits the proliferation and migration of androgen-independent prostate cancer cells

artículo científico publicado en 2015

The chemistry and biochemistry of Spiraea japonica complex.

artículo científico publicado en 2003

The small molecule CS1 inhibits mitosis and sister chromatid resolution in HeLa cells

artículo científico publicado en 2018

Three new antimicrobial metabolites of Phomopsis sp. ⬇️

artículo científico publicado en 2008

Tricarballylic ester formation during biosynthesis of fumonisin mycotoxins in Fusarium verticillioides

artículo científico publicado en 2013

Two 18-membered epothilones from Sorangium cellulosum So0157-2 ⬇️

artículo científico publicado en 2010

Two New Acorane-Type Sesquiterpenoids from Aschersonia sp. D20, an Endophytic Fungus of Annona squamosa

scientific article published on 05 October 2015

Unusual activities of the thioesterase domain for the biosynthesis of the polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes C3.

artículo científico publicado en 2011

Unusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics

artículo científico publicado en 2017

p-Terphenyl O-β-glucuronides, DNA topoisomerase inhibitors from Streptomyces sp. LZ35ΔgdmAI.

artículo científico publicado en 2014

Lista de obras de Yuemao Shen

17-ABAG, a novel geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition

17-DMCHAG, a new geldanamycin derivative, inhibits prostate cancer cells through Hsp90 inhibition and survivin downregulation

3-Acetonyl-3-hydroxyoxindole: a new inducer of systemic acquired resistance in plants.

4-Hydroxybenzoic acid is a diffusible factor that connects metabolic shikimate pathway to the biosynthesis of a unique antifungal metabolite in Lysobacter enzymogenes

8-Deoxy-Rifamycin Derivatives from Amycolatopsis mediterranei S699 ΔrifT Strain

A Single-Component Flavoenzyme Catalyzed Regioselective Halogenation of Pyrone in the Biosynthesis of Venemycins

A new cyclic peptide from the marine fungal strain Aspergillus sp. AF119

A new dihydroisocoumarin from the strain Aspergillus sp. CMM, an endophytic fungus of Cephalotaxus mannii

A new macrolide antibiotic with antitumor activity produced by Streptomyces sp. CS, a commensal microbe of Maytenus hookeri ⬇️

A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum.

A novel p-terphenyl derivative inducing cell-cycle arrest and apoptosis in MDA-MB-435 cells through topoisomerase inhibition.

Activation of a Cryptic Gene Cluster in Lysobacter enzymogenes Reveals a Module/Domain Portable Mechanism of Nonribosomal Peptide Synthetases in the Biosynthesis of Pyrrolopyrazines. ⬇️

Alteramide B is a microtubule antagonist of inhibiting Candida albicans

Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA.

Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.

Anti-Angiogenic Therapy: Strategies to Develop Potent VEGFR-2 Tyrosine Kinase Inhibitors and Future Prospect.

Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Bioactive natural products from Lysobacter.

Biosynthesis of 3,5-AHBA-derived natural products.

Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes

Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes.

CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles

Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy

Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification.

Chemical Constituents of the Endophytic Fungal StrainPhomopsis sp. NXZ-05 ofCamptotheca acuminata

Chemical and genetic diversity of Ligularia vellerea in Yunnan, China

Chemical constitutes from endophytic Streptomyces sp. W5 isolated from Trewia nudiflora L. ⬇️

Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.

Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum

Correction: Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation

Cytosporone B is an agonist for nuclear orphan receptor Nur77.

Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium

Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818.

Deacetylmycoepoxydiene is an agonist of Rac1, and simultaneously induces autophagy and apoptosis.

Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents.

Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents

Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors.

Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.

Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors

Direct Regulation of Extracellular Chitinase Production by the Transcription Factor LeClp in Lysobacter enzymogenes OH11.

Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches

Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors

Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors

Diversities within genotypes, bioactivity and biosynthetic genes of endophytic actinomycetes isolated from three pharmaceutical plants.

Diversity of Polyketide Chains Achieved by Deleting the Tailoring Genes in the Biosynthesis of Ansatrienins

Enhanced Heterologous Spinosad Production from a 79-kb Synthetic Multioperon Assembly

Expression of the Clifednamide Biosynthetic Pathway in Streptomyces Generates 27,28-seco-Derivatives

Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF

Five unusual natural carbohydrates from Actinosynnema pretiosum

Fusaric acid modulates Type Three Secretion System of Salmonella enterica serovar Typhimurium

Gambogic acid activates AMP-activated protein kinase in mammalian cells

Guanacastane-type diterpenoids from Coprinus plicatilis

Guanacastane-type diterpenoids with cytotoxic activity from Coprinus plicatilis

HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis

Heterocyclic Aromatic N-Oxidation in the Biosynthesis of Phenazine Antibiotics from Lysobacter antibioticus.

Heterologous Expression Guides Identification of the Biosynthetic Gene Cluster of Chuangxinmycin, an Indole Alkaloid Antibiotic.

Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029.

High diversity of Ligularia dictyoneura in chemical composition and DNA sequence

Identification and Characterization of the Anti-Methicillin-Resistant Staphylococcus aureus WAP-8294A2 Biosynthetic Gene Cluster from Lysobacter enzymogenes OH11 ⬇️

Identification and characterization of the cuevaene A biosynthetic gene cluster in streptomyces sp. LZ35.

Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22

Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B

Identification of the Bacterial Maytansinoid Gene Cluster asc Provides Insights into the Post-PKS Modifications of Ansacarbamitocin Biosynthesis

Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.

Inhibitory effects of Mycoepoxydiene on macrophage foam cell formation and atherosclerosis in ApoE-deficient mice

Introduction of the AAL-toxin polyketide synthase gene ALT1 into FUM1-disrupted Fusarium verticillioides produces metabolites with the fumonisin methylation pattern.

Isoflavone diglycosides from Glycosmis pentaphylla

Isolation of 11,12- seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain

Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF.

Juanlimycins A and B, Ansamycin Macrodilactams from Streptomyces sp.

Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium

Ligustrazine derivatives. Part 6: design, synthesis and evaluation of novel ligustrazinyl acylguanidine derivatives as potential cardiovascular agents

Ligustrazine derivatives. Part 8: design, synthesis, and preliminary biological evaluation of novel Ligustrazinyl amides as cardiovascular agents

Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the suppression of TRAF6 polyubiquitination [corrected]

Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice

Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways.

Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.

Nam7 Hydroxylase Is Responsible for the Formation of the Naphthalenic Ring in the Biosynthesis of Neoansamycins.

New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066. ⬇️