Lista de obras - Timothy D Warner - Dominio Público Uruguay

4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor

artículo científico publicado en 2010

96-well plate-based aggregometry.

artículo científico publicado en 2018

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect

scientific article published on 16 December 2020

Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis

artículo científico publicado en 2006

Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth.

artículo científico publicado en 2005

Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy

Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy

artículo científico publicado en 2011

Antiplatelet actions of statins and fibrates are mediated by PPARs

artículo científico publicado en 2009

Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel.

artículo científico publicado en 2011

Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2.

artículo científico publicado en 2008

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2

scholarly article by Serena Lucotti et al published 25 March 2019 in Journal of Clinical Investigation

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

artículo científico publicado en 2016

Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test

artículo científico publicado en 2013

Association of MicroRNAs and YRNAs With Platelet Function

artículo científico publicado en 2015

Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide

scientific article published on 03 September 2013

COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs

artículo científico publicado en 2006

COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

artículo científico publicado en 2008

COX-2 in cardiovascular disease

artículo científico publicado en 2006

COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks

artículo científico publicado en 2014

COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs

scientific article published on January 2008

Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox

scientific article published on 12 September 2019

Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.

artículo científico publicado en 2005

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay

artículo científico publicado en 2014

Circulating microRNAs as novel biomarkers for platelet activation.

artículo científico publicado en 2013

Clopidogrel withdrawal: is there a "rebound" phenomenon?

artículo científico publicado en 2010

Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy

scientific article published on 11 April 2020

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α

artículo científico publicado en 2014

Cyclo-oxygenase-2 inhibitors and cardiovascular events

artículo científico publicado en 2002

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

artículo científico publicado en 2012

Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension

artículo científico publicado en 2002

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?

artículo científico publicado en 2002

Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues

artículo científico publicado en 2004

Cyclooxygenases and the cardiovascular system

artículo científico publicado en 2020

Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic

artículo científico publicado en 2004

Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies

artículo científico publicado en 2013

Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy.

artículo científico publicado en 2015

Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists?

artículo científico publicado en 2010

Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study

artículo científico publicado en 2011

Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery.

artículo científico publicado en 2002

Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

artículo científico publicado en 2015

Effects of low-dose aspirin on acute inflammatory responses in humans.

artículo científico publicado en 2009

Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.

artículo científico publicado en 2002

Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond)

scientific article published on 19 April 2018

Endogenous epoxygenases are modulators of monocyte/macrophage activity

artículo científico publicado en 2011

Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis

artículo científico publicado en 2002

Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers

artículo científico publicado en 2012

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

artículo científico publicado en 2014

Expression and activation of the farnesoid X receptor in the vasculature

scholarly article

Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function.

artículo científico publicado en 2015

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets

artículo científico publicado en 2017

Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

artículo científico publicado en 2007

Gases help fuel the vascular debate

artículo científico publicado en 2008

Gasotransmitters and platelets

artículo científico publicado en 2011

HIF, stretching to get control of VEGF

scientific article published on 01 October 2003

Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods.

artículo científico publicado en 2009

High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition

artículo científico publicado en 2013

Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage

artículo científico publicado en 2019

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

artículo científico publicado en 2016

Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia

artículo científico publicado en 2013

Hypoxia Modulates Platelet Purinergic Signalling Pathways

scientific article published on 13 December 2019

Identification and characterization of a dysfunctional cardiac myocyte phenotype: role of bacteria, Toll-like receptors, and endothelin.

artículo científico publicado en 2007

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

artículo científico publicado en 2020

In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation ⬇️

artículo científico publicado el 1 de marzo de 2011

Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma.

artículo científico publicado en 2006

Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2

artículo científico publicado en 2006

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

artículo científico publicado en 2015

Inhibition of profibrotic microRNA-21 affects platelets and their releasate

artículo científico publicado en 2018

Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27.

artículo científico publicado en 2009

Interleukin-1beta, but not interleukin-6, enhances renal and systemic endothelin production in vivo

artículo científico publicado en 2008

Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy

artículo científico publicado en 2002

Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

artículo científico publicado en 2018

LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression

artículo científico publicado en 2013

Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment"

scientific article published on 01 May 2018

Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients

artículo científico publicado en 2020

Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis

artículo científico publicado en 2002

Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity

artículo científico publicado en 2021

Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies.

artículo científico publicado en 2017

Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets

artículo científico publicado en 2007

Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: as easy as ABC?

artículo científico publicado en 2003

Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry

article

Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction

artículo científico publicado en 2015

Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages.

artículo científico publicado en 2010

Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing

artículo científico publicado en 2011

Origins of prostaglandin E2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems

artículo científico publicado en 2002

P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation

artículo científico publicado en 2015

PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist

artículo científico publicado en 2003

PPARβ/δ Agonists Modulate Platelet Function via a Mechanism Involving PPAR Receptors and Specific Association/Repression of PKCα–Brief Report

artículo científico publicado en 2009

Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age

artículo científico publicado en 2020

Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties.

artículo científico publicado en 2017

Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels.

artículo científico publicado en 2018

Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

artículo científico publicado en 2011

Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin

artículo científico publicado en 2020

Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography

artículo científico publicado en 2015

Prostaglandins and the regulation of tumor growth.

artículo científico publicado en 2002

Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach

artículo científico publicado en 2015

Rapid and accurate method for the von Willebrand factor ristocetin cofactor assay using 96-well microtiter plates.

artículo científico publicado en 2009

Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy.

artículo científico publicado en 2009

Reply to Ricciotti et al.: Evidence for vascular COX isoforms

artículo científico publicado en 2013

Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs"

artículo científico publicado en 2015

Role for Nuclear Factor-κB and Signal Transducer and Activator of Transcription 1/Interferon Regulatory Factor-1 in Cytokine-Induced Endothelin-1 Release in Human Vascular Smooth Muscle Cells ⬇️

artículo científico publicado el 1 de octubre de 2003

Role of Shear Stress in Endothelial Cell Morphology and Expression of Cyclooxygenase Isoforms

artículo científico publicado en 2010

Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle

artículo científico publicado en 2005

Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta

artículo científico publicado en 2005

Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts

artículo científico publicado en 2005

Short thromboelastography and the identification of high platelet reactivity while on and off therapy

artículo científico publicado en 2012

Smoking, atherothrombosis and clopidogrel

scientific article published on 01 July 2012

Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings ⬇️

artículo científico publicado el 2 de agosto de 2011

Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events

scientific article published on 01 December 2006

The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo

artículo científico publicado en 2009

The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression

artículo científico publicado en 2006

The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells

artículo científico publicado en 2006

The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy.

artículo científico publicado en 2016

Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse

artículo científico publicado en 2011

Trapping of palindromic ligands within native transthyretin prevents amyloid formation

artículo científico publicado en 2010

Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness

artículo científico publicado en 2009

Lista de obras de Timothy D Warner

4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor

96-well plate-based aggregometry.

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect

Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis

Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth.

Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy

Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy

Antiplatelet actions of statins and fibrates are mediated by PPARs

Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel.

Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2.

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test

Association of MicroRNAs and YRNAs With Platelet Function

Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide

COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs

COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

COX-2 in cardiovascular disease

COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks

COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs

Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox

Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay

Circulating microRNAs as novel biomarkers for platelet activation.

Clopidogrel withdrawal: is there a "rebound" phenomenon?

Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α

Cyclo-oxygenase-2 inhibitors and cardiovascular events

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?

Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues

Cyclooxygenases and the cardiovascular system

Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic

Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies

Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy.

Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists?

Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study

Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery.

Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

Effects of low-dose aspirin on acute inflammatory responses in humans.

Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.

Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond)

Endogenous epoxygenases are modulators of monocyte/macrophage activity

Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis

Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

Expression and activation of the farnesoid X receptor in the vasculature

Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function.

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets

Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

Gases help fuel the vascular debate

Gasotransmitters and platelets

HIF, stretching to get control of VEGF

Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods.

High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition

Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia

Hypoxia Modulates Platelet Purinergic Signalling Pathways

Identification and characterization of a dysfunctional cardiac myocyte phenotype: role of bacteria, Toll-like receptors, and endothelin.

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation ⬇️

Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma.

Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Inhibition of profibrotic microRNA-21 affects platelets and their releasate

Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27.

Interleukin-1beta, but not interleukin-6, enhances renal and systemic endothelin production in vivo

Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy

Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression

Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment"

Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients

Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis

Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity

Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies.

Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets

Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: as easy as ABC?