Lista de obras - Hideaki Kakeya - Dominio Público Uruguay

5-Alkyl-1,2,3,4-tetrahydroquinolines, new membrane-interacting lipophilic metabolites produced by combined culture of Streptomyces nigrescens and Tsukamurella pulmonis.

artículo científico publicado en 2015

A 7-dimethylallyl tryptophan synthase from a fungal Neosartorya sp.: biochemical characterization and structural insight into the regioselective prenylation

artículo científico publicado en 2014

A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level

artículo científico publicado en 2017

A Competitive Enzyme-Linked Immunosorbent Assay System for Adenylation Domains in Nonribosomal Peptide Synthetases

artículo científico publicado en 2016

A Facile and Effective Screening Method for p21WAF1 Promoter Activators from Microbial Metabolites ⬇️

artículo científico publicado el 1 de octubre de 2001

A Multiple-Labeling Strategy for Nonribosomal Peptide Synthetases Using Active-Site-Directed Proteomic Probes for Adenylation Domains

artículo científico publicado en 2015

A bridge between chemistry and biology

artículo científico publicado en 2006

A chemical proteomic probe for detecting native carrier protein motifs in nonribosomal peptide synthetases

artículo científico publicado en 2016

A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.

artículo científico publicado en 2012

A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.

artículo científico publicado en 2002

Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains

artículo científico publicado en 2015

Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis

artículo científico publicado en 2000

Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.

artículo científico publicado en 2015

Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases

artículo científico publicado en 2019

Affinity Purification Method for the Identification of Nonribosomal Peptide Biosynthetic Enzymes Using a Synthetic Probe for Adenylation Domains

artículo científico publicado en 2016

Amycolapeptins A and B, Cyclic Nonadepsipeptides Produced by Combined Culture of <i>Amycolatopsis</i> sp. and <i>Tsukamurella pulmonis</i>

artículo científico publicado en 2021

An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes.

artículo científico publicado en 2019

Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells

artículo científico publicado en 2013

Asymmetric Total Synthesis of Heronamides A-C: Stereochemical Confirmation and Impact of Long-Range Stereochemical Communication on the Biological Activity

artículo científico publicado en 2016

Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor

artículo científico publicado en 2002

Asymmetric total synthesis of pseurotin A

artículo científico publicado en 2003

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

artículo científico publicado en 2008

Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp

scientific article published on 01 August 2002

Balance between Exocytosis and Endocytosis Determines the Efficacy of Sterol-Targeting Antibiotics

scholarly article by Shinichi Nishimura published in December 2014

Biosynthetic origins of the epoxyquinone skeleton in epoxyquinols A and B

artículo científico publicado en 2014

Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.

artículo científico publicado en 2002

Chemical Interactions of Cryptic Actinomycete Metabolite 5-Alkyl-1,2,3,4-tetrahydroquinolines through Aggregate Formation

scientific article published on 07 August 2019

Chemical tagging of a drug target using 5-sulfonyl tetrazole.

artículo científico publicado en 2013

Chlorocatechelins A and B from Streptomyces sp.: new siderophores containing chlorinated catecholate groups and an acylguanidine structure

artículo científico publicado en 2014

Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A.

artículo científico publicado en 2006

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

artículo científico publicado en 2006

Cryptic Chemical Communication: Secondary Metabolic Responses Revealed by Microbial Co-culture

scientific article published on 20 January 2020

Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

artículo científico publicado en 2018

Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo

artículo científico publicado en 2020

Cytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp

artículo científico publicado en 1999

Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors.

artículo científico publicado en 2015

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells

artículo científico publicado en 2005

Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008

scientific article published on 05 December 2018

Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines

scientific article published on 06 January 2020

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis.

artículo científico publicado en 2016

Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare ActinomyceteSaccharothrixsp. A1506

artículo científico publicado en 2018

Drinkable preparation of Theracurmin exhibits high absorption efficiency--a single-dose, double-blind, 4-way crossover study

artículo científico publicado en 2013

Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus

artículo científico publicado en 2019

Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives.

artículo científico publicado en 2006

Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene).

artículo científico publicado en 2016

Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

artículo científico publicado en 2019

Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity

artículo científico publicado en 2005

Epolactaene, a Novel Neuritogenic Compound in Human Neuroblastoma Cells, Produced by a Marine Fungus ⬇️

artículo científico publicado el 1 de julio de 1995

Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex.

artículo científico publicado en 2003

Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.

artículo científico publicado en 2002

Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

artículo científico publicado en 2008

Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.

artículo científico publicado en 2005

Erratum to: The Inhibitory Effects of Crucumin Glucuronide on p300-HAT Activity and Hypertrophic Phenylephrine-Induced Responses in Cardiomyocytes

article

Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.

artículo científico publicado en 2015

First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry

artículo científico publicado en 2005

Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.

artículo científico publicado en 2006

Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling

artículo científico publicado en 2015

Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation

artículo científico publicado en 2008

Highly Sensitive Labeling Reagents for Scarce Natural Products

scientific article published on 31 August 2020

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD

artículo científico publicado en 2016

Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.

artículo científico publicado en 2009

Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines

scientific article published on 01 February 2019

In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line.

artículo científico publicado en 2016

In Vivo Linking of Membrane Lipids and the Anion Transporter Band 3 with Thiourea-modified Amphiphilic Lipid Probes

artículo científico publicado en 2015

Inhibition of translation by cytotrienin A--a member of the ansamycin family

artículo científico publicado en 2010

Innovative preparation of curcumin for improved oral bioavailability.

artículo científico publicado en 2011

Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance

artículo científico publicado en 2013

Isolation and Structure Elucidation of Cytotoxic Saccharothriolides D to F from a Rare Actinomycete Saccharothrix sp. and Their Structure-Activity Relationship.

artículo científico publicado en 2016

Isolation of a novel substrate-competitive tyrosine kinase inhibitor, desmal, from the plant Desmos chinensis. ⬇️

artículo científico publicado en 1993

Isolation, Structure Elucidation, and Conformational Regulation of Myropeptins, Lipopeptides from the Fungus Myrothecium roridum

scientific article published on 09 September 2019

Isolation, Structure Elucidation, and Total Synthesis of Tryptopeptins A and B, New TGF-β Signaling Modulators from Streptomyces sp

artículo científico publicado en 2015

LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

artículo científico publicado en 2016

Longicatenamides A–D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596

artículo científico publicado en 2021

Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling

artículo científico

Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores

artículo científico publicado en 2016

Methylation deficiency disrupts biological rhythms from bacteria to humans

scientific article published on 06 May 2020

Multiple NF‐Y‐binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor‐associated gene ⬇️

artículo científico publicado el 26 de septiembre de 2011

Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification

artículo científico publicado en 2016

Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors

artículo científico publicado en 1997

Novel mammalian cell cycle inhibitors, cyclotroprostatins A–D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase

Novel non-peptide inhibitors targeting death receptor-Mediated apoptosis ⬇️

artículo científico publicado el 3 de noviembre de 2003

Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells

artículo científico publicado en 2002

Optimal dose-setting study of curcumin for improvement of left ventricular systolic function after myocardial infarction in rats

scientific article published on 19 November 2014

Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506

artículo científico publicado en 2016

Prediction and determination of the stereochemistry of the 1,3,5-trimethyl-substituted alkyl chain in verucopeptin, a microbial metabolite.

artículo científico publicado en 2014

Profiling Nonribosomal Peptide Synthetase Activities Using Chemical Proteomic Probes for Adenylation Domains

artículo científico publicado en 2015

Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans

artículo científico publicado en 2020

RK-95113, a New Angiogenesis Inhibitor Produced by Aspergillus fumigatus ⬇️

artículo científico publicado en 2006

RKS-1778, a new mammalian cell-cycle inhibitor and a key intermediate of the [11]cytochalasin group

artículo científico publicado en 1997

RNA-methylation-dependent RNA processing controls the speed of the circadian clock

scientific journal article

RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

artículo científico publicado en 2015

Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis

artículo científico publicado en 1999

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. ⬇️

artículo científico publicado en 2015

Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast

scientific article published on 20 April 2020

Specific enrichment of nonribosomal peptide synthetase module by an affinity probe for adenylation domains.

artículo científico publicado en 2013

Stereochemical Assignment and Biological Evaluation of BE-14106 Unveils the Importance of One Acetate Unit for the Antifungal Activity of Polyene Macrolactams.

artículo científico publicado en 2016

Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by (1)H NMR.

artículo científico publicado en 2016

Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete.

artículo científico publicado en 2015

Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes

artículo científico publicado en 2014

Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.

artículo científico publicado en 2004

Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage.

artículo científico publicado en 2006

Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein

artículo científico publicado en 2008

Synthesis of chemically stabilized phosmidosine analogues and the structure--activity relationship of phosmidosine.

artículo científico publicado en 2004

The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice

scientific article published on 28 April 2020

The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug

artículo científico publicado en 2008

Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol

artículo científico publicado en 2018

Thioamycolamides A-E, Sulfur-Containing Cycliclipopeptides Produced by the Rare Actinomycete Amycolatopsis sp

scientific article published on 02 April 2020

Total Synthesis and Antimicrobial Activity of Chlorocatechelin A

scientific article published on 05 June 2015

Total Synthesis and Antimicrobial Activity of Tumescenamide C and Its Derivatives

scientific article published on 26 February 2020

Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product

artículo científico publicado en 2009

Total synthesis of thioamycolamide A via a biomimetic route

scientific article published on 08 October 2020

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

artículo científico publicado en 2019

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

artículo científico publicado en 2015

Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models

artículo científico publicado en 2019

Visualization of sterol-rich membrane domains with fluorescently-labeled theonellamides

artículo científico publicado en 2013

Visualizing the Adenylation Activities and Protein-Protein Interactions of Aryl Acid Adenylating Enzymes

artículo científico publicado en 2017

pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols

artículo científico publicado en 2013

Lista de obras de Hideaki Kakeya

5-Alkyl-1,2,3,4-tetrahydroquinolines, new membrane-interacting lipophilic metabolites produced by combined culture of Streptomyces nigrescens and Tsukamurella pulmonis.

A 7-dimethylallyl tryptophan synthase from a fungal Neosartorya sp.: biochemical characterization and structural insight into the regioselective prenylation

A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level

A Competitive Enzyme-Linked Immunosorbent Assay System for Adenylation Domains in Nonribosomal Peptide Synthetases

A Facile and Effective Screening Method for p21WAF1 Promoter Activators from Microbial Metabolites ⬇️

A Multiple-Labeling Strategy for Nonribosomal Peptide Synthetases Using Active-Site-Directed Proteomic Probes for Adenylation Domains

A bridge between chemistry and biology

A chemical proteomic probe for detecting native carrier protein motifs in nonribosomal peptide synthetases

A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.

A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.

Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains

Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis

Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.

Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases

Affinity Purification Method for the Identification of Nonribosomal Peptide Biosynthetic Enzymes Using a Synthetic Probe for Adenylation Domains

Amycolapeptins A and B, Cyclic Nonadepsipeptides Produced by Combined Culture of <i>Amycolatopsis</i> sp. and <i>Tsukamurella pulmonis</i>

An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes.

Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells

Asymmetric Total Synthesis of Heronamides A-C: Stereochemical Confirmation and Impact of Long-Range Stereochemical Communication on the Biological Activity

Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor

Asymmetric total synthesis of pseurotin A

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp

Balance between Exocytosis and Endocytosis Determines the Efficacy of Sterol-Targeting Antibiotics

Biosynthetic origins of the epoxyquinone skeleton in epoxyquinols A and B

Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.

Chemical Interactions of Cryptic Actinomycete Metabolite 5-Alkyl-1,2,3,4-tetrahydroquinolines through Aggregate Formation

Chemical tagging of a drug target using 5-sulfonyl tetrazole.

Chlorocatechelins A and B from Streptomyces sp.: new siderophores containing chlorinated catecholate groups and an acylguanidine structure

Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A.

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

Cryptic Chemical Communication: Secondary Metabolic Responses Revealed by Microbial Co-culture

Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo

Cytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp

Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors.

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells

Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008

Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis.

Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare ActinomyceteSaccharothrixsp. A1506

Drinkable preparation of Theracurmin exhibits high absorption efficiency--a single-dose, double-blind, 4-way crossover study

Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus

Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives.

Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene).

Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity

Epolactaene, a Novel Neuritogenic Compound in Human Neuroblastoma Cells, Produced by a Marine Fungus ⬇️

Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex.

Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.

Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.

Erratum to: The Inhibitory Effects of Crucumin Glucuronide on p300-HAT Activity and Hypertrophic Phenylephrine-Induced Responses in Cardiomyocytes

Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.

First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry

Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.

Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling

Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation

Highly Sensitive Labeling Reagents for Scarce Natural Products

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD

Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.

Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines

In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line.

In Vivo Linking of Membrane Lipids and the Anion Transporter Band 3 with Thiourea-modified Amphiphilic Lipid Probes

Inhibition of translation by cytotrienin A--a member of the ansamycin family

Innovative preparation of curcumin for improved oral bioavailability.

Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance

Isolation and Structure Elucidation of Cytotoxic Saccharothriolides D to F from a Rare Actinomycete Saccharothrix sp. and Their Structure-Activity Relationship.

Isolation of a novel substrate-competitive tyrosine kinase inhibitor, desmal, from the plant Desmos chinensis. ⬇️

Isolation, Structure Elucidation, and Conformational Regulation of Myropeptins, Lipopeptides from the Fungus Myrothecium roridum

Isolation, Structure Elucidation, and Total Synthesis of Tryptopeptins A and B, New TGF-β Signaling Modulators from Streptomyces sp

LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

Longicatenamides A–D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596

Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling

Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores

Methylation deficiency disrupts biological rhythms from bacteria to humans

Multiple NF‐Y‐binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor‐associated gene ⬇️

Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification

Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors