Lista de obras - Robin J McAnulty - Dominio Público Uruguay

A novel transforming growth factor beta2 antisense transcript in mammalian lung.

artículo científico publicado en 1998

A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer

artículo científico publicado en 2008

A simplified method for quantitation of the relative amounts of type I and type III collagen in small tissue samples

artículo científico publicado en 1981

Age-related alterations in collagen and total protein metabolism determined in cultured rat dermal fibroblasts: age-related trends parallel those observed in rat skin in vivo.

artículo científico publicado en 1995

Age-related changes in collagen synthesis and degradation in rat tissues. Importance of degradation of newly synthesized collagen in regulating collagen production.

artículo científico publicado en 1991

Age-related changes in lung collagen metabolism. A role for degradation in regulating lung collagen production

artículo científico publicado en 1989

Age-related changes in rates of protein synthesis and degradation in rat tissues.

artículo científico publicado en 1991

Age-related changes in total protein and collagen metabolism in rat liver

artículo científico publicado en 1991

Airway deposition of nebulized gene delivery nanocomplexes monitored by radioimaging agents.

artículo científico publicado en 2013

An integrin-targeted non-viral vector for pulmonary gene therapy

artículo científico publicado en 2000

Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo.

artículo científico publicado en 2006

Angiotensin II and the fibroproliferative response to acute lung injury.

artículo científico publicado en 2003

Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor.

artículo científico publicado en 2000

Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome

artículo científico publicado en 2002

Anomalous tritium loss in the measurement of tissue hydroxy-[5-3H]proline specific activity following chloramine-T oxidation.

artículo científico publicado en 1982

Application of high-pressure liquid chromatography to studies of collagen production by isolated cells in culture

artículo científico publicado en 1990

Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol.

artículo científico publicado en 2004

Biochemical and histological changes in pulmonary fibrosis induced in rabbits with intratracheal bleomycin

scientific article published on 01 December 1981

Bleomycin-induced lung injury in the rat: effects of the platelet-activating factor (PAF) receptor antagonist BN 52021 and platelet depletion ⬇️

artículo científico publicado el 1 de abril de 1990

Cadmium selectively inhibits fibroblast procollagen production and proliferation

artículo científico publicado en 1994

Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices

artículo científico publicado en 2016

Changes in collagen metabolism in response to endothelin-1: evidence for fibroblast heterogeneity.

artículo científico publicado en 1996

Changes in collagen synthesis and degradation during skeletal muscle growth

Changes in lung volume, perfusion, ventilation and airway diameter in dogs with pulmonary eodema

artículo científico publicado en 1980

Characterization of murine pregnancy decidua transforming growth factor beta. I. Transforming growth factor beta 2-like molecules of unusual molecular size released in bioactive form

artículo científico publicado en 1995

Collagen synthesis and degradation in vivo. Evidence for rapid rates of collagen turnover with extensive degradation of newly synthesized collagen in tissues of the adult rat

artículo científico publicado en 1987

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.

artículo científico publicado en 2002

Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice

artículo científico publicado en 2001

Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung.

artículo científico publicado en 2002

Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis.

artículo científico publicado en 2017

Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis

artículo científico publicado en 2010

Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis.

artículo científico publicado en 2001

Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lung

scientific article published on 01 December 1996

Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis.

artículo científico publicado en 2018

Effect of endothelin receptor antagonists (BQ-485, Ro 47-0203) on collagen deposition during the development of bleomycin-induced pulmonary fibrosis in rats

artículo científico publicado en 1998

Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung.

artículo científico publicado en 2018

Efficient transfection of non-proliferating human airway epithelial cells with a synthetic vector system.

artículo científico publicado en 2004

Enhanced type III collagen gene expression during bleomycin induced lung fibrosis.

artículo científico publicado en 1993

Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis

artículo científico publicado en 2016

Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis

artículo científico publicado en 2008

Evaluation of a porcine model for pulmonary gene transfer using a novel synthetic vector

artículo científico publicado en 2002

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

artículo científico publicado en 2016

Extensive changes in collagen synthesis and degradation during compensatory lung growth

artículo científico publicado en 1988

Fibroblast mitogens in bronchoalveolar lavage (BAL) fluid from asbestos-exposed subjects with and without clinical evidence of asbestosis: no evidence for the role of PDGF, TNF-alpha, IGF-1, or IL-1 beta

artículo científico publicado en 1998

Fibroblasts and myofibroblasts: their source, function and role in disease.

artículo científico publicado en 2006

Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome

scientific article published on 01 November 2000

Functional prostaglandin-endoperoxide synthase 2 polymorphism predicts poor outcome in sarcoidosis

artículo científico publicado en 2006

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

artículo científico publicado en 2012

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

artículo científico publicado en 2017

Growth factor activity in the lung during compensatory growth after pneumonectomy: evidence of a role for IGF-1

artículo científico publicado en 1992

Heterogeneity of type III procollagen N-terminal peptides in BAL fluid from normal and fibrotic lungs

scientific article published on 01 November 1993

Increased collagen production in fibroblasts cultured from irradiated skin and effect of TGF beta(1)- clinical study.

artículo científico publicado en 2000

Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats

artículo científico publicado en 1998

Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro

artículo científico publicado en 1994

Increased type I procollagen mRNA transcripts in the lungs of mice during the development of bleomycin-induced fibrosis

scientific article published on 01 November 1994

Inhibition of neointimal hyperplasia in a rabbit vein graft model following non-viral transfection with human iNOS cDNA.

artículo científico publicado en 2013

Insulin-like growth factor-I is partially responsible for fibroblast proliferation induced by bronchoalveolar lavage fluid from patients with systemic sclerosis

artículo científico publicado en 1994

Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs.

artículo científico publicado en 2003

Long-term changes in mouse lung following inhalation of a fibrosis-inducing dose of 239PuO2: changes in collagen synthesis and degradation rates

artículo científico publicado en 1991

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

artículo científico publicado en 2009

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2

artículo científico publicado en 2000

Measurement of fibroblast collagen synthesis and degradation by reverse-phase high-pressure liquid chromatography

artículo científico publicado en 1989

Methods for measuring hydroxyproline and estimating in vivo rates of collagen synthesis and degradation

artículo científico publicado en 2005

Minicircle DNA Provides Enhanced and Prolonged Transgene Expression Following Airway Gene Transfer

artículo científico publicado en 2016

Models and approaches to understand the role of airway remodelling in disease.

artículo científico publicado en 2011

Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium.

artículo científico publicado en 2011

Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts

artículo científico publicado en 2002

Oral N-acetylcysteine reduces bleomycin-induced collagen deposition in the lungs of mice

artículo científico publicado en 1991

Oxygen-dependent protection of radiation lung damage in mice by WR 2721

scientific article published on 01 November 1984

Pathogenesis of lung fibrosis and potential new therapeutic strategies

artículo científico publicado en 1995

Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis

scientific article published on 01 February 2005

Prostanoid EP₂ Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

scholarly article by Jigisha A Patel published in August 2018

Protein metabolism during bleomycin-induced pulmonary fibrosis in rabbits. In vivo evidence for collagen accumulation because of increased synthesis and decreased degradation of the newly synthesized collagen

artículo científico publicado en 1983

Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis

artículo científico publicado en 2008

Pulmonary gene therapy. Realistic hope for the future, or false dawn in the promised land?

artículo científico publicado el 1 de enero de 2003

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling

artículo científico publicado en 2005

Regulation of matrix turnover: fibroblasts, forces, factors and fibrosis.

artículo científico publicado en 2007

Role of thrombin in pulmonary fibrosis

scientific article published on 01 October 1995

Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production.

artículo científico publicado en 2004

Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats.

artículo científico publicado en 2003

TGF-beta: its role in asthma and therapeutic potential

artículo científico publicado en 2006

Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma

artículo científico publicado en 2010

The effect of transforming growth factor beta on rates of procollagen synthesis and degradation in vitro

artículo científico publicado en 1991

The pathogenesis of pulmonary fibrosis: is there a fibrosis gene?

artículo científico publicado en 1997

The radiographic detection of acute pulmonary oedema. A comparison of radiographic appearances, densitometry and lung water in dogs

scientific article published on 01 April 1981

The regulation of collagen production in normal lung and during interstitial lung disease.

artículo científico publicado en 1988

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

artículo científico publicado en 1998

Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism

artículo científico publicado en 1998

Lista de obras de Robin J McAnulty

A novel transforming growth factor beta2 antisense transcript in mammalian lung.

A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer

A simplified method for quantitation of the relative amounts of type I and type III collagen in small tissue samples

Age-related alterations in collagen and total protein metabolism determined in cultured rat dermal fibroblasts: age-related trends parallel those observed in rat skin in vivo.

Age-related changes in collagen synthesis and degradation in rat tissues. Importance of degradation of newly synthesized collagen in regulating collagen production.

Age-related changes in lung collagen metabolism. A role for degradation in regulating lung collagen production

Age-related changes in rates of protein synthesis and degradation in rat tissues.

Age-related changes in total protein and collagen metabolism in rat liver

Airway deposition of nebulized gene delivery nanocomplexes monitored by radioimaging agents.

An integrin-targeted non-viral vector for pulmonary gene therapy

Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo.

Angiotensin II and the fibroproliferative response to acute lung injury.

Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor.

Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome

Anomalous tritium loss in the measurement of tissue hydroxy-[5-3H]proline specific activity following chloramine-T oxidation.

Application of high-pressure liquid chromatography to studies of collagen production by isolated cells in culture

Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol.

Biochemical and histological changes in pulmonary fibrosis induced in rabbits with intratracheal bleomycin

Bleomycin-induced lung injury in the rat: effects of the platelet-activating factor (PAF) receptor antagonist BN 52021 and platelet depletion ⬇️

Cadmium selectively inhibits fibroblast procollagen production and proliferation

Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices

Changes in collagen metabolism in response to endothelin-1: evidence for fibroblast heterogeneity.

Changes in collagen synthesis and degradation during skeletal muscle growth

Changes in lung volume, perfusion, ventilation and airway diameter in dogs with pulmonary eodema

Characterization of murine pregnancy decidua transforming growth factor beta. I. Transforming growth factor beta 2-like molecules of unusual molecular size released in bioactive form

Collagen synthesis and degradation in vivo. Evidence for rapid rates of collagen turnover with extensive degradation of newly synthesized collagen in tissues of the adult rat

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.

Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice

Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung.

Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis.

Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis

Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis.

Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lung

Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis.

Effect of endothelin receptor antagonists (BQ-485, Ro 47-0203) on collagen deposition during the development of bleomycin-induced pulmonary fibrosis in rats

Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung.

Efficient transfection of non-proliferating human airway epithelial cells with a synthetic vector system.

Enhanced type III collagen gene expression during bleomycin induced lung fibrosis.

Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis

Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis

Evaluation of a porcine model for pulmonary gene transfer using a novel synthetic vector

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

Extensive changes in collagen synthesis and degradation during compensatory lung growth

Fibroblast mitogens in bronchoalveolar lavage (BAL) fluid from asbestos-exposed subjects with and without clinical evidence of asbestosis: no evidence for the role of PDGF, TNF-alpha, IGF-1, or IL-1 beta

Fibroblasts and myofibroblasts: their source, function and role in disease.

Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome

Functional prostaglandin-endoperoxide synthase 2 polymorphism predicts poor outcome in sarcoidosis

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Growth factor activity in the lung during compensatory growth after pneumonectomy: evidence of a role for IGF-1

Heterogeneity of type III procollagen N-terminal peptides in BAL fluid from normal and fibrotic lungs

Increased collagen production in fibroblasts cultured from irradiated skin and effect of TGF beta(1)- clinical study.

Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats

Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro

Increased type I procollagen mRNA transcripts in the lungs of mice during the development of bleomycin-induced fibrosis

Inhibition of neointimal hyperplasia in a rabbit vein graft model following non-viral transfection with human iNOS cDNA.

Insulin-like growth factor-I is partially responsible for fibroblast proliferation induced by bronchoalveolar lavage fluid from patients with systemic sclerosis

Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs.

Long-term changes in mouse lung following inhalation of a fibrosis-inducing dose of 239PuO2: changes in collagen synthesis and degradation rates

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2

Measurement of fibroblast collagen synthesis and degradation by reverse-phase high-pressure liquid chromatography

Methods for measuring hydroxyproline and estimating in vivo rates of collagen synthesis and degradation

Minicircle DNA Provides Enhanced and Prolonged Transgene Expression Following Airway Gene Transfer

Models and approaches to understand the role of airway remodelling in disease.

Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium.

Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts

Oral N-acetylcysteine reduces bleomycin-induced collagen deposition in the lungs of mice

Oxygen-dependent protection of radiation lung damage in mice by WR 2721

Pathogenesis of lung fibrosis and potential new therapeutic strategies

Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis

Prostanoid EP₂ Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

Protein metabolism during bleomycin-induced pulmonary fibrosis in rabbits. In vivo evidence for collagen accumulation because of increased synthesis and decreased degradation of the newly synthesized collagen

Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis

Pulmonary gene therapy. Realistic hope for the future, or false dawn in the promised land?

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling

Regulation of matrix turnover: fibroblasts, forces, factors and fibrosis.

Role of thrombin in pulmonary fibrosis

Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production.