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Lista de obras de Manfred Kopf

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

A high-throughput alphavirus-based expression cloning system for mammalian cells.

artículo científico publicado en 2001

A lymphotoxin-driven pathway to hepatocellular carcinoma

artículo científico publicado en 2009

A role for antibodies in the generation of memory antifungal immunity

artículo científico publicado en 2003

A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice

artículo científico publicado en 2019

Aberrant acute-phase response in aged interleukin-6 knockout mice

artículo científico publicado en 2006

Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis

artículo científico publicado en 2003

Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cells.

artículo científico publicado en 2004

Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection

artículo científico publicado en 2014

Antifungal type 1 responses are upregulated in IL-10-deficient mice.

artículo científico publicado en 1999

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

scientific article published on 09 December 2019

Author Correction: Deciphering CD4+ T cell specificity using novel MHC-TCR chimeric receptors

artículo científico publicado en 2019

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

artículo científico publicado en 2018

Averting inflammation by targeting the cytokine environment

artículo científico publicado en 2010

B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24)

scientific journal article

B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis

scientific article published on 01 November 2019

Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism

artículo científico publicado en 2011

Balancing protective immunity and immunopathology

artículo científico publicado en 2002

Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells

scholarly article

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

scientific journal article

CD2 sets quantitative thresholds in T cell activation

artículo científico publicado en 1999

CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells

scholarly article

CD8(+) T cells mediate CD40-independent maturation of dendritic cells in vivo

artículo científico publicado en 1999

Cell-wall deficient L. monocytogenes L-forms feature abrogated pathogenicity

artículo científico publicado en 2014

Chemokines: more than just road signs

scientific article published on 01 February 2006

Combined vaccination against IL-5 and eotaxin blocks eosinophilia in mice

artículo científico publicado en 2010

Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection

artículo científico publicado en 2002

Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1

artículo científico publicado en 2005

Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy

artículo científico publicado en 2012

Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness

artículo científico publicado en 1997

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity

artículo científico publicado en 2011

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

artículo científico publicado en 2012

Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner

artículo científico publicado en 2010

Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

scientific article published on 01 March 2020

Cytokines and infectious diseases

scientific article published on 01 February 1997

Deciphering CD4+ T cell specificity using novel MHC-TCR chimeric receptors

artículo científico publicado en 2019

Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity

artículo científico publicado en 2003

Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells

artículo científico publicado en 1999

Discovery of a Highly Potent Anti-inflammatory Epoxyisoprostane-Derived Lactone

artículo científico publicado en 2014

Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells

artículo científico publicado en 2006

Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathway

scientific article published on 01 July 1996

Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity

artículo científico publicado en 2007

Effective T-cell immune responses in the absence of the serine/threonine kinase RIP2.

artículo científico publicado en 2008

Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens

artículo científico publicado en 2002

Endogenous interleukin 4 is required for development of protective CD4+ T helper type 1 cell responses to Candida albicans

artículo científico publicado en 1998

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

artículo científico publicado en 2014

Evidence for the divergence of innate and adaptive T-cell precursors before commitment to the αβ and γδ lineages

artículo científico publicado en 2011

Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

artículo científico publicado en 2013

Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development

scientific article published on 02 January 2020

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis

artículo científico publicado en 2010

Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection

artículo científico publicado en 2016

GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation

scientific article published on 20 September 2018

GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival

artículo científico publicado en 2008

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis

scientific article published on 27 June 2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

scientific article published on 01 October 2019

HVEM signalling promotes colitis

artículo científico publicado en 2011

IL-17-producing T cells in lung immunity and inflammation

artículo científico publicado en 2009

IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium

artículo científico publicado en 2010

IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo

artículo científico publicado en 2008

IL-21 induces death of marginal zone B cells during chronic inflammation

artículo científico publicado en 2010

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.

artículo científico publicado en 2012

IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3+ regulatory T cells

scientific article published on 14 January 2019

IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo

artículo científico publicado en 2006

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

artículo científico publicado en 2013

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

artículo científico publicado en 2009

IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance

article

IL-4Ralpha signaling is important for CD8+ T cell cytotoxicity in the absence of CD4+ T cell help

artículo científico publicado en 2005

IL-5 deficiency abolishes aspects of airway remodelling in a murine model of lung inflammation

artículo científico publicado en 2001

IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.

artículo científico publicado en 1996

IL-6 is required for glioma development in a mouse model

artículo científico publicado en 2004

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

artículo científico publicado en 2008

Immune responses of IL-4, IL-5, IL-6 deficient mice.

artículo científico publicado en 1995

Impaired mucosal immune responses in interleukin 4-targeted mice

artículo científico publicado en 1995

In vivo prime editing of a metabolic liver disease in mice

artículo científico publicado en 2022

Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection

artículo científico publicado en 2000

Induction of gut mucosal immune responses: importance of genetic background and Th1/Th2 cross-regulation.

artículo científico publicado en 1998

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.

artículo científico publicado en 2014

Influenza A virus uses the aggresome processing machinery for host cell entry

artículo científico publicado en 2014

Influenza virus: a novel method to assess viral and neutralizing antibody titers in vitro

artículo científico publicado en 1999

Inhibition of Poxvirus Gene Expression and Genome Replication by Bisbenzimide Derivatives

artículo científico publicado en 2017

Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis

artículo científico publicado en 2013

Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses

artículo científico publicado en 2005

Innate versus acquired immunity in listeriosis

artículo científico publicado en 1996

Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF

Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness).

artículo científico publicado en 1995

Interleukin 6 plays a key role in the development of antigen-induced arthritis

artículo científico publicado en 1998

Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection

artículo científico publicado en 2005

Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

scientific article published on 05 September 2019

Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses.

artículo científico publicado en 1999

Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system

artículo científico publicado en 1994

Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3

scientific article published on 01 January 2003

KappaBle fluorescent reporter mice enable low-background single-cell detection of NF-κB transcriptional activity in vivo

scholarly article

Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis

artículo científico publicado en 2003

Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-α and interleukin-1, but not by interferon-γ nor interleukin-6

article

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

artículo científico publicado en 2022

Lymphocyte development

artículo científico publicado en 2013

Lymphocyte subsets in experimental bronchopulmonary inflammation and hyperresponsiveness

artículo científico publicado en 1997

Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key

Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key.

artículo científico publicado en 2004

Malarial hemozoin is a Nalp3 inflammasome activating danger signal

artículo científico publicado en 2009

Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes

artículo científico publicado en 2014

Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response

artículo científico publicado en 1996

Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis

scientific article published on 01 November 2006

Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages

artículo científico publicado en 2008

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

scientific article published on 08 June 2011

PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development

artículo científico publicado en 2015

PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection

artículo científico publicado en 2016

PPAR-γ in innate and adaptive lung immunity

scientific article published on 16 May 2018

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

artículo científico publicado en 2021

PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation.

artículo científico publicado en 2017

Peroxisomes Are Critical for the Development and Maintenance of B1 and Marginal Zone B Cells but Dispensable for Follicular B Cells and T Cells

artículo científico publicado en 2022

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.

artículo científico publicado en 2015

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

artículo científico publicado en 2006

Protective effect of a germline, IL-17-neutralizing antibody in murine models of autoimmune inflammatory disease

artículo científico publicado en 2015

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses

scientific journal article

Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk

scientific journal article

Redox regulation of immunometabolism

artículo científico publicado en 2020

Regulatory T cells are required for normal and activin-promoted wound repair in mice

artículo científico publicado en 2018

Retarded Liver Growth in Interleukin-6-Deficient and Tumor Necrosis Factor Receptor-1-Deficient Mice1

artículo científico publicado en 2001

Role of GM-CSF signaling in cell-based tumor immunization

artículo científico publicado en 2009

Schistosoma mansoni in IL-4-deficient mice

scientific article published on 01 April 1996

Schistosoma mansoni: IL-4 is necessary for concomitant immunity in mice.

artículo científico publicado en 1999

Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent

artículo científico publicado en 2001

Synthesis and Structure–Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues

scientific article published on 08 May 2018

Synthesis of epoxyisoprostanes: effects in reducing secretion of pro-inflammatory cytokines IL-6 and IL-12.

artículo científico publicado en 2013

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

artículo científico publicado en 2015

T-cell fate and function: PKC-theta and beyond

artículo científico publicado en 2008

TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance

artículo científico publicado en 2014

Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia

artículo científico publicado en 2002

The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model

artículo científico publicado en 2003

The development and function of lung-resident macrophages and dendritic cells.

artículo científico publicado en 2015

The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice

artículo científico publicado en 1994

The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses

artículo científico publicado en 2009

The origin and fate of γδT cell subsets

artículo científico publicado el 3 de abril de 2013

The osteopontin - CD44 pathway is superfluous for the development of autoimmune myocarditis

artículo científico publicado en 2006

The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses

scientific article published on 01 March 2019

The thioredoxin-1 inhibitor Txnip restrains effector T cell and germinal center B cell expansion in mice

artículo científico publicado en 2020

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.

artículo científico publicado en 2018

Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

artículo científico publicado en 2020

Toll-like receptors: paving the path to T cell-driven autoimmunity?

artículo científico publicado en 2007

Total Synthesis of Prostaglandin 15d-PGJ2 and Investigation of its Effect on the Secretion of IL-6 and IL-12

scientific article published on 24 August 2015

Training myeloid precursors with fungi, bacteria and chips

artículo científico publicado en 2018

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.

artículo científico publicado en 2017

VSIG4, a B7 family-related protein, is a negative regulator of T cell activation

scientific journal article

Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis

artículo científico publicado en 2006

tEMPting Fate MaYBe the Solution

artículo científico publicado en 2015