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Lista de obras de Mutasem O. Taha

Antiproliferative activity of the isoindigo 5'-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0/G1 phase.

artículo científico publicado en 2015

Application of docking-based comparative intermolecular contacts analysis to validate Hsp90α docking studies and subsequent in silico screening for inhibitors

artículo científico publicado el 16 de junio de 2012

Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validation

scientific article published on 01 April 2006

Combining Stochastic Deformation/Relaxation and Intermolecular Contacts Analysis for Extracting Pharmacophores from Ligand-Receptor Complexes

artículo científico publicado en 2018

Combining docking, scoring and molecular field analyses to probe influenza neuraminidase–ligand interactions

artículo científico publicado en 2007

Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery of new check point kinase 1 inhibitors

artículo científico publicado en 2015

Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.

artículo científico publicado en 2008

Combining molecular dynamics simulation and ligand-receptor contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies

artículo científico publicado en 2016

Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2

scientific article published on 08 December 2020

Computational modeling of the bat HKU4 coronavirus 3CL(pro) inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus

artículo científico publicado en 2017

Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation.

artículo científico publicado en 2016

Cytotoxic activity of the novel heterocyclic compound G-11 is primarily mediated through intrinsic apoptotic pathway.

artículo científico publicado en 2016

Degradability of chitosan micro/nanoparticles for pulmonary drug delivery

scientific article published on 15 May 2019

Design and Synthesis of New Sulfonamides-Based Flt3 Inhibitors

scientific article published on 01 April 2019

Design, Synthesis and Biological Evaluation of N4-Sulfonamido-Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors.

artículo científico publicado en 2013

Development of predictive in silico model for cyclosporine- and aureobasidin-based P-glycoprotein inhibitors employing receptor surface analysis

scientific article published on 13 August 2008

Development of quantitative structure-property relationship models for pseudoternary microemulsions formulated with nonionic surfactants and cosurfactants: application of data mining and molecular modeling

artículo científico publicado en 2002

Discovery of DPP IV inhibitors by pharmacophore modeling and QSAR analysis followed by in silico screening.

artículo científico publicado en 2008

Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

scientific article published on 01 January 2019

Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling.

artículo científico publicado en 2016

Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.

artículo científico publicado en 2014

Discovery of new Gyrase β inhibitors via structure based modeling

artículo científico publicado en 2018

Discovery of new JNK3 inhibitory chemotypes via QSAR-Guided selection of docking-based pharmacophores and comparison with other structure-based pharmacophore modeling methods

artículo científico publicado en 2019

Discovery of new MurF inhibitors via pharmacophore modeling and QSAR analysis followed by in-silico screening.

artículo científico publicado en 2007

Discovery of new antifungal leads via pharmacophore modeling and QSAR analysis of fungal N-myristoyl transferase inhibitors followed by in silico screening.

artículo científico publicado en 2011

Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration.

artículo científico publicado en 2010

Discovery of new nanomolar peroxisome proliferator-activated receptor γ activators via elaborate ligand-based modeling

artículo científico publicado en 2011

Discovery of new potent human protein tyrosine phosphatase inhibitors via pharmacophore and QSAR analysis followed by in silico screening

artículo científico publicado en 2006

Discovery of new renin inhibitory leads via sequential pharmacophore modeling, QSAR analysis, in silico screening and in vitro evaluation

artículo científico publicado en 2011

Discovery of new selective cytotoxic agents against Bcl-2 expressing cancer cells using ligand-based modeling.

artículo científico publicado en 2016

Discovery of new β-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.

artículo científico publicado en 2010

Discovery of new β-D-glucosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.

artículo científico publicado en 2010

Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.

artículo científico publicado en 2010

Discovery of novel Flt3 inhibitory chemotypes through extensive ligand-based and new structure-based pharmacophore modelling methods

scientific article published on 22 January 2019

Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-β) via extensive ligand-based modeling and virtual screening

artículo científico publicado en 2016

Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.

artículo científico publicado en 2014

Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling

artículo científico publicado en 2016

Discovery of potent inhibitors of pseudomonal quorum sensing via pharmacophore modeling and in silico screening.

artículo científico publicado en 2006

Docking simulations and in vitro assay unveil potent inhibitory action of papaverine against protein tyrosine phosphatase 1B.

artículo científico publicado en 2009

Docking-Based Comparative Intermolecular Contacts Analysis as New 3-D QSAR Concept for Validating Docking Studies and in Silico Screening: NMT and GP Inhibitors as Case Studies

artículo científico publicado el 3 de marzo de 2011

Effect of Ionic Crosslinking on the Drug Release Properties ofChitosan Diacetate Matrices

artículo científico publicado en 2007

Effects of variable docking conditions and scoring functions on corresponding protein-aligned comparative molecular field analysis models constructed from diverse human protein tyrosine phosphatase 1B inhibitors

artículo científico publicado en 2005

Elaborate ligand-based modeling and subsequent synthetic exploration unveil new nanomolar Ca2+/calmodulin-dependent protein kinase II inhibitory leads

artículo científico publicado en 2011

Elaborate ligand-based modeling coupled with QSAR analysis and in silico screening reveal new potent acetylcholinesterase inhibitors

artículo científico publicado en 2013

Elaborate ligand-based modeling coupled with multiple linear regression and k nearest neighbor QSAR analyses unveiled new nanomolar mTOR inhibitors.

artículo científico publicado en 2013

Elaborate ligand-based modeling reveal new migration inhibitory factor inhibitors.

artículo científico publicado en 2013

Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors

artículo científico publicado en 2011

Elaborate ligand-based modeling reveals new nanomolar heat shock protein 90α inhibitors.

artículo científico publicado en 2010

Enhanced drug encapsulation and extended release profiles of calcium-alginate nanoparticles by using tannic acid as a bridging cross-linking agent

artículo científico publicado en 2014

Ethosuximide and phenobarbital promote wound healing via enhancing collagenization

artículo científico publicado en 2011

Evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3.

artículo científico publicado en 2013

Exploring the influence of culture conditions on kefir's anticancer properties

scientific article published on 01 March 2018

Extensive ligand-based modeling and in silico screening reveal nanomolar inducible nitric oxide synthase (iNOS) inhibitors.

artículo científico publicado en 2012

Famotidine inhibits glycogen synthase kinase-3β: an investigation by docking simulation and experimental validation.

artículo científico publicado en 2012

Homology modeling of MCH1 receptor and validation by docking/scoring and protein-aligned CoMFA.

artículo científico publicado en 2009

In silico screening for non-nucleoside HIV-1 reverse transcriptase inhibitors using physicochemical filters and high-throughput docking followed by in vitro evaluation.

artículo científico publicado en 2009

Inhibition of glycogen synthase kinase by curcumin: Investigation by simulated molecular docking and subsequent in vitro/in vivo evaluation.

artículo científico publicado en 2009

Innovative computer-aided methods for the discovery of new kinase ligands

artículo científico publicado en 2016

Ligand-based assessment of factor Xa binding site flexibility via elaborate pharmacophore exploration and genetic algorithm-based QSAR modeling

artículo científico publicado en 2005

Ligand-based computational modelling of platelet-derived growth factor beta receptor leading to new angiogenesis inhibitory leads.

artículo científico publicado en 2017

Ligand-based modeling followed by in vitro bioassay yielded new potent glucokinase activators.

artículo científico publicado en 2014

Ligand-based modeling of Akt3 lead to potent dual Akt1/Akt3 inhibitor

artículo científico publicado en 2018

Ligand-based modeling of diverse aryalkylamines yields new potent P-glycoprotein inhibitors

artículo científico publicado en 2016

Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads.

artículo científico publicado en 2011

Naproxen and Cromolyn as New Glycogen Synthase Kinase 3β Inhibitors for Amelioration of Diabetes and Obesity: An Investigation by Docking Simulation and Subsequent In Vitro/In Vivo Biochemical Evaluation

artículo científico publicado el 19 de junio de 2013

New leads for DPP IV inhibition: structure-based pharmacophore mapping and virtual screening study

artículo científico publicado en 2013

Novel anticancer compound [trifluoromethyl-substituted pyrazole N-nucleoside] inhibits FLT3 activity to induce differentiation in acute myeloid leukemia cells

artículo científico publicado en 2016

Novel nanoparticles based on chitosan-dicarboxylate conjugates via tandem ionotropic/covalent crosslinking with tripolyphosphate and subsequent evaluation as drug delivery vehicles

artículo científico publicado en 2017

Olanzapine inhibits glycogen synthase kinase-3beta: an investigation by docking simulation and experimental validation.

artículo científico publicado en 2008

Pharmacophore and QSAR Modeling of Neuronal Nitric Oxide Synthase Ligands and Subsequent Validation and In Silico Search for New Scaffolds

artículo científico publicado en 2015

Pharmacophore and QSAR modeling of estrogen receptor beta ligands and subsequent validation and in silico search for new hits.

artículo científico publicado en 2009

Pharmacophore modeling of JAK1: A target infested with activity-cliffs

scientific article published on 21 April 2020

Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone.

artículo científico publicado en 2013

Pharmacophore modeling, quantitative structure-activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3beta inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin.

artículo científico publicado en 2008

Pharmacophore modeling, quantitative structure-activity relationship analysis, and shape-complemented in silico screening allow access to novel influenza neuraminidase inhibitors

artículo científico publicado en 2009

Preparation and in vitro characterization of glibenclamide-loaded alginate hexyl-amide beads: a novel drug delivery system to improve the dissolution rate.

artículo científico publicado en 2013

Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties.

artículo científico publicado en 2011

QSAR studies in the discovery of novel type-II diabetic therapies

artículo científico publicado en 2015

QSPR modeling of pseudoternary microemulsions formulated employing lecithin surfactants: application of data mining, molecular and statistical modeling

artículo científico publicado en 2005

Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis.

artículo científico publicado en 2013

Rosmarinic acid reverses the effects of metronidazole-induced infertility in male albino rats.

artículo científico publicado en 2016

Simulated annealing molecular dynamics and ligand-receptor contacts analysis for pharmacophore modeling

artículo científico publicado en 2017

Sodium lauryl sulfate impedes drug release from zinc-crosslinked alginate beads: switching from enteric coating release into biphasic profiles

artículo científico publicado en 2007

Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation.

artículo científico publicado en 2010

Structure-Based Discovery and Bioactivity Evaluation of Novel Aurora-A Kinase Inhibitors as Anticancer Agents via Docking-Based Comparative Intermolecular Contacts Analysis (dbCICA)

artículo científico publicado en 2020

Sunitinib as an anti-endometriotic agent.

artículo científico publicado en 2013

Synthesis and antitumor activities of some new N1-(flavon-6-yl)amidrazone derivatives

artículo científico publicado en 2014

Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners.

artículo científico publicado en 2012

Synthesis and characterization of new derivatives of alginic acid and evaluation of their iron(III)-crosslinked beads as potential controlled release matrices

artículo científico publicado en 2013

Synthesis and structure-activity relationship exploration of some potent anti-cancer phenyl amidrazone derivatives.

artículo científico publicado en 2017

Synthesis of iron-crosslinked chitosan succinate and iron-crosslinked hydroxamated chitosan succinate and their in vitro evaluation as potential matrix materials for oral theophylline sustained-release beads.

artículo científico publicado en 2001

The anticancer activity of the substituted pyridone-annelated isoindigo (5'-Cl) involves G0/G1 cell cycle arrest and inactivation of CDKs in the promyelocytic leukemia cell line HL-60.

artículo científico publicado en 2015

The herbicide quinclorac as potent lipase inhibitor: Discovery via virtual screening and in vitro/in vivo validation

artículo científico publicado en 2019

The use of docking-based comparative intermolecular contacts analysis to identify optimal docking conditions within glucokinase and to discover of new GK activators

artículo científico publicado en 2014

Thujone corrects cholesterol and triglyceride profiles in diabetic rat model

artículo científico publicado en 2011

Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.

artículo científico publicado en 2017

β-Caryophyllene causes regression of endometrial implants in a rat model of endometriosis without affecting fertility

artículo científico publicado en 2013