Lista de obras - Angeles Canales - Dominio Público Uruguay

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

scientific article published on 08 October 2014

A rigid lanthanide binding tag for NMR structural analysis of carbohydrates

artículo científico publicado en 2011

A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.

artículo científico publicado en 2013

Antimicrobial peptides and their superior fluorinated analogues: structure-activity relationships as revealed by NMR spectroscopy and MD calculations.

artículo científico publicado en 2010

Avenues to Characterize the Interactions of Extended N-Glycans with Proteins by NMR Spectroscopy: The Influenza Hemagglutinin Case

article

Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by 15N NMR relaxation methods.

artículo científico

Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts.

artículo científico publicado en 2013

Breaking the Limits in Analyzing Carbohydrate Recognition by NMR Spectroscopy: Resolving Branch-Selective Interaction of a Tetra-Antennary N-Glycan with Lectins.

artículo científico publicado en 2017

Cell wall polysaccharides isolated from the fungus Neotestudina rosatii, one of the etiologic agents of mycetoma in man.

artículo científico publicado en 2009

Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors

artículo científico publicado en 2018

Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the (1)C(4) and (2)S(O) conformations of a bioactive heparin-like hexasaccharide.

artículo científico publicado en 2005

Conformational selection of the AGA*IA(M) heparin pentasaccharide when bound to the fibroblast growth factor receptor.

artículo científico publicado en 2011

Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440

artículo científico publicado en 2008

Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy

artículo científico publicado en 2006

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

artículo científico publicado en 2016

Dextrans produced by lactic acid bacteria exhibit antiviral and immunomodulatory activity against salmonid viruses.

artículo científico publicado en 2015

Enhanced signal dispersion in saturation transfer difference experiments by conversion to a 1D-STD-homodecoupled spectrum

artículo científico publicado en 2006

Exploring NMR methods as a tool to select suitable fluorescent nucleotide analogues.

artículo científico publicado en 2013

Glycosylated Cell-Penetrating Peptides (GCPPs)

scientific article published on 12 April 2019

Heparin Modulates the Mitogenic Activity of Fibroblast Growth Factor by Inducing Dimerization of its Receptor. A 3D View by Using NMR ⬇️

artículo científico publicado el 12 de agosto de 2013

Hevein domains: an attractive model to study carbohydrate-protein interactions at atomic resolution

artículo científico publicado en 2006

Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP.

artículo científico publicado en 2017

Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1.

artículo científico

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

artículo científico publicado en 2019

Insights into the C-terminal Peptide Binding Specificity of the PDZ Domain of Neuronal Nitric-oxide Synthase: CHARACTERIZATION OF THE INTERACTION WITH THE TIGHT JUNCTION PROTEIN CLAUDIN-3.

artículo científico publicado en 2016

Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach ⬇️

artículo científico publicado el 13 de mayo de 2011

Interactions between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods

artículo científico publicado en 2017

Isolation and structural determination of a unique polysaccharide containing mannofuranose from the cell wall of the fungus Acrospermum compressum.

artículo científico publicado en 2007

Lanthanide-chelating carbohydrate conjugates are useful tools to characterize carbohydrate conformation in solution and sensitive sensors to detect carbohydrate-protein interactions.

artículo científico

Limited flexibility of lactose detected from residual dipolar couplings using molecular dynamics simulations and steric alignment methods

artículo científico publicado en 2005

Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes ⬇️

artículo científico publicado el 20 de diciembre de 2011

Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches

scientific article published on 25 February 2014

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity ⬇️

artículo científico publicado el 16 de agosto de 2010

Molecular dynamics study of nanoconfined TIP4P/2005 water: how confinement and temperature affect diffusion and viscosity

artículo científico publicado en 2019

NMR determination of the bioactive conformation of peloruside A bound to microtubules.

artículo científico publicado en 2006

NMR experiments for the measurement of proton-proton and carbon-carbon residual dipolar couplings in uniformly labelled oligosaccharides

artículo científico publicado en 2003

NMR studies on the conformation of oligomannosides and their interaction with banana lectin

artículo científico publicado en 2007

New inhibitors of angiogenesis with antitumor activity in vivo

artículo científico publicado en 2015

New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.

artículo científico publicado en 2013

Novel pH-Stable Glycoside Hydrolase Family 3 β-Xylosidase from Talaromyces amestolkiae: an Enzyme Displaying Regioselective Transxylosylation.

artículo científico publicado en 2015

Recent advances on the application of NMR methods to study the conformation and recognition properties of carbohydrates

article

Review: use of residual dipolar couplings to determine the structure of carbohydrates ⬇️

artículo científico publicado el 1 de diciembre de 2012

Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.

artículo científico

Solution conformation of carbohydrates: a view by using NMR assisted by modeling

artículo científico publicado en 2015

Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin

artículo científico publicado en 2016

Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.

artículo científico publicado en 2012

Synthesis and NMR experiments of (4,5,6-13C)-deoxymannojirimycin. A new entry to 13C-labeled glycosidase inhibitors

scientific article published on 29 April 2007

Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications

artículo científico publicado en 2012

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).

artículo científico publicado en 2016

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

artículo científico publicado en 2014

Temperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experiments

article

Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin

artículo científico publicado en 2017

Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.

artículo científico publicado en 2012

Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations

artículo científico publicado en 2016

Unraveling the interaction between the LPS O-antigen of Burkholderia anthina and the 5D8 monoclonal antibody by using a multidisciplinary chemical approach, with synthesis, NMR, and molecular modeling methods

artículo científico

Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida ⬇️

artículo científico publicado el 16 de noviembre de 2010

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules ⬇️

artículo científico publicado el 22 de junio de 2012

Lista de obras de Angeles Canales

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

A rigid lanthanide binding tag for NMR structural analysis of carbohydrates

A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.

Antimicrobial peptides and their superior fluorinated analogues: structure-activity relationships as revealed by NMR spectroscopy and MD calculations.

Avenues to Characterize the Interactions of Extended N-Glycans with Proteins by NMR Spectroscopy: The Influenza Hemagglutinin Case

Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by 15N NMR relaxation methods.

Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts.

Breaking the Limits in Analyzing Carbohydrate Recognition by NMR Spectroscopy: Resolving Branch-Selective Interaction of a Tetra-Antennary N-Glycan with Lectins.

Cell wall polysaccharides isolated from the fungus Neotestudina rosatii, one of the etiologic agents of mycetoma in man.

Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors

Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the (1)C(4) and (2)S(O) conformations of a bioactive heparin-like hexasaccharide.

Conformational selection of the AGA*IA(M) heparin pentasaccharide when bound to the fibroblast growth factor receptor.

Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440

Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

Dextrans produced by lactic acid bacteria exhibit antiviral and immunomodulatory activity against salmonid viruses.

Enhanced signal dispersion in saturation transfer difference experiments by conversion to a 1D-STD-homodecoupled spectrum

Exploring NMR methods as a tool to select suitable fluorescent nucleotide analogues.

Glycosylated Cell-Penetrating Peptides (GCPPs)

Heparin Modulates the Mitogenic Activity of Fibroblast Growth Factor by Inducing Dimerization of its Receptor. A 3D View by Using NMR ⬇️

Hevein domains: an attractive model to study carbohydrate-protein interactions at atomic resolution

Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP.

Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1.

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Insights into the C-terminal Peptide Binding Specificity of the PDZ Domain of Neuronal Nitric-oxide Synthase: CHARACTERIZATION OF THE INTERACTION WITH THE TIGHT JUNCTION PROTEIN CLAUDIN-3.

Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach ⬇️

Interactions between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods

Isolation and structural determination of a unique polysaccharide containing mannofuranose from the cell wall of the fungus Acrospermum compressum.

Lanthanide-chelating carbohydrate conjugates are useful tools to characterize carbohydrate conformation in solution and sensitive sensors to detect carbohydrate-protein interactions.

Limited flexibility of lactose detected from residual dipolar couplings using molecular dynamics simulations and steric alignment methods

Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes ⬇️

Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity ⬇️

Molecular dynamics study of nanoconfined TIP4P/2005 water: how confinement and temperature affect diffusion and viscosity

NMR determination of the bioactive conformation of peloruside A bound to microtubules.

NMR experiments for the measurement of proton-proton and carbon-carbon residual dipolar couplings in uniformly labelled oligosaccharides

NMR studies on the conformation of oligomannosides and their interaction with banana lectin

New inhibitors of angiogenesis with antitumor activity in vivo

New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.

Novel pH-Stable Glycoside Hydrolase Family 3 β-Xylosidase from Talaromyces amestolkiae: an Enzyme Displaying Regioselective Transxylosylation.

Recent advances on the application of NMR methods to study the conformation and recognition properties of carbohydrates

Review: use of residual dipolar couplings to determine the structure of carbohydrates ⬇️

Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.

Solution conformation of carbohydrates: a view by using NMR assisted by modeling

Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin

Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.

Synthesis and NMR experiments of (4,5,6-13C)-deoxymannojirimycin. A new entry to 13C-labeled glycosidase inhibitors

Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

Temperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experiments

Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin

Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.

Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations

Unraveling the interaction between the LPS O-antigen of Burkholderia anthina and the 5D8 monoclonal antibody by using a multidisciplinary chemical approach, with synthesis, NMR, and molecular modeling methods

Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida ⬇️

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules ⬇️