Lista de obras - Marcel Bermudez - Dominio Público Uruguay

A panoramic view on GPCRs: the 1st Berlin Symposium for Interdisciplinary GPCR research

artículo científico publicado en 2018

Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities

artículo científico publicado en 2017

Biased Ligands Differentially Shape the Conformation of the Extracellular Loop Region in 5-HT<sub>2B</sub> Receptors

artículo científico publicado en 2020

Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist

artículo científico publicado en 2012

Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10.

artículo científico publicado en 2016

Community guidelines for GPCR ligand bias: IUPHAR review 32

Computational close up on protein-protein interactions: how to unravel the invisible using molecular dynamics simulations?

article

Does Divergent Binding Pocket Closure Drive Ligand Bias for Class A GPCRs?

artículo científico publicado en 2019

Dualsteric modulators of the M2 muscarinic acetylcholine receptor.

artículo científico publicado en 2014

Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity

artículo científico publicado en 2014

Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties

artículo científico publicado en 2019

Identification and characterization of a novel chemotype for human TLR8 inhibitors

artículo científico publicado en 2019

Identification of a pyrrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening.

artículo científico publicado en 2018

In silico virtual screening approaches for anti-viral drug discovery

artículo científico publicado en 2012

Interruption of the ionic lock in the bradykinin B2 receptor results in constitutive internalization and turns several antagonists into strong agonists

artículo científico publicado en 2012

Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor

artículo científico publicado en 2016

Ligand-Specific Restriction of Extracellular Conformational Dynamics Constrains Signaling of the M2 Muscarinic Receptor.

artículo científico publicado en 2017

Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt1]DALDA, and KGOP01, Binding to the mu Opioid Receptor

scientific article published on 29 April 2020

More than a look into a crystal ball: protein structure elucidation guided by molecular dynamics simulations.

artículo científico publicado en 2016

NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors

artículo científico publicado en 2013

Next generation 3D pharmacophore modeling

artículo científico publicado en 2020

Novel BQCA- and TBPB-Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism

scientific article published on 03 July 2019

Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291.

artículo científico publicado en 2017

Strategies for the discovery of biased GPCR ligands

scientific article published on 01 March 2019

Structural Characteristics of the Allosteric Binding Site Represent a Key to Subtype Selective Modulators of Muscarinic Acetylcholine Receptors

artículo científico publicado en 2015

Structural determinants of diphenethylamines for interaction with the κ opioid receptor: Synthesis, pharmacology and molecular modeling studies

artículo científico publicado en 2016

Structure versus function-The impact of computational methods on the discovery of specific GPCR-ligands

artículo científico

Structure-based identification of dual ligands at the A<sub>2A</sub>R and PDE10A with anti-proliferative effects in lung cancer cell-lines

artículo científico publicado en 2021

Systematic Data Mining Reveals Synergistic H3R/MCHR1 Ligands.

artículo científico publicado en 2017

The Role of Orthosteric Building Blocks of Bitopic Ligands for Muscarinic M1 Receptors

artículo científico publicado en 2020

The impact of molecular dynamics on drug design: applications for the characterization of ligand-macromolecule complexes

artículo científico publicado en 2015

Lista de obras de Marcel Bermudez

A panoramic view on GPCRs: the 1st Berlin Symposium for Interdisciplinary GPCR research

Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities

Biased Ligands Differentially Shape the Conformation of the Extracellular Loop Region in 5-HT<sub>2B</sub> Receptors

Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist

Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10.

Community guidelines for GPCR ligand bias: IUPHAR review 32

Computational close up on protein-protein interactions: how to unravel the invisible using molecular dynamics simulations?

Does Divergent Binding Pocket Closure Drive Ligand Bias for Class A GPCRs?

Dualsteric modulators of the M2 muscarinic acetylcholine receptor.

Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity

Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties

Identification and characterization of a novel chemotype for human TLR8 inhibitors

Identification of a pyrrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening.

In silico virtual screening approaches for anti-viral drug discovery

Interruption of the ionic lock in the bradykinin B2 receptor results in constitutive internalization and turns several antagonists into strong agonists

Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor

Ligand-Specific Restriction of Extracellular Conformational Dynamics Constrains Signaling of the M2 Muscarinic Receptor.

Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt1]DALDA, and KGOP01, Binding to the mu Opioid Receptor

More than a look into a crystal ball: protein structure elucidation guided by molecular dynamics simulations.

NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors

Next generation 3D pharmacophore modeling

Novel BQCA- and TBPB-Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism

Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291.

Strategies for the discovery of biased GPCR ligands

Structural Characteristics of the Allosteric Binding Site Represent a Key to Subtype Selective Modulators of Muscarinic Acetylcholine Receptors

Structural determinants of diphenethylamines for interaction with the κ opioid receptor: Synthesis, pharmacology and molecular modeling studies

Structure versus function-The impact of computational methods on the discovery of specific GPCR-ligands

Structure-based identification of dual ligands at the A<sub>2A</sub>R and PDE10A with anti-proliferative effects in lung cancer cell-lines

Systematic Data Mining Reveals Synergistic H3R/MCHR1 Ligands.

The Role of Orthosteric Building Blocks of Bitopic Ligands for Muscarinic M1 Receptors

The impact of molecular dynamics on drug design: applications for the characterization of ligand-macromolecule complexes