Lista de obras - Carmen Gil Ayuso-Gontán

5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding to human serum albumin.

artículo científico publicado en 2012

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

artículo científico publicado en 2012

A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice.

artículo científico publicado en 2016

Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles.

artículo científico publicado en 2005

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.

artículo científico publicado en 2018

Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: synthesis and comparative molecular field analysis.

artículo científico publicado en 2000

Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. study of structural requirements for biological activity

artículo científico publicado en 2003

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

scientific article published on 26 December 2019

Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease

scientific article published on 30 August 2017

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

article

CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example

artículo científico publicado en 2007

CODES/Neural Network Model: a Useful Tool for in Silico Prediction of Oral Absorption and Blood-Brain Barrier Permeability of Structurally Diverse Drugs

article

Chlorophenylmethyl benzothiadiazine dioxides derivatives: potent human cytomegalovirus inhibitors

artículo científico publicado en 1999

Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis.

artículo científico publicado en 2013

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

artículo científico publicado en 2014

Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

artículo científico publicado en 2018

Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors

artículo científico publicado en 2005

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators

article

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

scientific article published on 01 December 2020

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.

artículo científico publicado en 2008

Discovery of Amoebicidal Compounds by Combining Computational and Experimental Approaches

scientific article published on 23 November 2020

Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

artículo científico publicado en 2019

Drugs in clinical development for the treatment of amyotrophic lateral sclerosis

artículo científico publicado en 2017

Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice

artículo científico publicado en 2012

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

artículo científico publicado en 2012

Efficient solid-phase synthesis of highly functionalized 1,4-benzodiazepin-5-one derivatives and related compounds by intramolecular aza-Wittig reactions

artículo científico publicado en 2005

Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders

artículo científico publicado en 2016

Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia

artículo científico publicado en 2017

Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

artículo científico publicado en 2011

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

artículo científico

Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer′s Disease Treatment ⬇️

artículo científico publicado el 30 de junio de 2011

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

artículo científico publicado en 2012

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

artículo científico publicado en 2012

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

artículo científico publicado en 2012

Imidazole Derivatives as Promising Agents for the Treatment of Chagas Disease

scientific article published on 27 March 2019

Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

artículo científico publicado en 2013

Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?

artículo científico publicado en 2017

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

artículo científico publicado en 2017

Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents

artículo científico publicado en 2017

Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits.

artículo científico publicado en 2017

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

artículo científico publicado en 2012

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa.

artículo científico publicado en 2018

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

artículo científico publicado en 2014

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

artículo científico publicado en 2011

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

artículo científico publicado en 2016

New insights into the role of endosomal proteins for African swine fever virus infection

artículo científico publicado en 2022

Non-ATP competitive glycogen synthase kinase 3beta (GSK-3beta) inhibitors: study of structural requirements for thiadiazolidinone derivatives

artículo científico publicado en 2007

Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides

artículo científico publicado en 1999

On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds

Organic azides: an exploding diversity of a unique class of compounds

artículo científico publicado en 2005

PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury

artículo científico publicado en 2011

PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

artículo científico publicado en 2015

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

artículo científico

Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats.

artículo científico publicado en 2015

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

artículo científico publicado en 2011

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

artículo científico publicado en 2013

Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

artículo científico publicado en 2016

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis.

artículo científico publicado en 2017

Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis

artículo científico publicado en 2014

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

artículo científico publicado en 2010

QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease

scientific article published on 14 February 2019

Recent strategies in the development of new human cytomegalovirus inhibitors.

artículo científico publicado en 2001

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

artículo científico publicado en 2019

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

artículo científico publicado en 2014

Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

artículo científico publicado en 2016

Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa.

artículo científico publicado en 2017

Solid-phase synthesis of biologically active benzoannelated nitrogen heterocycles: an update.

artículo científico publicado en 2009

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

artículo científico

Supercritical fluid extraction of grape seeds: extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cells

article

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

artículo científico publicado en 2009

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects.

artículo científico publicado en 2017

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.

artículo científico publicado en 2016

The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis

artículo científico publicado en 2016

The Synthesis of 3-Substituted 6-Aryl-3H-benzo[a][1,2,3]triazinones Using Polymer-Bound Triazenes

artículo científico publicado en 2004

The recent impact of solid-phase synthesis on medicinally relevant benzoannelated nitrogen heterocycles.

artículo científico publicado en 2002

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools.

artículo científico publicado en 2009

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

scientific article published on 01 December 2020

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

artículo científico publicado en 2013

cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases

artículo científico

β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.

artículo científico publicado en 2013

Lista de obras de Carmen Gil Ayuso-Gontán

5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding to human serum albumin.

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice.

Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles.

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.

Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: synthesis and comparative molecular field analysis.

Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. study of structural requirements for biological activity

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example

CODES/Neural Network Model: a Useful Tool for in Silico Prediction of Oral Absorption and Blood-Brain Barrier Permeability of Structurally Diverse Drugs

Chlorophenylmethyl benzothiadiazine dioxides derivatives: potent human cytomegalovirus inhibitors

Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis.

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.

Discovery of Amoebicidal Compounds by Combining Computational and Experimental Approaches

Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

Drugs in clinical development for the treatment of amyotrophic lateral sclerosis

Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

Efficient solid-phase synthesis of highly functionalized 1,4-benzodiazepin-5-one derivatives and related compounds by intramolecular aza-Wittig reactions

Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders

Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia

Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer′s Disease Treatment ⬇️

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

Imidazole Derivatives as Promising Agents for the Treatment of Chagas Disease

Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents

Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits.

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa.

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

New insights into the role of endosomal proteins for African swine fever virus infection

Non-ATP competitive glycogen synthase kinase 3beta (GSK-3beta) inhibitors: study of structural requirements for thiadiazolidinone derivatives

Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides

On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds

Organic azides: an exploding diversity of a unique class of compounds

PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury

PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats.

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis.

Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease

Recent strategies in the development of new human cytomegalovirus inhibitors.

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa.

Solid-phase synthesis of biologically active benzoannelated nitrogen heterocycles: an update.

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

Supercritical fluid extraction of grape seeds: extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cells

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects.

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.

The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis

The Synthesis of 3-Substituted 6-Aryl-3H-benzo[a][1,2,3]triazinones Using Polymer-Bound Triazenes

The recent impact of solid-phase synthesis on medicinally relevant benzoannelated nitrogen heterocycles.

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools.

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases