Lista de obras - Marco Gobbi - Dominio Público Uruguay

5-HT3 serotonin hetero-receptors inhibit [3H]acethylcholine release in rat cortical synaptosomes.

artículo científico publicado en 1997

6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.

artículo científico publicado en 2013

A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors.

artículo científico publicado en 2016

A Surface Plasmon Resonance-based assay to measure serum concentrations of therapeutic antibodies and anti-drug antibodies

scientific article published in Scientific Reports

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

artículo científico publicado en 2016

A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)₁₋₄₀ and Aβ₁₋₄₂ from the corresponding depsipeptides

scientific article published on 24 December 2010

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10

artículo científico publicado en 2013

A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma

artículo científico publicado en 2014

A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation

artículo científico publicado en 2021

A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake

artículo científico publicado en 2012

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

scientific article published on March 2009

A validated, sensitive HPLC-MS/MS method for quantification of cis-para-methyl-4-methylaminorex (cis-4,4'-DMAR) in rat and human plasma: application to pharmacokinetic studies in rats

artículo científico publicado en 2016

Acute noise stress in rats increases the levels of diazepam binding inhibitor (DBI) in hippocampus and adrenal gland

artículo científico publicado en 1991

Acute noise stress reduces [3H]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine.

artículo científico publicado en 1993

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.

artículo científico publicado en 2012

Allosteric inhibition as a model to explain flatter displacement curves in binding experiments: application to "heterogeneous" serotonin receptors

artículo científico publicado en 1986

Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis

artículo científico publicado en 2011

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

artículo científico publicado en 2013

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

artículo científico

Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms

artículo científico publicado en 1993

Antagonist properties of 1-(2-pyrimidinyl)piperazine at presynaptic alpha 2-adrenoceptors in the rat brain

artículo científico publicado en 1990

Antiepileptic effects of botulinum neurotoxin E.

artículo científico publicado en 2005

Applications of surface plasmon resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes.

artículo científico publicado en 2012

Appraisal of the role of angiotensin II and aldosterone in ventricular myocyte apoptosis in adult normotensive rat.

artículo científico publicado en 2002

Autoradiographic localization of [(3)H]paroxetine specific binding in the rat brain

artículo científico publicado en 1990

Autoradiographic reevaluation of the binding properties of 125I-[Leu31,Pro34]peptide YY and 125I-peptide YY3-36 to neuropeptide Y receptor subtypes in rat forebrain

artículo científico publicado en 1999

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.

artículo científico publicado en 2013

Biochemical characterization of a new highly cardioselective beta-adrenoceptor antagonist

artículo científico publicado en 1988

Brain Disposition of cis-para-Methyl-4-Methylaminorex (cis-4,4'-DMAR) and Its Potential Metabolites after Acute and Chronic Treatment in Rats: Correlation with Central Behavioral Effects.

artículo científico publicado en 2017

Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice.

artículo científico publicado en 2015

Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine.

artículo científico publicado en 1997

Carrier-mediated Serotonin Release Induced by d-Fenfluramine: Studies with Human Neuroblastoma Cells Transfected with a Rat Serotonin Transporter ⬇️

artículo científico publicado el 1 de junio de 1997

Characterization of high affinity and stereospecific [ (3)H ]d- fenfluramine binding to rat brain

artículo científico publicado en 1988

Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation.

artículo científico publicado en 2016

Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide

artículo científico publicado en 2010

Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.

artículo científico publicado en 2010

Different components of 3H-imipramine binding in rat brain membranes: relation to serotonin uptake sites

artículo científico publicado en 1988

Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain

artículo científico publicado en 1994

Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models

scientific article published on 12 June 2018

Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial.

artículo científico publicado en 2014

Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest

artículo científico publicado en 2014

Effect of acute and chronic administration of buspirone on serotonin and benzodiazepine receptor subtypes in the rat brain: an autoradiographic study

artículo científico publicado en 1991

Effects of chronic treatment with fluoxetine and citalopram on 5-HT uptake, 5-HT1B autoreceptors, 5-HT3 and 5-HT4 receptors in rats ⬇️

artículo científico publicado el 1 de julio de 1997

Effects of denzimol on benzodiazepine receptors in the CNS: relationship between the enhancement of diazepam activity and benzodiazepine binding sites induced by denzimol in the rat.

artículo científico publicado en 1984

Effects of fluoxetine on basal and K(+)-induced tritium release from synaptosomes preloaded with [3H]serotonin.

artículo científico publicado en 1995

Effects of repeated oral doses of dexnorfenfluramine on 5-HT levels and 5-HT uptake sites in rat brain

artículo científico publicado en 1996

Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases.

artículo científico publicado en 2013

Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain.

artículo científico publicado en 2000

Evidence of an exocytotic-like release of [3H]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes

artículo científico publicado en 1993

Exposing native cyprinid (Barbus plebejus) juveniles to river sediments leads to gonadal alterations, genotoxic effects and thyroid disruption

artículo científico publicado en 2015

Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity

artículo científico publicado en 2013

Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus

artículo científico publicado en 2010

Further evidence of Ca(2+)-dependent, exocytotic-like serotonin release induced by D-fenfluramine

artículo científico publicado en 1997

Gene therapy in epilepsy: the focus on NPY.

artículo científico publicado en 2006

Good gene, bad gene: new APP variant may be both

artículo científico

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

artículo científico publicado en 1999

Immunopurification of pathological prion protein aggregates

artículo científico publicado en 2009

In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat

scientific article published on 01 May 1996

In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool

artículo científico publicado en 1998

In vivo and in vitro interaction of flunarizine with D-fenfluramine serotonergic effects

artículo científico publicado en 1996

Involvement of P-type Ca2+ channels in the K(+)- and d-fenfluramine-induced [3H]5-HT release from rat hippocampal synaptosomes

artículo científico publicado en 1994

Lipid-based nanoparticles with high binding affinity for amyloid-beta1-42 peptide.

artículo científico publicado en 2010

Localization of GABAA and GABAB receptor subtypes on serotonergic neurons

artículo científico publicado en 1986

Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus

artículo científico publicado en 2014

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

artículo científico publicado en 2011

Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds

artículo científico publicado en 2016

Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit

scientific journal article

N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents.

artículo científico publicado en 2008

Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats

artículo científico publicado en 2005

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

artículo científico publicado en 2008

Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reupta

artículo científico publicado en 2008

New insights into the molecular mechanisms underlying sensitivity/resistance to the atypical retinoid ST1926 in acute myeloid leukaemia cells: the role of histone H2A.Z, cAMP-dependent protein kinase A and the proteasome.

artículo científico publicado en 2012

New method based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) to monitor interaction between nanoparticles and the amyloid-β peptide

artículo científico publicado en 2010

Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds

artículo científico publicado en 2010

Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity.

artículo científico publicado en 1999

Overexpression of S100beta in transgenic mice does not protect from serotonergic denervation induced by 5,7-dihydroxytryptamine.

artículo científico publicado en 2002

PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.

artículo científico publicado en 2012

Pharmacology in the high tech age--new developments, opportunities and limitations

artículo científico publicado en 2013

Plasma and brain concentrations of doxycycline after single and repeated doses in wild-type and APP23 mice

scientific article published on 05 November 2018

Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin.

artículo científico publicado en 2005

Profile of in vitro binding affinities of neuroleptics at different rat brain receptors: cluster analysis comparison with pharmacological and clinical profiles

scientific article published on 01 July 1989

QSAR model for blood-brain barrier permeation.

artículo científico publicado en 2017

QSAR study for a novel series of ortho disubstituted phenoxy analogues of alpha1-adrenoceptor antagonist WB4101.

artículo científico publicado en 2006

QSAR study for a novel series of ortho monosubstituted phenoxy analogues of alpha1-adrenoceptor antagonist WB4101.

artículo científico publicado en 2005

Ranolazine ameliorates postresuscitation electrical instability and myocardial dysfunction and improves survival with good neurologic recovery in a rat model of cardiac arrest.

artículo científico publicado en 2014

Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension

artículo científico publicado en 2014

Recombinant C1 inhibitor in brain ischemic injury.

artículo científico publicado en 2009

Regional distribution of low-affinity GABA receptors coupled to benzodiazepine receptor subtypes in rat brain: an autoradiographic evaluation

artículo científico publicado en 1990

Regulation of leukocyte recruitment by the long pentraxin PTX3.

artículo científico publicado en 2010

Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser

artículo científico publicado en 1999

Releasing activities of d-fenfluramine and fluoxetine on rat hippocampal synaptosomes preloaded with [3H]serotonin

artículo científico publicado en 1992

Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin.

artículo científico publicado en 2015

Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y.

artículo científico publicado en 2002

Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury.

artículo científico publicado en 2013

Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans

artículo científico publicado en 2012

St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects.

artículo científico publicado en 2009

Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative

artículo científico publicado en 1984

Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of alpha 1 antagonist WB-4101.

artículo científico publicado en 2004

Substrate inhibitors and blockers of excitatory amino acid transporters in the treatment of neurodegeneration: critical considerations

artículo científico publicado en 2003

Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters

Synthesis of new β- and γ-benzyloxy-S-glutamic acid derivatives and evaluation of their activity as inhibitors of excitatory amino acid transporters

article published in 2009

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

artículo científico publicado en 2010

Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.

artículo científico publicado en 2012

Tetanus toxin inhibits depolarization-induced [3H]serotonin release from rat brain cortex synaptosomes

artículo científico publicado en 1993

Tetrahydro-β-carboline-based spirocyclic lactam as type II' β-turn: application to the synthesis and biological evaluation of somatostatine mimetics.

artículo científico publicado en 2013

The Anti-Amyloidogenic Action of Doxycycline: A Molecular Dynamics Study on the Interaction with Aβ42

artículo científico publicado en 2019

The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers

artículo científico publicado en 2016

The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration

artículo científico publicado en 2013

The antidepressant mechanism of Hypericum perforatum.

artículo científico publicado en 2004

The binding affinity of anti-Aβ1-42 MAb-decorated nanoliposomes to Aβ1-42 peptides in vitro and to amyloid deposits in post-mortem tissue.

artículo científico publicado en 2011

The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype

artículo científico publicado en 1990

The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity.

artículo científico publicado en 2016

Use of surface plasmon resonance to study the elongation kinetics and the binding properties of the highly amyloidogenic Aβ(1-42) peptide, synthesized by depsi-peptide technique

artículo científico publicado en 2010

Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease.

artículo científico publicado en 2012

WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).

artículo científico publicado en 2006

[3H]5-HT binding to 5-HT1nonA-nonB receptors in rat hypothalamus is not representative of 5-HT7 receptors

artículo científico publicado en 1997

p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro.

artículo científico publicado en 2002

Lista de obras de Marco Gobbi

5-HT3 serotonin hetero-receptors inhibit [3H]acethylcholine release in rat cortical synaptosomes.

6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.

A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors.

A Surface Plasmon Resonance-based assay to measure serum concentrations of therapeutic antibodies and anti-drug antibodies

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)₁₋₄₀ and Aβ₁₋₄₂ from the corresponding depsipeptides

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10

A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma

A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation

A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

A validated, sensitive HPLC-MS/MS method for quantification of cis-para-methyl-4-methylaminorex (cis-4,4'-DMAR) in rat and human plasma: application to pharmacokinetic studies in rats

Acute noise stress in rats increases the levels of diazepam binding inhibitor (DBI) in hippocampus and adrenal gland

Acute noise stress reduces [3H]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine.

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.

Allosteric inhibition as a model to explain flatter displacement curves in binding experiments: application to "heterogeneous" serotonin receptors

Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms

Antagonist properties of 1-(2-pyrimidinyl)piperazine at presynaptic alpha 2-adrenoceptors in the rat brain

Antiepileptic effects of botulinum neurotoxin E.

Applications of surface plasmon resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes.

Appraisal of the role of angiotensin II and aldosterone in ventricular myocyte apoptosis in adult normotensive rat.

Autoradiographic localization of [(3)H]paroxetine specific binding in the rat brain

Autoradiographic reevaluation of the binding properties of 125I-[Leu31,Pro34]peptide YY and 125I-peptide YY3-36 to neuropeptide Y receptor subtypes in rat forebrain

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.

Biochemical characterization of a new highly cardioselective beta-adrenoceptor antagonist

Brain Disposition of cis-para-Methyl-4-Methylaminorex (cis-4,4'-DMAR) and Its Potential Metabolites after Acute and Chronic Treatment in Rats: Correlation with Central Behavioral Effects.

Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice.

Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine.

Carrier-mediated Serotonin Release Induced by d-Fenfluramine: Studies with Human Neuroblastoma Cells Transfected with a Rat Serotonin Transporter ⬇️

Characterization of high affinity and stereospecific [ (3)H ]d- fenfluramine binding to rat brain

Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation.

Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide

Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.

Different components of 3H-imipramine binding in rat brain membranes: relation to serotonin uptake sites

Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain

Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models

Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial.

Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest

Effect of acute and chronic administration of buspirone on serotonin and benzodiazepine receptor subtypes in the rat brain: an autoradiographic study

Effects of chronic treatment with fluoxetine and citalopram on 5-HT uptake, 5-HT1B autoreceptors, 5-HT3 and 5-HT4 receptors in rats ⬇️

Effects of denzimol on benzodiazepine receptors in the CNS: relationship between the enhancement of diazepam activity and benzodiazepine binding sites induced by denzimol in the rat.

Effects of fluoxetine on basal and K(+)-induced tritium release from synaptosomes preloaded with [3H]serotonin.

Effects of repeated oral doses of dexnorfenfluramine on 5-HT levels and 5-HT uptake sites in rat brain

Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases.

Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain.

Evidence of an exocytotic-like release of [3H]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes

Exposing native cyprinid (Barbus plebejus) juveniles to river sediments leads to gonadal alterations, genotoxic effects and thyroid disruption

Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity

Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus

Further evidence of Ca(2+)-dependent, exocytotic-like serotonin release induced by D-fenfluramine

Gene therapy in epilepsy: the focus on NPY.

Good gene, bad gene: new APP variant may be both

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

Immunopurification of pathological prion protein aggregates

In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat

In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool

In vivo and in vitro interaction of flunarizine with D-fenfluramine serotonergic effects

Involvement of P-type Ca2+ channels in the K(+)- and d-fenfluramine-induced [3H]5-HT release from rat hippocampal synaptosomes

Lipid-based nanoparticles with high binding affinity for amyloid-beta1-42 peptide.

Localization of GABAA and GABAB receptor subtypes on serotonergic neurons

Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds

Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit

N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents.

Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reupta

New insights into the molecular mechanisms underlying sensitivity/resistance to the atypical retinoid ST1926 in acute myeloid leukaemia cells: the role of histone H2A.Z, cAMP-dependent protein kinase A and the proteasome.

New method based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) to monitor interaction between nanoparticles and the amyloid-β peptide

Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds

Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity.

Overexpression of S100beta in transgenic mice does not protect from serotonergic denervation induced by 5,7-dihydroxytryptamine.

PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.

Pharmacology in the high tech age--new developments, opportunities and limitations

Plasma and brain concentrations of doxycycline after single and repeated doses in wild-type and APP23 mice