Lista de obras - Miriam Cnop - Dominio Público Uruguay

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

artículo científico publicado en 2015

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

artículo científico publicado en 2015

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells

scientific article published on October 2008

BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells

artículo científico publicado en 2006

Beta cell imaging - a key tool in optimized diabetes prevention and treatment

artículo científico publicado en 2014

Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.

artículo científico publicado en 2002

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

artículo científico publicado en 2010

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

artículo científico publicado en 2012

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

scientific article published on 26 August 2020

Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients

artículo científico publicado en 2011

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

artículo científico publicado en 2012

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

artículo científico publicado en 2012

Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance

artículo científico publicado en 2012

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease

artículo científico publicado en 2011

Diabetes in Friedreich ataxia

artículo científico

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

artículo científico publicado en 2020

ER stress in pancreatic beta cells: the thin red line between adaptation and failure

artículo científico publicado en 2010

Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age.

artículo científico publicado en 2000

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

artículo científico publicado en 2017

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

scientific journal article

Endoplasmic reticulum stress, obesity and diabetes

artículo científico

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

artículo científico publicado en 2010

Epigenetic aspects of pancreatic beta cell function in type 2 diabetes

artículo científico publicado en 2014

Erratum

scholarly article published in Autophagy

Erratum to: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

scholarly article published in Diabetologia

Expression of adiponectin receptors in pancreatic beta cells

artículo científico publicado en 2003

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

artículo científico publicado en 2008

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

artículo científico publicado en 2004

Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia

artículo científico publicado en 2009

Future Perspectives for the Treatment of Diabetes: Importance of a Regulatory Framework

artículo científico publicado en 2018

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

scientific journal article

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

artículo científico publicado en 2009

High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach

artículo científico publicado en 2010

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

artículo científico publicado en 2015

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

artículo científico publicado en 2003

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

artículo científico publicado en 2018

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

artículo científico publicado en 2008

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

scientific article published on 26 May 2021

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

artículo científico publicado en 2001

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

artículo científico publicado en 2005

Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

artículo científico publicado en 2001

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway

artículo científico publicado en 2014

Lean non-alcoholic fatty liver disease (Lean-NAFLD): a major cause of cryptogenic liver disease

artículo científico publicado en 2011

Longevity of human islet α‐ and β‐cells ⬇️

artículo científico publicado el 1 de octubre de 2011

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue

artículo científico publicado en 2007

Low Density Lipoprotein Binding and Uptake by Human and Rat Isletβ Cells* ⬇️

artículo científico publicado el 1 de octubre de 1997

Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification

artículo científico publicado en 2002

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

artículo científico publicado en 2005

Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.

artículo científico publicado en 2012

Mining Genes in Type 2 Diabetic Islets and Finding Gold

artículo científico publicado en 2012

Modulation of adiponectin receptors AdipoR1 and AdipoR2 by phage display-derived peptides in in vitro and in vivo models

artículo científico publicado en 2020

Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn

artículo científico publicado en 2010

OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia

Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid

artículo científico publicado en 2011

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis

artículo científico publicado en 2009

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

artículo científico publicado en 2010

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

artículo científico publicado en 2017

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

artículo científico publicado en 2015

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

artículo científico publicado en 2020

Perioperative Management of Oral Glucose-lowering Drugs in the Patient with Type 2 Diabetes

artículo científico publicado en 2020

Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis

artículo científico publicado en 2014

Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

artículo científico publicado en 2007

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate

artículo científico publicado en 2013

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

scientific article published on 16 October 2019

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.

artículo científico publicado en 2003

Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction

artículo científico publicado en 2012

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

scientific journal article

The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.

artículo científico publicado en 2003

The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments

artículo científico publicado en 2002

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice

artículo científico publicado en 2003

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

artículo científico publicado en 2007

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

artículo científico publicado en 2012

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

artículo científico publicado en 2009

The role for endoplasmic reticulum stress in diabetes mellitus

artículo científico publicado en 2007

The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure

artículo científico publicado en 2019

The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses

artículo científico publicado en 2010

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

artículo científico

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction

scientific article published on 22 June 2009

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity

artículo científico publicado en 2002

Type 2 diabetes mellitus--an autoimmune disease?

artículo científico publicado en 2013

Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis

scientific journal article

Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia

artículo científico publicado en 2014

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

artículo científico publicado en 2021

tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans

artículo científico publicado en 2013

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de Miriam Cnop

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells

BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells

Beta cell imaging - a key tool in optimized diabetes prevention and treatment

Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease

Diabetes in Friedreich ataxia

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

ER stress in pancreatic beta cells: the thin red line between adaptation and failure

Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age.

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

Endoplasmic reticulum stress, obesity and diabetes

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

Epigenetic aspects of pancreatic beta cell function in type 2 diabetes

Erratum

Erratum to: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

Expression of adiponectin receptors in pancreatic beta cells

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia

Future Perspectives for the Treatment of Diabetes: Importance of a Regulatory Framework

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway

Lean non-alcoholic fatty liver disease (Lean-NAFLD): a major cause of cryptogenic liver disease

Longevity of human islet α‐ and β‐cells ⬇️

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue

Low Density Lipoprotein Binding and Uptake by Human and Rat Isletβ Cells* ⬇️

Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.

Mining Genes in Type 2 Diabetic Islets and Finding Gold

Modulation of adiponectin receptors AdipoR1 and AdipoR2 by phage display-derived peptides in in vitro and in vivo models

Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn

OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia

Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Perioperative Management of Oral Glucose-lowering Drugs in the Patient with Type 2 Diabetes

Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis

Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.

Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.

The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

The role for endoplasmic reticulum stress in diabetes mellitus

The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure

The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity