Lista de obras - Neil M Walker - Dominio Público Uruguay

A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes

artículo científico publicado en 2014

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

artículo científico publicado en 2006

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

artículo científico publicado en 2014

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations

artículo científico publicado en 2014

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility

artículo científico publicado en 2002

All or Nothing: The False Promise of Anonymity

All or Nothing: the False Promise of Anonymity

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

article

Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

artículo científico publicado en 2009

Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.

artículo científico publicado en 2009

Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1 Diabetes and Hardy-Weinberg Equilibrium Testing

article

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases

artículo científico publicado en 2006

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes

artículo científico publicado en 2004

Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes

artículo científico publicado en 2004

Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

artículo científico publicado en 2005

Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes

artículo científico publicado en 2006

Association of intercellular adhesion molecule-1 gene with type 1 diabetes

artículo científico publicado en 2003

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

artículo científico publicado en 2003

Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes

artículo científico publicado en 2007

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

artículo científico publicado en 2007

Better governance, better access: practising responsible data sharing in the METADAC governance infrastructure.

artículo científico publicado en 2018

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

artículo científico publicado en 2017

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

artículo científico publicado en 2009

Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene

artículo científico publicado en 2004

Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.

artículo científico publicado en 2009

Confirmation of novel type 1 diabetes risk loci in families

artículo científico publicado en 2012

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

artículo científico publicado en 2005

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes

artículo científico publicado en 2014

Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics

artículo científico publicado en 2004

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes

artículo científico publicado en 2006

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

artículo científico publicado en 2015

Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).

artículo científico publicado en 2015

Erratum: Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

artículo científico publicado en 2015

Evidence of association with type 1 diabetes in the SLC11A1 gene region.

artículo científico publicado en 2011

Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes

artículo científico publicado en 2012

Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.

artículo científico publicado en 2011

Experimental aspects of copy number variant assays at CCL3L1

artículo científico publicado en 2009

FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection

artículo científico publicado en 2011

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

artículo científico publicado en 2015

Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families.

artículo científico publicado en 2009

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

artículo científico publicado en 2011

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

artículo científico publicado en 2011

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

artículo científico publicado en 2009

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

artículo científico publicado en 2007

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

artículo científico publicado en 2010

Growth rates and risk of rupture of abdominal aortic aneurysms

artículo científico publicado en 1998

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.

artículo científico publicado en 2004

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

artículo científico publicado en 2015

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

artículo científico publicado en 2009

Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

artículo científico publicado en 2011

Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes

article

Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping

artículo científico publicado en 2004

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

artículo científico publicado en 2007

Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm

artículo científico publicado en 2002

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

artículo científico publicado en 2005

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

artículo científico publicado en 2007

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

artículo científico publicado en 2011

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

artículo científico publicado en 2008

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

artículo científico publicado en 2013

Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

artículo científico publicado en 2013

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

artículo científico publicado en 2017

No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases

article

No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility

article

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes

artículo científico publicado en 2005

PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes

artículo científico publicado en 2008

Parameters for reliable results in genetic association studies in common disease

article

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

artículo científico publicado en 2013

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes

artículo científico publicado en 2006

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

artículo científico publicado en 2013

Prepublication data sharing

artículo científico publicado en 2009

Probabilities of progression of aortic aneurysms: estimates and implications for screening policy

artículo científico publicado en 2002

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study

artículo científico publicado en 2015

Quantifying the risks of hypertension, age, sex and smoking in patients with abdominal aortic aneurysm

artículo científico publicado en 2000

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

artículo científico publicado en 2011

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

artículo científico publicado en 2009

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial

artículo científico publicado en 2014

Reduced expression of IFIH1 is protective for type 1 diabetes

artículo científico publicado en 2010

Regression mapping of association between the human leukocyte antigen region and Graves disease

artículo científico publicado en 2004

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

artículo científico publicado en 2016

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus

artículo científico publicado en 2004

Returning findings within longitudinal cohort studies: the 1958 birth cohort as an exemplar

artículo científico publicado en 2014

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

artículo científico publicado en 2007

Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.

artículo científico publicado en 2007

Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.

artículo científico publicado en 2008

Seven newly identified loci for autoimmune thyroid disease

artículo científico publicado en 2012

Shared and distinct genetic variants in type 1 diabetes and celiac disease

artículo científico publicado en 2008

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

artículo científico publicado en 2015

T1DBase, a community web-based resource for type 1 diabetes research

artículo científico publicado en 2005

T1DBase: integration and presentation of complex data for type 1 diabetes research

artículo científico publicado en 2006

Targeting regulatory T cells with Interleukin-2 treatment in type 1 diabetes: a response-adaptive, non-randomised, open-label trial of repeat doses of Aldesleukin (DILfrequency)

Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.

artículo científico publicado en 2003

The Gothenburg Breast Screening Trial

artículo científico publicado en 2003

The Long-term Benefits of a Single Scan for Abdominal Aortic Aneurysm (AAA) at Age 65

artículo científico publicado en 2001

The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes

artículo científico publicado en 2007

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

artículo científico publicado en 2017

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

artículo científico publicado en 2009

Type 1 diabetes genome-wide association analysis with imputation identifies five new risk regions

Validity of the family-based association test for copy number variant data in the case of non-linear intensity-genotype relationship.

artículo científico publicado en 2012

Lista de obras de Neil M Walker

A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility

All or Nothing: The False Promise of Anonymity

All or Nothing: the False Promise of Anonymity

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.

Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1 Diabetes and Hardy-Weinberg Equilibrium Testing

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes

Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes

Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes

Association of intercellular adhesion molecule-1 gene with type 1 diabetes

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Better governance, better access: practising responsible data sharing in the METADAC governance infrastructure.

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene

Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.

Confirmation of novel type 1 diabetes risk loci in families

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes

Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).

Erratum: Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

Evidence of association with type 1 diabetes in the SLC11A1 gene region.

Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes

Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.

Experimental aspects of copy number variant assays at CCL3L1

FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families.

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Growth rates and risk of rupture of abdominal aortic aneurysms

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes

Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases

No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes

PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes

Parameters for reliable results in genetic association studies in common disease

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

Prepublication data sharing

Probabilities of progression of aortic aneurysms: estimates and implications for screening policy

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study

Quantifying the risks of hypertension, age, sex and smoking in patients with abdominal aortic aneurysm

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial

Reduced expression of IFIH1 is protective for type 1 diabetes