Lista de obras - Frederick R. Maxfield - Dominio Público Uruguay

A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo

artículo científico publicado en 2018

A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele

artículo científico publicado en 2015

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.

artículo científico publicado en 2015

Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization.

artículo científico publicado en 2009

Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface ⬇️

artículo científico publicado el 22 de febrero de 1979

An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells.

artículo científico publicado en 1998

Analysis of Cholesterol Trafficking with Fluorescent Probes ⬇️

artículo científico publicado el 1 de enero de 2012

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells

artículo científico publicado en 2005

Bafilomycin A1 treatment retards transferrin receptor recycling more than bulk membrane recycling

artículo científico publicado en 1997

Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.

artículo científico publicado en 2014

Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells

artículo científico publicado en 2010

Cholesterol trafficking and distribution

artículo científico publicado en 2015

Cholesterol, the central lipid of mammalian cells

artículo científico publicado en 2010

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization ⬇️

artículo científico publicado el 1 de agosto de 1978

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

artículo científico publicado en 2017

Comment on 'Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol'

artículo científico publicado en 2018

Cyclized dipeptide model for a beta-bend ⬇️

artículo científico publicado el 1 de junio de 1979

Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling

artículo científico publicado en 2010

Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophages.

artículo científico publicado en 2010

Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells

artículo científico publicado en 2003

Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis

artículo científico publicado en 2019

Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells

artículo científico publicado en 2005

Effect of primary amines on interferon action

scientific article published on 01 March 1982

Effects of buffering intracellular free calcium on neutrophil migration through three-dimensional matrices

scientific article published on 01 May 1997

Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes.

artículo científico publicado en 2004

Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia.

artículo científico publicado en 2000

Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary

artículo científico publicado en 2012

Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation.

artículo científico publicado en 2007

Elevated plasma membrane cholesterol content alters macrophage signaling and function.

artículo científico publicado en 2005

Endocytic recycling

artículo científico publicado en 2004

Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails.

artículo científico publicado en 1999

Endocytosed Cation-Independent Mannose 6-Phosphate Receptor Traffics via the Endocytic Recycling Compartment en Route to thetrans-Golgi Network and a Subpopulation of Late Endosomes ⬇️

artículo científico publicado el 31 de octubre de 2003

Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits

artículo científico publicado el 1 de noviembre de 1979

Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HEp2 cells.

artículo científico publicado en 1995

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation.

artículo científico publicado en 2016

Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin.

artículo científico publicado en 2002

Flotillas of lipid rafts fore and aft.

artículo científico publicado en 2001

Fluorescence imaging in living animals. Focus on "Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy".

artículo científico publicado en 2004

High-density lipoprotein or cyclodextrin extraction of cholesterol from aggregated LDL reduces foam cell formation

scientific article published on 02 December 2019

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts ⬇️

artículo científico publicado el 21 de marzo de 2011

Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.

artículo científico publicado en 2017

Human bladder cancer diagnosis using Multiphoton microscopy

artículo científico publicado en 2009

Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages

artículo científico publicado en 1998

Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect

artículo científico publicado en 2010

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts

artículo científico publicado en 2021

Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization ⬇️

artículo científico publicado el 13 de junio de 1979

Intracellular sterol dynamics

artículo científico publicado en 2009

Intracellular sterol transport and distribution.

artículo científico publicado en 2006

Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics

artículo científico publicado en 2009

Lipid and cholesterol trafficking in NPC.

artículo científico publicado en 2004

Local and global changes in cytosolic free calcium in neutrophils during chemotaxis and phagocytosis

artículo científico publicado en 1990

Membrane domains.

artículo científico publicado en 2004

Membrane lipid organization is critical for human neutrophil polarization.

artículo científico publicado en 2003

Membrane transport in the endocytic pathway

artículo científico publicado en 1995

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor

artículo científico publicado en 1996

Microtubule asymmetry during neutrophil polarization and migration.

artículo científico publicado en 2002

Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol

artículo científico publicado en 2006

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation

artículo científico publicado en 2015

Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery

artículo científico publicado en 2011

Multiphoton microscopy in the evaluation of human bladder biopsies

artículo científico publicado en 2012

Multiphoton microscopy of prostate and periprostatic neural tissue: a promising imaging technique for improving nerve-sparing prostatectomy

artículo científico publicado en 2009

Niemann‐Pick type C disease: molecular mechanisms and potential therapeutic approaches ⬇️

artículo científico publicado el 7 de enero de 2011

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.

artículo científico publicado en 2014

Oxalic acid alters intracellular calcium in endothelial cells

artículo científico publicado en 2004

Parallel analysis of v-Src mutant protein function using reverse transfection cell arrays.

artículo científico publicado en 2006

Preparation of solutions with free calcium concentration in the nanomolar range using 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid

scientific article published on 01 February 1991

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control

artículo científico publicado en 2008

Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy

artículo científico publicado en 2012

Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts ⬇️

artículo científico publicado el 1 de junio de 1980

Regulation of endocytic processes by pH.

artículo científico publicado en 1988

Regulation of leukocyte locomotion by Ca2+.

artículo científico publicado en 1993

Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells

artículo científico publicado en 2001

Role of an acidic cluster/dileucine motif in cation-independent mannose 6-phosphate receptor traffic

artículo científico publicado en 2007

Role of endosomes and lysosomes in human disease.

artículo científico publicado en 2014

SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis.

artículo científico publicado en 2007

STARD4 Membrane Interactions and Sterol Binding.

artículo científico publicado en 2015

STARD4 abundance regulates sterol transport and sensing

artículo científico publicado en 2011

Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

artículo científico publicado en 1997

Sphingomyelinase Treatment Induces ATP-independent Endocytosis ⬇️

artículo científico publicado el 12 de enero de 1998

Sphingosine kinases are not required for inflammatory responses in macrophages

artículo científico publicado en 2013

Sterol, protein and lipid trafficking in Chinese hamster ovary cells with Niemann-Pick type C1 defect

artículo científico publicado en 2006

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis

artículo científico publicado en 2003

The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis.

artículo científico publicado en 2003

The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent.

artículo científico publicado en 1996

The endocytic pathway in microglia during health, aging and Alzheimer's disease

artículo científico publicado en 2016

The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells

artículo científico publicado en 2007

The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase activity.

artículo científico publicado en 2001

Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGN

artículo científico publicado en 1996

Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

artículo científico publicado en 1980

Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

artículo científico publicado en 1995

Treatment of Niemann--pick type C disease by histone deacetylase inhibitors.

artículo científico publicado en 2013

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

artículo científico publicado en 1999

Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle

artículo científico publicado en 2001

Yolk platelets in Xenopus oocytes maintain an acidic internal pH which may be essential for sodium accumulation

artículo científico publicado en 1994

Lista de obras de Frederick R. Maxfield

A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo

A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.

Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization.

Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface ⬇️

An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells.

Analysis of Cholesterol Trafficking with Fluorescent Probes ⬇️

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells

Bafilomycin A1 treatment retards transferrin receptor recycling more than bulk membrane recycling

Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.

Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells

Cholesterol trafficking and distribution

Cholesterol, the central lipid of mammalian cells

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization ⬇️

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

Comment on 'Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol'

Cyclized dipeptide model for a beta-bend ⬇️

Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling

Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophages.

Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells

Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis

Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells

Effect of primary amines on interferon action

Effects of buffering intracellular free calcium on neutrophil migration through three-dimensional matrices

Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes.

Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia.

Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary

Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation.

Elevated plasma membrane cholesterol content alters macrophage signaling and function.

Endocytic recycling

Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails.

Endocytosed Cation-Independent Mannose 6-Phosphate Receptor Traffics via the Endocytic Recycling Compartment en Route to thetrans-Golgi Network and a Subpopulation of Late Endosomes ⬇️

Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits

Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HEp2 cells.

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation.

Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin.

Flotillas of lipid rafts fore and aft.

Fluorescence imaging in living animals. Focus on "Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy".

High-density lipoprotein or cyclodextrin extraction of cholesterol from aggregated LDL reduces foam cell formation

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts ⬇️

Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.

Human bladder cancer diagnosis using Multiphoton microscopy

Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages

Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts

Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization ⬇️

Intracellular sterol dynamics

Intracellular sterol transport and distribution.

Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics

Lipid and cholesterol trafficking in NPC.

Local and global changes in cytosolic free calcium in neutrophils during chemotaxis and phagocytosis

Membrane domains.

Membrane lipid organization is critical for human neutrophil polarization.

Membrane transport in the endocytic pathway

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor

Microtubule asymmetry during neutrophil polarization and migration.

Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation

Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery

Multiphoton microscopy in the evaluation of human bladder biopsies

Multiphoton microscopy of prostate and periprostatic neural tissue: a promising imaging technique for improving nerve-sparing prostatectomy

Niemann‐Pick type C disease: molecular mechanisms and potential therapeutic approaches ⬇️

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.

Oxalic acid alters intracellular calcium in endothelial cells

Parallel analysis of v-Src mutant protein function using reverse transfection cell arrays.

Preparation of solutions with free calcium concentration in the nanomolar range using 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control

Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy

Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts ⬇️

Regulation of endocytic processes by pH.

Regulation of leukocyte locomotion by Ca2+.

Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells

Role of an acidic cluster/dileucine motif in cation-independent mannose 6-phosphate receptor traffic

Role of endosomes and lysosomes in human disease.

SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis.

STARD4 Membrane Interactions and Sterol Binding.

STARD4 abundance regulates sterol transport and sensing

Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

Sphingomyelinase Treatment Induces ATP-independent Endocytosis ⬇️