Lista de obras - Halina Dobrzynski - Dominio Público Uruguay

3D anatomical reconstruction of human cardiac conduction system and simulation of bundle branch block after TAVI procedure.

artículo científico publicado en 2016

3D virtual human atria: A computational platform for studying clinical atrial fibrillation

artículo científico publicado en 2011

A detailed 3D model of the rabbit right atrium including the sinoatrial node, atrioventricular node, surrounding blood vessels and valves

A sexy approach to pacemaking: differences in function and molecular make up of the sinoatrial node

scientific article published on 10 April 2019

Ageing-dependent remodelling of ion channel and Ca2+clock genes underlying sino-atrial node pacemaking

article

Altered profile of mRNA expression in atrioventricular node of streptozotocin‑induced diabetic rats.

artículo científico publicado en 2017

An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node

artículo científico publicado en 2003

Anatomical and molecular mapping of the left and right ventricular His–Purkinje conduction networks

artículo científico publicado en 2011

Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension. ⬇️

artículo científico publicado en 2016

Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance

artículo científico publicado en 2016

Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size

artículo científico publicado en 2007

Cellular Mechanisms of Sinoatrial Activity

Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction.

artículo científico publicado en 2011

Changes in the expression of ion channels, connexins and Ca2+-handling proteins in the sino-atrial node during postnatal development

artículo científico publicado en 2011

Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expression

artículo científico publicado en 2013

Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes

artículo científico publicado en 2007

Chronic effects of mild hyperglycaemia on left ventricle transcriptional profile and structural remodelling in the spontaneously type 2 diabetic Goto-Kakizaki rat.

artículo científico publicado en 2014

Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms

scientific article published on 29 August 2018

Comparison of formaldehyde and methanol fixatives used in the detection of ion channel proteins in isolated rat ventricular myocytes by immunofluorescence labelling and confocal microscopy

artículo científico publicado en 2015

Computational assessment of the functional role of sinoatrial node exit pathways in the human heart

artículo científico publicado en 2017

Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving

artículo científico publicado en 2006

Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area

artículo científico publicado en 2011

Computer three-dimensional reconstruction of the atrioventricular node

artículo científico publicado en 2008

Computer three-dimensional reconstruction of the sinoatrial node

artículo científico publicado en 2005

Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit

artículo científico publicado en 2015

Connexins and the atrioventricular node ⬇️

artículo científico publicado el 22 de octubre de 2012

Connexins in the sinoatrial and atrioventricular nodes.

artículo científico publicado en 2006

Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects

artículo científico

Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat

artículo científico publicado en 2016

Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit

artículo científico publicado en 2006

Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.

artículo científico publicado en 2006

Distribution of atrial natriuretic peptide and its effects on contraction and intracellular calcium in ventricular myocytes from streptozotocin-induced diabetic rat.

artículo científico publicado en 2005

Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.

artículo científico publicado en 2009

Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle

artículo científico publicado en 2008

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.

artículo científico publicado en 2012

Expression of Kir2.1 and Kir6.2 transgenes under the control of the α-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice

artículo científico publicado en 2006

Expression of connexin 43, ion channels and Ca2+-handling proteins in rat pulmonary vein cardiomyocytes.

artículo científico publicado en 2016

Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45

artículo científico publicado en 2006

From the Purkinje fibres to the ventricle: One dimensional computer simulation for the healthy and failing heart

artículo científico publicado en 2015

Functional, anatomical, and molecular investigation of the cardiac conduction system and arrhythmogenic atrioventricular ring tissue in the rat heart.

artículo científico publicado en 2013

Funny current and sudden cardiac death

Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAs

artículo científico publicado en 2021

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling

artículo científico

Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system

scientific journal article

Imaging the heart: computer 3-dimensional anatomic models of the heart

artículo científico publicado en 2005

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

artículo científico publicado en 2020

Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing

artículo científico publicado en 2014

Insights from echocardiography, magnetic resonance imaging, and microcomputed tomography relative to the mid-myocardial left ventricular echogenic zone.

artículo científico publicado en 2016

Ion channel transcript expression at the rabbit atrioventricular conduction axis.

artículo científico publicado en 2009

Ivabradine protects against ventricular arrhythmias in acute myocardial infarction in the rat.

artículo científico

Letter by Anderson et al Regarding Article, “Abnormal Conduction and Morphology in the Atrioventricular Node of Mice With Atrioventricular Canal–Targeted Deletion of Alk3/Bmpr1a Receptor”

artículo científico publicado en 2008

Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat

scientific journal article

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study.

artículo científico publicado en 2017

Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy

artículo científico publicado en 2009

Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart.

artículo científico publicado en 2019

Molecular Basis of Arrhythmias Associated with the Cardiac Conduction System

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

artículo científico publicado en 2015

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker

artículo científico publicado en 2009

Molecular architecture of the human specialised atrioventricular conduction axis

scientific article published on 21 January 2011

Morphological characteristics of the sinus node on postmortem tissue.

artículo científico publicado en 2015

New insights into pacemaker activity: promoting understanding of sick sinus syndrome

artículo científico publicado en 2007

Organisation of the mouse sinoatrial node: structure and expression of HCN channels

artículo científico publicado en 2006

P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions

artículo científico publicado en 2009

Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node

artículo científico publicado en 2006

Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle

artículo científico publicado en 2012

Reply to Matelot, Schnell, Kervio, Thillaye du Boullay, and Carre

artículo científico publicado en 2013

Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking

artículo científico publicado en 2004

Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heart

scientific article published on 29 September 2006

Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node

artículo científico publicado en 2007

STRUCTURE-FUNCTION RELATIONSHIPS OF THE SINOATRIAL NODE

Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat.

artículo científico publicado en 2008

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

artículo científico publicado en 2020

Simulation study of complex action potential conduction in atrioventricular node

artículo científico publicado en 2013

Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring

artículo científico publicado en 2019

Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart

artículo científico publicado en 2003

Sophisticated architecture is required for the sinoatrial node to perform its normal pacemaker function

artículo científico publicado en 2003

Structural and functional alterations in the atrioventricular node and atrioventricular ring tissue in ischaemia-induced heart failure.

artículo científico publicado en 2013

Structural and functional remodelling of the atrioventricular node with ageing in rats: the role of Hyperpolarization-activated cyclic-nucleotide gated and Ryanodine 2 channels

artículo científico publicado en 2017

Structural remodelling of the sinoatrial node in obese old rats

artículo científico publicado en 2009

Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues.

artículo científico

Structure-function relationship in the AV junction

artículo científico publicado en 2004

Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions

scientific article published on 01 September 2019

TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome

scientific article published on 13 October 2018

TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging

artículo científico publicado en 2011

Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.

artículo científico publicado en 2017

The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart

artículo científico publicado en 2018

The anatomy and physiology of the sinoatrial node--a contemporary review

artículo científico publicado en 2010

The anatomy of the cardiac conduction system

artículo científico publicado en 2009

The anatomy of the conduction system: implications for the clinical cardiologist

artículo científico publicado en 2012

The extent of the specialized atrioventricular ring tissues

artículo científico

The sinoatrial node is still setting the pace 100 years after its discovery.

artículo científico publicado en 2007

Three-dimensional computer model of the right atrium including the sinoatrial and atrioventricular nodes predicts classical nodal behaviours

artículo científico publicado en 2014

Viewpoint: Is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone?

artículo científico publicado en 2013

Visualization and quantification of whole rat heart laminar structure using high-spatial resolution contrast-enhanced MRI.

artículo científico publicado en 2011

What do we learn from double Cx40/Cx45-deficient mice about cardiac morphogenetic defects and conduction abnormalities?

artículo científico publicado en 2006

Lista de obras de Halina Dobrzynski

3D anatomical reconstruction of human cardiac conduction system and simulation of bundle branch block after TAVI procedure.

3D virtual human atria: A computational platform for studying clinical atrial fibrillation

A detailed 3D model of the rabbit right atrium including the sinoatrial node, atrioventricular node, surrounding blood vessels and valves

A sexy approach to pacemaking: differences in function and molecular make up of the sinoatrial node

Ageing-dependent remodelling of ion channel and Ca2+clock genes underlying sino-atrial node pacemaking

Altered profile of mRNA expression in atrioventricular node of streptozotocin‑induced diabetic rats.

An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node

Anatomical and molecular mapping of the left and right ventricular His–Purkinje conduction networks

Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension. ⬇️

Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance

Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size

Cellular Mechanisms of Sinoatrial Activity

Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction.

Changes in the expression of ion channels, connexins and Ca2+-handling proteins in the sino-atrial node during postnatal development

Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expression

Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes

Chronic effects of mild hyperglycaemia on left ventricle transcriptional profile and structural remodelling in the spontaneously type 2 diabetic Goto-Kakizaki rat.

Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms

Comparison of formaldehyde and methanol fixatives used in the detection of ion channel proteins in isolated rat ventricular myocytes by immunofluorescence labelling and confocal microscopy

Computational assessment of the functional role of sinoatrial node exit pathways in the human heart

Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving

Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area

Computer three-dimensional reconstruction of the atrioventricular node

Computer three-dimensional reconstruction of the sinoatrial node

Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit

Connexins and the atrioventricular node ⬇️

Connexins in the sinoatrial and atrioventricular nodes.

Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects

Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat

Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit

Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.

Distribution of atrial natriuretic peptide and its effects on contraction and intracellular calcium in ventricular myocytes from streptozotocin-induced diabetic rat.

Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.

Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.

Expression of Kir2.1 and Kir6.2 transgenes under the control of the α-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice

Expression of connexin 43, ion channels and Ca2+-handling proteins in rat pulmonary vein cardiomyocytes.

Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45

From the Purkinje fibres to the ventricle: One dimensional computer simulation for the healthy and failing heart

Functional, anatomical, and molecular investigation of the cardiac conduction system and arrhythmogenic atrioventricular ring tissue in the rat heart.

Funny current and sudden cardiac death

Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAs

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling

Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system

Imaging the heart: computer 3-dimensional anatomic models of the heart

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing

Insights from echocardiography, magnetic resonance imaging, and microcomputed tomography relative to the mid-myocardial left ventricular echogenic zone.

Ion channel transcript expression at the rabbit atrioventricular conduction axis.

Ivabradine protects against ventricular arrhythmias in acute myocardial infarction in the rat.

Letter by Anderson et al Regarding Article, “Abnormal Conduction and Morphology in the Atrioventricular Node of Mice With Atrioventricular Canal–Targeted Deletion of Alk3/Bmpr1a Receptor”

Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study.

Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy

Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart.

Molecular Basis of Arrhythmias Associated with the Cardiac Conduction System

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker

Molecular architecture of the human specialised atrioventricular conduction axis

Morphological characteristics of the sinus node on postmortem tissue.

New insights into pacemaker activity: promoting understanding of sick sinus syndrome

Organisation of the mouse sinoatrial node: structure and expression of HCN channels

P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions

Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node

Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle

Reply to Matelot, Schnell, Kervio, Thillaye du Boullay, and Carre

Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking

Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heart

Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node

STRUCTURE-FUNCTION RELATIONSHIPS OF THE SINOATRIAL NODE

Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat.

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

Simulation study of complex action potential conduction in atrioventricular node

Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring

Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart

Sophisticated architecture is required for the sinoatrial node to perform its normal pacemaker function

Structural and functional alterations in the atrioventricular node and atrioventricular ring tissue in ischaemia-induced heart failure.

Structural and functional remodelling of the atrioventricular node with ageing in rats: the role of Hyperpolarization-activated cyclic-nucleotide gated and Ryanodine 2 channels

Structural remodelling of the sinoatrial node in obese old rats