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Lista de obras de Laszlo Prokai

"All in the mind"? Brain-targeting chemical delivery system of 17β-estradiol (Estredox) produces significant uterotrophic side effect

artículo científico publicado en 2012

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy

artículo científico publicado en 2018

17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics

artículo científico publicado en 2020

17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma.

artículo científico publicado en 2013

2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma

artículo científico publicado en 2011

A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy

artículo científico publicado en 2019

A Survey of the Impact of Deyolking on Biological Processes Covered by Shotgun Proteomic Analyses of Zebrafish Embryos

artículo científico publicado en 2015

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

artículo científico publicado en 2016

A component of Premarin® enhances multiple cognitive functions and influences nicotinic receptor expression

artículo científico publicado el 19 de septiembre de 2010

A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents

artículo científico publicado en 2005

A strategy for delivering peptides into the central nervous system by sequential metabolism

artículo científico publicado en 1992

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

artículo científico publicado en 2017

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.

artículo científico publicado en 2014

Antifungal unsaturated cyclic Mannich ketones and amino alcohols: study of mechanism of action.

artículo científico publicado en 2008

Application of screening experimental designs to assess chromatographic isotope effect upon isotope-coded derivatization for quantitative liquid chromatography-mass spectrometry.

artículo científico publicado en 2014

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

artículo científico publicado en 2019

Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model

artículo científico publicado en 2020

Brain-targeted chemical delivery of [Leu2, Pip3]-TRH: synthesis and biological evaluation

artículo científico publicado en 2000

Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design

artículo científico publicado en 1996

Capture of the volatile carbonyl metabolite of flecainide on 2,4-dinitrophenylhydrazine cartridge for quantitation by stable-isotope dilution mass spectrometry coupled with chromatography

artículo científico publicado en 2012

Cardiovascular effects of neuropeptide FF antagonists

artículo científico publicado en 2006

Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium.

artículo científico publicado en 2004

Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation

artículo científico publicado en 2009

Chip-based nanoelectrospray ionization with Fourier transform mass spectrometric detection to screen for local anesthetics intended to mask limb sore in walking horses

artículo científico publicado en 2015

Cholinergic Neurons in the Basal Forebrain Promote Wakefulness by Actions on Neighboring Non-Cholinergic Neurons: An Opto-Dialysis Study

artículo científico publicado en 2016

Cognitive-impairing effects of medroxyprogesterone acetate in the rat: independent and interactive effects across time

artículo científico publicado el 12 de mayo de 2011

Combinatorial lead optimization of a neuropeptide FF antagonist.

artículo científico publicado en 2001

Comparative Proteomics Analysis Reveals Unique Early Signaling Response of <i>Saccharomyces cerevisiae</i> to Oxidants with Different Mechanism of Action

artículo científico publicado en 2020

Comparison of estrogen-derived ortho-quinone and para-quinol concerning induction of oxidative stress.

artículo científico publicado en 2007

Conversion of 3-nitrotyrosine to 3-aminotyrosine residues facilitates mapping of tyrosine nitration in proteins by electrospray ionization-tandem mass spectrometry using electron capture dissociation

artículo científico publicado en 2012

Correspondence regarding Schwend and Gustafsson, "False positives in MALDI-TOF detection of ERbeta in mitochondria".

artículo científico publicado en 2006

Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections

artículo científico publicado en 2016

De novo sequencing of a 21-kDa cytochrome c4 from Thiocapsa roseopersicina by nanoelectrospray ionization ion-trap and Fourier-transform ion-cyclotron resonance mass spectrometry.

artículo científico publicado en 2007

Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs

artículo científico publicado en 2013

Design, synthesis, and biological evaluation of novel, centrally-acting thyrotropin-releasing hormone analogues.

artículo científico publicado en 2002

Desorption chemical ionization, thermospray, and fast atom bombardment mass spectrometry of dihydropyridine in equilibrium with pyridinium salt-type redox systems

scientific article published on 01 August 1989

Detection and identification of 4-hydroxy-2-nonenal Schiff-base adducts along with products of Michael addition using data-dependent neutral loss-driven MS3 acquisition: method evaluation through an in vitro study on cytochrome c oxidase modificatio

artículo científico publicado en 2009

Determination of clodronate content in liposomal formulation by capillary zone electrophoresis

artículo científico publicado en 2003

Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry

artículo científico publicado en 2016

Drug identification problems in two suicides with neuromuscular blocking agents.

artículo científico publicado en 1989

Effect of chronic morphine exposure on the synaptic plasma-membrane subproteome of rats: a quantitative protein profiling study based on isotope-coded affinity tags and liquid chromatography/mass spectrometry

artículo científico publicado en 2005

Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques

artículo científico publicado en 2017

Electrospray ionization mass spectrometric and liquid chromatographic-mass spectrometric studies on the metabolism of synthetic dynorphin A peptides in brain tissue in vitro and in vivo

artículo científico publicado en 1998

Electrospray ionization mass spectrometric study of encapsulation of amino acids by cyclodextrins

artículo científico publicado en 1995

Enhancement of phosphoprotein analysis using a fluorescent affinity tag and mass spectrometry

artículo científico publicado en 2005

Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics.

artículo científico publicado en 2008

Fourier transform ion cyclotron resonance mass spectrometry of covalent adducts of proteins and 4-hydroxy-2-nonenal, a reactive end-product of lipid peroxidation

artículo científico publicado en 2007

Gel permeation chromatography coupled to fourier transform mass spectrometry for polymer characterization

artículo científico publicado en 1999

Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.

artículo científico publicado en 2007

Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration

artículo científico publicado en 2004

Identification of carbonylation sites in apomyoglobin after exposure to 4-hydroxy-2-nonenal by solid-phase enrichment and liquid chromatography-electrospray ionization tandem mass spectrometry.

artículo científico publicado en 2010

Identification of synaptic metabolites of dynorphin A (1-8) by electrospray ionization and tandem mass spectrometry

artículo científico publicado en 1998

Immobilized artificial membrane chromatography coupled with atmospheric pressure ionization mass spectrometry

artículo científico publicado en 2002

In vitro and in vivo study of water-soluble prodrugs of dexanabinol

scientific article published on 01 November 1999

Induction of mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical cancer cell.

artículo científico publicado en 2007

Integration of mass spectrometry into early‐phase discovery and development of central nervous system agents

artículo científico publicado el 1 de noviembre de 2001

Investigation of cytolysin variants by peptide mapping: enhanced protein characterization using complementary ionization and mass spectrometric techniques.

artículo científico publicado en 2002

Isotope-coded dimethyl tagging for differential quantification of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation.

artículo científico publicado en 2011

Label-free LC-MS/MS identification of phosphatidylglycerol-regulated proteins in Synechocystis sp. PCC6803.

artículo científico

Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.

artículo científico publicado en 1997

Leucine enkephalin-tyrosinase reaction products--identification and biological activity

artículo científico publicado en 1994

Mannich Ketones as Possible Antimycobacterial Agents.

artículo científico publicado en 2017

Mass spectrometric analysis of carisoprodol and meprobamate in rat brain microdialysates

artículo científico publicado en 2016

Mass spectrometry-based survey of age-associated protein carbonylation in rat brain mitochondria

artículo científico publicado en 2007

Measurement of Acetylcholine in Rat Brain Microdialysates by LC - Isotope Dilution Tandem MS.

artículo científico publicado en 2008

Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats.

artículo científico publicado en 2010

Metabolism of dynorphins by peptidases of pulmonary artery endothelial cells

artículo científico publicado en 2002

Metabolism-based brain-targeting system for a thyrotropin-releasing hormone analogue

artículo científico publicado en 1999

Micellar aggregation and membrane partitioning of bile salts, fatty acids, sodium dodecyl sulfate, and sugar-conjugated fatty acids: correlation with hemolytic potency and implications for drug delivery

artículo científico publicado en 2004

Microcolumn size-exclusion chromatography coupled with electrospray ionization mass spectrometry

artículo científico publicado en 1999

Misidentification of nitrated peptides: comments on Hong, S.J., Gokulrangan, G., Schöneich, C., 2007. Proteomic analysis of age-dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry

artículo científico publicado en 2009

Mitochondria play a central role in estrogen-induced neuroprotection.

artículo científico publicado en 2005

Mitochondrial localization of estrogen receptor beta

artículo científico publicado en 2004

Modifying peptide properties by prodrug design for enhanced transport into the CNS.

artículo científico publicado en 2003

Neuropharmacodynamic evaluation of the centrally active thyrotropin-releasing hormone analogue [Leu2]TRH and its chemical brain-targeting system.

artículo científico publicado en 2002

Non-Feminizing Estrogens Do Not Exhibit Antidepressant-like Activity

Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells.

artículo científico publicado en 2009

Ocular delivery of the beta-adrenergic antagonist alprenolol by sequential bioactivation of its methoxime analogue.

artículo científico publicado en 1995

Ocular-specific chemical delivery systems of betaxolol for safe local treatment of glaucoma.

artículo científico publicado en 1997

Ocular-specific delivery of timolol by sequential bioactivation of its oxime and methoxime analogs

scientific article published on 01 October 1997

Peptide drug delivery into the central nervous system.

artículo científico publicado en 1998

Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress.

artículo científico publicado en 2009

Polyamine-vectored iron chelators: the role of charge.

artículo científico publicado en 2005

Preoperative endovascular brain mapping for intraoperative volumetric image guidance: preliminary concept and feasibility in animal models.

artículo científico publicado en 2006

Prodrug design for brain delivery of small- and medium-sized neuropeptides

artículo científico publicado en 2011

Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2.

artículo científico publicado en 2003

Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria.

artículo científico publicado en 2011

Proteomic analysis of mouse brain microsomes: identification and bioinformatic characterization of endoplasmic reticulum proteins in the mammalian central nervous system

artículo científico

Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression

artículo científico publicado en 2013

Proteomic analysis of the synaptic plasma membrane fraction isolated from rat forebrain.

artículo científico publicado en 2003

Quantitative structure-activity relationships predicting the antioxidant potency of 17β-estradiol-related polycyclic phenols to inhibit lipid peroxidation.

artículo científico publicado en 2013

Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection

artículo científico publicado en 2003

Quinol-based metabolic cycle for estrogens in rat liver microsomes.

artículo científico publicado en 2003

Rapid characterization of covalent modifications to rat brain mitochondrial proteins after ex vivo exposure to 4-hydroxy-2-nonenal by liquid chromatography-tandem mass spectrometry using data-dependent and neutral loss-driven MS3 acquisition

artículo científico publicado en 2007

Rapid label-free identification of estrogen-induced differential protein expression in vivo from mouse brain and uterine tissue.

artículo científico publicado en 2009

Relative quantitation of protein nitration by liquid chromatography-mass spectrometry using isotope-coded dimethyl labeling and chemoprecipitation.

artículo científico publicado en 2012

Remodeling of phosphatidylglycerol in Synechocystis PCC6803.

artículo científico publicado en 2009

Retina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug

artículo científico publicado en 2020

RimJ-mediated context-dependent N-terminal acetylation of the recombinant Z-domain protein in Escherichia coli.

artículo científico publicado en 2012

Selective N-terminal fluorescent labeling of proteins using 4-chloro-7-nitrobenzofurazan: a method to distinguish protein N-terminal acetylation

artículo científico publicado en 2012

Selective chemoprecipitation and subsequent release of tagged species for the analysis of nitropeptides by liquid chromatography-tandem mass spectrometry

artículo científico publicado en 2011

Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis

artículo científico publicado en 2014

Separation of dansylated 17β-estradiol, 17α-estradiol, and estrone on a single HPLC column for simultaneous quantitation by LC–MS/MS

artículo científico publicado el 1 de febrero de 2013

Sequential bioactivation of methoxime analogs of beta-adrenergic antagonists in the eye

artículo científico publicado en 1995

Simultaneous Measurement of 17β-Estradiol, 17α-Estradiol and Estrone by GC-Isotope Dilution MS/MS.

artículo científico publicado en 2010

Site- and stereospecific ocular drug delivery by sequential enzymatic bioactivation

artículo científico publicado en 1990

Strategies to target kyotorphin analogues to the brain

artículo científico publicado en 1998

Synthesis and biological evaluation of 17beta-alkoxyestra-1,3, 5(10)-trienes as potential neuroprotectants against oxidative stress.

artículo científico publicado en 2001

Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.

artículo científico publicado en 2017

Targeting drugs to the brain by redox chemical delivery systems.

artículo científico publicado en 2000

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

artículo científico publicado en 2015

Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection

artículo científico publicado en 2013

To tag or not to tag: A comparative evaluation of immunoaffinity-labeling and tandem mass spectrometry for the identification and localization of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation

artículo científico publicado el 30 de julio de 2011

Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein levels and alters gene expression in middle-aged rats.

artículo científico publicado en 2009

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

artículo científico publicado en 2016

[99mTc-HYNIC-N-dodecylamide]: a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

artículo científico publicado en 2019

[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice

artículo científico publicado en 2010